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压缩机技术 2024年第2期 53-55,32页

作者：肖海燕中石化石油机械股份有限公司三机分公司湖北武汉430000

以某储气库压缩机为研究对象,分析气阀结构及阀片材料性能,根据工况参数开展气阀的运动状态模拟,设计出阀片运动规律仿真可视化图形用户输入界面,实时显示计算结果及阀片运动模拟曲线,降低研究开发的成本,为储气库气阀可靠性设计提供参考。

关键词：储气库压缩机气阀运动规律

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考研学生抑郁情绪干预的个案研究

山西大同大学学报（社会科学版） 2024年第3期38卷 151-154页

作者：马志强肖海雁梁晓燕苗小翠牛超山西大同大学煤炭工程学院山西大同037003 山西大同大学心理健康教育与咨询中心山西大同037009 山西大学教育科学学院山西太原030006 山西大同大学机电工程学院山西大同037003

为帮助某高校1名考研学生缓解抑郁或抑郁情绪,采用理性情绪疗法、系统脱敏法和森田疗法对其进行4个阶段共11次咨询;采用抑郁自评量表(SDS)、焦虑自评表(SAS)、强迫量表(Y-BOCS)进行测量,结合自评、社会功能恢复、他评、心理测量结果进... 详细信息

为帮助某高校1名考研学生缓解抑郁或抑郁情绪,采用理性情绪疗法、系统脱敏法和森田疗法对其进行4个阶段共11次咨询;采用抑郁自评量表(SDS)、焦虑自评表(SAS)、强迫量表(Y-BOCS)进行测量,结合自评、社会功能恢复、他评、心理测量结果进行咨询效果评估;结果显示,通过心理咨询,A某抑郁情绪状况、社会功能及强迫思维都有明显改善。最后对咨询过程进行反思,以期探索考研学生抑郁情绪干预新路径,为后续有针对性的干预提供参考。

关键词：考研学生抑郁情绪干预

Oral Arsenic-Containing Qinghuang Powder:A Potential Drug for Myelodysplastic Syndromes

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Chinese Journal of Integrative Medicine 2022年第8期28卷 762-768页

作者： MING Jing LIU Wei-yi xiao hai-yan XU Yong-gang MA Rou HU xiao-mei Department of Hematology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China

Qinghuang Powder(QHP),an oral arsenic,has become an effective drug in the treatment of myelodysplastic syndromes(MDS)in Xiyuan Hospital,China Academy of Chinese Medical Sciences for many years,and the action mechanism of the compound or active ingredient AsSof QHP has been *** the relatively safety,chemotherapy-free and convenient oral profile,QHP is widely used in the clinical treatment for MDS patients,especially for elderly *** this review,the authors document the efficacy and safety of oral arsenic-containing compound QHP in the treatment of MDS,with a special focus on the association of efficacy of QHP with the cytogenetics,prognostic risk,DNA methylation,gene mutation,blood arsenic concentration,mechanism of action of AsSand the countermeasures against adverse reactions of gastrointestinal tract.

关键词： arsenic Qinghuang Powder myelodysplastic syndromes review Chinese medicine

Comparing Arsenic-Containing Qinghuang Powder and Low-Intensity Chemotherapy in Elderly Patients with Acute Myeloid Leukemia

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Chinese Journal of Integrative Medicine 2023年第9期29卷 832-837页

作者： WU Yu-he xiao hai-yan QUAN Ri-cheng TANG Xu-dong LIU Wei-yi LYU yan CHEN Zhuo LIU Chi HU xiao-mei Department of Hematology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China Graduate School China Academy of Chinese Medical SciencesBeijing100700China

Objective To compare the clinical effect of arsenic-containing Qinghuang Powder(QHP)and low-intensity chemotherapy(LIC)in treatment of elderly acute myeloid leukemia(eAML)*** Clinical data of 80 eAML patients treated at Xiyuan Hospital of China Academy of Chinese Medical Sciences from January 2015 to December 2020 were retrospectively *** treatment scheme was designed by real world study according to patients’preference,and patients were divided into a QHP group(35 cases)and a LIC group(45 cases).The median overall survival(mOS),1-,2-,and 3-year OS rates,and incidence of adverse events were compared between the two *** The mOS of 80 patients was 11 months,and the 1-,2-,and 3-year OS rates were 45.51%,17.96%,and 11.05%,*** QHP and LIC groups demonstrated no significant difference in mOS(12 months vs.10 months),1-(48.57%vs.39.65%),2-(11.43%vs.20.04%),and 3-year OS rates(5.71%vs.13.27%,all P>0.05).Moreover,the related factors of mOS demonstrated no significant difference in patients with age>75 years(11 months vs.8 months),secondary AML(11 months vs.8 months),poor genetic prognosis(9 months vs.7 months),Eastern Cooperative Oncology Group performance status score≥(10 months vs.7 months)and hematopoietic stem cell transplant comorbidity index≥4(11 months vs.7 months)between the QHP and LIC groups(all P>0.05).However,the incidence of myelosuppression was significantly lower in the QHP group than that in the LIC group(28.57%vs.73.33%,P<0.01).Conclusions QHP and LIC had similar survival rates in eAML patients,but QHP had a lower myelosuppression ***,QHP can be an alternative for eAML patients who do not tolerate LIC.

关键词： acute myeloid leukemia elderly Qinghuang Powder low-intensity chemotherapy Chinese medicine

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箱式集成高转速往复式压缩机扭转振动分析

内燃机与配件 2024年第12期 50-52页

作者：肖海燕徐周旋王麟吴泽宁中石化石油机械股份有限公司三机分公司湖北武汉430000

针对气驱采油用往复式压缩机需要服务不同注气井口、排气压力高、管线布局复杂等问题,开展了高转速气驱采油箱式集成压缩机设计研究。首先进行了往复式压缩机选型,确定压缩机型号;然后建立了电机-联轴器-压缩机扭振分析模型,确定曲轴转... 详细信息

针对气驱采油用往复式压缩机需要服务不同注气井口、排气压力高、管线布局复杂等问题,开展了高转速气驱采油箱式集成压缩机设计研究。首先进行了往复式压缩机选型,确定压缩机型号;然后建立了电机-联轴器-压缩机扭振分析模型,确定曲轴转动惯量和扭转刚度;最后对压缩机轴系进行了扭振分析,优化了联轴器、飞轮转动惯量,避免了轴系共振。该研究成果弥补了国内油气开发需要35~52MPa增压设备的空白。

关键词：气驱采油往复式压缩机扭转振动

Text mining and data analysis identify potential drugs and pathways for polycystic ovary syndrome treatment

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生殖与发育医学(英文) 2024年第1期08卷 32-38页

作者： Yuan xiao-Jing Wang yan yang hai-yan Zhao Bin Medical Reproductive Center People’s Hospital of Jiuquan City 3. Jiuquan 735000 4. China Department of Gynecological Oncology The Fourth Affiliated Hospital of Guangxi Medical University 7. Liuzhou 545000 8. Xiamen Health and Medical Big Data Center 9. Xiamen 361001

Objective: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. This study aimed to use text mining and microarray data analysis to identify drugs that target genes and potential pathways associated with ***: We extracted a common set of genes associated with PCOS using text mining and the microarray dataset GSE48301. Next, we performed Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of these genes, as well as protein–protein interaction (PPI) network analysis. Additionally, we used MCODE and cytoHubba to cluster significant common genes in the PPI network and performed gene–drug interaction analyses to identify potential drugs for further investigation. Finally, we annotated pathways associated with the genes ***: Text mining and microarray analysis yielded 696 text mining genes (TMGs) and 2804 differentially expressed genes (DEGs). Among these, a set of 77 genes was found in both TMGs and DEGs. Interestingly, 67 of these genes participated in constructing the PPI network. Seven common hub genes were selected using the MCODE and CytoHubba methods. Finally, five out of seven genes were targeted by 15 existing ***: Four genes (FASLG, IL13, IL17A, andIL2RA), which are mainly related to the cytokine–cytokine receptor interaction pathway, could be prioritized as targets for PCOS.

关键词： Text mining Differentially expressed genes Polycystic ovary syndrome Drug discovery

Multi-endpoint assays reveal more severe toxicity induced by chloraminated effluent organic matter than chloraminated natural organic matter

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Journal of Environmental Sciences 2024年第1期135卷 310-317页

作者： hai-yan Wang De-Xiu Wu Ye Du xiao-Tong Lv Qian-Yuan Wu State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China Environmental Protection Key Laboratory of Microorganism Application and Risk Control Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental SafetyTsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China College of Architecture and Environment Sichuan UniversityChengdu 610000China

Disinfection by chloramination produces toxic byproducts and the difference in toxicity of reclaimed and drinking water treated by chloramination remains *** study investigated cytotoxic effects at the same concentrations of dissolved organic matter and showed that chloraminated effluent organic matter(EfOM)induced 1.7 times higher cytotoxicity than chloraminated natural organic matter(NOM)applied to simulate drinking *** EfOM induced more reactive nitrogen species than chloraminated NOM,and chloraminated EfOM and NOM induced similar and higher levels of reactive oxygen species than the negative control,***,intracellular macromolecule damage indicated by DNA/RNA damage marker 8–hydroxy-(deoxy)guanosine and the intracellular protein carbonyl concentration induced by chloraminated EfOM was higher and slightly more than that induced by chloraminated NOM,*** data were consistent with the effects on cell physiological *** cycle arrest mainly occurred in G2 phase by chloraminated EfOM and *** apoptotic cells,which could return to normal,increased upon exposure to high concentrations of chloraminated EfOM and ***,necrotic cells were significantly increased from 0.5%to 2.5%when the concentration increased from 20-to 60-fold chloraminated EfOM,but were not obviously changed by chloraminated *** results indicated that the comprehensive intracellular changes induced by toxic substances in chloraminated EfOM were more irreversible and induced more cell death than chloraminated NOM.

关键词： Cytotoxicity Intracellular active nitrogen/oxygen Intracellular oxidative damage Cell necrosis Reclaimed water

Research on casing deformation prevention technology based on cementing slurry system optimization

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Petroleum Science 2024年第2期21卷 1231-1240页

作者： yan yan Meng Cai Wen-hai Ma xiao-Chuan Zhang Li-Hong Han Yong-Hong Liu State Key Laboratory for Performance and Structure Safety of Petroleum Tubular Goods and Equipment Materials CNPC Tubular Goods Research InstituteXi©an710077ShaanxiChina College of Mechanical and Electrical Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Shale Gas Evaluation and Exploitation Key Laboratory of Sichuan Province Chengdu610095SichuanChina CNPC Daqing Oilfield Company Daqing163453HeilongjiangChina

The casing deformation prevention technology based on the optimization of cement slurry is proposed to reduce the casing deformation of shale oil and gas wells during hydraulic fracturing. In this paper, the fracture mechanism of hollow particles in cement sheath was firstly analyzed by discrete element method, and the effect of hollow particles in cement on casing deformation was investigated by laboratory experiment method. Finally, field test was carried out to verify the improvement effect of the casing deformation based on cement slurry modification. The results show that the formation displacement can be absorbed effectively by hollow particles inside the cement transferring the excessive deformation away from casing. The particles in the uncemented state provide deformation space during formation slipping. The casing with diameter of 139.7 mm could be passed through by bridge plug with the diameter of 99 mm when the mass ratio of particle/cement reaches 1:4. According to the field test feedback, the method based on optimization of cement slurry can effectively reduce the risk of casing deformation, and the recommended range of hollow microbeads content in the cement slurry is between 15% and 25%.

关键词： Cement slurry Hollow ceramsite Casing deformation Formation slip Field test

Computed tomography-based radiomics combined with machine learning allows differentiation between primary intestinal lymphoma and Crohn's disease

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World Journal of Gastroenterology 2024年第25期30卷 3155-3165页

作者： Meng-Jun xiao Yu-Teng Pan Jia-He Tan hai-Ou Li hai-yan Wang Department of Radiology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250000Shandong ProvinceChina University of California DavisCA 95616United States Qilu Hospital Cheeloo College of MedicineShandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND Due to similar clinical manifestations and imaging signs,differential diagnosis of primary intestinal lymphoma(PIL)and Crohn's disease(CD)is a challenge in clinical *** To investigate the ability of radiomics combined with machine learning methods to differentiate PIL from *** We collected contrast-enhanced computed tomography(CECT)and clinical data from 120 patients form center 1.A total of 944 features were extracted singlephase images of CECT *** the last absolute shrinkage and selection operator model,the best predictive radiographic features and clinical indications were *** from 54 patients were collected at center 2 as an external validation set to verify the robustness of the *** area under the receiver operating characteristic curve,accuracy,sensitivity and specificity were used for *** A total of five machine learning models were built to distinguish PIL from *** on the results from the test group,most models performed well with a large area under the curve(AUC)(>0.850)and high accuracy(>0.900).The combined clinical and radiomics model(AUC=1.000,accuracy=1.000)was the best model among all *** Based on machine learning,a model combining clinical data with radiologic features was constructed that can effectively differentiate PIL from CD.

关键词： Primary intestinal lymphoma Crohn's disease Radiomics Machine learning Diagnosis

Associations between Geriatric Nutrition Risk Index,bone mineral density and body composition in type 2 diabetes patients

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World Journal of Diabetes 2024年第3期15卷 403-417页

作者： xiao-xiao Zhu Kai-Feng Yao hai-yan Huang Li-Hua Wang Department of Pediatrics The Second Affiliated Hospital of Nantong UniversityFirst People’s Hospital of Nantong CityNantong 226001Jiangsu ProvinceChina Department of Nursing The Second Affiliated Hospital of Nantong UniversityFirst People’s Hospital of Nantong CityNantong 226001Jiangsu ProvinceChina Department of Endocrinology The Second Affiliated Hospital of Nantong UniversityFirst People’s Hospital of Nantong CityNantong 226001Jiangsu ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM),a fast-growing issue in public health,is one of the most common chronic metabolic disorders in older *** and sarcopenia are highly prevalent in T2DM patients and may result in fractures and *** people with T2DM,the association between nutrition,sarcopenia,and osteoporosis has rarely been *** To evaluate the connections among nutrition,bone mineral density(BMD)and body composition in patients with *** We enrolled 689 patients with T2DM for this cross-sectional *** patients underwent dual energy X-ray absorptiometry(DXA)examination and were categorized according to baseline Geriatric Nutritional Risk Index(GNRI)values calculated from serum albumin levels and body *** GNRI was used to evaluate nutritional status,and DXA was used to investigate BMD and body *** forward linear regression analysis was used to identify the factors associated with BMD and skeletal muscle mass *** Of the total patients,394 were men and 295 were *** with patients in tertile 1,those in tertile 3 who had a high GNRI tended to be younger and had lower HbA1c,higher BMD at all bone sites,and higher appendicular skeletal muscle index(ASMI).These important trends persisted even when the patients were divided into younger and older *** GNRI was positively related to ASMI(men:r=0.644,P<0.001;women:r=0.649,P<0.001),total body fat(men:r=0.453,P<0.001;women:r=0.557,P<0.001),BMD at all bone sites,lumbar spine(L1-L4)BMD(men:r=0.110,P=0.029;women:r=0.256,P<0.001),FN-BMD(men:r=0.293,P<0.001;women:r=0.273,P<0.001),and hip BMD(men:r=0.358,P<0.001;women:r=0.377,P<0.001).After adjustment for other clinical parameters,the GNRI was still significantly associated with BMD at the lumbar spine and femoral ***,a low lean mass index and higherβ-collagen special sequence were associated with low BMD at all bone *** was negatively correlated with

关键词： Geriatric Nutrition Risk Index Bone mineral density Skeletal muscle mass Type 2 diabetes