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Chinese Physics Letters 1998年第6期15卷 395-397页

作者： WANG xiao-guang YU rong-jin fu Jian-zheng Laboratory of Excited State Processes Changchun Institute of PhysicsChinese Academy of SciencesChangchun 130021 Department of Computer Engineering Changchun UniversityChangchun 130022

By factorizing a general one-bit transformation matrix for one-bit gates in quantum computer,a general unitary transformation is constructed,which can serve as(controlled)^(m) gate for the conditional quantum *** the quantized single-mode electromagnetic field containing n or no photons acts as the controlled bit,the quantum controlled-NOT gates and square root of the controlled-NOT gates in cavity-quantum electrodynamics are realized.

关键词： dynamics quantum Transformation

Convergence Rates of Tail Probabilities for Sums under Dependence Assumptions

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Acta Mathematica Sinica,English Series 2010年第8期26卷 1591-1600页

作者： xiao rong YANG Wei Dong LIU Ke Ang fu Lin Xin ZHANG School of Statistics and Mathematics Zhejiang Gongshang University Hangzhou 310018 P. R. China Department of Mathematics Zhejiang University Hangzhou 310027 P. R. China School of Statistics and Mathematics Zhejiang Gongshang University Han qzhou 310018 P. R. China

Let {X,X1,X2,……}be a zero mean strictly stationary Ф-mixing sequence. Set Sn=∑n k=1 and f（x^p）=∑∞n=1 n^r-2P（｜Sn｜≥x^p√ES2nlog n）,When ε〉（√2）1/p,for p〉1/2 and r〉1,the conditions for ∫∞ε f（x^p）dx 〈∞ to hold is established, by using coupled methods together withstrong approximation, which are different from the traditional symmetrization and Hoffman-JФrgensen inequality.

关键词： Complete convergence mixing sequences strong approximation

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CT导引经皮穿刺热化疗治疗肺、肝恶性肿瘤

实用放射学杂志 2001年第11期17卷 831-833页

作者：朱毅黄迪生贺国庆沈兰孙明沂付晓蓉吉加银四川省绵阳市中心医院放射科四川省绵阳市中心医院放射科四川绵阳621000

目的　评价CT导引下 ,经皮穿刺热化疗治疗肺、肝恶性肿瘤的价值。方法　 2 1例肝癌、肺癌和肝、肺转移癌患者行肿块热化疗。将化疗药物加热至 5 5～ 6 0℃ ,在CT引导下注入肿块内 ,注入量根据V =4/ 3π(r +0 .5 )cm3 t适当增减。重复治... 详细信息

目的　评价CT导引下 ,经皮穿刺热化疗治疗肺、肝恶性肿瘤的价值。方法　 2 1例肝癌、肺癌和肝、肺转移癌患者行肿块热化疗。将化疗药物加热至 5 5～ 6 0℃ ,在CT引导下注入肿块内 ,注入量根据V =4/ 3π(r +0 .5 )cm3 t适当增减。重复治疗 2～ 5次 ,并依治疗前后CT扫描密度和大小的变化以及生化指标、生存期作为疗效观察标准 ,治疗效果分为五级 :效佳、显效、有效、效差、无效。结果　效佳 6例 ,显效 9例 ,有效 3例 ,效差 2例 ,无效 1例 ,随访观察时间为 36个月 2 0例 ,病员生存时间 8～ 2 2个月 ,平均生存时间 16个月 ,1例病员结合肝动脉栓塞治疗 ,存活 2 8个月仍健在。治疗总有效率为 95 .2 %。结论　CT导引下经皮穿刺热化疗是治疗肺、肝恶性肿瘤的有效方法 ,尤其适合于不能手术切除的病人 ,结合肝动脉栓塞可提高疗效。

关键词：热化疗肿瘤治疗体层摄影,X线计算机

Recent advances in theoretical models of respiratory mechanics

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Acta Mechanica Sinica 2012年第1期28卷 1-7页

作者： Bo Huo Rui-rong fu Key Laboratory of Microgravity&Center for Biomechanicsand Bioengineering Institute of Mechanics Chinese Academy of Sciences100190 BeijingChina

As an important branch of biomedical engineering, respiratory mechanics helps to understand the physiology of the respiratory system and provides fundamental data for developing such clinical technologies as ventilators. To solve different clinical problems, researchers have developed numerous models at various scales that describe biological and mechanical properties of the respiratory system. During the past decade, benefiting from the continuous accumulation of clinical data and the dramatic progress of biomedical technologies （e.g. biomedical imaging）, the theoretical modeling of respiratory mechanics has made remarkable progress regarding the macroscopic properties of the respiratory process, complexities of the respiratory system, gas exchange within the lungs, and the coupling interaction between lung and heart. The present paper reviews the advances in the above fields and proposes potential future projects.

关键词： Respiratory mechanics Biomechanics Gas exchange

羟胺类Schiff碱及Cu(II)配合物的合成、表征与抑菌活性研究

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石河子大学学报（自然科学版） 2008年第2期26卷 171-174页

作者：肖芙蓉高英王运华马祥林冯春环石河子大学化学化工学院

采用香草醛、水杨醛和对羟基苯甲醛,以无水甲醇为溶剂,分别与盐酸羟胺反应,合成羟胺类Schiff碱配体,并用3种配体与乙酸铜(Ⅱ)合成配合物。通过元素分析、红外光谱、质谱、紫外-可见光谱、电导和热分析等测试手段对化合物进行了表征,确... 详细信息

采用香草醛、水杨醛和对羟基苯甲醛,以无水甲醇为溶剂,分别与盐酸羟胺反应,合成羟胺类Schiff碱配体,并用3种配体与乙酸铜(Ⅱ)合成配合物。通过元素分析、红外光谱、质谱、紫外-可见光谱、电导和热分析等测试手段对化合物进行了表征,确定了组成。同时,对Schiff碱配体及其相应配合物进行了抑菌活性实验,结果表明:配体和Cu(Ⅱ)配合物对大肠杆菌、枯草杆菌和八叠球菌均有一定的抑制作用,而且配合物比相应配体的抑菌活性强,其中水杨醛缩盐酸羟胺合铜对枯草杆菌抑菌效果最佳。

关键词： Schiff碱 Cu(Ⅱ)配合物合成抑菌活性

SARS-CoV-2 infection in infants under 1 year of age in Wuhan City, China

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World Journal of Pediatrics 2020年第3期16卷 260-266页

作者： Dan Sun Xue Chen Hui Li xiao-Xia Lu Han xiao fu-rong Zhang Zhi-Sheng Liu Department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Hematology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina Department of Respiratory Diseases Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Institute of Maternal and Child Health Wuhan Children's HospitalTongji Medical CollegeHuazhong University and TechnologyWuhanChina Department of Intensive Care Unit Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Background The clinical characteristics and outcome of COVID-19 in children are different from those in *** aimed to describe the characteristics of infants under 1 year of age (excluding newborns) with *** We retrospectively retrieved data of 36 infants with SARS-CoV-2 infection in Wuhan Children's Hospital from January 26 to March 22,*** features,chest imaging findings,laboratory tests results,treatments and clinical outcomes were *** The mean age of the infected infants was 6.43 months,with a range of 2-12 months.61.11% of the patients were males and 38.89% females.86.11% of the infants were infected due to family *** (77.78%) and fever (47.22%) were the most common clinical *** CT scan revealed 61.11% bilateral pneumonia and 36.11% unilateral pneumonia.47.22% of the infants developed *** leucocytes,neutrophils,lymphocytes,and thrombocytes were observed in 11.11,8.33,36.11 and 44.44% of infants,*** leucocytes,neutrophils,thrombocyte and hemoglobin were observed in 8.33,19.44,2.78 and 36.11% of infants,*** C-reactive protein,procalcitonin,lactate dehydrogenase,alanine aminotransferase,creatine kinase and D-dimer were observed in 19.44,67.74,47.22,19.44,22.22 and 20.69% of infants,*** one infant had a high level of ***-infections with other respiratory pathogens were observed in 62.86% of ***3 (20.69%),CD4 (68.97%),CD19 (31.03%) and Th/Ts (44.83%) were elevated;CD8 (6.9%) and CD16+CD56 (48.28%) was ***-4 (7.69%),IL-6 (19.23%),IL-10 (50%),TNF-α (11.54%) and IFN-γ (19.23%) were *** to March 22,97.22% of infants recovered,while a critical ill infant *** the infant's condition deteriorates rapidly,lymphocytopenia was ***,C-reactive protein,D-dimer,alanine aminotransferase,creatine kinase,creatinine,IL-6 and IL-10 increased *** In the cohort,we discover

关键词： COVID-19 Coronavirus infant infection SARS-CoV-2

添加腐植酸与生化抑制剂的稳定性增效尿素在黑土中的施用效果

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中国土壤与肥料 2022年第8期 47-55页

作者：肖富容李东坡薛妍宋玉超张可李永华郑野张金明崔永坤中国科学院沈阳应用生态研究所辽宁沈阳110016 中国科学院大学北京100049 北方华锦化学工业集团有限公司辽宁盘锦124021 锦西天然气化工有限责任公司辽宁葫芦岛125001 中国科学院沈阳生态实验站辽宁沈阳110107

研究同时添加生化抑制剂与生物刺激素腐植酸的稳定性增效尿素在黑土中的施用效果,明确在黑土中生物刺激素腐植酸与生化抑制剂结合对尿素态氮转化的调控作用,为研究适宜黑土的生物刺激素腐植酸与生化抑制剂结合的稳定性增效尿素专用配方... 详细信息

研究同时添加生化抑制剂与生物刺激素腐植酸的稳定性增效尿素在黑土中的施用效果,明确在黑土中生物刺激素腐植酸与生化抑制剂结合对尿素态氮转化的调控作用,为研究适宜黑土的生物刺激素腐植酸与生化抑制剂结合的稳定性增效尿素专用配方提供理论依据。试验以不施氮肥(CK)及施用普通尿素(N)为对照,在尿素中分别添加腐植酸(H)、脲酶抑制剂N-丁基硫代磷酰三胺(NBPT)、硝化抑制剂3,4-二甲基吡唑磷酸盐(DMPP)、2-氯-6(三氯甲基)-吡啶(CP)以及各生化抑制剂与腐植酸组合,共9个处理。通过盆栽试验,监测不同处理的土壤铵态氮、硝态氮、玉米生物学指标、产量,计算土壤硝化抑制率、玉米籽粒吸氮量、玉米植株总吸氮量及尿素肥料氮利用率等指标。结果表明,相比单独施用尿素肥料,腐植酸及生化抑制剂NBPT、DMPP、CP的添加均能显著提高玉米产量、吸氮量、氮肥利用效率等,同时对土壤铵态氮及硝态氮含量有显著影响(P<0.05)。施用添加腐植酸与NBPT尿素处理相比单独添加NBPT尿素处理显著提高了玉米苗期黑土硝化抑制率、玉米株高及叶片叶绿素含量,分别提高14.03%、6.31%、3.22%,但玉米产量、植株吸氮量、氮肥利用效率、玉米茎粗及叶面积均有所下降。施用添加腐植酸与DMPP的尿素处理相比单独添加DMPP尿素处理的玉米株高、叶绿素含量分别提高7.97%、20.17%,显著降低玉米苗期黑土硝化抑制率、玉米产量、经济系数、籽粒吸氮量、叶面积,同时植株总吸氮量、氮肥利用率及茎粗有所降低(P<0.05)。施用添加腐植酸与CP的尿素处理相比单独添加CP尿素处理显著提高玉米产量、叶绿素含量、总吸氮量、氮肥利用效率(P<0.05),玉米株高、玉米籽粒吸氮量也均有提高,但玉米茎粗及叶面积有所下降(P<0.05)。在黑土中,施用添加腐植酸与CP的尿素处理可以提高玉米产量、植株吸氮量、玉米株高、叶片叶绿素含量和肥料利用率。施用添加NBPT、DMPP与腐植酸配合的尿素处理降低玉米产量、植株吸氮量、氮肥利用效率,不利于玉米产量的增加及肥料利用率的提高。在黑土玉米种植区,氮肥管理建议将腐植酸与CP结合制成新型高效稳定性增效尿素肥料施用,有利于玉米的增产及尿素肥料利用率的提高,避免将腐植酸与NBPT、DMPP配合使用。

关键词：生物刺激素腐植酸脲酶抑制剂硝化抑制剂氮肥利用率

Synthesis and cytotoxicity evaluation of 3-amino-2-hydroxypropoxygenistein derivatives

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Chinese Journal of Natural Medicines 2017年第11期15卷 871-880页

作者： GENG xiao-Ting TANG Jing-Jing CHENG Kun-Peng fu Yuan-Tao HU rong LU Jin-rong Department of Organic Chemistry China Pharmaceutical University Nanjing 210009 China State Key Laboratory of Natrual Medicines Department of Phystology Chma Pharmaceutzcal University Nanjing 210009China

Soy isoflavones exhibit various biological activities, such as antioxidant, anti-tumor, anti-inflammatory, and cardiovascular protective effects. The present study was designed to investigate the effects of sixteen synthesized 3-amino-2-hydroxypropoxy genistein derivatives on cell proliferation and activation of Nrf2(Nuclear factor erythroid 2-related factor 2)/ARE(antioxidant response elements) pathway in human cancer cell lines. Most of the tested compounds exerted greater cytotoxic activity than genistein, as measured by MTT assay. Moreover, compound 8 c showed the highest ARE-luciferase reporter activity among the test compounds. It strongly promoted Nrf2 nuclear translocation and up-regulated the expression of total Nrf2 and downstream targets NQO-1 and HO-1 at protein level. The present study may provide a basis for the application of isoflavone derivatives as Nrf2/ARE pathway inducers for cancer therapy and cancer prevention.

关键词： Genistein derivatives Nrf2/ARE pathway Cytotoxicity Anti-cancer Isoflavone

Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center's observational study

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World Journal of Pediatrics 2020年第3期16卷 251-259页

作者： Dan Sun Hui Li xiao-Xia Lu Han xiao Jie Ren fu-rong Zhang Zhi-Sheng Liu Department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Hematology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Intensive Care Unit Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Institute of Maternal and Child Health Wuhan Children's HospitalTongji Medical CollegeHuazhong University and TechnologyWuhan 430015China

Background An outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 was first detected in Wuhan,Hubei,*** of all ages are susceptible to SARS-CoV-2 *** information on severe pediatric patients with COVID-19 has been *** aimed to describe the clinical features of severe pediatric patients with *** We included eight severe or critically ill patients with COVID-19 who were treated at the Intensive Care Unit (ICU),Wuhan Children's Hospital from January 24 to February *** collected information including demographic data,symptoms,imaging data,laboratory findings,treatments and clinical outcomes of the patients with severe *** The onset age of the eight patients ranged from 2 months to 15 years;six were *** most common symptoms were polypnea (8/8),followed by fever (6/8) and cough (6/8).Chest imaging showed multiple patch-like shadows in seven patients and ground-glass opacity in *** findings revealed normal or increased whole blood counts (7/8),increased C-reactive protein,procalcitonin and lactate dehydrogenase (6/8),and abnormal liver function (4/8).Other findings included decreased CD16 + CD56 (4/8) and Th/Ts*(1/8),increased CD3 (2/8),CD4 (4/8) and CD8 (1/8),IL-6 (2/8),IL-10 (5/8) and IFN-γ (2/8).Treatment modalities were focused on symptomatic and respiratory *** critically ill patients underwent invasive mechanical *** to February 24,2020,three patients remained under treatment in ICU,the other five recovered and were discharged *** In this series of severe pediatric patients in Wuhan,polypnea was the most common symptom,followed by fever and *** imaging changes included multiple patch-like shadows and ground-glass opacity;and a cytokine storm was found in these patients,which appeared more serious in critically ill patients.

关键词： Children COVID-19 Novel coronavirus 2019-nCoV Severe Critical ill Wuhan

Rate efect and coupled evolution of atomic motions and potential landscapes

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Acta Mechanica Sinica 2013年第5期29卷 676-681页

作者： Pan xiao Jun Wang rong Yang fu-Jiu Ke Meng-Fen Xia Yi-Long Bai State Key Laboratory of Nonlinear Mechanics (LNM) Institute of Mechanics Chinese Academy of Sciences School of Physics and Nuclear Energy Engineering Beihang University

Since rate effect of materials plays a key role in impact engineering, the microscopic mechanism of rate effect is investigated at molecular level in this paper. The results show that rate effect on the strength of atomic system is closely related to the coupled evolution of atomic motions and potential landscapes. Accordingly, it becomes possible to develop a new algorithm of molecular simulation, which could properly and efficiently demonstrate strain rate effect under a wide range of loading rates and unveil the mecha- nisms underlying the strain rate effects.

关键词： Strain rate effect Atomic motions - Potential landscape Molecular simulation