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Isorhamnetin Downregulates MMP2 and MMP9 to Inhibit Development of Rheumatoid Arthritis through SRC/ERK/CREB Pathway

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Chinese Journal of Integrative Medicine 2024年第4期30卷 299-310页

作者： liU xiao-rong li Shuo-fu mei Wen-ya liU Xiang-dan ZHOU Ri-bao College of Pharmacy Hunan University of Chinese MedicineChangsha(410208)China Department of Orthopaedics The First Hospital of Hunan University of Chinese MedicineChangsha(410007)China

Objective To investigate the effect of isorhamnetin on the pathology of rheumatoid arthritis(RA).Methods Tumor necrosis factor(TNF)-α-induced fibroblast-like synoviocytes(FLS)was exposed to additional isorhamnetin(10,20 and 40µmol/L).Overexpression vectors for matrix metalloproteinase-2(MMP2)or MMP9 or SRC were transfected to explore their roles in isorhamnetin-mediated RA-FLS ***-FLS viability,migration,and invasion were ***,a collagen-induced arthritis(CIA)rat model was *** were randomly divided to sham,CIA,low-,medium-,and high-dosage groups using a random number table(n=5 in each group)and administed with normal saline or additional isorhamnetin[2,10,and 20 mg/(kg·day)]for 4 weeks,*** index was calculated and synovial tissue inflammation was determined in CIA *** levels of MMP2,MMP9,TNF-α,interleukin-6(IL-6),and IL-1β,as well as the phosphorylation levels of SRC,extracellular regulated kinase(ERK),and cyclic adenosine monophosphate response element-binding(CREB),were detected in RA-FLS and synovial *** docking was also used to analyze the binding of isorhamnetin to *** In in vitro studies,isorhamnetin inhibited RA-FLS viability,migration and invasion(Plity,migration and invasion,as well as the negative regulation of MMP2 and MMP9(P<0.05).In in vivo studies,isorhamnetin decreased arthritis index scores(P<0.05)and alleviated synovial *** reduced the levels of MMP2,MMP9,TNF-α,IL-6,and IL-1β,as well as the phosphorylation of SRC,ERK,and CRE

关键词： rheumatoid arthritis isorhamnetin SRC/ERK/CREB matrix metalloproteinase

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Toward Improved Accuracy in Quasi-Static Elastography Using Deep Learning

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Computer Modeling in Engineering & Sciences 2024年第4期139卷 911-935页

作者： Yue mei Jianwei Deng Dongmei Zhao Changjiang xiao Tianhang Wang li Dong Xuefeng Zhu Department of Engineering Mechanics State Key Laboratory of Structural Analysis for Industrial EquipmentDalian University of TechnologyDalian116023China International Research Center for Computational Mechanics Dalian University of TechnologyDalian116023China DUT-BSU Joint Institute Dalian University of TechnologyDalian116023China Department of Automotive Engineering Tongji UniversityShanghai201804China *** SeattleWA98109USA School of Automotive Engineering Dalian University of TechnologyDalian116023China

Elastography is a non-invasive medical imaging technique to map the spatial variation of elastic properties of soft *** quality of reconstruction results in elastography is highly sensitive to the noise induced by imaging measurements and *** address this issue,we propose a deep learning(DL)model based on conditional Generative Adversarial Networks(cGANs)to improve the quality of nonhomogeneous shear modulus *** train this model,we generated a synthetic displacement field with finite element simulation under known nonhomogeneous shear modulus *** the simulated and experimental displacement fields are used to validate the proposed *** reconstructed results demonstrate that the DL model with synthetic training data is able to improve the quality of the reconstruction compared with the well-established optimization ***,we emphasize that our DL model is only trained on synthetic *** might provide a way to alleviate the challenge of obtaining clinical or experimental data in ***,this work addresses several fatal issues in applying the DL technique into elastography,and the proposed method has shown great potential in improving the accuracy of the disease diagnosis in clinical medicine.

关键词： Nonhomogeneous elastic property distribution reconstruction deep learning finite element method inverse problem elastography conditional generative adversarial network

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Geological features and genesis of Gaotaigou borate deposit, Jilin, China

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Journal of Geoscientific Research in Northeast Asia 2005年第1期8卷 65-71页

作者： xiao li-mei SUN Feng-yue College of Earth Sciences Jilin University Changchun 130061 Jilin China

Gaotaigou borate deposit in Ji'an area, southeastern Jilin, is located in the easten end of liaoning-Jilin (liaoji)Proterozoic paleo-rift, which is a medium-sized deposit and makes up 67% of the total borate reserves in Jilin *** original borate ore bodies were formed by sedimentary exhalative process in Paleoproterozoic, but were activated and enriched by later metamorphism. In late stage of metamorphism, hydrothermal fluid of metamorphic origin made wallrocks be altered and the borate ore bodies be reformed. Ore bodies are strictly controlled by strata and their lithologies. In addition, the shape and spatial distribution of ore bodies are also defined by the Gaotaigou syncline. Combined with the ore-controlling factors and mineralizing features, it has been proposed that Gaotaigou borate deposit is a metamorphosed and hydrothermally altered sedimentary exhalative deposit.

关键词： Gaotaigou borate deposit ascharite metamorphism liaoji Paleo-rift genesis of deposit

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Top-down Approach for Fabrication of Polymer Microspheres by Interfacial Engineering

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Chinese Journal of Polymer Science 2020年第12期38卷 1286-1293页

作者： Yue Fan De-Hui Wang Jin-Long Yang Jia-Ning Song xiao-mei li Cheng-lin Zhang Dong-Sheng Wang Long-Quan Chen Jia-Xi Cui Xu Deng Institute of Fundamental and Frontier Sciences Universityof Electronic Science and Technology of ChinaChengdu 610054China Deportment of Physics at Interfaces Max Planck Institute for Polymer ResearchAckermannweg 1055128MainzGermany School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinoChengdu 670054Chino School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China

Polymer microspheres with uniform size,composition,and surface property have gained extensive researches in past *** bottom-up approaches are using monomers or oligomers to build up desired polymer ***,directly shaping high-molecular-weight polymers into well-ordered polymer microspheres remains a great ***,we reported a facile and efficient top-down approach tofabricate microspheres with high-molecular-weight polymer *** harnessing interfacial engineering-control during the polymer microspheres formation,uniformly sized microspheres could be produced with widely ranged diameters(from 10μm to the capillary length of each polymer melt).The size limitation of this approach could be further extended by a controllable Plateau-Rayleigh instability ***,the top-down approach allows fabrication of microspheres by various polymer melts with surface energy higher than 25 mN/*** work paves a way for green,cost-effective,and customizable production of a variety of functional polymer microspheres without any chemical reaction assistant.

关键词： Superamphiphobic surfaces Microfluidic spinning Microfibers Microspheres

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Congener-derived template to construct lithiophilic organic-inorganic layer/interphase for high volumetric capacity dendrite-free li metal batteries

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Chinese Chemical Letters 2024年第3期35卷 453-460页

作者： Kang Yang Long li Yuanbin xiao Qiaoli Zhang Chenpeng Xi Borong li Yan Yu Chengkai Yang Key Laboratory of Advanced Materials Technologies International(HongKong Macao and Taiwan)Joint Laboratory on Advanced Materials TechnologiesCollege of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China

The development of lithium-metal batteries(LMBs)is seriously restricted by the out-of-control dendrites growth and infinite volume ***,a pervasive organic-inorganic layer construction strategy is reported for the composite lithium metal anode with congener-derived organic-inorganic solid electrolyte interphase(SEI).In this strategy,the organic-inorganic Ag@polydopamine(Ag@PDA)layer is coated on the arbitrary substrates by a simple two-step *** thin and stable congener-derived SEI is insitu formed with fewer inorganic components and more organic components during charging/*** polydopamine with sufficient adhesion groups and lithiophilic Ag layer realize near-zero nucleation overpotential during lithium *** low interface resistance and stable lithium deposition are ***,the practical areal and volumetric capacities of the composite anode with three-dimensional copper(3DCu)as the substrate are 10 mAh/cm^(2)and 1538 mAh/cm^3(*** mass of anode).The symmetrical cell shows very low polarization voltage(10 mV)and more than 2500 h cycles life at 1 mA/cm^(2)(1 mAh/cm^(2)).The liNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)-based full cells show improved capacity retention(82%)after 100 cycles at 0.5 *** modified lithiophilic anode with congener-derived interphase provides a promising strategy to realize the next-generation dendrite-free LMBs.

关键词： lithium metal anode Congener-derived lithiophilicity Volumetric capacity Organic-inorganic interphase

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Poly(3-hexylthio) thiophene Field-effect Transistor Device Performance: Impact of the Content of Hexylthio Side Chain on Backbone

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Chinese Journal of Polymer Science 2024年第1期42卷 14-23,I0005页

作者： Hao-Yu liu lian-He Han ling-Wei Kong li-Ping Zhu xiao-Lan Qiao mei-Fang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

Regioregular poly(3-hexylthio)thiopene(P3HTT) has emerged tremendous potential in organic electronic applications due to the strong noncovalent interactions from the sulfur atom linked to thiophene. However, P3HTT generally exhibits low charge mobility mostly due to poor solution processability attributed to dense arrangement of hexylthio side chain in polymer, which led to strong noncovalent interactions among sulfur atoms. To balance the nonvalent interaction and aggregation for P3HTT, herein, we systematically study the effect of hexylthio side chain content in polymer backbone on the structure and properties. A series of regioregular P3HTT-based homopolymers(P3HTT, P3HTT-50,P3HTT-33 and P3HTT-25) were prepared via Kumada catalyst transfer polycondensation method from a set of mono-, bi-, ter-and quarterthiophenes containing different contents of hexylthio side chain. The DFT calculation shows the planarity of polymers backbone could be improved through reducing the density of hexylthio side chain in polymer mainchain. And significant changes in their crystallinity, aggregation and optical properties were observed with the content of hexylthio side chain reducing. The P3HTT-33 displayed the highest field-effect transistor hole mobility of 2.83×10^(-2) cm^(2)·V^(-1)·s^(-1) resulting from a balance between the crystallinity and planarity. This study demonstrates modulating the content of hexylthio side chain in P3HTT is an effective strategy to optimize the opto-electronic properties of polymer obtaining excellent semiconductor device performance.

关键词： Conjugated polymer Polythiophene Noncovalent interaction Molecular aggregation Organic field-effect transistor

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Acoustic characterization of hydrate formation and decomposition in clay-bearing sediments

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Petroleum Science 2024年第04期21卷 2830-2838页

作者： Yi-Jian Zhu xiao-mei Yang Xing Huang Hao li xiao-Hui Wang Yi-Fei Sun Peng xiao Chang-Yu Sun Guang-Jin Chen State Key Laboratory of Heavy Oil Processing College of Chemical Engineering and Environment China University of Petroleum

Understanding the acoustic characteristics of hydrates in various sediments is crucial for hydrate resource detection and safe and efficient exploitation, as hydrate occurrence patterns vary greatly in different sediments. In this work, sediments with different bentonite contents, water saturations, and types were prepared to investigate the characteristics of P-wave velocity(reflecting the magnitude of hydrate saturation in the sediment) and amplitude(reflecting the degree of hydrate-sediment cementation) during hydrate formation and depressurization. During hydrate formation, the P-wave velocity and amplitude have similar trends. As clay content increases, the P-wave velocity increase rates quickened. On the other hand, the increased rate of P-wave velocity slows down with the increase of water saturation in the clay-bearing sediments. Comparing various types of sediment shows that the water absorption and swelling of bentonite reduce the pore space, speeding up the cementation of the hydrate with the sediment and increasing P-wave velocity at a faster rate. Correspondence between P-wave velocity and hydrate saturation is strongly related to sediment type, clay content, and water *** rapidly decreasing amplitude in the early stage of hydrate depressurization indicates that hydrate in clay-bearing sediments is weakly cemented to the sediments, which is prone to stratigraphic *** findings of this study offer guidance for hydrate resource assessments in clay-bearing sediments as well as geologic risk estimations during hydrate mining.

关键词： gas hydrate bentonite illite P-wave velocity amplitude

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Artemsieverolactones A—H,Eight Guaiane-Type Sesquiterpenoid Trimers from Artemisia sieversiana

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Chinese Journal of Chemistry 2024年第10期42卷 1084-1092页

作者： Wei Dong xiao-Yan Huang Tian-Ze li Yan-mei Weng Chang-An Geng Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China University of Chinese Academyof Sciences Beijing 100049China

Eight new guaiane-type sesquiterpenoid trimers,artemsieverolactones A—H,possessing unprecedented scaffolds via biocatalyzed[4+2]Diels−Alder cycloaddition reactions were identified from Artemisia *** structures were determined by comprehensive spectroscopic data,single-crystal X-ray diffraction analyses,and ECD *** terms of structure,artemsieverolactones A—H are first examples of sesquiterpenoid trimers from guaiane-type sesquiterpenoid through four different[4+2]Diels−Alder cycloaddition *** fibrosis assay suggested that five compounds exhibited activity against HSC-LX2 with IC_(50)values ranging from 37.8 to 117.1μmol/*** most active artemsieverolactone B(2)displayed significant inhibitory activity against HSC-LX2 with IC_(50)value of 37.8μmol/L,which was 3 times more active than the positive drug silybin(IC_(50),139.7μmol/L).Preliminary mechanism study revealed that artemsieverolactone B could inhibit the deposition of human collagen typeⅠ(ColⅠ),human hyaluronic acid(HA),and human laminin(HL)with IC_(50)values of 40.4μmol/L(Col I),55.1μmol/L(HL),47.3μmol/L(HA),which was 2 to 3-fold more potent than silybin.

关键词： Artemisia sieversiana Artemsieverolactones A-H Guaiane-type sesquiterpenoid trimers Antihepatic fibrosis Extracellular matrix Cancer NMR spectroscopy X-ray diffraction

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Impaired implicit emotion regulation in patients with panic disorder:An event-related potential study on affect labeling

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World Journal of Psychiatry 2024年第2期14卷 234-244页

作者： Hai-Yang Wang li-Zhu li Yi Chang xiao-mei Pang Bing-Wei Zhang Department of Neurology Jining No.1 People's HospitalShandong First Medical UniversityJining 272000Shandong ProvinceChina Department of Neurology and Psychiatry First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Department of Neurology Sixth Peoples'Hospital of ShenyangShenyang 110003Liaoning ProvinceChina

BACKGROUND Panic disorder(PD)involves emotion dysregulation,but its underlying mechanisms remain poorly *** research suggests that implicit emotion regulation may play a central role in PD-related emotion dysregulation and symptom ***,there is a lack of studies exploring the neural mechanisms of implicit emotion regulation in PD using neurophysiological *** To study the neural mechanisms of implicit emotion regulation in PD with eventrelated potentials(ERP).METHODS A total of 25 PD patients and 20 healthy controls(HC)underwent clinical *** study utilized a case-control design with random sampling,selecting participants for the case group from March to December *** performed an affect labeling task,using affect labeling as the experimental condition and gender labeling as the control *** and behavioral data were recorded to compare the late positive potential(LPP)within and between the *** Both PD and HC groups showed longer reaction times and decreased accuracy under the affect *** the HC group,late LPP amplitudes exhibited a dynamic pattern of initial increase followed by ***,a significant group×condition interaction effect was *** effect analysis revealed a reduction in the differences of late LPP amplitudes between the affect labeling and gender labeling conditions in the PD group compared to the HC ***,among PD patients under the affect labeling,the late LPP was negatively correlated with disease severity,symptom frequency,and *** PD patients demonstrate abnormalities in implicit emotion regulation,hampering their ability to mobilize cognitive resources for downregulating negative *** late LPP amplitude in response to affect labeling may serve as a potentially valuable clinical indicator of PD severity.

关键词： Panic disorder Implicit Emotion regulation Affect labeling Late positive potential

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MicroRNA-298 determines the radio-resistance of colorectal cancer cells by directly targeting human dual-specificity tyrosine(Y)-regulated kinase 1A

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1453-1464页

作者： mei-Zhu Shen Yong Zhang Fang Wu mei-Zhen Shen Jun-lin liang xiao-Long Zhang xiao-Jian liu Xin-Shu li Ren-Sheng Wang Department of Radiotherapy The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiotherapy People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Colorectal Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Medicine Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Radiotherapy stands as a promising therapeutic modality for colorectal cancer(CRC);yet,the formidable challenge posed by radio-resistance significantly undermines its efficacy in achieving CRC *** To elucidate the role played by microRNA-298(miR-298)in CRC *** To establish a radio-resistant CRC cell line,HT-29 cells underwent exposure to 5 gray ionizing radiation that was followed by a 7-d recovery *** quantification of miR-298 levels within CRC cells was conducted through quantitative RT-PCR,and protein expression determination was realized through Western *** viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and proliferation by clonogenic ***-induced apoptosis was discerned through flow cytometry *** We observed a marked upregulation of miR-298 in radio-resistant CRC ***-298 emerged as a key determinant of cell survival following radiation exposure,as its overexpression led to a notable reduction in radiation-induced ***,miR-298 expression exhibited a strong correlation with CRC cell *** investigation unveiled human dual-specificity tyrosine(Y)-regulated kinase 1A(DYRK1A)as miR-298’s direct *** Taken together,our findings underline the role played by miR-298 in bolstering radio-resistance in CRC cells by means of DYRK1A downregulation,thereby positioning miR-298 as a promising candidate for mitigating radioresistance in CRC.

关键词： MicroRNA-298 Human dual-specificity tyrosine(Y)-regulated kinase 1A Colorectal cancer Radio-resistance p53 binding protein 1

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