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Detection of fetal epigenetic biomarkers through genome-wide DNA methylation study for non-invasive prenatal diagnosis

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Detection of fetal epigenetic biomarkers through genome-wide...

Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

第十届全国遗传病诊断与产前诊断学术交流会暨海峡两岸医药卫生交流协会遗传与生殖专业委员会第一届年会

作者： Yue Gao xiao-dong huo Li-Tao Qin Liang-Jie Guo Shi-Xiu Liao Medical Genetic Institute of Henan Province People’s Hospital of Zhengzhou University

Background: The discovery of fetal cell-free DNA(cff DNA) in maternal plasma during pregnancy provides a new perspective for the development of non-invasive prenatal diagnosis(NIPD). In the large background of maternal DNA, the use of the cff DNA with the relatively low concentration is limited in NIPD. Therefore, in order to overcome the complication of the large background of maternal DNA and expand the scope of cff DNA application in clinical practice, there is a pressing need to find more universal fetal-specific DNA markers for the widespread clinical application of cff DNA. GeneChip Human Tiling 2.0R Array set is used for analysis of the methylation status of 12 placental tissue and maternal peripheral blood DNA samples in a whole-genome wide. Results: 5 fetus differential hypermethylation regions and 6 fetus differential hypomethylation regions are selected. Moreover, to verify the 11 selected methylation regions and detect the differential CpG sites, bisulfate direct sequencing strategy is used. Conclusions: 87 fetal differential methylation CpG sites are identified from 123 CpG sites. The detection of the fetal differential methylation DNA regions and CpG sites may be instrumental in the development of an efficient NIPD and in the expansion of the application fields in some other disorders.

关键词： DNA methylation GeneChip? Human Tiling 2.0R Array set bisulfate direct sequencing

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

Experimental Study on Diesel Spray and Flame Asymmetry Characteristics of Dual-Orifice Nozzles for a Medium-Speed Engine

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Journal of Thermal Science 2025年第1期34卷 303-322页

作者： JU Dehao LIU Rui ZHENG Liang DENG Jiahui ZHANG Wenzheng huo Jinlu HUANG Li Shanghai Marine Diesel Engine Research Institute National Key Laboratory of Marine Engine Science and Technology Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong University

The asymmetry of the multi-orifice spray will cause uneven heat load of the marine diesel engine,thereby affecting its working performance and service ***,an in-depth understanding of the spray and flame characteristics of multi-orifice nozzles will guide the optimization of the nozzle structure,needle design and diesel atomization and combustion *** this reason,four groups of dual-orifice nozzles with different hole diameters(0.1-0.55 mm) and mass flow rates covering the typical marine medium-speed diesel injections are designed and customized,and the constant volume chamber(CVC) with high temperature and pressure is used to simulate the actual in-cylinder working conditions of the diesel engine for the spray visualization *** study the asymmetry of the fuel sprays discharged from a diesel injector,the multi-orifice nozzle is simplified as a dual-orifice nozzle in this *** with X-ray Computed Tomography(CT) imaging technology,the influences of the nozzle internal structure on the spray and flame asymmetry are studied in the constructed supercritical *** is found that the asymmetry of the inlet angle and the equivalent length-diameter ratio is positively correlated with the inconsistency of the dual *** an increase in the injection pressure and nozzle diameter,the asymmetry of the dual spray becomes more pronounced,resulting in greater disparities in the ignition delay times and ignition positions of the two ***,the increase in nozzle diameter also leads to combustion instability,resulting in a flame with a serrated *** the increase of ambient temperature,the proportion of liquid phase in the jet decreases and the relative density of spray front decreases.

关键词： atomization dual-orifice nozzle nozzle structure spray flame asymmetry

Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao Cheng Chuankai Fu Geping Yin Liguang Wang Yongmin Wu Hua huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

Design and implementation of reconfigurable CNN accelerator architecture based on elastic storage

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The Journal of China Universities of Posts and Telecommunications 2025年

作者： Shan Rui Xu Jianing huo Ziqing College of Electronic Engineering， Xi'an University of Post and Telecommunications

With the rapid iteration of neural network algorithms， higher requirements was placed on the computational performance and memory access bandwidth of neural network accelerators. Simply increasing bandwidth cannot improve energy efficiency， so improving data reuse rate is a hot research topic. From the perspective of supporting data reuse， a reconfigurable convolutional neural networks (CNN) accelerator based on elastic storage was designed in this paper. By supporting elastic memory access and flexible data flow， it reduces data movement between the processor and memory， eases the bandwidth pressure and enhances CNN acceleration performance. The experimental results indicate that conducting 1×1 convolution and 3×3 convolution when performing convolution calculations， the execution speed increased by 25.00% and 61.61%， respectively. The 3×3 maximum pooling speed was increased by 76.04%.

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Research on Two-stage Voltage and Reactive Power Optimization Coordinated Control Method Considering Flexible On-load Tap Changer

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Dianwang Jishu/Power System Technology 2025年第1期49卷 272-283页

作者： Li, Jiaming huo, Qunhai Yin, Jingyuan Lu, Hao Zhou, Jing Zhu, Meisheng He, Wei dong, Hongwei Institute of Electrical Engineering Chinese Academy of Sciences Haidian District Beijing 100192 China School of Electronic Electrical and Communication Engineering University of Chinese Academy of Sciences Shijingshan District Beijing 100049 China Shanghai Jiguang Polytechnic College Baoshan District Shanghai 201901 China Three Gorges Electric Power Co. Ltd. Hubei Province Wuhan 430000 China

With the large-scale integration of distributed photovoltaic (DPV) in the distribution network, voltage exceeding limits and fluctuations are becoming increasingly severe. The voltage and reactive power optimization and coordination control method considering new power quality management devices needs to be further improved to adapt to the new changes in the power grid. This article considers the power quality regulation effect of the new flexible on-load tap changer (OLTC) and proposes a two-stage voltage and reactive power optimization coordinated control method. The first stage is the day before hour level scheduling stage. Based on distributed photovoltaic and load prediction data, the active output results of DPV and the switching results of flexible OLTC taps and capacitor banks are obtained through power flow calculation and iterative optimization. The second stage is the minute-level reactive power optimization stage. Based on the first stage, considering the reactive power output characteristics of flexible OLTC and DPV, adjusting the reactive power output of the equipment while correcting the capacitor bank switching combination in the first stage, further reducing the maximum voltage deviation of each node and making the distribution network voltage distribution more reasonable. An IEEE33 node distribution system simulation model is built in the paper. The proposed two-stage voltage and reactive power optimization coordination control method considering flexible OLTC can improve the DPV absorption level by 9.29% based on the conventional economic optimal goal of 88.07%, while meeting the requirement that the voltage deviation of the entire node is less than 0.1pu During the entire period, the overall economic efficiency improved by 7.8%. The results demonstrate the rationality and effectiveness of the proposed method. © 2025 Power System Technology Press. All rights reserved.

关键词： Quality management

Improved Bound of the Fourth Hankel Determinant for a Class of Analytic Functions with Bounded Turnings Involving Cardioid Domain

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Journal of Mathematical Research with Applications 2025年第1期 39-55页

作者： dong GUO huo TANG Xi LUO Zongtao LI School of Mathematical Sciences Yangzhou Polytechnic College College of Mathematics and Computer Science Chifeng University School of Mathematics Jiaying University Department of Mathematics Teaching Guangzhou Civil Aviation College

In the paper, a class of functions with bounded turnings involving cardioid domain,are studied in the region of the unit disc. The bounds of |a5|, |a6|, |a7| and the fourth Hankel determinant are obtained, which are m...

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All-day solar power generation enabled by photo/thermoelectric conversion and thermal energy storage

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Science China Chemistry 2025年

作者： Zijian Liu Chengzhi Chen Junda Liu Qi Sun Bingchen huo Chunyu Du Guangming Chen College of Materials Science and Engineering Shenzhen University

Thermoelectric materials hold promises for direct conversion of heat into electricity, making them viable power sources for electronic devices. However, their practical applications in diverse outdoor environment are hindered by limited and discontinuous electricity output. In this study, we propose an all-day solar power generator to achieve highly efficient and continuous electricity generation by harnessing the synergistic effects of photoelectric-thermoelectric conversion and latent thermal energy storage. The all-day solar power generator exhibits an average open-circuit voltage of 6.8 m V during daylight and a remaining 0.9 mV during nighttime. Importantly, the all-day solar power generator achieves dependable outdoor power supply for communication transmission in diverse environmental scenarios. Our research opens a new way for highly efficient and sustainable power generation.

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Research on performance optimization of virtual data space across WAN

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Frontiers of Computer Science 2024年第6期18卷 167-187页

作者： Jiantong huo Zhisheng huo Limin xiao Zhenxue HE State Key Laboratory of Software Development Environment Beihang UniversityBeijing 100191China School of Computer Science and Engineering Beihang UniversityBeijing 100191China High Performance Computing Center Beihang UniversityBeijing 100191China Hebei Key Laboratory of Agricultural Big Data Hebei Agricultural UniversityBaoding 071001China

For the high-performance computing in a WAN environment,the geographical locations of national supercomputing centers are scattered and the network topology is complex,so it is difficult to form a unified view of *** aggregate the widely dispersed storage resources of national supercomputing centers in China,we have previously proposed a global virtual data space named GVDS in the project of“High Performance Computing Virtual Data Space”,a part of the National Key Research and Development Program of *** GVDS enables large-scale applications of the high-performance computing to run efficiently across ***,the applications running on the GVDS are often data-intensive,requiring large amounts of data from multiple supercomputing centers across *** this regard,the GVDS suffers from performance bottlenecks in data migration and access across *** solve the above-mentioned problem,this paper proposes a performance optimization framework of GVDS including the multitask-oriented data migration method and the request access-aware IO proxy resource allocation *** a WAN environment,the framework proposed in this paper can make an efficient migration decision based on the amount of migrated data and the number of multiple data sources,guaranteeing lower average migration latency when multiple data migration tasks are running in *** addition,it can ensure that the thread resource of the IO proxy node is fairly allocated among different types of requests(the IO proxy is a module of GVDS),so as to improve the application’s performance across *** experimental results show that the framework can effectively reduce the average data access delay of GVDS while improving the performance of the application greatly.

关键词： storage aggregation across WANs large-scale applications GVDS data migration allocation of IO proxy resource