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Forecasting supernova observations with the CSST:*** samples

Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 164-177页

作者： Chengqi Liu Youhua Xu xianmin meng Xin Zhang Shi-Yu Li Yuming Fu Xiaofeng Wang Shufei Liu Zun Luo Guanghuan Wang Hu Zhan Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Key Laboratory of Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Beijing Planetarium Beijing Academy of Science and TechnologyBeijing 100044China Leiden Observatory Leiden UniversityNL-2300 RA LeidenThe Netherlands Kapteyn Astronomical Institute University of GroningenNL-9700 AV GroningenThe Netherlands Physics Department Tsinghua UniversityBeijing 100084China School of Astronomy and Space Science University of ChineseAcademy of SciencesBeijing 100049China

The China Space Station Telescope(CSST,also known as Xuntian)is a serviceable two-meter-aperture wide-field telescope operating in the same orbit as the China Space *** CSST plans to survey a sky area of 17,500 deg^(2)of the medium-to-high Galactic latitude to a depth of 25-26 AB mag in at least 6 photometric bands over 255-1,000 *** such a large sky area,slitless spectra will also be taken over the same wavelength range as the imaging *** though the CSST survey is not dedicated to time-domain studies,it would still detect a large number of transients,such as supernovae(SNe).In this paper,we simulate photometric SN observations based on a strawman survey plan using the Sncosmo *** its 10-year survey,the CSST is expected to observe about 5 million SNe of various *** quality cuts,we obtain a“gold”sample that comprises roughly 7,400 SNe Ia,2,200 SNe Ibc,and 6,500 SNeⅡcandidates with correctly classified percentages reaching 91%,63%,and 93%(formally defined as classification precision),*** same survey can also trigger alerts for the detection of about 15,500 SNe Ia(precision 61%)and 2,100 SNeⅡ(precision 49%)candidates at least two days before the light ***,the near-ultraviolet observations of the CSST will be able to catch hundreds of shock-cooling events serendipitously every *** results demonstrate that the CSST can make a potentially significant contribution to SN studies.

关键词： space-based ultraviolet optical and infrared telescopes supernovae data analysis

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Biomarkers for predicting efficacy of chimeric antigen receptor T cell therapy and their detection methods

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iLABMED 2024年第1期2卷 14-26页

作者： Bo Zou Yanzhou Song Ning Li Zhongyi Fan Jie Li Yuanzheng Peng Wanshan Wei Yuzi Zhang Yinan Su xianmin meng Hongzhou Lu Xingding Zhang Xiaohua Tan Qibin Liao Department of Oncology and Bio-Therapeutic Center Shenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina Molecular Cancer Research Center School of MedicineShenzhen Campus of Sun Yat-Sen UniversitySun Yat-Sen UniversityShenzhenChina Department of Hepato-Biliary Surgery Shenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina Institute for Hepatology National Clinical Research Centre for Infectious DiseasesShenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina Kidney Transplant Department(Liver Transplant Department) Transplant CenterNational Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated HospitalSouthern University of Science and TechnologyShenzhenChina Institute of Translational Medicine First Affiliated Hospital of Shenzhen UniversityShenzhen Second People's HospitalShenzhenGuangdongChina BASIS International School HuizhouGuangdongChina Department of Pharmacy Shenzhen Third People's HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhenChina

Cancer immunotherapy has emerged as the fourth most prevalent approach to tumor treatment,alongside surgery,radiotherapy,and *** several decades of development,chimeric antigen receptor T(CAR-T)cell therapy,a promising branch of adoptive T-cell therapy,has demonstrated superior efficacy and safety in comparison to other cell therapies in the treatment of *** present,CAR-T cells are predominantly used to treat hematological malignancies,although their application in solid tumors is being readily *** numerous studies have examined the biomarkers associated with the safety of CAR-T cell therapy,few have evaluated predictors of CAR-T cell therapeutic ***,the primary objective of this review article was to provide a comprehensive overview of the factors predicting the efficacy of CAR-T cell therapy,with a particular focus on biomarkers and their detection methods.

关键词： biomarkers cancer immunotherapy CAR-T cell detection methods therapeutic efficacy

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儿童面部获得性色素沉着斑7例

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中华皮肤科杂志 2024年第5期57卷 458-460页

作者：张玉丽季双双石秀艳孟宪敏刘文慧王冲聊城市人民医院皮肤科聊城252000

报道7例以额部色素沉着为特征的患儿。7例患儿中,男2例,女5例,发病年龄9~24(12.43±5.32)个月,病程1~4(2.57±1.27)个月。皮肤科检查:患儿额题部散在分布数量不等的咖啡色斑点、斑片,形状不规则,表面未见明显鳞屑。皮肤镜检查:可见多发... 详细信息

报道7例以额部色素沉着为特征的患儿。7例患儿中,男2例,女5例,发病年龄9~24(12.43±5.32)个月,病程1~4(2.57±1.27)个月。皮肤科检查:患儿额题部散在分布数量不等的咖啡色斑点、斑片,形状不规则,表面未见明显鳞屑。皮肤镜检查:可见多发的假网状黄褐色色素斑片,边界不规则,部分皮损可见线状血管。诊断:儿童面部获得性色素沉着斑。均未予特殊处理,随访2年,2例色素沉着斑完全消退,4例不同程度减轻,1例无变化。结合文献及本文病例推测儿童面部获得性色素沉着斑是一种独立的疾病。

关键词：皮肤色素沉着获得性色素沉着斑儿童额部

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Five E+A (post-starburst) galaxies as Brightest Cluster Galaxies

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Science China(Physics,Mechanics & Astronomy) 2012年第2期55卷 354-357页

作者： LIU FengShan WEN ZhongLue HAN JinLin meng xianmin College of Physical Science and Technology Shenyang Normal UniversityShenyang 110034China National Astronomical Observatories Chinese Academy of SciencesA20 Datun RoadBeijing 100012China

Brightest Cluster Galaxies （BCGs） are mostly elliptical galaxies and very rarely have prominent star formations. We found that five out of 8,812 BCGs are E＋A （i.e., post-starburst） galaxies, having an Hd absorption line with an equivalent width 〉2.5 A and no distinct emission lines in [O II] and Ha-. The E＋A features we identified from the BCGs for the first time are not as significant as those in general galaxies, indicating that historically the star formations were not very violent.

关键词： galaxies clusters general

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Value of CD4^(+)and CD8^(+)T-lymphocyte counts for clinical diagnostic classification and prognosis of coronavirus disease 2019

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China Medical Abstracts(Internal Medicine) 2021年第3期38卷 149-150页

作者： meng xianmin Dept Pharm Shanghai Public Health Clin CenterFudan UnivShanghai 201508

Objective To assess the value of CD4^(+)and CD8^(+)T-lymphocyte counts for the diagnostic classification and prognosis of coronavirus disease 2019(COVID-19).Methods A total of 95 COVID-19 adult patients admitted to Sh... 详细信息

关键词： admitted prognosis Clinical

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Sialic acid-mediated photochemotherapy enhances infiltration of CD8^(+)T cells from tumor-draining lymph nodes into tumors of immunosenescent mice

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Acta Pharmaceutica Sinica B 2023年第1期13卷 425-439页

作者： Dezhi Sui Changzhi Li Xueying Tang xianmin meng Junqiang Ding Qiongfen Yang Zhaowei Qi Xinrong Liu Yihui Deng Yanzhi Song College of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China

Immunoscenescence plays a key role in the initiation and development of ***,immunoscenescence also impacts drug delivery and cancer therapeutic *** reduce the impact of immunosenescence on anti-tumor therapy,this experimental plan aimed to use neutrophils with tumor tropism properties to deliver sialic acid(SA)-modified liposomes into the tumor,kill tumor cells via SA-mediated photochemotherapy,enhance infiltration of neutrophils into the tumor,induce immunogenic death of tumor cells with chemotherapy,enhance infiltration of CD8^(+)T cells into the tumordraining lymph nodes and tumors of immunosenescent mice,and achieve SA-mediated *** found that CD8^(+)T cell and neutrophil levels in 16-month-old mice were significantly lower than those in 2-and 8-month-old mice;16-month-old mice exhibited *** anti-tumor efficacy of SA-mediated non-photochemotherapy declined in 16-month-old mice,and tumors recurred after ***-mediated photochemotherapy enhanced tumor infiltration by CD8^(+)T cells and neutrophils,induced crusting and regression of tumors in 8-month-old mice,inhibited metastasis and recurrence of tumors and eliminated the immunosenescence-induced decline in antitumor therapeutic efficacy in 16-month-old mice via the light-heat-chemical-immunity conversion.

关键词： Immunosenescence Sialic acid Photochemotherapy CD8^(+)T cells Doxorubicin Neutrophils Indocyanine green Liposomes

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Tactile-sensing-based robotic grasping stability analysis

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Science China(Technological Sciences) 2024年第6期67卷 1817-1828页

作者： HUANG YanJiang WANG HaoNan ZHANG xianmin Guangdong Provincial Key Laboratory of Precision Equipment and Manufacturing Technology South China University of TechnologyGuangzhou510640China

Tactile signals play a crucial role in enabling robots to successfully manipulate unfamiliar *** robots to grasp unknown objects securely and without causing damage,it is essential that they can analyze grasping stability in real time through tactile signals and respond *** study introduces a novel method for analyzing the stability of robotic hand grasping,utilizing the Wilcoxon signed rank *** efficacy of this method is demonstrated through its static and dynamic performance,and evaluated across a series of *** findings of this research highlight the method’s ability to accurately detect when an object begins to slip from the robot’s *** this method allows the gripper to maintain a secure hold on objects by applying the minimal necessary *** also enables the gripper to dynamically adjust the force it applies in real time,thus preventing the object from slipping during the movement of the robotic ***,the gripper demonstrates the ability to stably grasp objects of varied weights and with unknown characteristics,showcasing the versatility and effectiveness of the proposed method.

关键词： grasping stability manipulation tactile sensors

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Transgelin as a potential target in the reversibility of pulmonary arterial hypertension second to congenital heart disease

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中国循环杂志 2018年第S1期33卷 165-166页

作者： Li Huang Li Li Tao Yang Wen Li Li Song xianmin meng Qing Gu Changming Xiong Jianguo He Pulmonary Vascular Disease Center National Center for Cardiovascular DiseasesFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background The reversibility of pulmonary arterial hypertension(PAH)in congenital heart disease(CHD)is of great importance for the operability of *** analysis found that transgelin was significantly upregulated in the lung tissue of CHD-PAH patients,especially in the irreversible ***,how exactly it participated in CHD-PAH development is unknown.

关键词： pulmonary arterial hypertension congenital heart disease CHD-PAH

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