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芪地糖肾方调控Akt1/HIF-1α/Bcl-xl信号通路提高糖尿病肾病足细胞自噬的机制

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中国实验方剂学杂志 2024年第15期30卷 90-97页

作者：高飞谢惠迪于博睿周盈史扬张先慧柳红芳北京市朝阳区中医医院北京100020 北京中医药大学东直门医院北京100700 中国人民解放军总医院第一医学中心北京100853 北京市普仁医院北京100062

目的:探讨芪地糖肾方(QDTS)减轻糖尿病肾病(DKD)足细胞损伤,降低尿蛋白的作用机制。方法:使用网络药理学方法,收集QDTS中的化学成分和靶标,以及DKD相关靶标,构建QDTS治疗DKD的药物-成分-靶标-疾病交互网络,系统阐释其作用机制。体内实验... 详细信息

目的:探讨芪地糖肾方(QDTS)减轻糖尿病肾病(DKD)足细胞损伤,降低尿蛋白的作用机制。方法:使用网络药理学方法,收集QDTS中的化学成分和靶标,以及DKD相关靶标,构建QDTS治疗DKD的药物-成分-靶标-疾病交互网络,系统阐释其作用机制。体内实验将db/db小鼠分为模型组、芪地糖肾方(3.34 g·kg^(-1))和缬沙坦胶囊(10.29 mg·kg^(-1))组,db/m小鼠作为正常组,每组8只,连续干预8周。末次给药后处死小鼠,检查小鼠尿微量白蛋白排泄率(UAER)、肾脏病理变化及蛋白激酶B1(Akt1)、低氧诱导因子-1α(HIF-1α)、磷酸化B细胞淋巴瘤放大因子(p-Bcl-xl)和自噬活性指标微管相关蛋白1轻链3(LC3)、p62、自噬关键分子酵母Atg6同系物(Beclin1)蛋白表达水平。体外实验将小鼠足细胞分为正常糖组(5.5 mmol·L^(-1)葡萄糖),高糖组(35 mmol·L^(-1)),二甲基亚砜(DMSO)组(35 mmol·L^(-1)葡萄糖+200 mg·L^(-1)DMSO)和QDTS组(35 mmol·L^(-1)葡萄糖+200 mg·L^(-1)QDTS冻干粉),干预48 h后检测足细胞中Akt1、HIF-1α、磷酸化(p)-Bcl-xl、LC3、p62、Beclin1蛋白表达水平。结果:QDTS治疗DKD的有效成分有34种,作用靶点143个,其中与自噬相关的靶点有55个,Akt1、HIF-1α和Bcl-xl是其关键靶点。与正常组比较,模型组小鼠UAER显著升高,小鼠肾小球肥大,蓝色胶原纤维沉积,肾小球基底膜增厚,部分节段伴有明显足细胞足突融合,小鼠肾脏中p-Akt1、HIF-1α、p62蛋白表达增强,p-Bcl-xl、LC3和Beclin1蛋白表达明显减弱(P<0.05);与模型组比较,QDTS组和缬沙坦组小鼠UAER含量明显降低(P<0.05),小鼠肾脏病理损伤明显减轻,小鼠肾脏中p-Akt1、HIF-1α和p62蛋白表达减弱,p-Bcl-xl、LC3和Beclin1蛋白表达增强(P<0.05);与正常糖组比较,高糖组小鼠足细胞中p-Akt1、HIF-1α和p62蛋白表达增强,p-Bcl-xl、LC3和Beclin1蛋白表达减弱(P<0.05);与高糖组比较,QDTS组小鼠足细胞中p-Akt1、HIF-1α和p62蛋白表达减弱,p-Bcl-xl、LC3和Beclin1蛋白表达增强(P<0.05)。结论:QDTS减轻DKD足细胞损伤,降低尿蛋白与其调控Akt1/HIF-1α/Bcl-xl信号通路,提高足细胞自噬活性有关。

关键词：芪地糖肾方糖尿病肾病足细胞损伤自噬信号通路分子机制

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基于模糊综合评判法的区域治理效果评价方法研究

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中国煤炭地质 2024年第7期36卷 49-54页

作者：张现辉卢玲敏方向清冀中能源股份有限公司河北邢台054000 中煤地华盛水文地质勘察有限公司河北邯郸056004

区域治理技术目前已广泛应用于华北型煤田深部煤层底板隔水层加固,治理效果评价主要采用突水系数方法,没有考虑治理工程质量。采用九分度法建立了治理效果评价的4个一级评价指标和15种二级评价指标的权重,并且给出了治理效果评价的模糊... 详细信息

区域治理技术目前已广泛应用于华北型煤田深部煤层底板隔水层加固,治理效果评价主要采用突水系数方法,没有考虑治理工程质量。采用九分度法建立了治理效果评价的4个一级评价指标和15种二级评价指标的权重,并且给出了治理效果评价的模糊综合判别等级标准,大于等于0.63为合格,小于0.63为不合格。将评价方法应用于邢东矿-980m以深区域奥灰探查治理效果评价,综合评价等级M的量值为0.947,评价等级为合格,与实际矿井涌水量观测结果结论一致。

关键词：矿井突水区域注浆治理效果评价模糊综合判别质量标准邢东矿

国外帕金森病专科护士角色定位研究现状及启示

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护理研究 2024年第2期38卷 336-338页

作者：张仙慧陈一萍乔彩虹侯丽媛杨辉山西医科大学山西030001 山西医科大学第一医院

对国内外帕金森病专科护士发展现状、国外帕金森病专科护士角色定位进行综述,并分析其对我国帕金森病专科护士发展的启示,以期为我国帕金森病专科护士队伍建设提供参考。

关键词：帕金森病专科护士角色定位护理管理综述

Power-to-chemicals:sustainable liquefaction of food waste with plasma-electrolysis

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Frontiers of Chemical Science and Engineering 2023年第5期17卷 594-605页

作者： Wenquan Xie xianhui zhang Dengke Xi Rusen Zhou Size Yang Patrick Cullen Renwu Zhou Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Fujian Engineering Research Center for EDAFujian Provincial Key Laboratory of Electromagnetic Wave Science and Detection TechnologyXiamen Key Laboratory of Multiphysics Electronic InformationInstitute of Electromagnetics and AcousticsXiamen UniversityXiamen 361005China School of Chemical and Biomolecular Engineering University of SydneySydney NSW 2006Australia State Key Laboratory of Electrical Insulation and Power Equipment Centre for Plasma BiomedicineXi’an Jiaotong UniversityXi’an 710049China

The increasing amount of food waste from various industrial,agricultural,and household sources is an environmental burden if managed *** waste management approaches have been developed for the disposal of food waste,but still suffer from either high cost,production of toxic by-products,or secondary environmental ***,we report a new and sustainable plasma electrolysis biorefinery route for the rapid and efficient liquefaction of food *** the plasma electrolysis process,only the solvent is added to liquefy the waste,and anions in the waste can contribute to catalyzing the biowaste *** liquefying the waste,the highly reactive species produced in the plasma electrolysis process can efficiently reduce the content of O,N,and Cl in the liquefied products and oxidize most of the metals into solid ***,the removal rate of Na and K elements was greater than 81%,which is significantly higher than using the traditional oil bath liquefaction,resulting in a relatively high-quality biocrude oil with a high heating value of 25.86 MJ·kg^(-1).Overall,this proposed strategy may provide a new sustainable and eco-friendly avenue for the power-to-chemicals valorization of food waste under benign conditions.

关键词： plasma electrolysis food waste liquefaction resource recovery

基于MAPK/ERK/NF-κB信号通路探讨中西医结合治疗原发性痛经的研究进展

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实用中医内科杂志 2024年第5期38卷 90-93页

作者：王蓉张怡王丽丽章宪慧王新斌甘肃中医药大学中西医结合学院甘肃兰州730000

痛经(Dysmenorrhea)是临床常见妇科疾病,中医亦称“经行腹痛”,是指女性在行经前后或月经期,下腹部出现痉挛性疼痛,亦可放射至腰骶部,伴或不伴有恶心呕吐、腹泻及头晕乏力等全身症状。痛经可分为原发性和继发性两类,其中原发性痛经指生... 详细信息

痛经(Dysmenorrhea)是临床常见妇科疾病,中医亦称“经行腹痛”,是指女性在行经前后或月经期,下腹部出现痉挛性疼痛,亦可放射至腰骶部,伴或不伴有恶心呕吐、腹泻及头晕乏力等全身症状。痛经可分为原发性和继发性两类,其中原发性痛经指生殖器官无器质性病变者;继发性痛经则是由于盆腔器质性疾病,如子宫内膜异位症、子宫腺肌症、子宫肌瘤、盆腔炎或宫颈狭窄等引起者。目前西医治疗原发性痛经多以解痉止痛的药物治疗,疗效虽显著而快速,但是副作用较大,停药后易复发;而中医在临床上四诊合参,辨证论治,不仅可以标本同治,也有助于预防调摄。通过梳理归纳近10年国内外原发性痛经的文献资料,基于MAPK/ERK/NF-κB信号通路探析原发性痛经的中西医研究进展,以期为中医药防治原发性痛经提供理论依据。现将原发性痛经的研究现状综述如下。

关键词：原发性痛经 MAPK/ERK/NF-κB信号通路西医治疗中医治疗

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一种短时猝发GMSK扩频多普勒估计算法研究

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遥测遥控 2024年第1期45卷 60-66页

作者：欧家成廖小海张显辉王慧许洋北京遥测技术研究所北京100076 中国航天电子技术研究院北京100094

多普勒估计是猝发传输背景下的GMSK(Gaussian Filtered Minimum Shift Keying,高斯最小频移键控)扩频通信系统接收端同步过程中的关键一环。针对短时猝发GMSK扩频通信系统信息传输时间极短的特点,搭建了系统接收端同步段结构,并以此为... 详细信息

多普勒估计是猝发传输背景下的GMSK(Gaussian Filtered Minimum Shift Keying,高斯最小频移键控)扩频通信系统接收端同步过程中的关键一环。针对短时猝发GMSK扩频通信系统信息传输时间极短的特点,搭建了系统接收端同步段结构,并以此为基础设计了适应该短时猝发同步段结构的多普勒估计算法,建立了短时猝发多普勒估计算法模型,推导该算法公式的同时对算法模型进行了理论分析,详细阐述了该算法进行多普勒估计的实现过程,并对该算法进行仿真实验。实验结果表明,该算法在信噪比为1 dB时,多普勒估计准确度可达到97.2%,信噪比≥3 dB时,准确度均能在99%及以上,该结果验证了该算法应用在猝发传输背景下的GMSK扩频通信系统中的有效性、可行性,同时也表明当通信系统处于弱信号的条件下时,该多普勒估计算法性能依然能达到一个较为优异的准确度值。

关键词：多普勒估计多普勒频移扩频通信 GMSK 猝发传输

Using silk-derived magnetic carbon nanocomposites as highly efficient Nanozymes and electromagnetic absorbing agents

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中国化学快报:英文版 2023年第9期34卷 321-328页

作者： Hao Wang xianhui zhang Yonghua Tang Weifeng Rong Jiachen Zhao Chaoyu Fan Zhisen zhang Zhijun Sun Yun Yang Youhui Lin Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen 361005China Fujian Provincial Key Laboratory of Naval Architecture and Ocean Engineering Xiamen Key Laboratory of Marine Corrosion and Smart Protective MaterialsJimei UniversityXiamen 361021China School of Chemical Engineering Shandong University of TechnologyZibo 255049China

Functional carbon nanomaterials have become the stars of many active research fields,such as electronics,energy,catalysis,imaging,sensing and ***,a facile and one-pot strategy for generating ferromagnetic nanoparticles loaded on N-doped carbon nanosheets(Fe-N-CNS)is presented by salt-assisted high-temperature carbonization of natural silk *** to their graphitic structures,N-doping and ferromagnetic nanoparticles(FeN_(x),FeO_(y),FeC_(z)),the silk-derived Fe-N-CNS can act as excellent mimics of both peroxidase and *** from the combined character of the graphene-like structures and enzyme-like activities,Fe-N-CNS can be further applied to highly efficient dye removal via synergistic adsorption and ***,the as-prepared Fe-N-CNS with intrinsic magnetism and electrical conductivity can also serve as an efficient electromagnetic wave absorption *** broadest effective absorption bandwidth(EAB)of as-obtained absorbing material yields a 6.73 GHz with 1 mm thickness,with a maximum reflection loss of-37.33 dB(11.41 GHz).The EAB can cover2~18 GHz with a tunable absorber thickness from 1.0 mm to 5.0 ***,Fe-N-CNS,as a dualfunctional material,can tackle the aggravating environmental pollution issues of both dyes and electromagnetic waves.

关键词： Silk Enzyme-like activity Dye removal Electromagnetic wave absorption Fe-N-CNS

Knee osteoarthritis:A review of animal models and intervention of traditional Chinese medicine

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Animal Models and Experimental Medicine 2024年第2期7卷 114-126页

作者： Xuyu Song Ying Liu Siyi Chen Lei zhang Huijie zhang xianhui Shen Hang Du Rong Sun Orthopaedic trauma surgery The Second Hospital of Shandong UniversityJinanShandongChina Academy of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina Department of Traditional Chinese Medicine The Second Hospital of Shandong UniversityJinanShandongChina College of pharmacy Shandong University of Traditional Chinese MedicineJinanShandongChina The Second Clinical College of Shandong University Shandong UniversityJinanShandongChina Advanced Medical Research Institute Shandong UniversityJinanShandongChina The Second Hospital of Shandong University JinanShandongChina

Background:Knee osteoarthritis(KOA)characterized by degeneration of knee cartilage and subsequent bone hyperplasia is a prevalent joint condition primarily affecting aging *** pathophysiology of KOA remains poorly understood,as it involves complex mechanisms that result in the same ***,researchers are interested in studying KOA and require appropriate animal models for basic *** herbal compounds,which consist of multiple herbs with diverse pharmacological properties,possess characteristics such as multicomponent,multipathway,and multitarget *** potential benefits in the treatment of KOA continue to attract ***:This study aims to provide a comprehensive overview of the advantages,limitations,and specific considerations in selecting different species and methods for KOA animal *** will help researchers make informed decisions when choosing an animal ***:Online academic databases(e.g.,PubMed,Google Scholar,Web of Science,and CNKI)were searched using the search terms“knee osteoarthritis,”“animal models,”“traditional Chinese medicine,”and their combinations,primarily including KOA studies published from 2010 to ***:Based on literature retrieval,this review provides a comprehensive overview of the methods of establishing KOA animal models;introduces the current status of advantages and disadvantages of various animal models,including mice,rats,rabbits,dogs,and sheep/goats;and presents the current status of methods used to establish KOA animal ***:This study provides a review of the animal models used in recent KOA research,discusses the common modeling methods,and emphasizes the role of traditional Chinese medicine compounds in the treatment of KOA.

关键词： animal models knee osteoarthritis system review traditional Chinese medicine

Continuous flow removal of acid fuchsine by dielectric barrier discharge plasma water bed enhanced by activated carbon adsorption

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Frontiers of Chemical Science and Engineering 2019年第2期13卷 340-349页

作者： Rusen Zhou Renwu Zhou xianhui zhang Kateryna Bazaka Kostya (Ken) Ostrikov School of Chemistry Physics and Mechanical EngineeringQueensland University of TechnologyBrisbaneQLD 4000Australia CSIRO-QUT Joint Sustainable Processes and Devices Laboratory CSIROLindfieldNSW 2070Australia Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Institute of Electromagnetics and AcousticsDepartment of Electronic ScienceSchool of Electronic Science and EngineeringXiamen UniversityXiamen 361005China

Continuous processes which allow for large amount of wastewater to be treated to meet drainage standards while reducing treatment time and energy consumption are urgently needed. In this study, a dielectric barrier discharge plasma water bed system was designed and then coupled with granular activated carbon (GAC) adsorption to rapidly remove acid fuchsine (AF) with high efficiency. Effects of feeding gases, treatment time and initial concentration of AF on removal efficiency were investigated. Results showed that compared to the N2 and air plasmas treatments, O2 plasma processing was most effective for AF degradation due to the strong oxidation ability of generated activated species, especially the OH radicals. The addition of GAC significantly enhanced the removal efficiency of AF in aqueous solution and shorten the required time by 50%. The effect was attributed to the ability of porous carbon to trap and concentrate the dye, increasing the time dye molecules were exposed to the plasma discharge zone, and to enhance the production of OH radicals on/in GAC to boost the degradation of dyes by plasma as well as in situ regenerate the exhausted GAC. The study offers a new opportunity for continuous effective remediation of wastewater contaminated with organic dyes using plasma technologies.

关键词： continuous removal dye-containing wastewater dielectric barrier discharge plasma water bed activated carbon adsorption