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Cell Research 1994年第1期4卷 47-56页

作者： YAN SHANGJUN chenGWU MA xianhua chen SHANHONG WAN ZUYU LUO(Physiology and Biophysics Department, Fudan University,Shanghai 200433, China) Physiology and Biophysics Department Fudan University Shanghai China

The inhibitory effect of parvovirus H-1 on the colonyforming ability in vitro of QGY-7703, a cultured human hepatoma cell line, and on the formation and growth of its tumors in nude mice was studied. With higher multiplicity of infection (MOI) of H-1 given, survival of the QGY-7703 cells was found to be decreased. H-1 DNA amplification level at 30 h postinfection(p.i.) was detected to be 7.4 times higher than that at 2 h by dispersed cells assay, while the cells were delayed to enter into S *** were formed in the indicator cells (new-born human kidney cell line, NBK) by progeny H-1 virus particles released from the infected QGY-7703 cells by infectious cell center assay. The formation of tumors in nude mice by QGY-7703 cells which were injected s c at 2 h postinfection was observed to be prevented in 2 groups with given MOI 25 and 50. The tumor growth of MOI 10 group occurred at a lower exponential rate than that of control,after a 20 d latent period. It was evident that parvovirus H-1 exhibited a direct inhibitory effect on the formation and growth of human hepatoma cells in vivo as well as in vitro.

关键词： Parvovirus H-1 human hepatoma cell line colony formation nude mice inhibitory effect

Prediction for asphalt pavement water film thickness based on artificial neural network

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Journal of Southeast University(English Edition) 2017年第4期33卷 490-495页

作者： Ma Yaolu Geng Yanfen chen xianhua Lu Yankun 东南大学交通学院南京210096 辽宁省交通规划设计院有限责任公司沈阳110000

In order to study the variation o f the asphalt pavement water film thickness influenced by multi-factors,anew method for predicting water film thickness was developed by the combination o f the artificial neural network(ANN)a d two-dimensional shallow water equations based on hydrodynamic ***-factors included the rainfall intensity,pavement width,cross slope,longitudinal slope a d pavement roughness *** two-dimensional hydrodynamic method was validated by a natural rainfall *** on the design scheme o f Shen-Sha expressway engineering project,the limited training data obtained by the two-dimensional hydrodynamic simulation model was used to predict water film ***,the distribution of the water film thickness influenced by multi-factors on the pavement was *** accuracy o f the ANN model was verified by the18sets o f data with a precision o *** simulation results indicate that the water film thickness increases from the median strip to the edge o f the *** water film thickness variation is obviously influenced by rainfall *** the condition that the pavement width is20m and t e rainfall intensity is3m m/h,t e water film thickness is below10mm in the fast lane and20mm in t e lateral *** there is fluctuation due to the amount oftraining data,compared with the calculation on the basis o f the existing criterion and theory,t e ANN model exhibits a better performance for depicting the macroscopic distribution of the asphalt pavement water film.

关键词： pavement engineering water film thickness artificial neural network hydrodynamic method prediction analysis

Multi-Branch High-Dimensional Guided Transformer-Based 3D Human Posture Estimation

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Computers, Materials & Continua 2024年第3期78卷 3551-3564页

作者： xianhua Li Haohao Yu Shuoyu Tian Fengtao Lin Usama Masood School of Mechanical Engineering Anhui University of TechnologyHuainan232001China School of Artificial Intelligence Anhui University of TechnologyHuainan232001China Key Laboratory of Conveyance Equipment(East China Jiaotong University) Ministry of EducationNanchang330013China

The human pose paradigm is estimated using a transformer-based multi-branch multidimensional directed the three-dimensional(3D)method that takes into account self-occlusion,badly posedness,and a lack of depth data in the per-frame 3D posture estimation from two-dimensional(2D)mapping to 3D ***,by examining the relationship between the movements of different bones in the human body,four virtual skeletons are proposed to enhance the cyclic constraints of limb ***,multiple parameters describing the skeleton are fused and projected into a high-dimensional *** a multi-branch network,motion features between bones and overall motion features are extracted to mitigate the drift error in the estimation ***,the estimated relative depth is projected into 3D space,and the error is calculated against real 3D data,forming a loss function along with the relative depth *** article adopts the average joint pixel error as the primary performance *** to the benchmark approach,the estimation findings indicate an increase in average precision of 1.8 mm within the Human3.6M sample.

关键词： Key point detection 3D human posture estimation computer vision deep learning

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高模量镁基材料的研究现状及展望

中国材料进展 2018年第7期37卷 526-531页

作者：涂腾陈先华重庆大学材料科学与工程学院重庆400044 重庆大学国家镁合金材料工程技术研究中心重庆400045

提高模量对扩大镁基材料的应用范围意义重大,高模量镁基材料的研究开发正受到国内外学者们的广泛关注和高度重视。综述了国内外高模量镁基材料的最新研究进展,阐述了工艺条件、合金化以及复合化对提高镁合金弹性模量的作用及效果,分析... 详细信息

提高模量对扩大镁基材料的应用范围意义重大,高模量镁基材料的研究开发正受到国内外学者们的广泛关注和高度重视。综述了国内外高模量镁基材料的最新研究进展,阐述了工艺条件、合金化以及复合化对提高镁合金弹性模量的作用及效果,分析了弹性模量提升的内在机制,并介绍了高模量镁基材料的力学性能。通过合金化在镁合金中加入一定量的合金元素,和通过复合化在镁基体中添加陶瓷颗粒、晶须或纤维等各种增强体,均能显著提高镁基材料的弹性模量。最后讨论了高模量镁基材料研究目前存在的主要问题,并对今后高模量镁基材料的发展趋势进行了展望。

关键词：镁合金弹性模量合金化复合材料增强相

Proactive Caching at the Wireless Edge:A Novel Predictive User Popularity-Aware Approach

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1997-2017页

作者： Yunye Wan Peng chen Yunni Xia Yong Ma Dongge Zhu Xu Wang Hui Liu Weiling Li xianhua Niu Lei Xu Yumin Dong College of Computer Science Chongqing UniversityChongqing400044China School of Computer and Software Engineering Xihua UniversityChengdu610039China School of Computer and Information Engineering Jiangxi Normal UniversityNanchang330022China Electric Power Research Institute of State Grid Ningxia Electric Power Co. Ltd.Yinchuan750002China College of Mechanical and Vehicle Engineering Chongqing UniversityChongqing400030China School of Computer Science and Technology Beijing Institute of TechnologyBeijing100083China School of Computer Science and Technology Dongguan University of TechnologyDongguan523808China School of Emergency Management Xihua UniversityChengdu610039China College of Computer and Information Science Chongqing Normal UniversityChongqing401331China

Mobile Edge Computing(MEC)is a promising technology that provides on-demand computing and efficient storage services as close to end users as *** an MEC environment,servers are deployed closer to mobile terminals to exploit storage infrastructure,improve content delivery efficiency,and enhance user ***,due to the limited capacity of edge servers,it remains a significant challenge to meet the changing,time-varying,and customized needs for highly diversified content of ***,techniques for caching content at the edge are becoming popular for addressing the above *** is capable of filling the communication gap between the users and content providers while relieving pressure on remote cloud ***,existing static caching strategies are still inefficient in handling the dynamics of the time-varying popularity of content and meeting users’demands for highly diversified entity *** address this challenge,we introduce a novel method for content caching over MEC,i.e.,*** synthesizes a content popularity prediction model,which takes users’stay time and their request traces as inputs,and a deep reinforcement learning model for yielding dynamic caching *** results demonstrate that PRIME,when tested upon the MovieLens 1M dataset for user request patterns and the Shanghai Telecom dataset for user mobility,outperforms its peers in terms of cache hit rates,transmission latency,and system cost.

关键词： Mobile edge computing content caching system average cost deep reinforcement learning collaborative mechanism

Establishment and application of minigene models for studying pre-mRNA alternative splicing

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Science China(Life Sciences) 2004年第3期47卷 211-218页

作者： LI Jing chen xianhua LIN Wanmin LI Lishu HAN Yu XU Ping Laboratory of Genomic Physiology School of Life Sciences Fudan University Shanghai 200433 China

The objective of the present study is to establish a minigene model for studying pre-mRNA alternative splicing. To prepare the minigene DNA constructs, with human or mouse genomic DNA as templates, GluR-B , FGF-2R and Zis 搈inigene?fragments were amplified us-ing PCR and cloned to the eukaryotic expression vectors. The three constructed minigenes and the expression vectors of Tra2b1 and Zis2 were co-transfected in Hela cells. RT-PCR analysis was performed to semi-quantitatively determine the spliced products from the minigenes. The results demonstrated that the constructed minigenes are useful in studying the pre-mRNA al-ternative splicing in cultured cells. With the established Zis minigene, we for the first time found that Zis2 isoform regulates the alternative splicing of Zis minigene.

关键词： minigene GluR-B FGF-2R Zis Tra2β pre-mRNA splicing.

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镁合金功能材料的研究进展（英文）

稀有金属材料与工程 2016年第9期45卷 2269-2274页

作者：陈先华耿玉晓潘复生重庆大学重庆400045 国家镁合金材料工程技术研究中心重庆400045 重庆市科学技术研究院重庆401123

与其它结构金属材料相比,镁合金具有质轻的显著优点,因此被广泛应用于交通运输和航空等领域。随着研究的深入和研究范围的扩大,镁合金更多的优点被开发利用:较高的理论能量密度,较大的阻尼容量和屏蔽效能以及良好的生物相容性。因此镁... 详细信息

与其它结构金属材料相比,镁合金具有质轻的显著优点,因此被广泛应用于交通运输和航空等领域。随着研究的深入和研究范围的扩大,镁合金更多的优点被开发利用:较高的理论能量密度,较大的阻尼容量和屏蔽效能以及良好的生物相容性。因此镁合金具有作为储氢材料、可再充电电池、阻尼材料、可生物降解的植入材料、电磁屏蔽材料、导热材料的潜力,但是每一种功能材料都存在未解决的瓶颈问题。本文针对近年来大量的研究工作进行了概括,总结了镁及镁合金作为以上6种功能材料的主要研究方向及研究进展,讨论了未来主要的研究方向。

关键词：镁合金功能材料新工艺性能合金化

A Review of Intelligent Configuration and Its Security for Complex Networks

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Chinese Journal of Electronics 2024年第4期33卷 920-947页

作者： Yue ZHAO Bin YANG Fei TENG xianhua NIU Ning HU Bo TIAN Science and Technology on Communication Security Laboratory School of Computer and Information Engineering Chuzhou University School of Computing and Artificial Intelligence Southwest Jiaotong University School of Computer and Software Engineering Xihua University Cyberspace Institute of Advanced Technology Guangzhou University

Complex networks are becoming more complex because of the use of many components with diverse technologies. In fact, manual configuration that makes each component interoperable has breed latent danger to system security. There is still no comprehensive review of these studies and prospects for further research. According to the complexity of component configuration and difficulty of security assurance in typical complex networks, this paper systematically reviews the abstract models and formal analysis methods required for intelligent configuration of complex networks, specifically analyzes, and compares the current key technologies such as configuration semantic awareness, automatic generation of security configuration, dynamic deployment, and verification evaluation. These technologies can effectively improve the security of complex networks intelligent configuration and reduce the complexity of operation and maintenance. This paper also summarizes the mainstream construction methods of complex networks configuration and its security test environment and detection index system, which lays a theoretical foundation for the formation of the comprehensive effectiveness verification capability of configuration security. The whole lifecycle management system of configuration security process proposed in this paper provides an important technical reference for reducing the complexity of network operation and maintenance and improving network security.

关键词： Complex networks Intelligent configuration Configuration security Software defined network Lifecycle management SOFTWARE ALGORITHM AGENT

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减速度非线性变化对制动距离影响分析

东南大学学报（自然科学版） 2011年第4期41卷 848-853页

作者：杨军张伟光陈先华东南大学交通学院南京210096

为避免减速度线性变化的假设造成制动距离计算值与实测值之间的偏差,回归了减速度与时间非线性关系式,并推导了减速度非线性变化时制动距离计算公式.建立轮胎-路面三维有限元模型,计算了在干燥与潮湿2种路表状况下制动减速度线性和非线... 详细信息

为避免减速度线性变化的假设造成制动距离计算值与实测值之间的偏差,回归了减速度与时间非线性关系式,并推导了减速度非线性变化时制动距离计算公式.建立轮胎-路面三维有限元模型,计算了在干燥与潮湿2种路表状况下制动减速度线性和非线性变化时的制动距离.结果表明:减速度线性和非线性变化计算所得制动距离,对于干燥路表差别不大,潮湿路表则差别十分明显;在潮湿路表状况下,相比于非线性变化,线性变化所得结果往往偏小,说明在分析水膜润滑导致制动距离延长方面,考虑线性变化的制动减速度是不合适的.

关键词：制动距离减速度非线性变化有限元模型干燥路表潮湿路表

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沥青混合料局部三轴压缩试验方法

东南大学学报（自然科学版） 2014年第4期44卷 838-844页

作者：张建同杨军陈先华陈小兵东南大学交通学院南京210096

为了优化常规三轴压缩试验与单轴贯入试验,介绍了局部三轴压缩试验原理、试验设计方法及过程等.基于与沥青路面实际受力情况相似的原则,通过ANASYS有限元论证了该方法的可行性.认为公称最大粒径及试件提供的围压是影响压头直径的主要影... 详细信息

为了优化常规三轴压缩试验与单轴贯入试验,介绍了局部三轴压缩试验原理、试验设计方法及过程等.基于与沥青路面实际受力情况相似的原则,通过ANASYS有限元论证了该方法的可行性.认为公称最大粒径及试件提供的围压是影响压头直径的主要影响因素,实际路面层厚与试件径高比是确定试件高度的主要因素,并设计了压头和试件的直径与高度.对AC13,SMA13和PA13三种级配沥青混合料进行局部三轴压缩试验,结果发现,该试验与常规三轴压缩试验的结果规律性一致.该试验具有应力状态明确,符合实际路面围压情况,所得参数的规律性、稳定性和准确性较好,且试验方法简单的优点.

关键词：沥青混合料局部三轴压缩试验有限元模拟高温性能应力应变关系