检索结果-南通市图书馆

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

在线全文

学校读者我要写书评

暂无评论

Science China Life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye yan Sun Jing Cai Fubing yu Haiping Wen Xiuwei Yi Taikang Li Mingwei Chen Jiayun Chen Ge Song Chuanbin yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

同方期刊数据库

Clinical characteristics and treatment of splenic infarction in children with systemic lupus erythematosus

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第5期20卷 525-531页

作者： yan Li yu-Rong Piao Tong-Xin Han Hua-Wei mao Department of Immunology Ministry of Education Key Laboratory of Major Diseases in ChildrenBeijing Key Laboratory for Genetics of Birth DefectsNational Center for Children’s HealthBeijing Children’s HospitalCapital Medical UniversityNo.56 Nan Li Shi LuBeijing100045China

Splenic infarction(SI)is a rare clinical phenomenon that occurs when the blood supply to the spleen is interrupted,resulting in tissue ischemia and necrosis[1].There are many causes of SI;in adult patients,cardioembolism,hematological malignancy,and infectious disease are the most common[2].Rheumatic diseases,especially systemic lupus erythematosus(SLE)and granulomatosis with polyangitis,can also lead to SI[3];however,only a few cases have been *** are currently no statistically meaningful data on the etiology of SI in *** most patients with SI can recover after conservative treatment,a small number of patients develop complications,such as splenic abscess,splenic rupture,splenic hemorrhage,and hemoperitoneum,and may even undergo splenectomy in severe cases.

关键词： erythematosus lupus treatment

Enhanced electrochemical CO_(2)reduction coupled with urea oxidation using bifunctional atomically dispersed CuNi catalysts

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2025年第1期18卷 208-216页

作者： Wenjie Wu Haoyang Zhou Ying Liu Yifei Pan Qingqing Chen yu Zhang Junjie mao Wenjie Ma Ping yu Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living BiosystemsInstitute of ChemistryChinese Academy of Sciences(CAS)Beijing 100190China College of Chemistry and Materials Science Anhui Normal UniversityWuhu 241002China University of Chinese Academy of Sciences Beijing 100049China

The electrochemical conversion of carbon dioxide(CO_(2))into chemical fuels represents a promising approach for addressing global carbon balance ***,this process is hindered by the kinetic limitations of anodic reactions,usually the oxygen evolution reaction,resulting in less efficient production of high value-added ***,we report an integrated electrocatalytic system that couples CO_(2)reduction reaction(CO_(2)RR)with urea oxidation reaction(UOR)using a bifunctional electrocatalyst with atomically dispersed dual-metal CuNi sites anchored on bamboo-like nitrogen-doped carbon nanotubes(CuNi-CNT),which were synthesized through a one-step pyrolysis *** bifunctional CuNi-CNT catalyst exhibits a near 100%CO Faraday efficiency for CO_(2)RR over a wide potential range and outstanding UOR performance with a negatively shifted potential of 210 mV at 10 mA·cm^(-2).In addition,we assemble a two-electrode electrolyzer using bifunctional CuNi-CNT-modified carbon fiber paper electrodes as both cathode and anode,capable of operating at a remarkably low cell voltage of 1.81 V at 10 mA·cm-2,significantly lower than conventional *** study provides a novel avenue to achieving an efficient carbon cycle with reduced electric power consumption.

关键词： electrochemical conversion bimetallic site catalyst bifunctional electrocatalyst carbon dioxide reduction urea oxidation

Up-regulation of HCN2 channels in a thalamocortical circuit mediates allodynia in mice

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

National Science Review 2023年第2期10卷 107-122页

作者： Jun-Ma yu Rui Hu yu mao Yingju Tai Sen Qun Zhi Zhang Danyang Chen yan Jin Department of Anesthesiology The Third Affiliated Hospital of Anhui Medical University (The First People's Hospital of Hefei) Department of Anesthesiology The First Affiliated Hospital of Anhui Medical University Department of Biophysics and Neurobiology Division of Life Sciences and Medicine University of Science and Technology of China Stroke Center and Department of Neurology The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China

Chronic pain is a significant problem that afflicts individuals and society,and for which the current clinical treatment is *** addition,the neural circuit and molecular mechanisms subserving chronic pain remain largely *** we identified enhanced activity of a glutamatergic neuronal circuit that encompasses projections from the ventral posterolateral nucleus(VPLGlu) to the glutamatergic neurons of the hindlimb primary somatosensory cortex(S1HLGlu),driving allodynia in mouse models of chronic *** inhibition of this VPLGlu→S1HLGlucircuit reversed allodynia,whereas the enhancement of its activity provoked hyperalgesia in control *** addition,we found that the expression and function of the HCN2(hyperpolarization-activated cyclic nucleotide-gated channel 2) were increased in VPLGluneurons under conditions of chronic *** in vivo calcium imaging,we demonstrated that downregulation of HCN2 channels in the VPLGluneurons abrogated the rise in S1HLGluneuronal activity while alleviating allodynia in mice with chronic *** these data,we propose that dysfunction in HCN2 channels in the VPLGlu→S1HLGluthalamocortical circuit and their upregulation occupy essential roles in the development of chronic pain.

关键词： chronic pain HCN2 channels neural circuit in vivo recordings

Research on Hydrodynamic Interference Suppression of Bottom-Mounted Monitoring Platform with Fairing Structure

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

China Ocean Engineering 2018年第1期32卷 51-61页

作者： WANG Zhen ZHENG Yi mao yu-feng WANG Ya-zhou yu yan-ting LIU Hong-ning Institute of Oceanographic Instrumentation Qilu University of Technology(Shandong Academy of Sciences)Qingdao 266061China Shandong Provincial Key Laboratory of Ocean Environmental Monitoring Technology Qingdao 266061China National Engineering and Technological Research Center of Marine Monitoring Equipment Qingdao 266061China

In the disturbance of unsteady flow field under the sea, the monitoring accuracy and precision of the bottom-mounted acoustic monitoring platform will decrease. In order to reduce the hydrodynamic interference, the platform wrapped with fairing structure and separated from the retrieval unit is described. The suppression effect evaluation based on the correlation theory of sound pressure and particle velocity for spherical wave in infinite homogeneous medium is proposed and the difference value between them is used to evaluate the hydrodynamic restraining performance of the bottom-mounted platform under far field condition. Through the sea test, it is indicated that the platform with sparse layers fairing structure(there are two layers for the fairing, in which the inside layer is 6-layers sparse metal net, and the outside layer is 1-layer polyester cloth, and then it takes sparse layers for short) has no attenuation in the sound pressure response to the sound source signal, but obvious suppression in the velocity response to the hydrodynamic noise. The effective frequency of the fairing structure is decreased below 10 Hz, and the noise magnitude is reduced by 10 d B. With the comparison of different fairing structures, it is concluded that the tighter fairing structure can enhance the performance of sound transmission and flow restraining.

关键词： bottom-mounted fairing hydrodynamic interference acoustic impedance transmission loss

Aerial edge computing for 6G

在线全文

学校读者我要写书评

暂无评论

The Journal of China Universities of Posts and Telecommunications 2022年第1期29卷 50-63页

作者： mao Sun Zhang yan College of Computer Science Sichuan Normal UniversityChengdu 610101China Department of Informatics University of OsloOslo 0316Norway

In the 6 th generation mobile communication system(6 G) era, a large number of delay-sensitive and computation-intensive applications impose great pressure on resource-constrained Internet of things(IoT) devices. Aerial edge computing is envisioned as a promising and cost-effective solution, especially in hostile environments without terrestrial infrastructures. Therefore, this paper focuses on integrating aerial edge computing into 6 G for providing ubiquitous computing services for IoT devices. This paper first presents the layered network architecture of aerial edge computing for 6 G. The benefits, potential applications, and design challenges are also discussed in detail. Next, several key techniques like unmanned aerial vehicle(UAV) deployment, operation mode, offloading mode, caching policy, and resource management are highlighted to present how to integrated aerial edge computing into 6 G. Then, the joint UAV deployment optimization and computation offloading method is designed to minimize the computing delay for a typical aerial edge computing network. Numerical results reveal the significant delay reduction of the proposed method compared with the other benchmark methods. Finally, several open issues for aerial edge computing in 6 G are elaborated to provide some guidance for future research.

关键词： mobile edge computing unmanned aerial vehicle the 6th generation mobile communication system

An unequal fracturing stage spacing optimization model for hydraulic fracturing that considers cementing interface integrity

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2023年第4期20卷 2165-2186页

作者： Xu Han Fu-Ping Feng Xiao-Chuan Zhang Jing Cao Jun Zhang yu Suo yan yan mao-Sen yan Department of Petroleum Engineering Northeast Petroleum UniversityDaqing163318HeilongjiangChina Daqing Oil Field Limited-Liability Company Daqing163453HeilongjiangChina Tubular Goods Research Institute of CNPC Xi’an710000ShaanxiChina

Determining reasonable fracturing stage spacing is the key to horizontal well *** from traditional stage spacing optimization methods based on the principle of maximum stimulated reservoir volume,in this paper,by considering the integrity of the wellbore interface,a fracture propagation model was established based on displacement discontinuity method and the competition mechanism of multifracture joint expansion,leading to the proposal of an unequal stage spacing optimization *** results show that in the first stage,the interfacial fractures spread symmetrically along the axis of the central point during that stage,while in the second and subsequent stages,the interfacial fractures of each cluster extend asymmetrically along the left and right *** are two kinds of interface connectivity behaviour:in one,the existing fractures first extend and connect within the stage,and in the other,the fractures first extend in the direction close to the previous stage,with the specific behaviour depending on the combined effect of stress shadow and flow competition during hydraulic fracture *** stage spacing is positively correlated with the number of fractures and Young’s modulus of the cement and formation and is negatively correlated with the cluster spacing and horizontal principal stress *** sensitivity is the strongest when the Young’s modulus of the cement sheath is 10-20 GPa,and the sensitivity of the horizontal principal stress difference is the weakest.

关键词： Hydraulic fracturing Cementing interface Fracture propagation Fracturing stage spacing Wellbore integrity

The status quo and challenges of genetic diagnosis in children with steroid-resistant nephrotic syndrome

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2018年第2期14卷 105-109页

作者： yan-yan Jin Bing-yu Feng Jian-Hua mao Department of Nephrology Children's HospitalZhejiang University School of Medicine#57 Zhugan LaneHangzhou 310003China Department of Paediatrics The First People's Hospital of HuzhouHuzhou 313000China

Introduction Idiopathic nephrotic syndrome(INS)is one of the most common renal diseases in the pediatric population,which is characterized by massive proteinuria,hypoalbuminemia,edema,and hyperlipidemia[1].

关键词： diagnosis nephrotic diseases

3DTS:A 3D tolerancing system based on mathematical definition

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第11期7卷 1810-1818页

作者： CAO yan-long LIU yu-sheng mao Jian yanG Jiang-xim Faculty of Mechanical and Energy Engineering Zhejiang University Hangzhou 310027 China State Key Lab of CAD ＆ CG Zhejiang University Hangzhou 310027 China

Tolerance is almost ubiquitous during the whole product lift cycle and is imperative for seamless integration of CAD and CAM. Based on the mathematical definition of tolerance, a 3D tolerancing system, 3DTS, is presented with its design prin- ciple, system architecture and key functions. The following functional modules, tolerance modeling, semantics interpretation, 3D tolerance analysis, are described in detail. To make the tolerancing system robust and efficient, many techniques such as hierar- chical tolerance representation, rule-based evaluation and non-intersection determination of tolerance zone have been devised. Tested by many samples, this system shows good robustness and practicability.

关键词： Tolerance Mathematical definition CAD/CAM