检索结果-南通市图书馆

Curcumin co-treatment ameliorates resistance to gefitinib in drug-resistant NCI-H1975 lung cancer cells

Journal of Traditional Chinese Medicine 2017年第3期37卷 355-360页

作者： Jin Xin Wang Jue Shen Huifen Ran Ran Xu Kai Tong xiangming Zhang Weiping feng Li Institute of Hematology the First Affiliated Hospital of Medical School of Zhejiang University Department of Oncology the Third Affiliated Hospital of Zhejiang Chinese Medical University Institute of Hematology Zhejiang Provincial People's Hospital Traditional Chinese Medicine Department of National Cancer Center/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

OBJECTIVE: To examine whether a combinative treatment with curcumin enhances the effects of the epidermal growth factor receptor-tyrosine kinase inhibitor(EGFR-TKI) gefitinib on cell proliferation, clonogenic capacity and apoptosis in the drug-resistant lung cancer cell line NCI-H1975, and further investigate the molecular mechanisms ***: NCI-H1975 cells were treated with curcumin and gefitinib alone or in combination, and cell proliferation, clonogenic capacity and apoptosis were examined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay, clone forming experiments, and flow cytometry, respectively, while p38, extracellular regulated protein kinase(ERK)1/2, and protein kinase B(AKT)phosphorylation were examined using Western ***: Compared with the effects of either agent alone, the combination of curcumin and gefitinib had a stronger suppressive effect on proliferation and the clonogenic capacity(P < 0.05), and showed an increased ability to promote apoptosis(P < 0.05) and reduce p38, ERK1/2, and AKT phosphorylation(P < 0.05).CONCLUSION: Co-treatment of curcumin and gefitinib significantly improves the ability of gefitinib to inhibit cell proliferation, suppress the clonogenic capacity and enhance apoptosis in NCI-H1975 cells,and these effects are possibly mediated via a decrease in phosphorylation of proteins in downstream pathways of the epidermal growth factor receptor.

关键词： Lung neoplasms Cell line, tumor Cur-cumin Cell proliferation Apoptosis Receptor, epi-dermal growth factor Gefitinib

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

运用绵羊颈外静脉构建面颈部静脉畸形动物模型

引用

实用口腔医学杂志 2024年第1期40卷 43-46页

作者：杨霞沈艳玲郭军刘源闫志伟杨向明吴炜冯瑶杨耀武口颌系统重建与再生全国重点实验室国家口腔疾病临床医学研究中心陕西省口腔疾病临床医学研究中心空军军医大学第三附属医院口腔颌面头颈肿瘤科西安710032 洛阳市中心医院口腔科空军军医大学第三附属医院口腔影像医学科空军军医大学第三附属医院组织病理科佳木斯大学附属口腔医院牙髓病科

目的:通过外科手术改建绵羊颈外静脉,初步建立面颈部静脉畸形(VMs)动物模型。方法:解剖、观察并测量5只健康成年绵羊颈外静脉的位置、走行、分支和外径。通过近心端静脉主干缝扎缩窄、远心端分支静脉结扎或缩窄等方法构建具有汇入静脉... 详细信息

目的:通过外科手术改建绵羊颈外静脉,初步建立面颈部静脉畸形(VMs)动物模型。方法:解剖、观察并测量5只健康成年绵羊颈外静脉的位置、走行、分支和外径。通过近心端静脉主干缝扎缩窄、远心端分支静脉结扎或缩窄等方法构建具有汇入静脉和回流静脉的VMs动物模型。术后4周,通过多普勒超声、大体观察以及组织学观察对动物模型进行评价。结果:绵羊颈外静脉位于双侧颈部侧面,主干由上颌静脉、舌面静脉汇合而成,外径为6~12 mm,平均外径9.3 mm。颈外静脉经过近心端静脉主干缝扎缩窄、远心端分支静脉结扎或缩窄处理后即刻血液回流速度减慢,模型区域静脉鼓起变粗。术后4周,大体观察见多数静脉收缩变细,部分静脉管腔内血栓形成,部分标本中心区隆起扩张,部分模型外周侧支静脉扩张。多普勒超声检查显示制备成的VMs模型静脉管腔较粗,回流静脉、汇入静脉较细,管腔内可见彩色血流。组织学观察显示静脉血管内皮及管壁结构与正常静脉接近,部分标本血管壁增厚。结论:绵羊颈外静脉构建的VMs动物模型基本符合要求,有望用于面颈部VMs治疗方法学的研究。

关键词：绵羊颈外静脉静脉畸形动物模型面颈部

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In-depth investigation of the exothermic reactions between lithiated graphite and electrolyte in lithium-ion battery

引用

Journal of Energy Chemistry 2022年第6期31卷 593-600,I0017页

作者： Yuejiu Zheng Zhihe Shi Dongsheng Ren Jie Chen Xiang Liu Xuning feng Li Wang Xuebing Han Languang Lu xiangming He Minggao Ouyang College of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China College of Electrical Engineering University of Beijing JiaotongBeijing 100044China

Thermal runaway is a critical issue for the large application of lithium-ion *** reactions between lithiated graphite and electrolyte play a crucial role in the thermal runaway of lithium-ion ***,the role of each component in the electrolyte during the exothermic reactions with lithiated graphite has not been fully *** this paper,the exothermic reactions between lithiated graphite and electrolyte of lithium-ion battery are investigated through differential scanning calorimetry(DSC) and evolved gas *** lithiated graphite in the presence of electrolyte exhibit three exothermic peaks during DSC *** reactions between lithiated graphite and LiPF_(6) and ethylene carbonate are found to be responsible for the first two exothermic peaks,while the third exothermic peak is attributed to the reaction between lithiated graphite and *** contrast,diethylene carbonate and ethyl methyl carbonate contribute little to the total heat generation of graphite-electrolyte *** reaction mechanism between lithiated graphite and electrolyte,including the major reaction equations and gas products,are ***,DSC tests on samples with various amounts of electrolyte are performed to clarify the quantitative relationship between lithiated graphite and electrolyte during the exothermic reactions.2.5 mg of lithiated graphite (Li_(0.8627)C_(6)) can fully react with around 7.2 mg electrolyte,releasing a heat generation of 2491 J g^(-1).The results presented in this study can provide useful guidance for the safety improvement of lithium-ion batteries.

关键词： Lithium-ion battery Battery safety Thermal runaway Exothermic reaction Li-intercalated graphite Electrolyte

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermal Runaway of Lithium-Ion Batteries Employing Flame-Retardant Fluorinated Electrolytes

引用

Energy & Environmental Materials 2023年第1期6卷 333-339页

作者： Junxian Hou Li Wang Xuning feng Junpei Terada Languang Lu Shigeaki Yamazaki Anyu Su Yoshiko Kuwajima Yongjiang Chen Tomoya Hidaka xiangming He Hewu Wang Minggao Ouyang State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Daikin Industries Ltd.1-1Nishi-HitotsuyaSettsu Osaka 566-8585Japan Sichuan New Energy Vehicle Innovation Center Yibin 644002China

Fluorinated electrolytes possess good antioxidant capacity that provides high compatibility to high-voltage cathode and flame retardance;thus,they are considered as a promising solution for advanced lithium-ion batteries carrying both high-energy density and high ***,the fluorinated electrolytes are widely used to form stable electrolyte interphase,due to their chemical reactivity with lithiated graphite or ***,the influence of this reactivity on the thermal safety of batteries is seldom ***,we demonstrate that the flame-retardant fluorinated electrolytes help to reduce the flammability,while the lithium-ion batteries with flame-retardant fluorinated electrolytes still undergo thermal runaway and disclose their different thermal runaway pathway from that of battery with conventional *** reduction in fluorinated components(e.g.,LiPF 6 and fluoroethylene carbonate(FEC))by fully lithiated graphite accounts for a significant heat release during battery thermal *** 13%of total heat is sufficient to trigger the chain reactions during battery thermal *** study deepens the understanding of the thermal runaway mechanism of lithium-ion batteries employing flame-retardant fluorinated electrolytes,providing guidance on the concept of electrolyte design for safer lithium-ion batteries.

关键词： battery safety flame retardance fluorinated electrolytes lithium-ion battery thermal runaway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A lysosomal polarity-specific two-photon fluorescent probe for visualization of autophagy

引用

Chinese Chemical Letters 2021年第5期32卷 1803-1808页

作者： Zixiang Yuan Jun Chen Qin Zhou Ao Liu Zeming Qiang Min Fang Man Chen Yan feng Haizhu Yu Xiuli Yang xiangming Meng School of Chemistry and Chemical Engineering&Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials Anhui UniversityHefei 230601China Key Laboratory for Advanced Technology in Environmental Protection of Jiangsu Province Yancheng Institute of TechnologyYancheng 224051China Institute of Physical Science and Information Technology Anhui UniversityHefei 230601China Anhui Golden Sun Biochemical Pharmaceuticals Limited Company Fuyang 236000China

Autophagy plays a vital role in maintaining the balance of normal physiological state of living *** this paper,a polarity-specific two-phot on fluorescent probe Lyso-NA based on naphthalimide was synthesized for the purpose of monitoring autophagy during biological *** results of photophysical properties and theoretical calculation con firmed that different polarities of solvents mainly effected fluorescent intensities of *** nt intensity,quantum yield and fluorescence lifetime of probe kept a good linear relationship with polarity *** addition,due to its low toxicity and selective accumulation in lysosomes,Lyso-NA is suitable for detecting changes in lysosomal polarity of living *** with the imaging results of plasmid transfection,a better performed realtime long-term fluoresce nt visualization of autophagy in living cells was *** Lyso-NA can work as an efficient and cost effective imaging tool for visualizing autophagy in living cells.

关键词： Two-photon fluorescent probe Lysosomal polarity Autophagy Visualization Plasmid transfection

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Thermal Runaway Characteristics and Modeling of LiFePO4 Power Battery for Electric Vehicles

引用

Automotive Innovation 2023年第3期6卷 414-424页

作者： Tao Sun Luyan Wang Dongsheng Ren Zhihe Shi Jie Chen Yuejiu Zheng Xuning feng Xuebing Han Languang Lu Li Wang xiangming He Minggao Ouyang School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China State Key Laboratory of Automotive Safety and Energy Tsinghua UniversityBeijing 100084China

LiFePO_(4)(LFP)lithium-ion batteries have gained widespread use in electric vehicles due to their safety and longevity,but thermal runaway(TR)incidents still have been *** paper explores the TR characteristics and modeling of LFP batteries at different states of charge(SOC).Adiabatic tests reveal that TR severity increases with SOC,and five stages are identified based on battery temperature *** kinetics parameters of exothermic reactions in each TR stage are extracted,and TR models for LFP batteries are *** models accurately simulate TR behaviors at different SOCs,and the simulated TR characteristic temperatures also agree well with the experimental results,with errors of TR characteristic temperatures less than 3%.The prediction errors of TR characteristic temperatures under oven test conditions are also less than 1%.The results provide a comprehensive understanding of TR in LFP batteries,which is useful for battery safety design and optimization.

关键词： Lithium-ion battery Safety Thermal runaway Thermal runaway model State of charge

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Two-step model of paleohexaploidy, ancestral genome reshuffling and plasticity of heat shock response in Asteraceae

引用

Horticulture Research 2023年第6期10卷 82-95页

作者： xiangming Kong Yan Zhang Ziying Wang Shoutong Bao Yishan feng Jiaqi Wang Zijian Yu feng Long Zejia Xiao Yanan Hao Xintong Gao Yinfeng Li Yue Ding Jianyu Wang Tianyu Lei Chuanyuan Xu Jinpeng Wang Department of Bioinformatics School of Life Sciencesand Center for Genomics and Computational BiologyNorth China University of Science and TechnologyTangshanHebei 063000China State Key Laboratory of Systematic and Evolutionary Botany Institute of BotanyChinese Academy of ScienceBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China

An ancient hexaploidization event in the most but not all Asteraceae plants,may have been responsible for shaping the genomes of many horticultural,ornamental,and medicinal plants that promoting the prosperity of the largest angiosperm family on the ***,the duplication process of this hexaploidy,as well as the genomic and phenotypic diversity of extant Asteraceae plants caused by paleogenome reorganization,are still poorly *** analyzed 11 genomes from 10 genera in Asteraceae,and redated the Asteraceae common hexaploidization(ACH)event∼70.7–78.6 million years ago(Mya)and the Asteroideae specific tetraploidization(AST)event∼41.6–46.2 ***,we identified the genomic homologies generated from the ACH,AST and speciation events,and constructed a multiple genome alignment framework for ***,we revealed biased fractionations between the paleopolyploidization produced subgenomes,suggesting the ACH and AST both are allopolyplodization ***,the paleochromosome reshuffling traces provided clear evidence for the two-step duplications of ACH event in ***,we reconstructed ancestral Asteraceae karyotype(AAK)that has 9 paleochromosomes,and revealed a highly flexible reshuffling of Asteraceae *** specific significance,we explored the genetic diversity of Heat Shock Transcription Factors(Hsfs)associated with recursive whole-genome polyploidizations,gene duplications,and paleogenome reshuffling,and revealed that the expansion of Hsfs gene families enable heat shock plasticity during the genome evolution of *** study provides insights on polyploidy and paleogenome remodeling for the successful establishment of Asteraceae,and is helpful for further communication and exploration of the diversification of plant families and phenotypes.

关键词： shuffling shock plasticity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

CsPbBr_(3)-DMSO merged perovskite micro-bricks for efficient X-ray detection

引用

Nano Research 2023年第7期16卷 9983-9989页

作者： Tongyu Shi Wenjun Liu Jiongtao Zhu Xiongsheng Fan Zhengyu Zhang Xingchen He Rui He Jiahong Wang Kezhen Chen Yongshuai Ge xiangming Sun Yanliang Liu Paul K.Chu Xue-feng Yu Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China Nano Science and Technology Institute University of Science and Technology of ChinaSuzhou 215123China Key Laboratory of Quark and Lepton Physics(MOE) Central China Normal UniversityWuhan 430079China Department of Physics Department of Materials Science and Engineeringand Department of Biomedical EngineeringCity University of Hong KongHong Kong 999077China

Inorganic perovskite wafers with good stability and adjustable sizes are promising in X-ray detection but the high synthetic temperature is a ***,dimethyl sulfoxide(DMSO)is used to prepare the CsPbBr_(3)micro-bricks powder at room *** CsPbBr_(3)powder has a cubic shape with few crystal defects,small charge trap density,and high crystallinity.A trace amount of DMSO attaches to the surface of the CsPbBr_(3)micro-bricks via Pb-O bonding,forming the CsPbBr_(3)-DMSO *** hot isostatic processing,the released DMSO vapor merges the CsPbBr_(3)micro-bricks,producing a compact and dense CsPbBr_(3)wafer with minimized grain boundaries and excellent charge transport *** CsPbBr_(3)wafer shows a large mobility-lifetime(μτ)product of 5.16×10^(-4)cm^(2)·V^(-1),high sensitivity of 14,430μC·Gyair^(-1)·cm^(-2),low detection limit of 564 nGyair·s^(-1),as well as robust stability in X-ray *** results reveal a novel strategy with immense practical potential pertaining to high-contrast X-ray detection.

关键词： CsPbBr_(3)-DMSO inorganic perovskites wafer grain growth crystal defect X-ray detector

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

一个新的社会稳定风险评估分析框架：风险感知的视角

引用

中国行政管理 2014年第4期 102-108页

作者：胡象明王锋北京航空航天大学公共管理学院湖州师范学院

主流风险评估强调成本—收益分析、环境风险分析等经济、环境层面评估,忽视对公众风险感知的心理、文化层面的分析与评估,致使作为风险承担者的公众被排斥在风险管理和决策之外。从风险感知视角构建社会稳定风险评估分析框架,有助于揭... 详细信息

主流风险评估强调成本—收益分析、环境风险分析等经济、环境层面评估,忽视对公众风险感知的心理、文化层面的分析与评估,致使作为风险承担者的公众被排斥在风险管理和决策之外。从风险感知视角构建社会稳定风险评估分析框架,有助于揭示社会风险产生的内在机理和演进逻辑,弥补有关公众风险感知评估内容的缺失。北京六里屯垃圾填埋场个案研究表明,公众的心理焦虑、信任、社会经济背景等变量与公众抗争意愿具有一定的相关性,女性、本地人、年轻人、低教育程度者、较高收入者、居住年限较长者的抗争意愿更强;焦虑程度越高者、感知到的负面风险越大者、对风险设施运营方越是不信任者,抗争意愿越强。

关键词：风险评估风险感知焦虑信任

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association of Serum Soluble Receptor for Advanced Glycation End Products (sRAGE), S100A12, and VCAM-1 Levels with Further Post-Coronary Angiogram Endothelial Injury in Elderly and Younger Patients

引用

World Journal of Cardiovascular Diseases 2018年第1期8卷 48-58页

作者： Deeraj Mungun Iyan Zakaria xiangming Wang Tiantian Tu Chuyan feng Yan Guo Department of Gerontology The first affiliated hospital of Nanjing Medical University Nanjing China Department of Cardiology Jiangsu Shengze Hospital Suzhou China

Objective: Coronary Angiography (CAG) refers to an aggressive process that is likely to lead to endothelial injury and possibly drive further interpretation of the cause for patients within current atherosclerotic illnesses. Therefore, this study aims to test certain correlations among concentration of sRAGE, VCAM-1, as well as S100A12 pre- and post-coronary angiography alongside likelihood of endothelial injury among various patients in different ages including the younger and the geriatric groups, thereby offering a full connection upon CAG impacts of patients having atherosclerosis. Method: In this study, the whole patients chosen had been grouped into two major groups on the basis of ages: the younger patient aged less than 65 years old (Group 1), and the elderly patient aged over 65 years old (Group 2). Soluble RAGE (sRAGE), VCAM-1 and S100A12 degrees in blood sampling gathered followed by measurements of CAG session for evaluating the inflammatory responses and likelihood of endothelial injury caused via CAG. All data was analyzed using SPSS version 21.0. Findings: Significant enhancement among concentration of serum VCAM-1 (P = 0.007) in younger patients and sRAGE (P = 0.019) in elderly patients had been observed, but that of serum S100A12 was still unaltered. Conclusions: Enhanced concentration of sRAGE and VCAM-1 post-CAG of patients having CAD are able to be related to follow-up endothelial injury, thus contributing to different pathway in exacerbating endothelial injury among younger and elderly patients.

关键词： Coronary Angiography Typical sRAGE VCAM-1 S100A12

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：