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认知行为护理应用在甲状腺结节患者的术后护理中对其心理状态的影响分析

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中外医疗 2024年第16期43卷 121-124页

作者：关祥敏李祥梅杨军滕州市中医医院重症医学科山东枣庄277599

目的分析对甲状腺结节手术患者施以认知行为护理对其心理状态的改善作用。方法简单随机选取2021年9月—2022年8月滕州市中医医院接诊的70例甲状腺结节手术患者为研究对象,随机数表法分为两组,每组35例。对照组接受常规护理,研究组接... 详细信息

目的分析对甲状腺结节手术患者施以认知行为护理对其心理状态的改善作用。方法简单随机选取2021年9月—2022年8月滕州市中医医院接诊的70例甲状腺结节手术患者为研究对象,随机数表法分为两组,每组35例。对照组接受常规护理,研究组接受认知行为护理,比较两组心理状态、自护能力、认知水平、护理满意度、生活质量。结果研究组护理后抑郁自评量表(36.13±5.28)分、焦虑自评量表(35.47±4.37)分低于对照组,自护能力评分(88.23±8.41)分、(38.58±4.76)分、(45.83±3.16)分以及认知水平评分均高于对照组,差异有统计学意义(t=6.543、6.674、6.518、4.614、11.384、15.521、13.279,P均<0.05)。研究组患者护理总满意度(97.14%)高于对照组(80.00%),差异有统计学意义(P<0.05)。护理后,研究组患者生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论对甲状腺结节手术患者施以认知行为护理效果良好,不但可使心理状态、自护能力、认知水平提高,同时可提高护理满意度,利于生活质量提高。

关键词：甲状腺结节术后认知行为护理心理状态

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数字减影全脑血管造影和支架植入术的围术期护理

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中外医疗 2024年第13期43卷 134-137页

作者：李祥梅关祥敏杨军邵鹏滕州市中医医院重症医学科山东枣庄277599 滕州市中心人民医院外科山东枣庄277599

目的研究数字减影全脑血管造影和支架植入术的围术期护理。方法随机选取2021年1月—2023年7月在滕州市中医医院进行数字减影全脑血管造影和支架植入术的70例患者为研究对象,依照计算机随机分配的方式分为观察组(n=35)、对照组(n=35)。... 详细信息

目的研究数字减影全脑血管造影和支架植入术的围术期护理。方法随机选取2021年1月—2023年7月在滕州市中医医院进行数字减影全脑血管造影和支架植入术的70例患者为研究对象,依照计算机随机分配的方式分为观察组(n=35)、对照组(n=35)。对照组采取常规护理,观察组采取围术期护理干预,对比两组并发症发生率、护理满意度以及生活质量评分。结果观察组满意度(97.14%)显著高于对照组(82.86%),差异有统计学意义(χ^(2)=3.968,P<0.05);观察组并发症发生率(11.43%)显著低于对照组(31.43%),差异有统计学意义(χ^(2)=4.158,P<0.05);观察组生活质量评分高于对照组,差异有统计学意义(P<0.05)。结论将围术期护理应用于数字减影全脑血管造影和支架植入术中,可显著改善患者预后生活状态,提高生活质量,降低并发症发生率,有着较高安全性。

关键词：数字减影全脑血管造影支架植入术围术期护理

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UAT2数据链发射机编码及调制技术

西华大学学报（自然科学版） 2024年第6期43卷 53-62页

作者：文旌宇汤新民冯文源管祥民南京航空航天大学民航学院江苏南京210016 中国民航大学天津市城市空中交通系统技术与装备重点实验室天津300300 中国民航大学交通科学与工程学院天津300300 中国民航管理干部学院民航通用航空运行重点实验室北京100102

为应对低空空域飞行器数量的增加及航空产业对未来城市空中交通(UAM)飞行器的监视跟踪需求,文章对UAT2数据链发射机的编码与调制技术进行研究:搭建UAT2数据链发射机系统结构,针对UAM飞行器监视需求,提出可寻址数据上行链路通信编码及飞... 详细信息

为应对低空空域飞行器数量的增加及航空产业对未来城市空中交通(UAM)飞行器的监视跟踪需求,文章对UAT2数据链发射机的编码与调制技术进行研究:搭建UAT2数据链发射机系统结构,针对UAM飞行器监视需求,提出可寻址数据上行链路通信编码及飞行器健康状况监测下行链路编码规则算法,旨在全面覆盖UAM的安全运行需求;开发一种UAT2报文的轻量高速化RS编码算法,以减少执行时间和内存占用;基于直接数字频率合成DDS技术,实现连续相位频移键控CPFSK调制,符合UAT2数据链信号要求,确保了频谱能量的集中分布。关键编码和调制技术经过测试分析与性能评估,能够有效适用于UAT2数据链发射机。

关键词： UAT2数据链信源编码规则算法 RS编码改进算法直接数字频率合成

Thrombolysis and extracorporeal cardiopulmonary resuscitation for cardiac arrest due to pulmonary embolism:A case report

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World Journal of Critical Care Medicine 2025年第1期14卷 111-117页

作者： guan-Xing Yuan Zhi-Ping Zhang Jia Zhou Department of Emergency Wuhan Asia General HospitalWuhan 430056Hubei ProvinceChina Department of Neurosurgery Central Theater Command General HospitalWuhan 430000Hubei ProvinceChina

BACKGROUND Cardiac arrest caused by acute pulmonary embolism(PE)is the most serious clinical circumstance,necessitating rapid identification,immediate cardiopulmonary resuscitation(CPR),and systemic thrombolytic *** CPR(ECPR)is typically employed as a rescue therapy for selected patients when conventional CPR is failing in settings where it can be *** SUMMARY We present a case of a 69-year-old male who experienced a prolonged cardiac arrest in an ambulance with pulseless electrical *** arrival at the emergency department with ongoing manual chest compressions,bedside pointof-care ultrasound revealed an enlarged right ventricle without *** PE was suspected as the cause of cardiac arrest,and intravenous thrombolytic therapy with 50 mg tissue plasminogen activator was administered during mechanical chest *** 31 minutes of CPR,return of spontaneous circulation was not achieved until 8 minutes after initiation of Veno-arterial extracorporeal membrane oxygenation(ECMO)*** ECMO support,the hemodynamic status and myocardial contractility significantly ***,the patient ultimately did not survive due to intracerebral hemorrhagic complications,leading to death a few days later in the *** This case illustrates the potential of combining systemic thrombolysis with ECPR for refractory cardiac arrest caused by acute PE,but it also highlights the increased risk of significant bleeding complications,including fatal intracranial hemorrhage.

关键词： Pulmonary embolism Cardiac arrest Thrombolytic therapy Cardiopulmonary resuscitation Extracorporeal membrane oxygenation Intracranial hemorrhage Case report

Decreased levels of phosphorylated synuclein in plasma are correlated with poststroke cognitive impairment

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Neural Regeneration Research 2025年第9期20卷 2598-2610页

作者： Yi Wang Yuning Li Yakun Gu Wei Ma Yuying guan Mengyuan Guo Qianqian Shao Xunming Ji Jia Liu Department of Clinical Laboratory Beijing Bo’ai HospitalChina Rehabilitation Research CenterCapital Medical UniversityBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Science and TechnologyCollaborative Innovation Center for Brain DisordersBeijing Advanced Innovation Center for Big Data-based Precision MedicineCapital Medical UniversityBeijingChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina

Poststro ke cognitive impairment is a major secondary effect of ischemic stroke in many patients;however,few options are available for the early diagnosis and treatment of this *** aims of this study were to(1)determine the specific relationship between hypoxic andα-synuclein during the occur of poststroke cognitive impairment and(2)assess whether the serum phosphorylatedα-synuclein level can be used as a biomarker for poststro ke cognitive *** found that the phosphorylatedα-synuclein level was significantly increased and showed pathological aggregation around the cerebral infa rct area in a mouse model of ischemic *** addition,neuronalα-synuclein phosphorylation and aggregation were observed in the brain tissue of mice subjected to chronic hypoxia,suggesting that hypoxia is the underlying cause ofα-synuclein-mediated pathology in the brains of mice with ischemic *** phosphorylatedα-synuclein levels in patients with ischemic stroke were significantly lower than those in healt hy subjects,and were positively correlated with cognition levels in patients with ischemic ***,a decrease in serum high-density lipoprotein levels in stroke patie nts was significantly correlated with a decrease in phosphorylatedα-synuclein *** ischemic stroke mice did not show significant cognitive impairment or disrupted lipid metabolism 14 days after injury,some of them exhibited decreased cognitive function and reduced phosphorylatedα-synuclein *** together,our results suggest that serum phosphorylatedα-synuclein is a potential biomarker for poststroke cognitive impairment.

关键词： biomarker high-density lipoprotein ischemic stroke phosphorylatedα-synuclein poststroke cognitive impairment

Antiviral therapy for hepatitis B virus infection is beneficial for the prognosis hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 1-9页

作者： Hui Wan Yu-Xin Zhang guan-Yue Shan Jun-Ya Cheng Duan-Rui Qiao Yi-Ying Liu Wen-Na Shi Hai-Jun Li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of Liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

In this editorial,we comment on the article by Mu et al,published in the recent issue of the World Journal of Gastrointestinal *** pay special attention to the immune tolerance mechanism caused by hepatitis B virus(HBV)infection,the pathogenesis of hepatocellular carcinoma(HCC),and the role of antiviral therapy in treating HCC related to HBV *** infection leads to systemic innate immune tolerance by directly inhibiting pattern recognition receptor recognition and antiviral signaling pathways,as well as by inhibiting the immune functions of macrophages,natural killer cells and dendritic *** addition,HBV leads to an immunosuppressive cascade by expressing inhibitory molecules to induce exhaustion of HBV-specific cluster of differentiation 8+T cells,ultimately leading to long-term viral *** loss of immune cell function caused by HBV infection ultimately leads to ***-term antiviral therapy can improve the prognosis of patients with HCC and prevent tumor recurrence and metastasis.

关键词： Hepatitis B virus Hepatocellular carcinoma Hepatitis B virus-DNA Immune tolerance Antiviral therapy

Endoplasmic reticulum stress and autophagy in cerebral ischemia/reperfusion injury:PERK as a potential target for intervention

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Neural Regeneration Research 2025年第5期20卷 1455-1466页

作者： Ju Zheng Yixin Li Ting Zhang Yanlin Fu Peiyan Long Xiao Gao Zhengwei Wang Zhizhong guan Xiaolan Qi Wei Hong Yan Xiao Key Laboratory of Endemic and Ethnic Diseases Ministry of Education&Key Laboratory of Medical Molecular Biology of Guizhou ProvinceGuizhou Medical UniversityGuiyangGuizhou ProvinceChina Guizhou Center for Disease Control and Prevention GuiyangGuizhou ProvinceChina Department of Histology and Embryology Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Collaborative Innovation Center for Prevention and Control of Endemic and Ethnic Regional Diseases Co-constructed by the Province and Ministry GuiyangGuizhou ProvinceChina

Several studies have shown that activation of unfolded protein response and endoplasmic reticulum(ER)stress plays a crucial role in severe cerebral ischemia/reperfusion *** occurs within hours after cerebral ischemia,but the relationship between ER stress and autophagy remains *** this study,we established experimental models using oxygen-glucose deprivation/reoxygenation in PC12 cells and primary neurons to simulate cerebral ischemia/reperfusion *** found that prolongation of oxygen-glucose deprivation activated the ER stress pathway protein kinase-like endoplasmic reticulum kinase(PERK)/eukaryotic translation initiation factor 2 subunit alpha(e IF2α)-activating transcription factor 4(ATF4)-C/EBP homologous protein(CHOP),increased neuronal apoptosis,and induced ***,inhibition of ER stress using inhibitors or by si RNA knockdown of the PERK gene significantly attenuated excessive autophagy and neuronal apoptosis,indicating an interaction between autophagy and ER stress and suggesting PERK as an essential target for regulating *** autophagy with chloroquine exacerbated ER stress-induced apoptosis,indicating that normal levels of autophagy play a protective role in neuronal injury following cerebral ischemia/reperfusion *** from this study indicate that cerebral ischemia/reperfusion injury can trigger neuronal ER stress and promote autophagy,and suggest that PERK is a possible target for inhibiting excessive autophagy in cerebral ischemia/reperfusion injury.

关键词： apoptosis ATF4 autophagy C/EBP homologous protein cerebral ischemia/reperfusion injury eIF2α endoplasmic reticulum stress PERK

Enhancing insights into Global Cancer Statistics 2022: implications for cancer control

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Science China Life Sciences 2025年第01期 294-296页

作者： Jingtong Xu Runtian Wang Xiaoxiang guan Department of Oncology the First Affiliated Hospital of Nanjing Medical University Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical University

Globally, there has been a marked escalation in tumor morbidity and mortality,cementing tumors as the predominant cause of death in numerous *** the current tumor burden across various regions is imperative to discern potential risk factors and formulate efficacious strategies for tumor ***, the International Agency for Research on Cancer(IARC) provided a status report on the global tumor burden,estimating the incidence and mortality of 36 cancers in 185 countries(Bray et al.,2024).

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu guan Mengting Qiu Na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission