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Sec3对中性粒细胞弹性蛋白酶诱导的气道上皮细胞黏蛋白分泌的影响

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华中科技大学学报（医学版） 2014年第3期43卷 266-269页

作者：何芳周向东重庆医科大学附属第二医院呼吸内科重庆400010

目的探讨栓链因子复合物亚基Sec3对中性粒细胞弹性蛋白酶(NE)诱导的气道上皮细胞黏蛋白(MUC)分泌的影响。方法体外培养人气道上皮细胞16HBE,随机分为8组:空白对照组、表皮生长因子受体(EGFR)磷酸化抑制剂AG1487组、Sec3siRNA组、阴性si... 详细信息

目的探讨栓链因子复合物亚基Sec3对中性粒细胞弹性蛋白酶(NE)诱导的气道上皮细胞黏蛋白(MUC)分泌的影响。方法体外培养人气道上皮细胞16HBE,随机分为8组:空白对照组、表皮生长因子受体(EGFR)磷酸化抑制剂AG1487组、Sec3siRNA组、阴性siRNA对照组、NE组、NE+AG1478、NE+Sec3siRNA组、NE+阴性siRNA组。采用Western blot法检测Sec3蛋白及pEGFR的相对含量;ELISA、RT-PCR法分析细胞培养上清液中MUC5AC的相对含量及细胞中MUC5AC mRNA水平。结果 Sec3siRNA转染显著降低Sec3蛋白表达,提示转染成功,且加入NE对转染效果无干扰。单纯NE刺激组上清液中MUC5AC含量,细胞中MUC5AC mRNA、pEGFR水平显著高于空白对照组(P0.05)。结论在NE诱导的人气道上皮黏液高分泌过程中,栓链因子复合物亚基Sec3对黏蛋白出胞有重要的介导作用。

关键词：黏蛋白中性粒细胞弹性蛋白酶栓链因子复合物表皮生长因子受体

Application of ~1H-NMR-based Metabolomics for the Species Differentiation of Traditional Chinese Medicine and Tibetan Medicine from Various Species

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Application of ~1H-NMR-based Metabolomics for the Species Di...

Biomimetic Lightweight Design of Legged Robot Hydraulic Drive Unit Shell Inspired by Geometric Shape of Fish Bone Rib Structure

第十四届全国中药和天然药物学术研讨会

作者： Gang Fan xiangdong zhou Yi Zhang WeiZao Luo Er Tan JiaLi You Cheng du University of Traditional Chinese Medicine

＜正＞Traditional Chinese medicine and Tibetan medicine mostly originates from various *** situation may cause a large variability in phytochemical profile,and consequently result in unstable quality and clinical ***,...

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Journal of Bionic Engineering 2024年第3期21卷 1238-1252页

作者： Zhipeng Huang Xinjie Li Xikang Guan Xueqing Sun Chenxu Wang Yuepeng Xu Bin Yu xiangdong Kong School of Mechanical Engineering Yanshan UniversityQinhuangdao066004China School of Arts and Design Yanshan UniversityQinhuangdao066004China Hebei Provincial Key Laboratory of Heavy Machinery Fluid Power Transmission and Control Qinhuangdao066004China

The lightweight design of hydraulic quadruped robots,especially the lightweight design of the leg joint Hydraulic Drive Unit(HDU),can improve the robot's response speed,motion speed,endurance,and load ***,the lightweight design of HDU is a huge challenge due to the need for structural *** paper is inspired by the geometric shape of fish bones and biomimetic reinforcing ribs on the surface of the HDU shell are designed to increase its strength and reduce its ***,a HDU shell with biomimetic fish bone reinforcing ribs structure is ***,the MATLAB toolbox and ANSYS finite element analysis module are used to optimize the parameters of the biomimetic reinforcing ribs structure and the overall layout of the ***,the HDU shell is manufactured using additive manufacturing technology,and a performance testing platform is built to conduct dynamic and static performance tests on the designed *** experimental results show that the HDU with biomimetic fish bone reinforcing ribs has excellent dynamic performance and better static performance than the prototype model,and the weight of the shell is reduced by 20%compared to the prototype *** work has broad application prospects in the lightweight and high-strength design of closed-pressure vessel components.

关键词： Hydraulic drive unit Lightweight design of shell Biomimetic fish bone structure design Dynamic and static performance testing

大规模MIMO蜂窝网与D2D混合网络物理层安全性能研究

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重庆邮电大学学报（自然科学版） 2017年第1期29卷 19-28页

作者：颉满刚贾向东周猛西北师范大学计算机科学与工程学院兰州730070 南京邮电大学江苏省无线通信重点实验室南京210003

随着量子计算机等计算设备的飞速发展,传统的加密技术正面临着挑战;由于物理层安全充分利用了无线信道的特性,其被认为是一种有效的解决方案。为此,提出了一种安全的混合网络模型,其中,端到端(device-to-device,D2D)网络覆盖于大规模多... 详细信息

随着量子计算机等计算设备的飞速发展,传统的加密技术正面临着挑战;由于物理层安全充分利用了无线信道的特性,其被认为是一种有效的解决方案。为此,提出了一种安全的混合网络模型,其中,端到端(device-to-device,D2D)网络覆盖于大规模多入多出(multiple-input multiple-output,MIMO)宏蜂窝之上,被动的恶意窃听者(eavesdropper,Eve)能够窃听所有的无线信道;同时,为了提高能量效率,D2D发射机不仅可以从专用的PB(power beacon)收集能量,还可以从附近的射频干扰信号中收集能量。对此混合网络模型,假设所有网络元素的位置都服从独立泊松点过程,利用随机几何,得到了任一D2D发射机采集足够能量的概率;基于此概率,获得了蜂窝网用户和D2D用户的各态历经速率和安全中断概率。结果表明,由于D2D发射机可以从周围的射频干扰信号中采集能量,系统的能量效率得到显著提升,同时将专用PB的信号视作一种人工噪声,有效地提高了网络的安全性能。

关键词：大规模MIMO D2D 蜂窝网能量收集物理层安全人工噪声

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超支化阳离子抗静电剂的合成及性能研究

印染助剂 2013年第11期30卷 13-18页

作者：陈焜周向东苏州大学纺织与服装工程学院江苏苏州215123 现代丝绸国家工程实验室江苏苏州215021

以改性超支化聚酯(WHBP)、丙烯酰胺(AM)和烯丙基缩水甘油醚(AGE)为原料,过硫酸铵为引发剂,合成一种高分子型超支化阳离子抗静电剂P(WHBP-AM-AGE).探讨了影响抗静电剂P(WHBP-AM-AGE)性能的主要因素.优化工艺为:m(AM)∶m(AGE)∶m(WHBP)=1... 详细信息

以改性超支化聚酯(WHBP)、丙烯酰胺(AM)和烯丙基缩水甘油醚(AGE)为原料,过硫酸铵为引发剂,合成一种高分子型超支化阳离子抗静电剂P(WHBP-AM-AGE).探讨了影响抗静电剂P(WHBP-AM-AGE)性能的主要因素.优化工艺为:m(AM)∶m(AGE)∶m(WHBP)=1∶1∶2,反应温度80℃,反应时间5 h,引发剂用量1.5%(对单体质量).并将此抗静电剂应用于涤纶织物,研究了抗静电剂用量、焙烘温度和焙烘时间对抗静电性能的影响,结果表明,当抗静电剂用量为25 g/L,焙烘温度为170℃,焙烘时间为2 min时,感应静电压为0.13 kV,半衰期为0.09 s;水洗10次后,感应静电压为0.48 kV,半衰期为0.56 s.对整理后及水洗后织物的SEM和XPS测试表明,所合成的抗静电剂具有良好的耐久性.

关键词：高分子超支化阳离子抗静电剂

有机硅柔软剂的结构、性能、表征及其吸附模型(待续)

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印染助剂 2019年第9期36卷 7-12页

作者：陈焜周向东杭州美高华颐化工有限公司浙江杭州311231 苏州大学纺织与服装工程学院江苏苏州215021

有机硅由于独特的结构和性能,在纺织助剂领域展现出巨大的应用空间和发展潜力。介绍了有机硅柔软剂的常用表征方法,并综述了有机硅结构与性能、吸附模型之间的关系,最后对有机硅柔软剂今后的发展进行了展望。

关键词：有机硅柔软剂结构吸附模型

Effect of safety valve types on the gas venting behavior and thermal runaway hazard severity of large-format prismatic lithium iron phosphate batteries

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Journal of Energy Chemistry 2024年第2期89卷 195-207,I0006页

作者： Zhuangzhuang Jia Yuanyuan Min Peng Qin Wenxin Mei xiangdong Meng Kaiqiang Jin Jinhua Sun Qingsong Wang State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026AnhuiChina Gotion High-Tech Co. Ltd.Hefei 230012AnhuiChina

The safety valve is an important component to ensure the safe operation of lithium-ion batteries(LIBs).However,the effect of safety valve type on the thermal runaway(TR)and gas venting behavior of LIBs,as well as the TR hazard severity of LIBs,are not *** this paper,the TR and gas venting behavior of three 100 A h lithium iron phosphate(LFP)batteries with different safety valves are investigated under *** to previous studies,the main contribution of this work is in studying and evaluating the effect of gas venting behavior and TR hazard severity of LFP batteries with three safety valve *** significant results are obtained:(Ⅰ)the safety valve type dominates over gas venting pressure of battery during safety venting,the maximum gas venting pressure of LFP batteries with a round safety valve is 3320 Pa,which is one order of magnitude higher than other batteries with oval or cavity safety valve;(Ⅱ)the LFP battery with oval safety valve has the lowest TR hazard as shown by the TR hazard assessment model based on gray-fuzzy analytic hierarchy *** study reveals the effect of safety valve type on TR and gas venting,providing a clear direction for the safety valve design.

关键词： Lithium iron phosphate battery Safety valve Thermal runaway Gas venting behavior Thermal runaway hazard severity Gray-fuzzy analytic hierarchy process

The Performance of Downward Shortwave Radiation Products from Satellite and Reanalysis over the Transect of Zhongshan Station to Dome A, East Antarctica

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Advances in Atmospheric Sciences 2024年第8期41卷 1574-1588,1671-1675页

作者： Jiajia JIA Zhaoliang ZENG Wenqian ZHANG xiangdong ZHENG Yaqiang WANG Minghu DING State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China

The downward shortwave radiation(DSR) is an important part of the Earth's energy balance, driving Earth's system's energy, water, and carbon cycles. Due to the harsh Antarctic environment, the accuracy of DSR derived from satellite and reanalysis has not been systematically evaluated over the transect of Zhongshan station to Dome A, East ***, this study aims to evaluate DSR reanalysis products(ERA5-Land, ERA5, MERRA-2) and satellite products(CERES and ICDR) in this area. The results indicate that DSR exhibits obvious monthly and seasonal variations, with higher values in summer than in winter. The ERA5-Land(ICDR) DSR product demonstrated the highest(lowest) accuracy,as evidenced by a correlation coefficient of 0.988(0.918), a root-mean-square error of 23.919(69.383) W m^(–2), a mean bias of –1.667(–28.223) W m^(–2) and a mean absolute error of 13.37(58.99) W m^(–2). The RMSE values for the ERA5-Land reanalysis product at seven stations, namely Zhongshan, Panda 100, Panda 300, Panda 400, Taishan, Panda 1100, and Kunlun, were 30.938, 29.447, 34.507, 29.110, 20.339, 17.267, and 14.700 W m^(-2), respectively;with corresponding bias values of 9.887, –12.159, –19.181, –15.519, –8.118, 6.297, and 3.482 W m^(–2). Regarding seasonality, ERA5-Land, ERA5,and MERRA-2 reanalysis products demonstrate higher accuracies during spring and summer, while ICDR products are least accurate in autumn. Cloud cover, water vapor, total ozone, and severe weather are the main factors affecting DSR. The error of DSR products is greatest in coastal areas(particularly at the Zhongshan station) and decreases towards the inland areas of Antarctica.

关键词： downward shortwave radiation East Antarctic reanalysis product satellite product validation

慢性机械压力诱导气道上皮黏蛋白5AC的表达

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第三军医大学学报 2010年第15期32卷 1594-1597页

作者：吴砚樵周向东重庆医科大学附属第二医院呼吸内科重庆400010

目的探讨慢性机械压力能否诱导气道上皮黏蛋白(mucin,MUC)5AC表达及通过的相关信号通路。方法培养大鼠气道上皮细胞建立气液相界面(air liquid interface,ALI),通过对Transwell培养板上的气道上皮细胞每天施加10、20、30 cmH2O水平的气... 详细信息

目的探讨慢性机械压力能否诱导气道上皮黏蛋白(mucin,MUC)5AC表达及通过的相关信号通路。方法培养大鼠气道上皮细胞建立气液相界面(air liquid interface,ALI),通过对Transwell培养板上的气道上皮细胞每天施加10、20、30 cmH2O水平的气体压力1 h并持续7 d来模拟慢性机械压力作用,并以表皮生长因子受体(epidermal growthfactor receptor,EGFR)特异性抑制剂AG1478、细胞外信号调节激酶(extracellular signal regulated kinase,ERK)激酶抑制剂PD98059分别作为干预因素处理细胞。将细胞分为空白对照组、单纯压力组、AG1478+30 cmH2O压力组、PD98059+30 cmH2O压力组,单纯压力组分为10、20、30 cmH2O3个压力水平。RT-PCR检测MUC5AC mRNA表达水平,ELISA法检测MUC5AC蛋白含量,Western blot检测磷酸化ERK(p-ERK)、磷酸化c-Jun氨基末端激酶(phosphorylated c-Jun N-terminalkinase,p-JNK)和磷酸化P38(p-P38)水平。结果与空白对照组比较,单纯压力组MUC5AC蛋白及mRNA表达水平随压力水平的升高而升高(P0.05)。30 cmH2O压力水平MUC5AC蛋白及mRNA表达水平[(0.65±0.09)、(0.62±0.04)]明显高于空白对照组[(0.28±0.04)、(0.20±0.05),P<0.01],p-ERK蛋白含量(0.68±0.05)较空白对照组(0.27±0.07)显著增加(P<0.01)。应用AG1478和PD98059分别预处理后,MUC5AC蛋白、mRNA表达水平及p-ERK蛋白水平在AG1478+30 cmH2O压力组分别为(0.39±0.08)、(0.40±0.06)、(0.25±0.04),PD98059+30 cmH2O压力组分别为(0.36±0.09)、(0.38±0.13)、(0.26±0.11),与单纯压力组30 cmH2O水平比较均显著降低(P<0.05)。结论慢性机械压力能诱导气道上皮MUC5AC表达增加,这一作用可能通过机械压力压缩侧面胞间隙来实现,而EGFR及ERK信号通路参与其中。

关键词：压力黏蛋白类表皮生长因子受体细胞外信号调节MAP激酶类气管上皮细胞大鼠