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Asian Pacific Journal of Tropical Medicine 2023年第9期16卷 418-424页

作者： Bin Liu Liang Li Lei Liu Min Ye Wei Zhang xiangdong zhou Qi Li Department of Respiratory Medicine the First Affiliated Hospital of Hainan Medical UniversityHaikou 570100China Hainan Province Clinical Medical Center of Respiratory Disease Haikou 579199China International School of Nursing Hainan Medical UniversityHaikou 571199China Department of Respiratory and Critical Care Medicine the First Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Kang'an Hospital of Mudanjiang Mudanjiang 157000China

Objective:To evaluate the clinical safety and efficacy of Lianhuaqingwen(LHQW)capsules in patients with high-risk common type COVID-19 ***:A retrospective multicenter study on 383 high-risk common type COVID-19 pneumonia cases was *** were categorized as the standard treatment(SDT)group(n=168)and the LHQW+SDT group(n=215).The primary endpoint was the rate of symptom(fever,fatigue,coughing)recovery and the secondary endpoints included the time to symptom recovery,the proportion of patients with improvement in chest CT images,the proportion of patients with clinical cure,the timing and rate of negative conversion of SARS-CoV-2 RNA ***:The recovery rate was significantly higher in the LHQW+SDT group as compared with the SDT group(89.7%vs.72.0%,P0.05).No serious adverse events were ***:LHQW capsules could be recommended to ameliorate clinical symptoms and reduce the rate of deteriorating to severe cases for high-risk common type COVID-19 pneumonia.

关键词： Lianhuaqingwen capsules COVID-19 pneumonia High-risk common type Clinical efficacy

基于SWMM模型的重庆某工业园区海绵城市设计验证分析

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重庆建筑 2024年第7期23卷 10-12,27页

作者：陈泳帆周向栋李春刘雅丽吴晓林李响中机中联工程有限公司重庆400039 永定河流域投资有限公司朔州分公司山西朔州036002 重庆菲力特机电工程有限公司重庆400039 中煤科工重庆设计研究院(集团)有限公司重庆400042

为评估工业园区典型海绵城市设计对年径流总量控制率、径流峰值、节点积水的控制效果,以重庆某工业园区作为研究区域,运用SWMM模型对该区域海绵城市设计进行建模,并进行改进Horton下渗模型计算。研究表明:工业园区年径流控制率主要通过... 详细信息

为评估工业园区典型海绵城市设计对年径流总量控制率、径流峰值、节点积水的控制效果,以重庆某工业园区作为研究区域,运用SWMM模型对该区域海绵城市设计进行建模,并进行改进Horton下渗模型计算。研究表明:工业园区年径流控制率主要通过源头LID设施实现,在难以实现时可采用末端调蓄设施;削峰效果仅在重现期P≤1a时可主要通过源头LID设施实现;应合理设计洼地地形及面积,以解决源头LID设施无法吸收的局部积水问题;末端调蓄设施是应对连续降雨产流影响的有效措施。验证分析结果旨在探寻工业园区源头LID设施及末端调蓄设施在满足不同功能时的海绵性能以及两者的搭配原则,以为工业园区海绵城市设计提供技术参考。

关键词：海绵城市 SWMM 工业园区 LID设施验证

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Intravitreal bevacizumab with or without triamcinolone acetonide for diabetic macular edema： a meta-analysis of randomized controlled trials

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Chinese Medical Journal 2014年第19期127卷 3471-3476页

作者： Liu xiangdong zhou Xiaodong Wang Zhi Li Tao Jiang Bo Department of Ophthalmology Jinshan Hospital Fudan UniversityShanghai 201508 China

Background Intravitreal anti-vascular endothelial growth factor （anti-VEGF） drugs and corticosteroids are being widely used to treat diabetic macular edema （DME）. The purpose of this study was to evaluate further the efficacy and safety of intravitreal bevacizumab （IVB） alone in comparison with intravitreal bevacizumab combined with triamcinolone acetonide （IVB/IVT） in the treatment of DME. Methods Pertinent publications were identified through CNKI, PubMed, Medline, EMBASE, and the Cochrane Controlled Trials Register up to November 30, 2013. Two investigators independently assessed the quality of the trials, and changes in central macular thickness （CMT） and best-corrected visual acuity （BCVA） were extracted at 6 weeks and 3, 6, 12, and 24 months after the initial treatment. A meta-analysis was carried out to compare the results between the groups receiving IVB and IVB/IVT using the software RevMan 5.0. Results A total of six randomized controlled trials （RCTs） were identified and included. The meta-analysis revealed that a significant reduction of the CMT was observed at 3 months after the initial treatment in the IVB/IVT group compared to the IVB group （P=-0.001）. Also, changes in CMT at 6 weeks and 6, 12, and 24 months did not vary significantly between the IVB and IVB/IVT groups （P=0.53, 0.76, 0.34, and 0.09, respectively）. Similarly, changes in BCVA at 6 weeks and 3, 6, 12, and 24 months also did not vary significantly between the two groups （P=-0.66, 0.98, 0.81, 0.07, and 0.80, respectively）. The results were robust to sensitivity analyses. However, the rate of intraocular pressure （IOP） rise after intravitreal injections varied significantly between the IVB and IVB/IV＇r groups （P 〈0.01）. A publication bias was not detected by funnel plots, the Egger method, or the Begg method. Conclusions Results of this meta-analysis showed that the treatments with IVB alone and combined IVB/IVT were similarly effective in improving the visual acuity, and, to some degree; c

关键词： intravitreal injection bevacizumab triamcinolone acetonide diabetic macular edema meta-analysis

Peroxidase-like nanozyme based microenvironment-responsive injectable hydrogel for bacteria-infected wound healing

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Science China Technological Sciences 2024年第10期67卷 3247-3260页

作者： zhou Wei LI XiaNan TANG MengCheng PAN LingFeng WANG BeiBei ZHANG Hao ZHANG Han WANG ShiBo KONG xiangdong Institute of Smart Biomaterial Materials School of Materials Science and EngineeringZhejiang University of Science & Technology Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering Zhejiang University of Science & Technology

Hydrogel stands out as one of the most attractive wound dressings due to its excellent moisturizing properties and capacity to absorb wound exudates. However, conventional hydrogel dressings often lack responsiveness to the microenvironment, merely acting as protective barriers for the wound. Consequently, they exhibit limited effectiveness in preventing infection and facilitating wound repair. To address these problems, we have developed a multifunctional injectable hydrogel, CF/MS@HG, based on peroxidase-like nanozymes, aiming at rapidly healing bacterial-infected wounds. The hydrogel is mainly composed of oxidized sodium alginate, aminated gelatin, and polylysine, encapsulating MIL-101(CuFe) NPs(CF) and manganese selenide nanoparticles(MnSe2NPs, or MS NPs). After injection, the complex rapidly gelatinizes at the infected wound site through a Schiff base reaction. In vitro experiments have demonstrated the hydrogel's strong adhesion and self-healing ***, CF exhibiting peroxidase(POD)-like activity, catalyzes in situ hydrogen peroxide(H2O2) to generate highly toxic hydroxyl radicals(·OH) within the wound microenvironment, inducing oxidative damage to bacteria. Meanwhile, MS decomposes into H2Se in the slightly acidic wound microenvironment, disrupting bacterial metabolism and inhibiting *** addition of polylysine further enhances the hydrogel's antibacterial properties. In vivo experiments have shown that the hydrogel exhibits excellent biological safety and significantly promotes wound healing. This multifunctional smart hydrogel holds great promise for the treatment of bacterial-infected wounds.

关键词： peroxidase-like nanozyme manganese selenide injectable hydrogel bacterial infection wound healing

Q-Type非球面小畸变全景环带光学系统设计

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光学学报 2015年第7期35卷 291-297页

作者：周向东白剑浙江大学光电信息工程学系现代光学仪器国家重点实验室浙江杭州310027

通过动态链接库方式在Zemax中建立Q-type非球面接口,利用Q-type非球面设计了一款工作在可见光波段,垂直半视场为30°-110°,焦距为-1.25 mm,F数为5,系统总长为28.7 mm的全景环带光学系统（PAL）。该光学系统由7片透镜组成,包含6片球面... 详细信息

通过动态链接库方式在Zemax中建立Q-type非球面接口,利用Q-type非球面设计了一款工作在可见光波段,垂直半视场为30°-110°,焦距为-1.25 mm,F数为5,系统总长为28.7 mm的全景环带光学系统（PAL）。该光学系统由7片透镜组成,包含6片球面镜和一片两面均为Q-type面型的非球面镜片。对设计结果进行了分析,全视场FTheta畸变小于1%,在奈奎斯特空间频率83 lp/mm处调制传递函数（MTF）高于0.5,成像效果接近衍射极限。为验证Q-type非球面在PAL设计中的优越性,实际设计了一个与Q-type面型PAL具有相同参数的偶次非球面PAL,对两者进行了分析比较。结果表明,在相同的计算平台下,Q-type非球面多项式系数的有效数字比对应的偶次非球面的多3-6位,有效减小了优化过程中计算机数字系统截断误差对优化过程的影响,有利于提高光学系统优化设计效率、提高非球面光学零件的加工精度和检测精度。

关键词：光学设计全景环带光学系统 Q-type非球面畸变校正

Topologically protected entanglement switching around exceptional points

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Light(Science & Applications) 2024年第8期13卷 1631-1644页

作者： Zan Tang Tian Chen Xing Tang xiangdong Zhang Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081 BeijingChina

The robust operation of quantum entanglement states is crucial for applications in quantum information,computing,and communications^(1–3).However,it has always been a great challenge to complete such a task because of decoherence and ***,we propose theoretically and demonstrate experimentally an effective scheme to realize robust operation of quantum entanglement states by designing quadruple degeneracy exceptional *** encircling the exceptional points on two overlapping Riemann energy surfaces,we have realized a chiral switch for entangled states with high *** to the topological protection conferred by the Riemann surface structure,this switching of chirality exhibits strong robustness against perturbations in the encircling ***,we have experimentally validated such a scheme on a quantum walk *** work opens up a new way for the application of non-Hermitian physics in the field of quantum information.

关键词： exceptional quantum Riemann

Beware of the serious harm of veterinary drug poisoning:a case report

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World Journal of Emergency Medicine 2024年第2期15卷 153-155页

作者： Ping Dai Jin Sun Tongyue Zhang Zhiqiang zhou Zixi Wen Tianzi Jian Aerbusili Genjiafu Baotian Kan xiangdong Jian Department of Poisoning and Occupational Diseases Emergency MedicineQilu HospitalCheeloo College of MedicineShandong UniversityJinan 250012China Emergency Department Affiliated the Jianhu Clinical Medical College of Yangzhou UniversityYancheng 224700China Department of Occupational and Environmental Health School of Public HealthCheeloo College of MedicineShandong UniversityJinan 250012China School of Nursing and Rehabilitation Cheeloo College of MedicineShandong UniversityNursing Theory&Practice Innovation Research Center of Shandong UniversityJinan 250012China Department of Geriatric Medicine Qilu HospitalNursing Theory Innovation and Research Center of Shandong UniversityCheeloo College of MedicineShandong UniversityJinan 250012China

Veterinary drugs are substances(including pharmaceutical feed additives)used to prevent,treat,and diagnose diseases or regulate the physiological functions of *** drug poisoning in humans is relatively rare both in China and the rest of the ***,we report a case of death from veterinary drug poisoning from ***-closantel is a broad-spectrum antiparasitic drug,which has high efficacy against a variety of trematodes and nematodes.

关键词： drug drugs diseases

Current status of early gastric cancer screening research

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Cancer Biology & Medicine 2024年第3期21卷 218-222页

作者： Can Hu Li Yuan xiangdong Cheng Department of Gastric surgery Zhejiang Cancer HospitalHangzhou Institute of Medicine(HIM)Chinese Academy of SciencesHangzhouZhejiang 310022China Key Laboratory of Prevention Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang ProvinceHangzhou 310022China Zhejiang Provincial Research Center for Upper Gastrointestinal Tract Cancer Zhejiang Cancer HospitalHangzhou 310022China

Gastric cancer is a predominant threat to the health and well-being of China's residents. Data from the World Health Organization(WHO) in 2020 revealed that gastric cancer in China notably accounted for 44.0% of new c... 详细信息

关键词： cancer Gastric gastric

Anti-angiogenesis effect of Demethyl bryoanthrathiophene(DBT) in vitro

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The Chinese-German Journal of Clinical Oncology 2011年第2期10卷 63-69页

作者： Chen Zhong xiangdong zhou Minghui Zhang Yide Hu Third Department of Oncology Xinqiao Hospital Third Military Medical University Chongqing 400037 China Department of Pharmacochemistry of Third Military Medical University Chongqing 400037 China

Objective:The aim of the study was to investigate the effect of Demethyl bryoanthrathiophene(DBT) on proliferations of human umbilical vein endothelial cells(HUVECs) and human lung adenocarcinoma cell line A549,and antiangiogenic effect of DBT on HUVECs in ***:MTT assay was used to observe the effect of DBT on proliferations of HUVECs and A549 cells,flat plate scarification assay and tube formation in vitro test were used to observe the impact of DBT on migration and vaso-formed ability of *** effects of DBT on apoptosis and cell cycle of HUVECs were calculated by flow ***:MTT assay showed that treatment with DBT resulted in strong inhibition to the growth of HUVECs and A549 *** inhibition effects of DBT on HUVECs and A549 cells were related to dosage and times of *** different doses of DBT(0.16,0.32 and 0.48 μmol/L) of flat plate scarification for 24 h,inhibition rates of DBT to migration of HUVECs were 14.70%,38.23% and 58.82%,*** dose of DBT from 0.04,0.20 to 0.40 μmol/L for 24 h in tube formation,there were significance differences(P < 0.01) in the decreasing number of angiogenesis and incomplete blood vessel compared with control *** results showed that DBT promoted the apoptosis rate of HUVECs,and the increase of concentration of DBT accompanied the acceleration of apoptosis ***:DBT could inhibit the proliferations of HUVECs and A549 cells,and effectively suppress angiogenesis in vitro.

关键词： Demethyl bryoanthrathiophene(DBT) angiogenesis human umbilical vein endothelial cells(HUVECs) human lung adenocarcinoma cell line A549

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Light(Science & Applications) 2024年第2期13卷 333-346页

作者： Yifan Sun Qian Li Ling-Jun Kong xiangdong Zhang Key Laboratory of advanced optoelectronic quantum architecture and measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081BeijingChina

Compared with electrical neural networks,optical neural networks(ONNs)have the potentials to break the limit of the bandwidth and reduce the consumption of energy,and therefore draw much attention in recent *** far,several types of ONNs have been ***,the current ONNs cannot realize the acceleration as powerful as that indicated by the models like quantum neural *** to construct and realize an ONN with the quantum speedup is a huge ***,we propose theoretically and demonstrate experimentally a new type of optical convolutional neural network by introducing the optical *** is called the correlated optical convolutional neural network(COCNN).We show that the COCNN can exhibit“quantum speedup”in the training *** character is verified from the two *** is the direct illustration of the faster convergence by comparing the loss function curves of the COCNN with that of the traditional convolutional neural network(CNN).Such a result is compatible with the training performance of the recently proposed quantum convolutional neural network(QCNN).The other is the demonstration of the COCNN’s capability to perform the QCNN phase recognition circuit,validating the connection between the COCNN and the ***,we take the COCNN analog to the 3-qubit QCNN phase recognition circuit as an example and perform an experiment to show the soundness and the feasibility of *** results perfectly match the theoretical *** proposal opens up a new avenue for realizing the ONNs with the quantum speedup,which will benefit the information processing in the era of big data.

关键词： process quantum convolution