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经营主体提交电子文档申请登记改革研究

中国市场监管研究 2024年第7期 60-63页

作者：周向东东莞市市场监管局

《市场主体登记管理条例》是我国第一部统一规范各类市场主体登记管理的行政法规,规定了登记形式审查原则,明确了材料真实性的责任主体是申请人。但由于长期以来的工作习惯、思维习惯,对登记申请事项进行形式审查并没有完全得到体现。... 详细信息

《市场主体登记管理条例》是我国第一部统一规范各类市场主体登记管理的行政法规,规定了登记形式审查原则,明确了材料真实性的责任主体是申请人。但由于长期以来的工作习惯、思维习惯,对登记申请事项进行形式审查并没有完全得到体现。本文建议改变经营主体登记收取申请材料原件的要求,以电子文档代替纸质材料。这在现行法律制度框架下具有可行性及合法性,既是形式审查原则的生动实践,也可以有效解决目前困扰登记机关纸质档案保管的难题,为非全程电子化登记模式的经营主体登记全国通办提供实现路径。

关键词：经营主体登记规范电子文档档案保管

Seam Tracking Technology for Hyperbaric Underwater Welding

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Chinese Journal of Mechanical Engineering 2009年第2期22卷 265-269页

作者： JIAO xiangdong YANG Yongyong zhou Canfeng Research Center of Offshore Engineering Joining Technology Beijing Institute of Petrochemical Technology Beijing 102617 China

Automatic weld seam tracking technology to be used in hyperbaric underwater damaged pipeline repair welding is much more important, because of poor bevel preparation and severe working condition. A weld seam tracking system based on digital signal processing（DSP） passive light weld image processing technology has been established. A convenient charge coupled device（CCD） camera system was used in the high pressure environment with the help of an aperture and focus altering mechanism to guarantee overall image visibility in the scope of pressure below 0.7 MPa. The system can be used in the hyperbaric environment to pick up the real welding image of both the welding arc and the welding pool. The newly developed DSP technology was adopted to achieve the goal of system real time characteristics. An effective weld groove edge recognition technique including narrow interesting window opening, middle value wave filtering, Sobel operator weld edge detecting and edge searching in a defined narrow area was proposed to remove the guide error and system accuracy was ensured. The results of tracking simulation and real tracking application with arc striking have proved the validity and the accuracy of the mentioned system and the image processing method.

关键词： hyperbaric underwater welding seam tracking weld edge recognition

COVID-19相关肺纤维化的病因机制及治疗的研究进展

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海南医学院学报 2024年第17期30卷 1346-1352页

作者：王梓源李琪黄娅黄建鑫周向东海南医学院第一附属医院呼吸内科海南海口570102 海南省呼吸疾病中心海南海口570100

新型冠状病毒肺炎(COVID-19)是一种由SARS-CoV-2感染所引起的急性呼吸道传染性疾病。随着近期COVID-19疫情的常态化流行,COVID-19患者的影像学及病理学研究表明,部分患者SARS-CoV-2感染后可出现肺纤维化改变,COVID-19相关肺纤维化正成... 详细信息

新型冠状病毒肺炎(COVID-19)是一种由SARS-CoV-2感染所引起的急性呼吸道传染性疾病。随着近期COVID-19疫情的常态化流行,COVID-19患者的影像学及病理学研究表明,部分患者SARS-CoV-2感染后可出现肺纤维化改变,COVID-19相关肺纤维化正成为影响患者预后生存质量的重要影响因素,严重威胁患者的生命健康。目前,COVID-19相关肺纤维化的发病机制尚未明确,治疗方案多基于既往肺纤维化疾病的诊治经验,本文通过总结SARS-CoV-2感染后肺损伤及纤维化的发生机制和相关治疗方案,为临床的防治及干预提供一定参考。

关键词：新型冠状病毒肺炎肺纤维化发病机制抗纤维化治疗

Syntheses of oxysterol receptors'(LXRs) ligands

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Chinese Science Bulletin 2003年第3期48卷 247-254页

作者： zhou xiangdong ZHEN Hui zhou Weishan Department of Pharnmcy The Third Millitary Medical UniversityChongqing 400038China Shanghai Institute of Organic Chemistry Chinese Academy of SciellcesShanghai 200032China

The LXRs?agonist, 24S,25-epoxycholesterol 1,was synthesized stereoselectively (100% d.e.) in 56% overall yield from methyl hyodeoxycholanate 4 in 9 steps with des-mosterol acetate 11 as the key intermediate and the modified Sharpless asymmetric dihydroxylation as the key step. TheLXRa subtype selective agonist 5a,6a:24S,25-diepoxycho-lesterol 2 and the novel LXRs?ligand 5b,6b:24S,25-diepo-xycholesterol 3 were also synthesized from 1.

关键词： methyl hyodeoxycholanate desmosterol acetate 24S 25-epoxycholesterol sharpless catalytic asymmetric dihydoxylation LXRs'agonists.

早期生物标志物在病毒性和细菌性脓毒症鉴别诊断中的应用价值

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海南医学院学报 2024年第11期30卷 861-867页

作者：黄娅李琪徐超群黄建鑫周向东海南医学院急诊创伤学院海南海口570102 海南医学院第一附属医院呼吸内科海南海口570100 海南省呼吸疾病临床医学中心海南海口570100

脓毒症是机体对感染反应失调引起的危及生命的器官功能障碍,可由多种病原体引起,通常以细菌为代表。一直以来,病毒引起的脓毒症往往被忽视,直到新冠肺炎疫情大流行,其严重性使病毒性脓毒症成为全球关注的焦点。生物标志物在脓毒症的早... 详细信息

脓毒症是机体对感染反应失调引起的危及生命的器官功能障碍,可由多种病原体引起,通常以细菌为代表。一直以来,病毒引起的脓毒症往往被忽视,直到新冠肺炎疫情大流行,其严重性使病毒性脓毒症成为全球关注的焦点。生物标志物在脓毒症的早期诊断中具有重要作用,由于确定病原体具有挑战性,临床上一直缺乏一种能在脓毒症发展初期广泛区分病毒和细菌感染的生物标志物。因此,该文对降钙素原、C-反应蛋白、血清淀粉样蛋白A、中性粒细胞CD64及钙卫蛋白在病毒性和细菌性脓毒症早期鉴别中的价值进行阐述,以期为临床医务工作者提供参考,同时提高对病毒性脓毒症的认识。

关键词：病毒性脓毒症细菌性脓毒症流行病学发病机制生物标志物

基于数据包络分析法的医养结合型养老机构中护理人力资源效率评价指标体系的构建及评价

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中华健康管理学杂志 2024年第2期18卷 99-106页

作者：何明欣李艳艳杨雅楼朱宏锐高淑红周诗铭张华周向东北京大学深圳医院重症监护室深圳518036 海南医学院国际护理学院海口571199 海南省托老院海口570311 海南省呼吸疾病临床医学中心海口570102

目的基于数据包络分析法(DEA)构建医养结合型养老机构护理人力资源效率评价指标体系并进行评价。方法本研究属于横断面调查研究。运用文献研究及调查法初步建立护理人力资源效率评价指标体系库,采用德尔菲法对17名专家(护理管理、养老... 详细信息

目的基于数据包络分析法(DEA)构建医养结合型养老机构护理人力资源效率评价指标体系并进行评价。方法本研究属于横断面调查研究。运用文献研究及调查法初步建立护理人力资源效率评价指标体系库,采用德尔菲法对17名专家(护理管理、养老机构管理、医养结合型养老机构管理、卫生经济学管理、公共卫生等领域的专家)展开两轮函询。通过专家积极性、专家权威程度、专家意见集中程度与协调程度等因素判断指标体系的可靠性,结合专家意见对指标进行调整、修改及完善,以确立最终的指标体系。并于2022年8—12月在该指标体系基础上运用DEA模型对海口市12家医养结合型养老机构进行效率评价。结果构建的评价指标体系分为3级68项,包括一级指标9项,二级指标19项,三级指标40项。两轮专家函询积极系数为100%和94.1%,权威系数为0.88与0.92,肯德尔和谐系数为0.471和0.348,变异系数均值为0.16和0.12(P<0.001)。DEA评价的12家医养结合型养老机构结果显示,综合效率(OE)、技术效率(TE)和规模效率(SE)值均为1.000的DEA有效机构有5家;非DEA有效机构有7家,其中包括SE值<1.000但TE值=1.000的4家,SE值及TE值均<1.000的3家。结论构建的评价指标体系其函询专家的参与积极性高,权威系数和协调度好,对指标体系认可性高,内容涵盖全面、层次分明、可获取强、具有较强的专科特性。DEA模型评价的结果能客观有效地反映医养结合型养老机构护理人力资源效率发挥情况,实用性较强。

关键词：护理卫生资源效率评价养老机构医养结合数据包络分析

Central nervous system efficacy of aumolertinib versus gefitinib in patients with untreated,EGFR-mutated,advanced non-small cell lung cancer:data froma randomized phase III trial(AENEAS)

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Cancer Communications 2024年第9期44卷 1005-1017页

作者： Shun Lu Xiaorong Dong Hong Jian Jianhua Chen Gongyan Chen Yuping Sun Yinghua Ji ZipingWang Jianhua Shi Junguo Lu Shaoshui Chen Dongqing Lv Guojun Zhang Chunling Liu Juan Li Xinmin Yu Zhong Lin Zhuang Yu ZhehaiWang Jiuwei Cui Xingxiang Xu Jian Fang Jifeng Feng Zhi Xu RuiMa Jie Hu Nong Yang xiangdong zhou XiaohongWu Chengping Hu Zhihong Zhang You Lu Yanping Hu Liyan Jiang Qiming wang Renhua Guo Jianying zhou Baolan Li Chunhong Hu Wancheng Tong Helong Zhang LinMa Yuan Chen Zhijun Jie Yu Yao Longzhen Zhang JieWeng Weidong Li Jianping Xiong Xianwei Ye Jianchun Duan Haihua Yang Meili Sun HongyingWei JiaweiWei Zheyu Zhang QiongWu Department of Medical Oncology Shanghai Chest Hospital Shanghai JiaoTong UniversityShanghaiP.R.China Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Medical Oncology-Chest Hunan Cancer Hospital&The Affiliated Cancer Hospital of Central South University Xiangya School of MedicineChangshaHunanP.R.China Thoracic OncologyMedicine HarbinMedical University Cancer HospitalHarbinHeilongjiangP.R.China Department of Oncology Jinan Central HospitalJinanShandongP.R.China Department of Oncology First Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanP.R.China Department of Chest Medicine Beijing Cancer HospitalBeijingP.R.China Department of Internal Medicine Linyi Cancer HospitalLinyiShandongP.R.China Department of Respiratory Medicine Nantong Tumor HospitalNantongJiangsuP.R.China Department of Oncology Binzhou Medical University HospitalBinzhouShandongP.R.China Breath Internal Medicine Taizhou Hospital of Zhejiang ProvinceLinhaiZhejiangP.R.China Department of Respiration The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Lung Internal Medicine Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqiXinjiangP.R.China Department of Thoracic Oncology Sichuan Cancer HospitalChengduSichuanP.R.China Thoracic Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)HangzhouZhejiangP.R.China Department of Thoracic Oncology The Fifth Subsidiary Sun Yat-sen University HospitalZhuhaiGuangdongP.R.China Department of Oncology The Affiliated Hospital of QingdaoUniversityQingdaoShandongP.R.China Department of Oncology Shandong Cancer HospitalJinanShandongP.R.China Department of Oncology The First BethuneHospital of Jilin UniversityChangchunJilinP.R.China Department of Respiration Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityYangzhouJiangsuP.R.China Department of Internal

Background:The initial randomized,double-blinded,actively controlled,phase III ANEAS study(NCT03849768)demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal growth factor receptor(EGFR)-mutated advanced non-small cell lung cancer(NSCLC).Metastatic disease in the central nervous system(CNS)remains a challenge in the management of *** study aimed to compare the efficacy of aumolertinib versus gefitinib among patients with baseline CNS metastases in the ANEAS ***:Eligible patients were enrolled and randomly assigned in a 1:1 ratio to orally receive either aumolertinib or gefitinib in a double-blinded *** with asymptomatic,stable CNS metastases were ***-up imaging of the same modality as the initial CNS imaging was performed every 6 weeks for 15 months,then every *** responsewas assessed by a neuroradiological blinded,independent central review(neuroradiological-BICR).The primary endpoint for this subgroup analysis was CNS progression-free survival(PFS).Results:Of the 429 patients enrolled and randomized in the ANEAS study,106 patients were found to have CNS metastases(CNS Full Analysis Set,cFAS)at baseline by neuroradiological-BICR,and 60 of them had CNS target lesions(CNS Evaluable for Response,cEFR).Treatment with aumolertinib significantly prolonged median CNS PFS compared with gefitinib in both cFAS(29.0 vs.8.3 months;hazard ratio[HR]=0.31;95%confidence interval[CI],0.17-0.56;P<0.001)and cEFR(29.0 vs.8.3 months;HR=0.26;95%CI,0.11-0.57;P<0.001).The confirmed CNS overall response rate in cEFRwas 85.7%and 75.0%in patients treated with aumolertinib and gefitinib,*** risk analysis showed that the estimated probability of CNS progression without prior non-CNS progression or death was consistently lower with aumolertinib than with gefitinib in patients with and without CNSmetastases at *** new safety findings were ***:The

关键词： aumolertinib brain metastasis non-small cell lung cancer third-generation EGFR-TKI

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口腔外甜味受体生物学作用的研究进展

海南医学院学报 2024年第19期30卷 1514-1520页

作者：余善君徐超群唐香周向东李琪海南医科大学第一附属医院呼吸内科海南海口570102 海南医科大学急诊与创伤学院海南海口579199 海南省呼吸疾病临床医学中心海南海口570102

甜味受体(STR)是1型味觉受体的一种主要类型,可感知甜味并与不同的糖类和人工甜味剂相结合。虽然它最初被发现于口腔味蕾,但近来许多研究表明其在心脏、肾脏、胰腺、胃肠道、呼吸道和大脑等口腔外组织中均有表达,并发挥多种口外味觉效应... 详细信息

甜味受体(STR)是1型味觉受体的一种主要类型,可感知甜味并与不同的糖类和人工甜味剂相结合。虽然它最初被发现于口腔味蕾,但近来许多研究表明其在心脏、肾脏、胰腺、胃肠道、呼吸道和大脑等口腔外组织中均有表达,并发挥多种口外味觉效应,如参与摄食活动、能量稳态调节、内分泌代谢调节、内皮通透性调节、免疫防御调控和认知功能调节等。对此,本文综述STR的信号途径及其在口外组织中生物学作用的研究进展,旨在为STR相关的深入研究提供参考。

关键词：甜味受体(sweet taste receptors,STR) 信号途径生物学作用

Expedient Synthesis of （R）-Curcuphenol： A Chiral Pool Strategy

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Chinese Journal of Chemistry 2013年第1期31卷 23-26页

作者： Jing Feng Guili Zhu Bo Liu xiangdong zhou Key Laboratory of Green Chemistry & Technology of Ministry of Education College of Chemistry Sichuan Uni- versity Chengdu Sichuan 610064 China Department of Medicinal Chemistry College of Pharmacy The Third Military Medical University Chongqing 400038 China Key Laboratory of Synthetic Chemistry of Natural Substances Shanghai Institute of Organic Chemistry 345 Lingling Road Shanghai 200032 China

Curcuphenol is an interesting sesquiterpenoid with diverse bioactivities. Exploration of a concise and scalable synthetic route is still of significance in spite that many asymmetric total syntheses have been achieved. We report an expedient asymmetric synthesis of （R）-curcuphenol from citronellal, which features only two purification opera- tions in the overall six-step synthesis.

关键词： sesquiterpenoid curcuphenol total synthesis