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Topologically protected entanglement switching around exceptional points

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Light(Science & Applications) 2024年第8期13卷 1631-1644页

作者： Zan Tang tian Chen Xing Tang xiangdong Zhang Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081 BeijingChina

The robust operation of quantum entanglement states is crucial for applications in quantum information,computing,and communications^(1–3).However,it has always been a great challenge to complete such a task because of decoherence and ***,we propose theoretically and demonstrate experimentally an effective scheme to realize robust operation of quantum entanglement states by designing quadruple degeneracy exceptional *** encircling the exceptional points on two overlapping Riemann energy surfaces,we have realized a chiral switch for entangled states with high *** to the topological protection conferred by the Riemann surface structure,this switching of chirality exhibits strong robustness against perturbations in the encircling ***,we have experimentally validated such a scheme on a quantum walk *** work opens up a new way for the application of non-Hermitian physics in the field of quantum information.

关键词： exceptional quantum Riemann

胫骨结节远端单平面截骨对踝关节冠状面角度的影响

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中国组织工程研究 2024年第21期28卷 3349-3354页

作者：尹岳桐朱光宇田向东谭冶彤马晟薛志鹏胡元一李晓敏北京中医药大学第三临床医学院北京市100029 北京中医药大学第三附属医院微创关节科北京市100029

背景:胫骨结节远端单平面截骨作为一种内侧单间室膝骨关节炎的手术治疗方法,目前缺乏其对踝关节影响的研究。目的:观察胫骨结节远端单平面截骨对患者负重位下肢X射线片上踝关节冠状面角度的影响。方法:回顾分析2021年3月至2022年3月行... 详细信息

背景:胫骨结节远端单平面截骨作为一种内侧单间室膝骨关节炎的手术治疗方法,目前缺乏其对踝关节影响的研究。目的:观察胫骨结节远端单平面截骨对患者负重位下肢X射线片上踝关节冠状面角度的影响。方法:回顾分析2021年3月至2022年3月行胫骨结节远端单平面截骨的膝骨关节炎患者共40例(41膝),其中女31例,男9例;左膝20例,右膝21例;年龄49-75岁,平均(63.44±6.57)岁。收集术前及术后第2,48周的负重位下肢全长X射线片资料,测量髋-膝-踝关节角、距骨倾斜角、踝关节倾斜角、胫骨踝穴角、胫骨远端关节面角的术前术后变化。结果与结论:①髋-膝-踝关节角由术前的(-6.24±3.69)°改善为术后第2周的(2.59±3.49)°,至第48周为(2.15±3.49)°;踝关节倾斜角由术前的(-7.90±3.11)改变为术后第2周的(-2.51±2.59)°,至第48周为(-2.46±2.42)°,差异均有显著性意义(P<0.001);②距骨倾斜角、胫骨踝穴角及胫骨远端关节面角的术前、术后2次随访差异无显著性意义;③第2周与第48周各角度差异均无显著性意义;④提示胫骨结节远端单平面截骨在纠正膝内翻的同时,能够改善踝关节的角度异常,且在48周负重活动后该角度保持稳定。

关键词：膝骨关节炎胫骨结节远端单平面截骨踝关节冠状面影像学

Periostin mediates epithelial-mesenchymal transition through the MAPK/ERK pathway in hepatoblastoma

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Cancer Biology & Medicine 2019年第1期16卷 89-99页

作者： Lu Chen xiangdong tian Wenchen Gong Bo Sun Guangtao Li Dongming Liu Piao Guo Yuchao He Ziye Chen Yuren Xia tianqiang Song Hua Guo Department of Tumor Cell Biology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer

Objective: The aim of the present study was to analyze the prognostic factors in patients with hepatoblastoma(HB) in our single center and to evaluate periostin(POSTN) expression in HB and its association with clinicopathological variables. In addition, the underlying mechanism of how POSTN promotes HB progression was ***: POSTN expression was investigated in HB tumors by immunohistochemistry(IHC), immunofluorescence(IF) and Western blot(WB). The association among POSTN expression, clinicopathological features and overall survival(OS) was also evaluated. The migration and adhesion ability of HB cells were measured using chemotaxis and cell-matrix adhesion assays,respectively. Epithelial-mesenchymal transition(EMT)-associated markers and activation of the ERK pathway were detected by ***: HB patients had poor prognosis which displayed lymph node metastasis, vascular invasion, POSTN and vimentin expression. POSTN expression was also associated with lymph node metastasis. Furthermore, overexpressed POSTN promoted migration and the adhesive ability of HB cells in vitro. In addition, we demonstrated that POSTN activated the MAPK/ERK pathway, upregulated the expression of Snail and decreased the expression of OVOL2. Finally, POSTN promoted the expression of EMT-associated ***: POSTN might modulate EMT via the ERK signaling pathway, thereby promoting cellular migration and *** study also suggests that POSTN may serve as a therapeutic biomarker in HB patients.

关键词： Periostin hepatoblastoma EMT MAPK/ERK

Development of a stable attenuated double-mutant of tobacco mosaic virus for cross-protection

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Journal of Integrative Agriculture 2024年第7期23卷 2318-2331页

作者： Xiaojie Xu Shaoyan Jiang Chunju Liu Xujie Sun Qing Zhu Xiuzhai Chen Pengchao Jiang Fenglong Wang Yanping tian xiangdong Li The Engineering Research Institute of Agriculture and Forestry Ludong UniversityYantai 264025China Laboratory of Plant Virology Department of Plant PathologyCollege of Plant ProtectionShandong Agricultural UniversityTai’an 271018China Weifang Tobacco Corporation Weifang 261031China Linyi Tobacco Corporation Linyi 276000China Tobacco Research Institute Chinese Academy of Agricultural SciencesQingdao 266101China

Tobacco(Nicotiana tabacum)and tomato(Solanum lycopersicum)are two major economic crops in *** mosaic virus(TMV;genus Tobamovirus)is the most prevalent virus infecting both ***,some widely cultivated tobacco and tomato cultivars are susceptible to TMV and there is no effective strategy to control this ***-protection can be a safe and environmentally friendly strategy to prevent viral ***,stable attenuated TMV mutants are *** this study,we found that the substitutions in the replicase p126,arginine at position 196(R^(196))with aspartic acid(D),glutamic acid at position 614(E^(614))with glycine(G),serine at position 643(S^(643))with phenylalanine(F),or D at position 730(D^(730))with S,significantly reduced the virulence and replication of ***,only the mutation of S^(643) to F reduced the RNA silencing suppression activity of TMV p126.A double-mutant TMV-E614G-S643F induced no visible symptom and was genetically stable through six successive passages in tobacco ***,our results showed that TMV-E614G-S643F double-mutant could provide effective protection against the wild-type TMV infection in tobacco and tomato *** study reports a promising mild mutant for cross-protection to control TMV in tobacco and tomato plants.

关键词： cross-protection double-mutant p126 tobacco mosaic virus virulence

六经辨证手法经络推拿联合针刺治疗神经根型颈椎病临床效果观察

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四川中医 2024年第2期42卷 189-193页

作者：王嘉嘉田向东黎展文文永海钟潇羽庞金海廖健明梁一新廖信祥玉林市中医医院推拿科广西玉林537000 北京中医药大学第三附属医院微创关节科北京100029

目的:探讨六经辨证手法经络推拿联合针刺治疗神经根型颈椎病临床效果及优势。方法:选取2019年10月~2021年10月在广西玉林市中医医院推拿科二区住院的诊断为神经根型颈椎病患者90例作为研究对象,采用随机方法将其分成治疗组和对照组(各45... 详细信息

目的:探讨六经辨证手法经络推拿联合针刺治疗神经根型颈椎病临床效果及优势。方法:选取2019年10月~2021年10月在广西玉林市中医医院推拿科二区住院的诊断为神经根型颈椎病患者90例作为研究对象,采用随机方法将其分成治疗组和对照组(各45人)。治疗组采用六经辨证手法经络推拿综合针刺疗法,对照组采用非经络辨证推拿手法综合针刺疗法,两组持续治疗时间为2周,以治疗前、治疗后及出院后1周、出院后4周为时间点进行考察,并采用中医评价量表、日本骨科协会评分(JOA)、视觉模拟痛觉评分(VAS)、颈椎功能障碍指数评分(NDI)进行记录,比较两组患者症状改善情况。结果:两组患者均完成全部治疗无不良事件发生。经治疗后,治疗组总有效率95.6%,对照组总有效率82.2%,治疗组中医评价高于对照组,差异有统计学意义(P0.05),治疗组的治疗后即时、出院后1周、出院后4周的VAS评分、NDI评分低于对照组,JOA评分高于对照组,差异具有明显统计学意义(P<0.05)。研究总结:六经辨证经络手法推拿联合针刺治疗具有个体化的优势,可明显改善神经根型颈椎病放射性疼痛、麻木、乏力的三大临床症状,较普通推拿手法和针刺治疗而言,更具有推广意义。

关键词：六经辨证循经论治手法推拿神经根型颈椎病

揿针联合加味骨痹汤治疗肩袖损伤(气滞血瘀证)临床观察

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中国中医急症 2024年第9期33卷 1618-1622页

作者：付泽佳朱光宇尹岳桐田向东王荣田张伟谭冶彤薛志鹏胡元一北京中医药大学北京100029 北京中医药大学第三附属医院北京100029 北京中医药大学“中医骨伤治疗与运动康复智能化”教育部工程研究中心北京100029

目的观察揿针联合加味骨痹汤治疗肩袖损伤(气滞血瘀证)的临床疗效,为肩袖损伤治疗提供一种简单、有效的方法。方法对2022年6月至2023年6月收治的66名肩袖损伤患者进行回顾性分析,并根据治疗方法将其分为观察组与对照组各33例。观察组采... 详细信息

目的观察揿针联合加味骨痹汤治疗肩袖损伤(气滞血瘀证)的临床疗效,为肩袖损伤治疗提供一种简单、有效的方法。方法对2022年6月至2023年6月收治的66名肩袖损伤患者进行回顾性分析,并根据治疗方法将其分为观察组与对照组各33例。观察组采用了揿针联合加味骨痹汤,对照组仅使用加味骨痹汤,两组患者均配合功能锻炼。以视觉模拟疼痛(VAS)评分、Constant-Murley肩关节评分量表、美国加州大学(UCLA)肩关节评分系统及关节活动度(ROM)及总有效率为观察指标,记录患者肩关节疼痛、肩关节功能和患者整体满意度,比较治疗前及治疗后4周各项指标的变化。结果观察组的总有效率显著高于对照组,治疗后4周,2组的VAS评分均有所下降,Constant-Murley评分、UCLA肩关节评分和ROM均有所提高,且观察组优于对照组,差异均有统计学意义(P<0.05)。结论揿针联合加味骨痹汤可有效缓解肩袖损伤(气滞血瘀证)患者疼痛症状,在改善肩关节活动度方面治疗效果更佳。

关键词：肩袖损伤气滞血瘀揿针加味骨痹汤经筋理论

Crocus genome reveals the evolutionary origin of crocin biosynthesis

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1878-1891页

作者： Zhichao Xu Shanshan Chen Yalin Wang Ya tian Xiaotong Wang tianyi Xin Zishan Li Xin Hua Shengnan Tan Wei Sun xiangdong Pu Hui Yao Ranran Gao Jingyuan Song Key Lab of Chinese Medicine Resources Conservation State Administration of Traditional Chinese Medicine of the People's Republic of ChinaInstitute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100193China State Key Laboratory of Basis and New Drug Development of Natural and Nuclear Drugs Engineering Research Center of Chinese Medicine ResourceMinistry of EducationBeijing 100193China College of Life Science Northeast Forestry UniversityHarbin 150040China Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine China Academy of Chinese Medical SciencesInstitute of Chinese Materia MedicaBeijing 100700China Analysis and Testing Center of Northeast Forestry University Harbin 150040China School of Pharmacy Anhui Medical UniversityInflammation and Immune Mediated Diseases Laboratory of Anhui ProvinceHefei 230032China

Crocus sativus (saffron) is a globally autumn-flowering plant, and its stigmas are the most expensive spice and valuable herb medicine. Crocus specialized metabolites, crocins, are biosynthesized in distant species, Gardenia (eudicot) and Crocus (monocot), and the evolution of crocin biosynthesis remains poorly understood. With the chromosome-level Crocus genome assembly, we revealed that two rounds of lineage-specific whole genome triplication occurred, contributing important roles in the production of carotenoids and apocarotenoids. According to the kingdom-wide identification, phylogenetic analysis, and functional assays of carotenoid cleavage dioxygenases (CCDs), we deduced that the duplication, site positive selection, and neofunctionalization of Crocus-specific CCD2 from CCD1 members are responsible for the crocin biosynthesis. In addition, site mutation of CsCCD2 revealed the key amino acids, including I143, L146, R161, E181, T259, and S292 related to the catalytic activity of zeaxanthin cleavage. Our study provides important insights into the origin and evolution of plant specialized metabolites, which are derived by duplication events of biosynthetic genes.

关键词： Crocus sativus WGT Crocin biosynthesis Carotenoids Apocarotenoids CCDs

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燕麦麸膳食纤维脱色工艺及对产品特性的影响

农业工程学报 2008年第11期24卷 247-250页

作者：陈季旺刘英孙勤田向东武汉工业学院食品科学与工程学院武汉430023 山西金绿禾燕麦研究所孝义032300

为了改善燕麦麸膳食纤维色泽,提高产品质量,该文采用双氧水进行燕麦麸膳食纤维的氧化脱色研究,并对产品的营养成份和功能性质进行分析。确定脱色的较佳工艺条件为:4%H2O2、pH11、40℃、4h。在此条件下燕麦麸膳食纤维的白度由5.6%增加到3... 详细信息

为了改善燕麦麸膳食纤维色泽,提高产品质量,该文采用双氧水进行燕麦麸膳食纤维的氧化脱色研究,并对产品的营养成份和功能性质进行分析。确定脱色的较佳工艺条件为:4%H2O2、pH11、40℃、4h。在此条件下燕麦麸膳食纤维的白度由5.6%增加到36.2%,效果明显。脱色前后燕麦麸膳食纤维的主要成分变化不大,其中总膳食纤维、β-葡聚糖含量略有增高,蛋白质、脂肪含量略有降低。脱色后燕麦麸膳食纤维的膨胀力由2mL/g增加到4mL/g,持水力由3.12%增加到3.77%,结合水力由1.3%增加到2.5%。

关键词：食品加工工艺食品营养成分燕麦麸膳食纤维双氧水脱色白度

Research Progress of Measuring Tools for Patient Medication Compliance

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Journal of Biosciences and Medicines 2024年第2期12卷 225-235页

作者： Chengping Jian xiangdong Peng Haiyan tian Liying Wang Yanan Zhang Defang Cai School of Nursing Dali University Dali China Department of Cardiothoracic Surgery Mianyang Central Hospital Mianyang China Nursing Department of Yuxi People’s Hospital Yuxi China

This paper introduced the content, compilation process, reliability and validity, scoring method of the evaluation tool for patients’ medication compliance at home and abroad, and reviewed the research progress of the tool. The evaluation method, dimension, scoring method, evaluation content and application scope of the tool were compared, so as to provide reference for nurses to comprehensively and accurately evaluate patients’ medication status.

关键词： Medication Compliance Assessment Tool Research Progress