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Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

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World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun Huang Zhu Chen Heng Xiao Hai-Yang Hu xing-Yu Chen Cheng-You Du xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting xiang xiangxin xing Xuyun Hua Yuwen Zhang Xin Xue Jiajia Wu Mouxiong Zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang Li xing Cheng Peiqiang Su Yong Wan xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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某地仿古高层建筑的结构设计

山西建筑 2025年第1期51卷 55-59页

作者：卓郅颖余兴广西壮族自治区城乡规划设计院广西南宁530015 华蓝设计(集团)有限公司广西南宁530012

以位于7度抗震设防区内的某仿古高层建筑为工程背景,介绍了拥有大型坡屋面的仿古高层建筑项目的特点以及在设计中遇到的重、难点问题。该建筑因建筑造型要求导致结构具有大开洞、跃层柱、体型收进、刚度不连续等抗震不利的特点,该项目... 详细信息

以位于7度抗震设防区内的某仿古高层建筑为工程背景,介绍了拥有大型坡屋面的仿古高层建筑项目的特点以及在设计中遇到的重、难点问题。该建筑因建筑造型要求导致结构具有大开洞、跃层柱、体型收进、刚度不连续等抗震不利的特点,该项目采用了YJK结构设计软件进行设计分析,采用合并标准层的设计方法来避免软件出现不合理的薄弱层判定;采用弹性时程分析来补充计算结构顶层因抽柱形成空旷房间的情况。计算结果表明,该项目结构设计合理,经济安全。文中列举了计算结果,分析阐述了针对设计中遇到的重、难点问题的处理方法,如何在设计中调整各设计参数以避免结构被判定为超限建筑,从而实现缩短设计周期并满足现行结构设计技术规范的要求,并对同类型项目提出了设计建议。

关键词：高层建筑弹性时程分析跃层柱体型收进仿古屋盖

Analytical solution methods for eigenbuckling of symmetric cross-ply composite laminates

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Chinese Journal of Aeronautics 2017年第1期30卷 282-291页

作者： xing Yufeng xiang Wei Institute of Solid Mechanics Beihang University School of Mechanical Engineering Southwest Jiaotong University

Based on the first-order shear deformation theory, this paper explores the analytical methods for eigenbuckling of symmetric cross-ply rectangular composite laminates with a pair of parallel edges simply supported and the remaining two edges arbitrarily constrained. The main contribution of present paper lies in two aspects： one is to present a simple and effective analytical method, namely, the separation-of-variables method, which can generate the closed-form buckling solutions without any computational difficulty; the other is to incorporate the accurate computation method of exponential matrix into the state space technique to avoid the inevitable numerically illconditioned problems reported in several literatures. The results obtained via both analytical methods are identical, and a good agreement with their counterparts in literature is observed. The separation-of-variables method can generate exact solutions within 1 s, which is impossible if the state space method is employed. Besides, the combination of the accurate computation method of exponential matrix and the state space method greatly improves the computational efficiency and gives correct results compared with the straightforward use of state space method.

关键词： Accurate computation Analytical solution Composite laminates Eigenbuckling Separation of variablesState space

Cradle for the newborn Monochamus saltuarius:Microbial associates to ward off entomopathogens and disarm plant defense

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Insect Science 2023年第4期30卷 1165-1182页

作者： Si-Xun Ge Jia-xing Li zhuo-Heng Jiang Shi-xiang Zong Li-Li Ren Bejing Key Laboratory for Forest Pest Control Bejing Forestry UniversityBeijingChina School of Science Westlake UniversityHangzhouChina Sino-French Joint Laboratory for Invasive Forest Pests in Eurasia Bejing Forestry University-French National Research Institute for AgricultureFood and Environment(INRAE)BejingChina

The Japanese pine sawyer,Monochamus saltuarius,as a beetle vector of Bur-saphelenchus xylophilus(pine wood nematode),is an economically important forest pest in *** feed on the phloem and xylem of conifers,*** needs to overcome various stress factors,including coping with entomopathogenic bacteria and also various plant secondary compounds(PSCs).As an important adaptation strategy to colonize host trees,*** deposit eggs in oviposition pits to shield their *** pits har-bor bacterial communities that are involved in the host adaptation of *** to the ***,the composition,origin,and functions of these oviposition pit bacteria are rarely *** this study,we investigated the bacterial community associated with *** oviposition pits and their ability to degrade *** showed that the bacterial community structure of *** oviposition pits significantly differed from that of uninfected ***,the oviposition pit bacteria were predicted to be enriched in PSC degradation *** microbial community also harbored a lethal strain of Serratia,which was significantly ***,metatranscriptome anal-ysis indicated that genes involved in PSCs degradation were expressed complementarily among the microbial communities of oviposition pits and *** vitro degrada-tion showed that bacteria cultured from oviposition pits degraded more monoterpenes and flavonoids than bacteria cultured from uninfected phloem *** of ovipo-sition pits increased the mortality of newly hatched larvae and resulted in a significant decrease in body weight in the early ***,our results reveal that *** construct oviposition pits that harbor a diverse microbial community,with stronger PSCs degradation abilities and a low abundance of entomopathogenic bacteria,resulting in the increased fitness of newly hatched larvae.

关键词： community structure entomopathogenic bacteria host plant adaptation plant secondary metabolites symbiotic bacteria

Beyond catalytic materials:Controlling local gas/liquid environment in the catalyst layer for CO_(2)electrolysis

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Journal of Energy Chemistry 2022年第3期31卷 45-51,I0003页

作者： zhuo xing Kaige Shi Xun Hu Xiaofeng Feng School of Material Science and Engineering University of JinanJinan 250022ShandongChina Department of Physics University of Central FloridaOrlandoFL 32816United States Renewable Energy and Chemical Transformations(REACT)Cluster University of Central FloridaOrlandoFL 32816United States

Electrochemical reduction of CO_(2)to value-added chemicals using renewable electricity provides a promising strategy to achieve sustainable fuel production and carbon *** with the development of electrocatalysts,fow cells with gas-diffusion electrodes(GDEs)have been used to reach commercially viable current densities for CO_(2)electrolysis,while the local environment and CO_(2)mass transport in the electrodes remain to be *** this review article,we highlight some insights into the microenvironment in the catalyst layer for CO_(2)electrolysis,including typical mass transport models for CO_(2)reduction in H-type cells and GDE fow cells,the effect of a hydrophobic microenvironment on CO_(2)mass transport and catalytic performance,and the formation of a gas/liquid balance and solid–liquid–gas interfaces for CO_(2)*** insights and discussions in this article can provide important guidelines on the design of catalysts,electrodes,and electrolyzers for CO_(2)electrolysis,as well as other gas-involving electrocatalytic reactions.

关键词： Electrocatalysis CO_(2)reduction Gas-diffusion electrode Microenvironment Activity

Unraveling the therapeutic potential of Calculus Bovis in liver cancer:A novel step for targeted cancer treatment

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World Journal of Gastroenterology 2025年第3期31卷 127-129页

作者： xing-Yu Chen xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

Hepatocellular carcinoma is one of the leading causes of cancer-related deaths globally,and effective treatments are urgently *** present study aimed to investigate the inhibitory effect of Calculus Bovis(CB)on liver cancer and the underlying *** inhibited M2 tumor-associated macrophage polarization and modulated the Wnt/β-catenin signaling pathway,thereby suppressing the proliferation of liver cancer *** inhibitory effect on liver cancer growth was confirmed by both in vivo and in vitro experiments(detailed by Huang et al).The present study provides a theoretical basis for the application of CB for the treatment of liver cancer,providing new avenues for liver cancer treatment.

关键词： Calculus Bovis Liver cancer M2 tumor-associated macrophage polarization Wnt/β-catenin Pathway Tumor microenvironment

Optimizing hemicelluloses pre-extraction in eucalyptus kraft pulping:A pathway towards enhancing pulp mill biorefineries

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Chinese Journal of Chemical Engineering 2024年第6期70卷 162-172页

作者： Yuhan Wang Danqi Xue Jingjing zhuo Zhouyang xiang State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China

A critical pathway towards enhancing pulp mill biorefineries is to integrate the extraction and utilization of hemicelluloses into the pulping ***,an industrial pre-extraction strategy for hemicelluloses targeting eucalyptus kraft pulping process was *** solution or pulping white liquor was used to pre-extract hemicelluloses before the actual pulping *** response surface methodology(RSM)technique was applied to investigate the most suitable conditions to maximize the yield of these hemicelluloses while simultaneously minimizing the damage to pulp yields and ***(105 to 155℃),alkali concentration(3%to 8%),sulfidity(20%to 30%)and retention time(19 to 221 min)were combined to evaluate their effects on hemicellulose yields and chemical *** optimal pre-extraction conditions identified in this work(5.75%NaOH concentration,25%sulfidity at 135℃for 60 min)successfully allowed recovering 4.8%of hemicelluloses(based on the wood dry mass)and limited damages to pulp yields and *** cellulose content in pulp can even be increased by about 10%.Hemicellulose emulsification properties were also evaluated,which were comparable to synthetic *** study provides an industrial pathway to effectively separate and utilize wood hemicelluloses from the pulping process,which has the potential to improve the economy and material utilization of pulp and paper mills.

关键词： Hemicelluloses Xylan Pre-extraction Kraft pulping Emulsifying Response surface methodology(RSM)