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The mechanism of dentine hypersensitivity:Stimuli-induced directional cation transport through dentinal tubules

Nano Research 2023年第1期16卷 991-998页

作者： Nuo Chen Jingjing Deng Shengjie Jiang xiang-yu kong Teng Zhou Kai Zhao Zuohui Xiao Huimin Zheng Weipeng Chen Congcong Zhu Xinyu Liu Liping Wen Yan Wei Xuliang Deng Lei Jiang Beijing Laboratory of Biomedical Materials Department of Geriatric DentistryPeking University School and Hospital of StomatologyBeijing 100081China Central Laboratory Peking University School and Hospital of StomatologyBeijing 100081China CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Mechanical and Electrical Engineering College Hainan UniversityHainan 570228China School of Future Technology University of Chinese Academy of Sciences Beijing 100049China

Dentine hypersensitivity is an annoying worldwide disease,yet its mechanism remains *** long-used hydrodynamic theory,a stimuli-induced fluid-flow process,describes the pain ***,no experimental evidence supports the ***,we demonstrate that stimuli-induced directional cation transport,rather than fluid-flow,through dentinal tubules actually leads to dentine *** in vitro/in vivo electro-chemical and electro-neurophysiological approaches reveal the cation current through the nanoconfined negatively charged dentinal tubules coming from external stimuli(pressure,pH,and temperature)on dentin surface and further triggering the nerve impulses causing the dentine ***,the cationic-hydrogels blocked dentinal tubules could significantly reduce the stimuli-triggered nerve action potentials and the anionhydrogels counterpart enhances those,supporting the cation-flow transducing dentine ***,the inspired ion-blocking desensitizing therapies have achieved remarkable pain relief in clinical *** proposed mechanism would enrich the basic knowledge of dentistry and further foster breakthrough initiatives in hypersensitivity mitigation and cure.

关键词： dentine hypersensitivity cation transport dentinal tubules Ionic-current-rectification

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Polymer-to-Monomers Chemically Recyclable Poly(imide-imine)Plastics with Extreme-Condition Resistance and Flame Retardancy

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Chinese Journal of Polymer Science 2024年第10期42卷 1525-1535,I0012页

作者： Zhen-yu Wang Xiao-kong Liu State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun130012China

Polyimides are a family of high-tech plastics that have irreplaceable applications in the fields of aerospace,defense,and opto-electronics,but polyimides are difficult to be reprocessed and recycled at the end of their service life,resulting in a significant waste of ***,it is of great significance to develop recyclable polyimides with comparable properties to the commercial ***,we report a novel polymer-to-monomers chemically recyclable poly(imide-imine)(PtM-CR-PII)plastic,synthesized by cross-linking the amine-terminated aromatic bisimide monomer and the hexa-vanillin terminated cyclophosphazene monomer via dynamic imine *** PtM-CR-PII plastic exhibits comparable mechanical and thermal properties as well as chemical stability to the commercial *** PtM-CR-PII plastic possesses a high Young’s modulus of≈3.2 GPa and a tensile strength as high as≈108 MPa,which also exhibits high thermal stability with a glass transition temperature of≈220℃.Moreover,the PtM-CR-PII plastic exhibits outstanding waterproofness,acid/alkali-resistance,and solvent-resistance,its appearance and mechanical properties can be well maintained after long-term soaking in water,highly concentrated acid and base,and various organic ***,the cyclophosphazene moieties endow the PtM-CR-PII plastic with excellent flame *** PtM-CR-PII plastic exhibits the highest UL-94 flame-retarding rating of V-0 and a limiting oxygen index(LOI)value of 45.5%.Importantly,the PtM-CR-PII plastic can be depolymerized in an organic solvents-acid mixture medium at room temperature,allowing easy separation and recovery of both monomers in high *** recovered pure monomers can be used to regenerate new PtM-CR-PII plastics,enabling sustainable polymer-monomers-polymer circulation.

关键词： Chemical recyclability Polyimides Polyimines Dynamic imine bonds Mechanical properties Chemical stability

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Light-Induced Heat Driving Active Ion Transport Based on 2D MXene Nanofluids for Enhancing Osmotic Energy Conversion

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CCS Chemistry 2021年第4期3卷 1325-1335页

作者： Pei Liu Teng Zhou yunfei Teng Lin Fu yuhao Hu xiangbin Lin xiang-yu kong Lei Jiang Liping Wen CAS Key Laboratory of Bio-Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190 School of Future Technology University of Chinese Academy of SciencesBeijing 100049 College of Mechanical and Electrical Engineering Hainan UniversityHaikou 570228

Osmotic energy from the ocean,also called blue energy,serves as a clean,renewable,and vast energy source for the energy demands of the *** electrodialysis-based blue energy harvesting via ion-selective membranes,by the regulation and manipulation of directional ion transport,has been greatly developed *** particular,light has been employed to enhance directional ion transport for energy conversion through an increase in photo-induced surface ***,the authors demonstrate a novel nanofluidic regulation strategy based on the phenomenon of light-induced heat-driven active ion transport through the lamellar MXene *** to the great light-induced heat effect,a temperature gradient appears as soon as illumination is applied to an off-center position,inducing an actively temperature gradient-driven ionic species *** employing this phenomenon,the authors conducted light-induced heat-enhanced osmotic energy conversion and doubled the osmotic energy conversion power *** study has extended the scope of light-enhanced osmotic energy conversion and could further bring other photothermal materials into this ***,the proposed system provides a new avenue of light-controlled ionic transport for ion gathering,desalination,and energy conversion applications.

关键词： active ion transport light energy conversion 2D MXene nanofluids photothermal

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An integrative mathematical model of microwave ion thruster for mHz-frequency thrust noise analysis

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Chinese Journal of Aeronautics 2024年第4期37卷 121-136页

作者： xiang NIU Hui LIU Daren yu Plasma Propulsion Laboratory Harbin Institute of TechnologyHarbin 150001China

Many high-precision space missions need thrusters to produce thrust with low noise to compensate for disturbances and ensure satellite platform stability. Microwave ion thruster is characterized with a wide thrust range and potential for these missions. A cost-effective and accurate mathematical model is crucial for mHz-frequency thrust noise analysis and feedback controller design. The Particle-In-Cell(PIC) and global models are two common simulation tools. The PIC model is characterized with high accuracy but huge computation cost, which is difficult to analyze long-time performance characteristics. Now, the global model is only used for the discharge chamber with low accuracy and cannot reflect ion extraction properties. In this paper, an integrative mathematical model is built for a 1-cm microwave ion thruster and can reflect ion beamlet divergence and impingement on the Accelerator Grid(AG). Simulation results show good agreement with experiments at 0.06 sccm. However, the model demonstrates worse consistency with experiments when the flux increases to 0.1 sccm, which may be because the influence of neutral gas on the Electron Cyclotron Resonance(ECR) is not considered in the model. A long-time(1000 s) simulation is conducted with this model under 35 μN. It takes 3 hrs, and the thrust noise reaches 1 μN/Hz^(0.5) at 1 mHz.

关键词： Electric propulsion Microwave ion thruster Integrative model Sheath property Ion beamlet divergence Thrust noise Plasma

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Temperature prediction model in multiphase flow considering phase transition in the drilling operations

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Petroleum Science 2024年第3期21卷 1969-1979页

作者： Yang Zhang Yong-An Li xiang-Wei kong Hao Liu Teng-Fei Sun College of Mechanical and Electrical Engineering Beijing University of Chemical TechnologyBeijing 100027China School of Petroleum Engineering Yangtze UniversityWuhan430000HubeiChina

The study considers gas compression properties,gas slippage,back pressure(BP),phase transition(PT),well depth,and differences in gas-liquid physical properties.A new temperature model for multiphase flow is proposed by considering phase transition in the drilling *** mathematical model of multiphase flow is solved using the finite difference method with annulus mesh division for grid nodes,and a module for multiphase flow calculation and analysis is *** results indicate that the temperature varies along the annulus with the variation of gas influx at the bottom of the *** the process of controlled pressure drilling,as gas slips along the annulus to the wellhead,its volume continuously expands,leading to an increase in the gas content within the annulus,and consequently,an increase in the pressure drop caused by gas *** temperature increases with the increase in BP and decreases in gas influx rate and wellbore *** gas influx,the thermal conductivity coefficient for the gas-drilling mud two phases is significantly weakened,resulting in a considerable change in temperature along the *** the context of MPD,the method of slightly changing the temperature along the annulus by controlling the back pressure is feasible.

关键词： Managed pressure drilling Phase transition Temperature Gas-drilling mud two phase

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Advances in the research of intestinal fungi in Crohn's disease

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World Journal of Gastroenterology 2024年第39期30卷 4318-4323页

作者： Mo-Wei kong Yang yu Peng Wang Ying Wan yu Gao Chun-xiang Zhang Department of Cardiology The Affiliated Hospital of Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of General Surgery Xinqiao HospitalArmy Medical UniversityChongqing 400037China School of Basic Medical Sciences Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Endocrinology Affiliated Hospital of Chengde Medical UniversityChengde 067000Hebei ProvinceChina

This article reviews of the original research published by Wu et al in the World Journal of Gastroenterology,delving into the pivotal role of the gut microbiota in the pathogenesis of Crohn's disease(CD).Insights were gained from fecal microbiota transplantation(FMT)in mouse models,revealing the intricate interplay between the gut microbiota,mesenteric adipose tissue(MAT),and creeping *** study uncovered the characteristics of inflammation and fibrosis in the MAT and intestinal tissues of patients with CD;moreover,through the FMT mouse model,it observed the impact of samples from healthy patients and those with CD on *** pathogenesis of CD is complex,and its etiology remains unclear;however,it is widely believed that gut microbiota dysbiosis plays a significant ***,with the development and application of next-generation sequen-cing technology,research on the role of fungi in the pathogenesis and chronicity of CD has *** editorial serves as a supplement to the research by Wu et al who discussed advances related to the study of fungi in CD.

关键词： Intestinal microbiota Crohn's disease pathogenesis Fecal microbiota trans-plantation Mesenteric adipose tissue Gut fungal dynamics

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Microstructure and mechanical properties of a cast TRIP-assisted multiphase stainless steel

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China Foundry 2024年第3期21卷 221-228页

作者： Meng-xin Wang Zi-xiang Wu Jing-yu He xiang Chen School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

Stainless steels are used in a wide range of complex environments due to their excellent corrosion *** stainless steels can offer an excellent combination of strength,toughness and corrosion resistance due to the coexistence of different *** microstructure and mechanical properties of a novel cast multiphase stainless steel,composed of martensite,ferrite,and austenite,were investigated following appropriate heat treatment processes:solution treatment at 1,050℃ for 0.5 h followed by water quenching to room temperature,and aging treatment at 500℃ for 4 h followed by water quenching to room *** show reversed austenite is formed by diffusion of Ni element during aging process,and the enrichment of Ni atoms directly determines the mechanical stability of *** austenite with a lower Ni content undergoes a martensitic transformation during plastic *** tensile strength of the specimen exceeds 1,100 MPa and the elongation exceeds 24%after solid solution,and further increases to 1,247 MPa and 25%after aging *** enhancement is due to the TRIP effect of austenite and the precipitation of the nanoscale G-phase pinning dislocations in ferrite and martensite.

关键词： multiphase stainless steel mechanical properties TRIP effect reversed austenite G-phase

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Al-modified yolk-shell silica particle-supported NiMo catalysts for ultradeep hydrodesulfurization of dibenzothiophene and 4,6-dimethyldibenzothiophene:Efficient accessibility of active sites and suitable acidity

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Petroleum Science 2024年第1期21卷 654-666页

作者： Ke yu Wei-Min kong Zhen Zhao Ai-Jun Duan Lian kong Xi-Long Wang State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China Institute of Catalysis for Energy and Environment College of Chemistry and Chemical EngineeringShenyang Normal UniversityShenyang 110034LiaoningChina

Yolk-shell SiO2 particles(YP)with center-radial meso-channels were fabricated through a simple and effective ***-containing YP-supported NiMo catalysts with different Al amounts(NiMo/AYP-x,x=Si/Al molar proportion)were prepared and dibenzothiophene(DBT)and 4,6-dimethyl-dibenzothiophene(4,6-DMDBT)were employed as the probes to evaluate the hydrodesulfurization(HDS)catalytic *** as-prepared AYP-x carriers and corresponding catalysts were characterized by some advanced characterizations to obtain deeper correlations between physicochemical properties and the HDS *** average pore sizes of series AYP-x supports are above 6.0 nm,which favors the mass transfer of organic *** cavity between the yolk and the shell is beneficial for the enrichment of S-containing compounds and the accessibility between reactants and active *** embedded into the silica framework could facilitate the formation of Lewis(L)and Brønsted(B)acid sites and adjust the metal-support interaction(MSI).Among all the as-synthesized catalysts,NiMo/AYP-20 catalyst shows the highest HDS *** improved HDS activity of NiMo/AYP-20 catalyst is attributed to the perfect combination of excellent structural properties of the yolk-shell mesoporous silica,enhanced acidity,moderate MSI,and good accessibility/dispersion of active components.

关键词： Al-containing yolk-shell silica particles Accessibility Acidity Metal-support interaction Hydrodesulfurization

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Integrating remote sensing and 3-PG model to simulate the biomass and carbon stock of Larix olgensis plantation

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Forest Ecosystems 2024年第4期11卷 543-555页

作者： yu Bai Yong Pang Dan kong Key Laboratory of National Forestry and Grassland Administration on Forestry Remote Sensing and Information System Institute of Forest Resource Information

Accurate estimations of biomass and its temporal dynamics are crucial for monitoring the carbon cycle in forest ecosystems and assessing forest carbon sequestration *** studies have shown that integrating process-based models(PBMs)with remote sensing data can enhance simulations from stand to regional scales,significantly improving the ability to simulate forest growth and carbon stock ***,the utilization of PBMs for large-scale simulation of larch carbon storage distribution is still *** this study,we applied the parameterized 3-PG(Physiological Principles Predicting Growth)model across the Mengjiagang Forest Farm(MFF)to make broad-scale predictions of the biomass and carbon stocks of Larix olgensis *** model was used to simulate average diameter at breast height(DBH)and total biomass,which were later validated with a wide range of observation data including sample plot data,forest management inventory data,and airborne laser scanning *** results showed that the 3-PG model had relatively high accuracy for predicting both DBH and total biomass at stand and regional scale,with determination coefficients ranging from 0.78 to *** on the estimation of total biomass,we successfully produced a carbon stock map of the Larix olgensis plantation in MFF with a spatial resolution of 20 m,which helps with relevant management *** findings indicate that the integration of 3-PG model and remote sensing data can well predict the biomass and carbon stock at regional and even larger *** addition,this integration facilitates the evaluation of forest carbon sequestration capacity and the development of forest management plans.

关键词： 3-PG model Larch Biomass Carbon stock ALS

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Study of inter-well interference in shale gas reservoirs by a robust production data analysis method based on deconvolution

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Petroleum Science 2024年第4期21卷 2502-2519页

作者： Wen-Chao Liu Cheng-Cheng Qiao Ping Wang Wen-Song Huang xiang-Wen kong yu-Ping Sun He-Dong Sun yue-Peng Jia School of Civil and Resource Engineering University of Science and Technology Beijing PetroChina Research Institute of Petroleum Exploration and Development

In order to overcome the defects that the analysis of multi-well typical curves of shale gas reservoirs is rarely applied to engineering, this study proposes a robust production data analysis method based on deconvolution, which is used for multi-well inter-well interference research. In this study, a multi-well conceptual trilinear seepage model for multi-stage fractured horizontal wells was established, and its Laplace solutions under two different outer boundary conditions were obtained. Then, an improved pressure deconvolution algorithm was used to normalize the scattered production data. Furthermore, the typical curve fitting was carried out using the production data and the seepage model solution. Finally,some reservoir parameters and fracturing parameters were interpreted, and the intensity of inter-well interference was compared. The effectiveness of the method was verified by analyzing the production dynamic data of six shale gas wells in Duvernay area. The results showed that the fitting effect of typical curves was greatly improved due to the mutual restriction between deconvolution calculation parameter debugging and seepage model parameter debugging. Besides, by using the morphological characteristics of the log-log typical curves and the time corresponding to the intersection point of the log-log typical curves of two models under different outer boundary conditions, the strength of the interference between wells on the same well platform was well judged. This work can provide a reference for the optimization of well spacing and hydraulic fracturing measures for shale gas wells.

关键词： Shale gas Inter-well interference Deconvolution Production data analysis Typical curves Multi-stage fractured horizontal well

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