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Phospholipase A2 enzymes PLA2G2A and PLA2G12B as potential diagnostic and prognostic biomarkers in cholangiocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 289-306页

作者： Chen Qiu yu-Kai xiang Xuan-Bo Da Hong-Lei Zhang xiang-yu kong Nian-Zong Hou Cheng Zhang Fu-Zhou Tian yu-Long Yang Center of Gallbladder Disease Shanghai East HospitalInstitute of Gallstone DiseaseSchool of MedicineTongji UniversityShanghai 200092China General Surgery Center Chengdu Military General HospitalChengdu 610083Sichuan ProvinceChina

BACKGROUND Phospholipase A2(PLA2)enzymes are pivotal in various biological processes,such as lipid mediator production,membrane remodeling,bioenergetics,and maintaining the body surface ***,these enzymes play a significant role in the development of diverse *** To systematically and comprehensively explore the expression of the PLA2 family genes and their potential implications in cholangiocarcinoma(CCA).METHODS We conducted an analysis of five CCA datasets from The Cancer Genome Atlas and the Gene Expression *** study identified differentially expressed genes between tumor tissues and adjacent normal tissues,with a focus on PLA2G2A and *** Set Enrichment Analysis was utilized to pinpoint associated ***,relevant hub genes and microRNAs for PLA2G2A and PLA2G12B were predicted,and their correlation with the prognosis of CCA was *** PLA2G2A and PLA2G12B were discerned as differentially expressed in CCA,manifesting significant variations in expression levels in urine and serum between CCA patients and healthy *** expression of PLA2G2A was correlated with poorer overall survival in CCA ***,the study delineated pathways and miRNAs associated with these *** Our findings suggest that PLA2G2A and PLA2G12B may serve as novel potential diagnostic and prognostic markers for *** increased levels of these genes in biological fluids could be employed as non-invasive markers for CCA,and their expression levels are indicative of prognosis,underscoring their potential utility in clinical settings.

关键词： PLA2G2A PLA2G12B Diagnostic Prognostic biomarkers cholangiocarcinoma

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A promising solution for highly reversible zinc metal anode chemistry:Functional gradient interphase

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Nano Research Energy 2024年第2期3卷 3-6页

作者： Xiaofeng He xiang-yu kong Liping Wen CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Rechargeable zinc(Zn)metal batteries have long been plagued by dendrite growth and parasitic reactions due to the absence of a stable Zn-ion conductive solid-electrolyte interphase(SEI).Although the current strategies assist in suppressing dendritic Zn growth,it is still a challenge to obtain the operation-stability of Zn anode with high Coulombic efficiency(CE)required to implement a sustainable and long-cycling life of Zn metal *** this perspective,we summarize the advantages of the functional gradient interphase(FGI)and try to fundamentally understand the transport behaviors of Zn ions,based on recently an article understanding Zn *** correlation between the function-orientated design of gradient interphase and key challenges of Zn metal anodes in accelerating Zn2+transport kinetics,improving electrode reversibility,and inhibiting Zn dendrite growth and side reactions was particularly ***,the rational design and innovative directions are provided for the development and application of functional gradient interphase in rechargeable Zn metal battery systems.

关键词： zinc metal battery dendrite gradient solid-electrolyte interphase energy storage

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The connection between meridians and physiological functions:A quantum principle

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Nano Research 2023年第11期16卷 12817-12820页

作者： xiang-yu kong Min xiang Jiancheng Fang Dong Han Bo Song Lei Jiang CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Science and Technology Center for Quantum Biology National Institute of Extremely-Weak Magnetic Field InfrastructureHangzhou 310051China CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China School of Optical-Electrical Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China School of Future Technology University of Chinese Academy of SciencesBeijing 100049China

In the long history of traditional Chinese medicine(TCM),meridians play essential roles as the critical network to regulate the normal physiological functions of the human *** are regarded to be the channels connecting the internal organs with the body surface and various parts of the *** there are many studies and doctrines trying to reveal the nature of meridians for their validation in TCM,the mechanism underlying the meridians remains ***,based on our macroscopic quantum state concept of ion channels(i.e.,sub-nanometer scale channels),we propose a quantum principle of *** acupoints and organ symptom are in a macroscopic coherence state of the ion channels in *** applying TCM treatments(e.g.,TCM massage,acupuncture,moxibustion,and electroacupuncture)on the acupoint,the corresponding organ symptom could be well regulated with help of quantum meridian state.

关键词： traditional Chinese medicine meridians macroscopic quantum state external stimulation

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Delay-dependent Non-fragile H_∞ Control for Linear Systems with Interval Time-varying Delay

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International Journal of Automation and computing 2015年第1期12卷 109-116页

作者： Jun-Jun Hui He-Xin Zhang xiang-yu kong The Xi'an Research Institute of High Technology

This paper considers the problem of delay-dependent non-fragile H∞control for a class of linear systems with interval time-varying delay. Based on the direct Lyapunov method, an appropriate Lyapunov-Krasovskii functional(LKF) with triple-integral terms and augment terms is introduced. Then, by using the integral inequalities and convex combination technique, an improved H∞performance analysis criterion and non-fragile H∞controller are formulated in terms of linear matrix inequalities(LMIs), which can be easily solved by using standard numerical packages. At last, two numerical examples are provided to demonstrate the effectiveness of the obtained results.

关键词： Lyapunov-Krasovskii functional(LKF) non-fragile H∞control linear matrix inequality(LMI) interval time-varying delay

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On Improved Delay-dependent Robust Stability Criteria for Uncertain Systems with Interval Time-varying Delay

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International Journal of Automation and computing 2015年第1期12卷 102-108页

作者： Jun-Jun Hui He-Xin Zhang xiang-yu kong Xin Zhou The Xi'an Research Institute of High Technology The Baoji Research Institute of High Technology

This paper considers the problem of delay-dependent robust stability for uncertain systems with interval time-varying delays. By using the direct Lyapunov method, a new Lyapunov-Krasovskii(L-K) functional is introduced based on decomposition approach, when dealing with the time derivative of L-K functional, a new tight integral inequality is adopted for bounding the cross terms. Then, a new less conservative delay-dependent stability criterion is formulated in terms of linear matrix inequalities(LMIs),which can be easily solved by optimization algorithms. Numerical examples are given to show the effectiveness and the benefits of the proposed method.

关键词： Lyapunov-Krasovskii(L-K) functional delay decomposition approach linear matrix inequality(LMI) interval timevarying delay robust stability

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On the Discrete-Time Dynamics of Cross-Coupled Hebbian Algorithm

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Journal of Computer Science & Technology 2022年第1期37卷 252-265页

作者： Xiao-Wei Feng xiang-yu kong Chuan He Dong-Hui Xu Xi'an Research Institute of High Technology Xi'an 710025China

Principal/minor component analysis(PCA/MCA),generalized principal/minor component analysis(GPCA/GMCA),and singular value decomposition(SVD)algorithms are important techniques for feature *** the convergence analysis of these algorithms,the deterministic discrete-time(DDT)method can reveal the dynamic behavior of PCA/MCA and GPCA/GMCA algorithms ***,the dynamic behavior of SVD algorithms has not been studied quantitatively because of their special *** this paper,for the first time,we utilize the advantages of the DDT method in PCA algorithms analysis to study the dynamics of SVD ***,taking the cross-coupled Hebbian algorithm as an example,by concatenating the two cross-coupled variables into a single vector,we successfully get a PCA-like DDT ***,we analyze the discrete-time dynamic behavior and stability of the PCA-like DDT system in detail based on the DDT method,and obtain the boundedness of the weight vectors and learning ***,further discussion shows the universality of the proposed method for analyzing other SVD *** a result,the proposed method provides a new way to study the dynamical convergence properties of SVD algorithms.

关键词： deterministic discrete-time(DDT)system singular value decomposition(SVD) cross-correlation matrix discrete-time dynamic behavior

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A universal functionalization strategy for biomimetic nanochannel via external electric field assisted non-covalent interaction

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Nano Research 2021年第5期14卷 1421-1428页

作者： yunfei Teng xiang-yu kong Pei Liu Yongchao Qian yuhao Hu Lin Fu Weiwen Xin Lei Jiang Liping Wen CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing100190China School of Future Technology University of Chinese Academy of SciencesBeijing100049China

Biological ion channels, as fundamental units participating in various daily behaviors with incredible mass transportation and signal transmission, triggered booming researches on manufacturing their artificial prototypes. Biomimetic ion channel with the nanometer scale for smart responding functions has been successfully realized in sorts of materials by employing state-of-art nanotechnology. Ion track-etching technology, as crucial branches of fabricating solid-state nanochannels, exhibits outstanding advantages, such as easy fabrication, low cost, and high customization. To endow the nanochannel with smart responsibility, various modification methods are developed, including chemical grafting, non-covalent adsorption, and electrochemical deposition, enriching the reservoir of accessible stimuli-responses combinations, whereas were limited by their relatively lengthy and complex procedure. Here, based on the electric field induced self-assembly of polyelectrolytes, a universal customizable modifying strategy has been proposed, which exhibits superiorities in their functionalization with convenience and compatibility. By using this protocol, the channels’ ionic transport behaviors could be easily tuned, and even the specific ionic or molecular responding could be realized with superior performance. This strategy surely accelerates the nanochannels functionalization into fast preparing, high efficiency, and large-scale application scenarios.

关键词： biomimetic ionic nanofluidics ionic rectification solid-state nanopore nanochannel

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Robust sulfonated poly(ether ether ketone) nanochannels for high-performance osmotic energy conversion

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National Science Review 2020年第8期7卷 1349-1359页

作者： yuanyuan Zhao Jin Wang xiang-yu kong Weiwen Xin Teng Zhou Yongchao Qian Linsen Yang Jinhui Pang Lei Jiang Liping Wen CAS Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and Chemistry Chinese Academy of Sciences University of Chinese Academy of Sciences Key Laboratory of Super Engineering Plastic of Ministry of Education Jilin University School of Future Technology University of Chinese Academy of Sciences Mechanical and Electrical Engineering College Hainan University School of Science Northwestern Polytechnical University

The membrane-based reverse electrodialysis(RED) technique has a fundamental role in harvesting clean and sustainable osmotic energy existing in the salinity gradient. However, the current designs of membranes cannot cope with the high output power density and robustness. Here, we construct a sulfonated poly(ether ether ketone)(SPEEK) nanochannel membrane with numerous nanochannels for a membrane-based osmotic power generator. The parallel nanochannels with high space charges show excellent cation-selectivity, which could further be improved by adjusting the length and charge density of nanochannels. Based on numerical simulation, the system with space charge shows better conductivity and selectivity than those of a surface-charged nanochannel. The output power density of our proposed membrane-based device reaches up to 5.8 W/m2by mixing artificial seawater and river water. Additionally,the SPEEK membranes exhibit good mechanical properties, endowing the possibility of creating a high-endurance scale-up membrane-based generator system. We believe that this work provides useful insights into material design and fluid transport for the power generator in osmotic energy conversion.

关键词： SPEEK membrane nanochannel ion-selectivity salinity gradient power generation

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A coupling eigen-pair extraction algorithm based on Newton method

A coupling eigen-pair extraction algorithm based on Newton m...

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第36届中国控制会议

作者： Ben Wang xiang yu kong Ze Hao Cao Fan Gu Xi’an Research Institute of High Technology

ISBN: (纸本)9781538629185

Neural network algorithms on MCA(minor component analysis) are of importance in signal *** algorithm can mitigate the speed-stability problem which exists in most non-coupled *** some coupled algorithms have been proposed so far,there exists complex computation in *** this paper,based on a novel information criterion and by modifying the Newton’s method,we propose one algorithm which is *** the derivation of our algorithms,it is more accurate and faster to obtain the results compared with traditional methods,because it is not needed to calculate the inverse Hessian *** experimental results show that the proposed algorithm has higher accuracy,faster convergence and better robust performance than the existing coupling algorithm.

关键词： MCA speed-stability problem Newton’s method coupled algorithm

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Ion transport regulation through triblock copolymer/PET asymmetric nanochannel membrane:Model system establishment and rectification mapping

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Chinese Chemical Letters 2021年第2期32卷 822-825页

作者： Linsen Yang Pei Liu Congcong Zhu yuanyuan Zhao Miaomiao yuan xiang-yu kong Liping Wen Lei Jiang Key Laboratory of Bio-inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China School of Future Technology University of Chinese Academy of ScienceBeijing 100049China The Eighth Affiliated Hospital Sun Yat-sen UniversityShenzhen 518033China

Controlling ions transport across the membrane at different pH environments is essential for the physiological process and artificial *** efforts have been devoted to pH-responsive ion gating,while rarely systems can maintain the rectification in pH-changing ***,a composite nanochannel system is fabricated,which shows unidirectional rectification with high performance in a wide pH *** the system,block copolymer(BCP) and polyethylene te rephthalate(PET) are employed for the amphoteric nanochannels *** on the composite system,a model is built for the theoretical ***,rectification mapping is conducted on the system,which can provide abundant info rmation about the relations between charge distribution and ions transport prope *** proposed rectification mapping can definitely help to design new materials with special ion transport properties,such as high-performance membranes used in the salinity gradient power generation field.

关键词： Nanochannel Unidirectional rectification Composited membrane Ion transport Rectification mapping

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