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骨外露创面扩创术修复后负压封闭引流联合局部氧疗的疗效及预后分析

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中国现代医学杂志 2021年第4期31卷 86-91页

作者：郑军佟向阳徐州市第一人民医院骨科江苏徐州221000

目的探讨骨外露创面扩创术修复后给予负压封闭引流(VSD)联合局部氧疗的疗效及预后。方法选取2017年1月—2018年1月徐州市第一人民医院收治的88例行骨外露创面扩创修复术患者。按随机数字法分为VSD+氧疗组和机械治疗组。VSD+氧疗组行VSD... 详细信息

目的探讨骨外露创面扩创术修复后给予负压封闭引流(VSD)联合局部氧疗的疗效及预后。方法选取2017年1月—2018年1月徐州市第一人民医院收治的88例行骨外露创面扩创修复术患者。按随机数字法分为VSD+氧疗组和机械治疗组。VSD+氧疗组行VSD联合局部氧疗,机械治疗组行传统清创联合换药方式治疗。比较两组创面愈合情况、临床治疗指标、创口微环境检测指标及不良反应情况。结果VSD+氧疗组临床基本愈合率较机械治疗组高(P<0.05)。VSD+氧疗组换药次数、完全愈合时间及住院时间较机械治疗组低(P<0.05)。两组渗液酸碱度、伤口温度及C反应蛋白比较,差异有统计学意义(P<0.05)。VSD+氧疗组不良反应率较机械治疗组低(P<0.05)。结论骨外露创面扩创术修复后给予VSD联合局部氧疗,能够改善创面愈合效果,改善创口微环境,提升临床治愈率和安全性。

关键词：负压伤口疗法物理治疗技术局部氧疗治疗结果预后

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加热功率对感应重熔涂层性能的影响

材料保护 2018年第6期51卷 64-67页

作者：吴勉潘邻童向阳马飞孙文武汉材料保护研究所特种表面保护材料及应用技术国家重点实验室湖北武汉430030 机械科学研究总院青岛分院山东青岛266000

为明确重熔工艺参数对感应重熔涂层表面状态、硬度及成分的影响,优化重熔工艺参数,采用预涂和感应重熔方法以不同加热功率在20钢柱塞杆上制备Ni60重熔层,并分析了重熔层的微观形貌、硬度和成分。结果表明:感应加热功率合适(40 kW)时,工... 详细信息

为明确重熔工艺参数对感应重熔涂层表面状态、硬度及成分的影响,优化重熔工艺参数,采用预涂和感应重熔方法以不同加热功率在20钢柱塞杆上制备Ni60重熔层,并分析了重熔层的微观形貌、硬度和成分。结果表明:感应加热功率合适(40 kW)时,工件表面平整光洁,涂层组织致密均匀,涂层表面平均硬度为758.9 HV_(1 N);感应重熔过程主要为基体中Fe元素向涂层内部扩散,而涂层中Ni、Cr元素向基体扩散较少。

关键词：柱塞杆感应重熔加热功率扩散涂层性能

Short-term and long-term outcome of early invasive therapy in patients with non-ST-segment elevation acute coronary syndrome:a meta-analysis

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Short-term and long-term outcome of early invasive therapy i...

Alcohol consumption and carotid atherosclerosis in China:the cardiovascular risk surve

第十三次全国心血管病学术会议

作者： YU Zi-xiang,MA Yi-tong,yang Yi-ning,LIU Fen Department of Cardiology,First affiliated Hospital,Xinjiang Medical University,Urumqi 830054,China

Objective To determine the short-term and long-term outcome of an invasive compared to a conservative strategy for treating UA/*** We searched The Cochrane Library(Issue 1.2011),MEDLINE(1996 to September 2010), EMBASE(1974 to September 2010),CBM(1989 to 2011),CNKI(1997 to 2011),VIP(1989 to 2011).The quality of included studies was critically *** analyses were performed with The Cochrane Collaboration’ s Revman 5.0 software. Results Seven randomized controlled trials met the including *** meta-analysis showed the incidence of all-

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Alcohol consumption and carotid atherosclerosis in China:the...

Interaction between COX-2 G-765C and smoking in relation to coronary artery disease in a Chinese Uighur population

第十三次全国心血管病学术会议

作者： XIE xiang,MA Yi-tong,yang Yi-ning,FU Zhen-yan,HUANG Ding, MA xiang,CHEN Bang-dang,LIU Fen Department of Cardiology,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China

Objective The relationship between alcohol consumption and carotid atherosclerosis has been reported in some epidemiological studies,but the results were *** investigated the association between alcohol intake and carotid atherosclerosis in the Han,Uygur,and Kazakh populations in Xinjiang in western *** The study population sample comprised 13 037 Chinese people(5277 Han,4572 Uygur,and 3188 Kazakh) aged>35 years who participated in a cardio-

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Interaction between COX-2 G-765C and smoking in relation to ...

Microglia lactylation in relation to central nervous system diseases

第十三次全国心血管病学术会议

作者： XIE xiang,MA Yi-tong,yang Yi-ning,FU Zhen-yan, LI Xiao-mei,HUANG Ding,MA xiang,LIU Fen Department of Cardiology,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China

Objective To explore the relationship between the interaction of cyclooxygenase-2(COX-2) gene polymorphism and smoking and CAD in a Uighur *** Using a case-control study of Chinese Uighur CAD patients(n= 430) and healthy controls(n=470),we investigated the roles of G-765C polymorphism in the COX-2 gene(PTGS2) by the use of polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) *** The PTGS2 GG gen-

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui yang Nan Mo Le tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

Study on the hydrogen absorption properties of a YGdTbDyHo rare-earth high-entropy alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 127-135页

作者： tongyue Li Ziliang Xie Wenjiao Zhou Huan tong Dawen yang Anjia Zhang Yuan Wu Xiping Song State Key Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Whole Win(Beijing)Materials Sci.&Tech.Co. Ltd.Beijing 100083China

This study investigated the microstructure and hydrogen absorption properties of a rare-earth high-entropy alloy(HEA),*** indicated that the YGdTbDyHo alloy had a microstructure of equiaxed grains,with the alloy elements distributed *** hydrogen absorption,the phase structure of the HEA changed from a solid solution with an hexagonal-close-packed(HCP)structure to a high-entropy hydride with an faced-centered-cubic(FCC)structure without any secondary phase *** alloy demonstrated a maximum hydrogen storage capacity of 2.33 H/M(hydrogen atom/metal atom)at 723 K,with an enthalpy change(ΔH)of-141.09 kJ·mol^(-1)and an entropy change(ΔS)of-119.14 J·mol^(-1)·K^(-1).The kinetic mechanism of hydrogen absorption was hydride nucleation and growth,with an apparent activation energy(E_(a))of 20.90 kJ·mol^(-1).Without any activation,the YGdTbDyHo alloy could absorb hydrogen quickly(180 s at 923 K)with nearly no incubation period *** reason for the obtained value of 2.33 H/M was that the hydrogen atoms occupied both tetrahedral and octahedral *** results demonstrate the potential application of HEAs as a high-capacity hydrogen storage material with a large H/M ratio,which can be used in the deuterium storage field.

关键词： rare-earth high-entropy alloy hydrogen absorption capacity pressure–composition–temperature curves kinetics

Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

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World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun Huang Zhu Chen Heng Xiao Hai-yang Hu Xing-Yu Chen Cheng-You Du xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control

Targeting Epac2 and GluA3-containing AMPARs:a novel therapeutic strategy for Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3223-3224页

作者： tong Zhang Martina Schmidt Department of Molecular Pharmacology Groningen Research Institute of PharmacyUniversity of GroningenGroningenThe Netherlands School of Pharmacy Tianjin Medical UniversityTianjinChina

Alzheimer's disease(AD)is a neurodegenerative disease that manifests progressive decline in memory and *** the early stage of AD,memory retrieval is impaired preceding memory acquisition and consolidation(Roy et al.,2016).Prior to the onset of symptoms,pathological amyloid-β(Aβ)plagues and tau protein tangles accumulate in extracellular and intracellular spaces,respectively,leading to *** these hallmark pathologies,Aβ is proposed to be the primary etiology by triggering a cascade of pathogenic events,including neuroinflammation,oxidative stress,tau hyperphosphorylation,synaptic/neuronal dysfunction,and neuronal death(Zhang et al.,2023b).

关键词： Alzheimer impaired Aβ