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Gas Chromatography–Mass Spectrometry for Quantitative and Qualitative Analysis of Essential Oil from Curcuma wenyujin Rhizomes

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World Journal of Traditional Chinese Medicine 2021年第1期7卷 138-145页

作者： xiang-sheng zhao Yue-xiang Zeng Ya-Kui Zhou Rong-Tao Li Mei-Hua Yang Key Laboratory of Resources Conservation and Development of Southern Medicine of Hainan Province&Hainan Branch of the Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeHaikou 570311China School of Life and Pharmaceutical Sciences Hainan UniversityHaikou 570228China Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China

Objectives:A rapid and sensitive gas chromatography–mass spectrometry(GC–MS)method for quantitative and qualitative analysis of essential oil from Curcuma wenyujin rhizomes was ***:The essential oil of *** rhizomes was extracted by supercritical CO2 extraction(SFE).Six main bioactive compounds(eucalyptol,β-elemene,curzerene,germacrone,curdione,and curcumol)were analyzed in selected ion monitoring mode(SIM).Results:Curzerene is not originally present in *** rhizomes,but is a product of the transformation of furanodiene at high *** six target components demonstrated good linearity(R2>0.9979)over a relatively wide concentration *** interday and intraday variations had relative standard deviation values less than 5%and the average recovery ranged from 96.95%to 100.04%.The limit of quantitation ranged from 0.032 to 0.235μg/*** developed method was successfully used to analyze the six compounds in 17 samples collected from different *** variation was observed for the concentrations of the six *** addition,51 constituents were identified in *** rhizome essential oil,consisting of 87.66%of the total essential oil,including curdione,curzerene,dehydrocurdione,germacrone,1,4-bis(2-benzimidazoyl)benzene,neocurdione,curcumenone,andβ-***:The proposed method will be useful in the quality control of *** rhizome essential oil production.

关键词： Curcuma wenyujin essential oil gas chromatography–mass spectrometry quantitative analysis supercritical CO2 extraction

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Is traumatic meniscal lesion associated with acute fracture morphology changes of tibia plateau? A series of arthroscopic analysis of 67 patients

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World Journal of Clinical Cases 2021年第1期9卷 81-90页

作者： Yan-Dong Chen Shu-xiang Chen Hong-Guang Liu xiang-sheng zhao Wen-Huan Ou Huan-Xi Li Hong-Xing Huang 3^rd Institute of Clinical Medicine Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Department of Joint Trauma Jiangmen Wuyi Hospital of Traditional Chinese MedicineAffiliated Jiangmen Traditional Chinese Medicine Hospital of Jinan UniversityJiangmen 529031Guangdong ProvinceChina Department of Radiology Jiangmen Wuyi Hospital of Traditional Chinese MedicineJiangmen 529031Guangdong ProvinceChina Science and Education Section The Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510378Guangdong ProvinceChina

BACKGROUND Computed tomography(CT)has become a routine preoperative examination for tibial plateau fractures(TPFs).Assessing the location of the fragment and intercondylar eminence fracture can provide clinicians with valuable information;however,the evaluation of traumatic meniscal lesion(TML)and arthroscopic management are *** To predict TML by three-dimensional skeletal anatomy changes in unilateral TPF and bilateral TPF on preoperative thin layer *** Acute fracture of tibial plateau patients undergoing arthroscopic surgery between December 2017 and December 2019 were included in this retrospective *** type,zone,and location of TMLs were diagnosed based on the operation records and/or arthroscopic *** of three-dimensional fracture morphology included the following:Frontal fragment width of plateau,sagittal fragment subsiding distance(FSD),sagittal fracture line distance,sagittal posterior tibial slope,and transversal area ratio of fragment area)on preoperative CT three-dimensional *** correlation of TML with skeletal values was calculated according to unicondylar TPFs and bicondylar *** A total of 67 patients were enrolled in this study,among which 30 patients had TMLs,lateral/medial(23/7).FSD was a particularly positive factor to predict TML,with odds ratio of 2.31(1.26-5.63).On sagittal view of CT,FSD degree of 8 mm and posterior tibial slope exceeding 11.74°implied enhanced risk of TML in bicondylar *** coronal view,once fragment width of plateau surpassed 3 cm,incidence of TML reached 100%.On transverse view,area ratio of fragment as enhanced risk of 5.5%and FSD>4.3 mm for predicting TML were observed in unicondylar *** TML can be predicted by different parameters on preoperative CT views according to unicondylar fractures and bicondylar TPFs.

关键词： Traumatic meniscal lesion Knee Three-dimensional computerized tomography Posterior tibial slope Unicondylar fracture Bicondylar fracture

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Dalbergia odorifera Essential Oil Protects against Myocardial Ischemia through Upregulating Nrf2 and Inhibiting Caspase Signaling Pathways in Isoproterenol-Induced Rats

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World Journal of Traditional Chinese Medicine 2023年第3期9卷 338-347页

作者： Can-Hong Wang Bao Gong Hui Meng Yu-Lan Wu xiang-sheng zhao Jian-He Wei Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikouChina Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikouChina Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical College Ministry of Education and National Engineering Laboratory for Breeding of Endangered Medicinal Materials Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Objective:Dalbergia odorifera has long been used as a Chinese herbal medicine for the treatment of cardiovascular and cerebrovascular *** study aimed to determine the potential myocardial protective effect and possible mechanism of action of *** ife ra essential oil(DOEO).Materials and Methods:The essential oil of *** was extracted by *** cardioprotective effects of DOEO were examined by histopathological observation,myocardial enzyme detection,peroxidation,anti-oxidant level detection,and related protein *** compounds in the blood were identified by gas chromatography-mass ***:These results showed that DOEO had significant myocardial cell protection,with IC50 values ranging from 17.64 to 24.78μg/mL in *** to the myocardial ischemia group,the DOEO pretreatment groups had lower levels of myocardial injury,creatinine kinase,lactate dehydrogenase,alanine transaminase,aspartate transaminase,hydrogen peroxide,and nitric oxide,and higher levels of glutathione and superoxide *** addition,DOEO pretreatment significantly increased Na+-K+-ATPase and Ca2+-ATPase *** r,immunohistochemical e xperiments showed that DOEO remarkably increased the protein levels of NF-E2-related nuclear factor 2(Nrf2)and heme oxygenase-1(HO-1)and reduced the expression of apoptotic caspases,including caspase 3 and caspase *** main components of the blood were transnerolidol and nerolidol ***,the study showed that DOEO displayed myocardial protection by upregulating the NF-E2-related nuclear factor-antioxidant response element(Nrf2-ARE)and caspase *** has a therapeutic effect on MI by inhibiting the oxidant and apoptotic ***:*** may be a potential candidate drug for treating myocardial ischemic injury.

关键词： Anti-apoptosis Anti-oxidation Dalbergia odorifera essential oil Isoproterenol Myocardial ischemia

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生物组织磁聚焦电导率成像原理及反演算法

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电波科学学报 2006年第2期21卷 249-254页

作者：傅林黄卡玛向胜昭四川大学电子信息学院四川成都610064

生物组织磁聚焦电导率成像系统利用多圈螺旋电感线圈形成聚焦磁场激励和检测导电目标,达到了提高成像空间分辨率的目的。根据所推导的频率变化与分层生物组织电导率的关系,引入遗传算法对目标电导率进行反演优化计算,获得了充足的成像... 详细信息

生物组织磁聚焦电导率成像系统利用多圈螺旋电感线圈形成聚焦磁场激励和检测导电目标,达到了提高成像空间分辨率的目的。根据所推导的频率变化与分层生物组织电导率的关系,引入遗传算法对目标电导率进行反演优化计算,获得了充足的成像数据。对于给定的十层分层生物组织模型,反演优化所得电导率除最深层有较大偏差需要进行数据处理外,其余均与目标一致,成像数据非常可靠;成像速度为百毫秒数量级但是具有很大提高潜力。计算结果表明该方法能够有效地对生物组织进行分层媒质建模计算,进一步采取措施能够实现较高分辨率的实时成像。

关键词：磁聚焦电导率成像聚焦线圈优化计算遗传算法

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磁聚焦电导率成像系统的硬件设计与实现

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航天医学与医学工程 2006年第1期19卷 74-78页

作者：傅林黄卡玛向胜昭四川大学电子信息学院四川成都610064

目的设计磁聚焦电导率成像系统硬件,实现数据采集。方法利用阵列信号源接成调频式检测电路实现多频检测；其中检测线圈具有良好的聚焦特性,能够提高成像的空间分辨率；将检测到的频率变化信号采集后存储于乒乓工作方式的数据存储系统,... 详细信息

目的设计磁聚焦电导率成像系统硬件,实现数据采集。方法利用阵列信号源接成调频式检测电路实现多频检测；其中检测线圈具有良好的聚焦特性,能够提高成像的空间分辨率；将检测到的频率变化信号采集后存储于乒乓工作方式的数据存储系统,然后经过传输速率达到115.2kHz的串行通信接口电路送入计算机。结果信号源阵列的频率稳定度均达到0.2％,失真度(total harmonic distortion,THD)小于-43dB,输出最大电压幅度时信噪比(signaI noise ratio,SNR)均在58dB至62dB之间。存储系统存储深度为131072×16bits。系统具有良好的频率分辨率,经过数据采集后很容易进行分析和处理。对给定的分层媒质模型,检测后通过反演计算,所得电导率与模型基本符合。结论通过理论分析、计算和实例测试,系统具有较高的灵敏度,能够有效地对分层生物组织传导率进行检测和反演成像。

关键词：磁聚焦电导率成像阵列信号源磁聚焦线圈数据采集

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Coronary artery bypass grafting with concomitant resection for carcinoma of lung

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The Journal of Biomedical Research 2010年第1期24卷 77-80页

作者： Yangyang Zhang,Yanhu Wu ,Biao Yuan,xiang Liu,sheng zhao,Zhi Li,Yu Xia Department of Cardiothoracic Surgery,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China Department of Cardiothoracic Surgery the First Affiliated Hospital of Nanjing Medical University Nanjing 210029 Jiangsu Province China.

A 69-year-old woman with angina had a lesion in the left lower lobe on chest film. Angiography revealed coronary artery disease in three vessels. Combined off pump coronary artery bypass grafting （CABG） and left lower lobectomy were performed through median sternotomy. This approach avoids complications due to staged operations and cardiopulmonary bypass （CPB）. This report shows that simultaneous off pump CABG and pulmonary operations can be performed safely in patients with coronary artery disease （CAD） associated with lung cancer.

关键词： lung cancer coronary artery disease luo- resection off-pump coronary artery bypass grafting

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Subretinal fibrosis secondary to neovascular age-related macular degeneration:mechanisms and potential therapeutic targets

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Neural Regeneration Research 2025年第2期20卷 378-393页

作者： Jingxiang Zhang Xia sheng Quanju Ding Yujun Wang Jiwei zhao Jingfa Zhang Department of Ophthalmology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Urology People’s Hospital of Huangdao DistrictQingdaoShandong ProvinceChina Department of Ophthalmology Shanghai General Hospital(Shanghai First People’s Hospital)Shanghai Jiao Tong University School of MedicineShanghaiChina National Clinical Research Center for Eye Diseases Shanghai Key Laboratory of Ocular Fundus DiseasesShanghai Engineering Center for Visual Science and PhotomedicineShanghai Engineering Center for Precise Diagnosis and Treatment of Eye DiseasesShanghaiChina

Subretinal fibrosis is the end-stage sequelae of neovascular age-related macular *** causes local damage to photoreceptors,retinal pigment epithelium,and choroidal vessels,which leads to permanent central vision loss of patients with neovascular age-related macular *** pathogenesis of subretinal fibrosis is complex,and the underlying mechanisms are largely ***,there are no effective treatment options.A thorough understanding of the pathogenesis of subretinal fibrosis and its related mechanisms is important to elucidate its complications and explore potential *** current article reviews several aspects of subretinal fibrosis,including the current understanding on the relationship between neovascular age-related macular degeneration and subretinal fibrosis;multimodal imaging techniques for subretinal fibrosis;animal models for studying subretinal fibrosis;cellular and non-cellular constituents of subretinal fibrosis;pathophysiological mechanisms involved in subretinal fibrosis,such as aging,infiltration of macrophages,different sources of mesenchymal transition to myofibroblast,and activation of complement system and immune cells;and several key molecules and signaling pathways participating in the pathogenesis of subretinal fibrosis,such as vascular endothelial growth factor,connective tissue growth factor,fibroblast growth factor 2,platelet-derived growth factor and platelet-derived growth factor receptor-β,transforming growth factor-βsignaling pathway,Wnt signaling pathway,and the axis of heat shock protein 70-Toll-like receptors 2/*** review will improve the understanding of the pathogenesis of subretinal fibrosis,allow the discovery of molecular targets,and explore potential treatments for the management of subretinal fibrosis.

关键词： choroidal neovascularization epithelial-mesenchymal transition mesenchymal transition myofibroblast neovascular age-related macular degeneration submacular fibrosis subretinal fibrosis therapeutic targets transforming growth factor-β vascular endothelial growth factor

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MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self‑Powered Motion Sensing

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Nano-Micro Letters 2025年第3期17卷 265-279页

作者： Yu‑Ze Wang Yu‑Chang Wang Ting‑Ting Liu Quan‑Liang zhao Chen‑Sha Li Mao‑sheng Cao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China School of Materials Science and Engineering Peking UniversityBeijing 100871People’s Republic of China School of Mechanical and Material Engineering North China University of TechnologyBeijing 100144People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education of the People’s Republic of ChinaHeilongjiang UniversityHarbin 150080People’s Republic of China

Polymeric microwave actuators combining tissue-like softness with programmablemicrowave-responsive deformation hold great promise for mobile intelligentdevices and bionic soft robots. However, their application is challenged by restricted electromagneticsensitivity and intricate sensing coupling. In this study, a sensitized polymericmicrowave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx(MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique spacechargepolarization and interfacial polarization, resulting in significant improvements of230% in the dielectric loss factor and 830% in the apparent efficiency of electromagneticenergy harvest. The sensitized microwave actuation demonstrates as the shortenedresponse time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (upto 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combinesdriving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of ~ 3 mV) duringactuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approachfor developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan zhao Yidan Zhang Xin Liu Jian Zhang Ya Gao Shuyue Li Cui Chang xiang Liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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Substrate bias effects in p-channel GaN-on-Si transistors

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Science China(Information Sciences) 2025年第1期68卷 404-405页

作者： Mengyao zhao Jie MA Lanlan YANG Chuanqi PAN Denggui WANG Jianjun ZHOU sheng LI Jiaxing WEI Long ZHANG Siyang LIU Weifeng SUN National ASIC System Engineering Research Center School of Integrated Circuits Southeast University National Center of Technology Innovation for Electronic Design Automation Southeast University National Key Laboratory of Solid-State Microwave Devices and Circuits

The drain current （ID） of the n-channel GaN field-effecttransistor （n-FET） is influenced by the substrate-to-source bias voltage (VBS)（substrate bias effect）[1].Actually,nonzero VBSis also likely to occur in p-FET in real application,because the source electrode of p-FET is usually connected to high *** study reports the dependency between IDand VBSin p-FET for the first time,and analyzes the underlying mechanisms from the perspective of vertical electric field （EF） distribution.

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