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Risk factors and prediction model for inpatient surgical site infection after elective abdominal surgery

World Journal of Gastrointestinal Surgery 2023年第3期15卷 387-397页

作者： Jin Zhang Fei Xue Si-Da Liu Dong Liu Yun-Hua Wu Dan Zhao Zhou-ming Liu Wen-Xing Ma Ruo-Lin Han Liang Shan xiang-Long Duan Second Department of General Surgery Shaanxi Provincial People's HospitalXi’an 710068Shaanxi ProvinceChina Institute of Medical Research Northwestern Polytechnical UniversityXi’an 710072Shaanxi ProvinceChina Second Department of General Surgery Third Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710068Shaanxi ProvinceChina Computer Science School Universiti Sains MalaysiaPenang 11800Malaysia Medical Service Shaanxi Provincial People's HospitalXi’an 710068Shaanxi ProvinceChina

BACKGROUND Surgical site infections(SSIs) are the commonest healthcare-associated infection. In addition to increasing mortality, it also lengthens the hospital stay and raises healthcare expenses. SSIs are challenging to predict, with most models having poor predictability. Therefore, we developed a prediction model for SSI after elective abdominal surgery by identifying risk *** To analyse the data on inpatients undergoing elective abdominal surgery to identify risk factors and develop predictive models that will help clinicians assess patients *** We retrospectively analysed the inpatient records of Shaanxi Provincial People’s Hospital from January 1, 2018 to January 1, 2021. We included the demographic data of the patients and their haematological test results in our analysis. The attending physicians provided the Nutritional Risk Screening 2002(NRS 2002)scores. The surgeons and anaesthesiologists manually calculated the National Nosocomial Infections Surveillance(NNIS) scores. Inpatient SSI risk factors were evaluated using univariate analysis and multivariate logistic regression. Nomograms were used in the predictive models. The receiver operating characteristic and area under the curve values were used to measure the specificity and accuracy of the *** A total of 3018 patients met the inclusion criteria. The surgical sites included the uterus(42.2%), the liver(27.6%), the gastrointestinal tract(19.1%), the appendix(5.9%), the kidney(3.7%), and the groin area(1.4%). SSI occurred in 5% of the patients(n = 150). The risk factors associated with SSI were as follows: Age;gender;marital status;place of residence;history of diabetes;surgical season;surgical site;NRS 2002 score;preoperative white blood cell, procalcitonin(PCT), albumin, and low-density lipoprotein cholesterol(LDL) levels;preoperative antibiotic use;anaesthesia method;incision grade;NNIS score;intraoperative blood loss;intraoperative drainage tube placement;surgica

关键词： Surgical site infections Risk factors Abdominal surgery Prediction model

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Assessment of Iron Bioavailability in Ten Kinds of Chinese Wheat Flours Using an in vitro Digestion/Caco-2 cell Model

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Biomedical and Environmental Sciences 2012年第5期25卷 502-508页

作者： LEI Ji ZHANG Yong CHEN xiang Gui ZHANG ming Qiu BAI Lin HUANG Cheng Yu Ortiz Monasterio IVAN School of Bioengineering Xihua UniversityChengdu 610039SichuanChina West China School Of PublicHealth Sichuan UniversityChengdu 610041SichuanChina Institute of Crop Science Chinese Academy ofAgricultural SciencesBeijing 100081China International Maize and Wheat Improvement Center(CIMMYT) 06600 MexicoD.F.Mexico

Abstract Objective To compare iron bioavailability （Fe BV） from ten selected kinds of Chinese wheat flours in order to provide scientific basis for further human trials and enable plant breeding programs to screen biofortified wheat cultivars. Methods An in vitro digestion/Caco-2 cell model was used to assess Fe BV of ten flour samples from six leading Chinese wheat cultivars and the stability of Fe BV in one cultivar was studied across three growing environments. Results Significant differences were observed in both Fe BV and Fe bioavailability per gram of food （Fe BVPG） among cultivars （P〈0.01） grown at the same location with the same flour extraction rate. Zhongyou 9507 and Jingdong 8 had Fe BV 37%-54% and Fe BVP（3 103%-154% higher than the reference control. In the Anyang environment, Zhongyou 9507 had a higher wheat flour-Fe level and Fe BVPG. Differences in Fe BV were detected in cultivars with different flour extraction rates. Conclusion Zhongyou 9507 and Jingdong 8 were identified as the most promising cultivars for further evaluation of efficacy by using human subjects. The growing environments had no effect on Fe BV, but did have a significant effect on Fe BVPG. Fe bioavailabilities in low-extraction （40%） flours were higher than those in high-extraction （78%） flours.

关键词： Iron biofortification, Bioavailability Caco-2 cells

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SnO_2纳米粒子的制备与表征

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无机化学学报 2005年第6期21卷 925-928,F011页

作者：孙明余林郝志峰孙建汕头大学化学系汕头515063 广东工业大学轻工化工学院广州510090

The SnO2 nano-particles with rutile structure were prepared by a Water/Oil (W/O) microemulsion system, composed of Triton X-100+1-hexanol/Cyclohexane/Water. The particles were also compared with that synthesized by citric acid method. The powders were characterized by thermogravimetric analysis (TGA), X-ray diffraction (XRD), transmission electron microscopy (TEM) and infrared spectroscopy (IR). The result showed that the SnO2 particles prepared by microemulsion had fine shape and narrow range of particle size distribution. The crystallite size calcined at 600 ℃ was 11.49 nm,while the crystallite size prepared by citric acid method was about 17.4 nm.

关键词：二氧化锡纳米粒子微乳液法制备结构表征

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Chinese Guideline on the Management of Polypoidal Choroidal Vasculopathy (2022)

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Chinese Medical Sciences Journal 2023年第2期38卷 77-93页

作者： You-Xin Chen Yu-Qing Zhang Chang-Zheng Chen Hong Dai Su-Yan xiang Ma Xiao-Dong sun Shi-Bo Tang Yu-Sheng Wang Wen-Bin Wei Feng Wen Ge-Zhi Xu Wei-Hong Yu Mei-Xia Zhang ming-Wei Zhao Yang Zhang Fang Qi Xun Xu Xiao-Xin Li Department of Ophthalmology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing China Key Laboratory of Ocular Fundus Diseases Chinese Academy of Medical Sciences&Peking Union Medical College Department of Health Research Methods Evidenceand ImpactMc Master University Ningbo Nottingham GRADE center University of Nottingham Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences CEBIM(Center for Evidence Based Integrative Medicine)-Clarity Collaboration Guang'anmen HospitalChina Academy of Chinese Medical Sciences Department of Ophthalmology Renmin Hospital of Wuhan University Department of Ophthalmology Beijing Hospital Department of Ophthalmology Xuzhou Municipal Hospital Affiliated to Xuzhou medical University Department of Ophthalmology the First Affiliated Hospital of Dalian Medical University Department of Oph thalmology Shanghai General HospitalShanghai Jiao Tong University School of Medicine Aire Eye Hospital Department of Ophthalmology Xijing HospitalFouth Military Medical University Department of Ophthalmology Beijing Tongren Hospital State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University Ophthalmology the Affiliated Eye and ENT HospitalShanghai Medical SchoolFudan University Department of Ophthalmology West China School of MedicineWest China HospitalSichuan University Department of Ophthalmology Peking University People’s Hospital Systematic Review Solutions Ltd Department of Ophthalmology Shanghai General Hospital Eye Center of Xiamen University People Eye Center of People’s Hospital Peking University

Background In China's Mainland,patients with neovascular age-related macular degeneration(nAMD)have approximately an 40%prevalence of polypoidal choroidal vasculopathy(PCV).This disease leads to recurrent retinal pigment epithelium detachment(PED),extensive subretinal or vitreous hemorrhages,and severe vision *** has introduced various treatment modalities in the past years and gained comprehensive experience in treating *** A total of 14 retinal specialists nationwide with expertise in PCV were empaneled to prioritize six questions and address their corresponding outcomes,regarding opinions on inactive PCV,choices of anti-vascular endothelial growth factor(anti-VEGF)monotherapy,photodynamic therapy(PDT)monotherapy or combined therapy,patients with persistent subretinal fluid(SRF)or intraretinal fluid(IRF)after loading dose anti-VEGF,and patients with massive subretinal *** evidence synthesis team conducted systematic reviews,which informed the recommendations that address these *** guideline used the GRADE(Grading of Recommendations,Assessment,Development,and Evaluation)approach to assess the certainty of evidence and grade the strengths of *** The panel proposed the following six conditional recommendations regarding treatment choices.(1)For patients with inactive PCV,we suggest observation over treatment.(2)For treatment-na?ve PCV patients,we suggest either anti-VEGF monotherapy or combined anti-VEGF and PDT rather than PDT monotherapy.(3)For patients with PCV who plan to initiate combined anti-VEGF and PDT treatment,we suggest later/rescue PDT over initiate PDT.(4)For PCV patients who plan to initiate anti-VEGF monotherapy,we suggest the treat and extend(TE)regimen rather than the pro re nata(PRN)regimen following three monthly loading doses.(5)For patients with persistent SRF or IRF on optical coherence tomography(OCT)after three monthly anti-VEGF treatments,we suggest proceeding with anti-VEGF treatment r

关键词： polypoidal choroidal vasculopathy anti-vascular endothelial growth factor photodynamic therapy surgery

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高数值孔径二次谐波显微术的分子取向探测

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光子学报 2007年第11期36卷 2129-2133页

作者：王湘晖林列曾明南开大学现代光学研究所光电信息技术科学教育部重点实验室天津300071 天津大学电气与自动化工程学院天津300072

基于矢量衍射理论和格林函数法,利用坐标变换分析高数值孔径条件下二次谐波强度随胶原纤维取向的变化规律.研究结果表明,当胶原纤维垂直于z轴时,聚焦光场Ey、Ez分量的增强导致二次谐波相对强度极小值的上升;随着胶原纤维极角的改变,二... 详细信息

基于矢量衍射理论和格林函数法,利用坐标变换分析高数值孔径条件下二次谐波强度随胶原纤维取向的变化规律.研究结果表明,当胶原纤维垂直于z轴时,聚焦光场Ey、Ez分量的增强导致二次谐波相对强度极小值的上升;随着胶原纤维极角的改变,二次谐波强度的整体变化趋势发生变化,同时前向和后向二次谐波之间的强度变化也出现明显差异.

关键词：二次谐波显微术高数值孔径矢量衍射理论格林函数法

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Association between folate intake, serum folate levels and the risk of lung cancer： a systematic review and meta-analysis

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Chinese Medical Journal 2013年第10期126卷 1957-1964页

作者： DAI Wei-min YANG Bo CHU xiang-yang WANG Yu-qi ZHAO ming CHEN Li ZHANG Guo-qing Department of General Thoracic SurgeryChinese People's Liberation Army General Hospital Beijing 100853 China Department of EmergencyChinese People's Liberation Army General Hospital Beijing 100853 China Department Clinic Oncology of Tumor Research CenterChinese People's Liberation Army General Hospital Beijing 100853 China

Background Folate plays a critical role in nucleotide synthesis and DNA methylation, and was considered to be associated with anti-carcinogenesis. Results from studies that concern the relationship between the folate intake or serum folate levels and lung cancer risk showed no consistency, which requires our further comprehensive meta- analysis. Methods Systematic literature search was conducted to identify the relevant studies （published prior to February 2013） according to standard protocol. Estimated effects were calculated under both random-effects and fixed-effects models. Heterogeneity between studies and publication bias were also evaluated. Results A total of 4390 cases and 6138 controls from 6 case-control studies revealed a significant overall inverse association between folate intake and lung cancer risk （OR = 0.74, 95% CI = 0.65-0.84, P〈 0.001）. Summary of 1438 cases and 2582 controls from 4 case-control studies and 44 cases out of a cohort of 1988 participants suggested a marginal association without significance （OR = 0.78, 95% CI = 0.60-1.02, P = 0.075） between high serum folate levels and less lung cancer susceptibility; however, subgroup analysis about population-based case-control studies showed that high serum folate levels significantly associated with the reduced lung cancer risk （OR = 0.76, 95% CI = 0.58-1.00, P = 0.048）. Conclusion Higher folate intake can be a protective factor against lung cancer risk, and higher serum folate level is probably associated with reduced lung cancer risk in marginal manner, though more studies are warranted to confirm these associations.

关键词： folate intake serum folate lung cancer meta-analysis

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突变理论在海河流域地下水环境风险评价中的应用

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水利学报 2007年第11期38卷 1312-1317页

作者：李绍飞孙书洪王向余天津农学院水利工程系天津300384 清华大学土木工程系北京100084

介绍了突变理论基本原理及评价方法,根据海河流域地下水环境特征及几十年的演变过程,提出了地下水环境风险评价指标体系,并将其应用于流域内天津、沧州、衡水、石家庄和唐山等5个典型区域的地下水环境风险评价中。应用结果表明,该方法... 详细信息

介绍了突变理论基本原理及评价方法,根据海河流域地下水环境特征及几十年的演变过程,提出了地下水环境风险评价指标体系,并将其应用于流域内天津、沧州、衡水、石家庄和唐山等5个典型区域的地下水环境风险评价中。应用结果表明,该方法的评价结果与相关资料显示的各区域地下水环境实际情况基本吻合,与应用较成熟的模糊综合评价结果基本一致,并验证了突变理论方法用于地下水环境风险评价的可行性。相对于以往评价方法,突变理论评价法无需确定指标权重,减少人为主观因素,且计算简便,为区域地下水环境质量综合评价提供了新的方法。

关键词：突变理论地下水环境风险评价指标体系海河流域

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什么决定着用户对产品的完整体验?

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心理科学进展 2011年第1期19卷 94-106页

作者：刘静孙向红中国科学院心理研究所脑与认知科学国家重点实验室北京100101 中国科学院研究生院北京100049 索尼爱立信移动通信产品(中国)有限公司北京100102

用户体验是以用户与产品的交互为基础而形成的用户对产品的完整感受。研究其决定因素可以有针对性地提高用户体验。早期研究表明,可用性、美感和情感都有重要影响但皆不是唯一的决定因素,近年来的研究重点关注于多因素整合理论及其模型... 详细信息

用户体验是以用户与产品的交互为基础而形成的用户对产品的完整感受。研究其决定因素可以有针对性地提高用户体验。早期研究表明,可用性、美感和情感都有重要影响但皆不是唯一的决定因素,近年来的研究重点关注于多因素整合理论及其模型的建立。在总结实效/享乐结构理论、用户-企业-产品双层结构理论和四种过程模型以提取用户体验影响因素的基础上,提出目前研究的突破点可在三方面,一是深入探讨各因素的作用,二是揭示社会型产品用户体验的形成规律,三是揭示用户体验随时间变化的规律。

关键词：用户体验社会型产品美感可用性任务场景

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超磁致伸缩换能器磁路设计及优化

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浙江大学学报（工学版） 2006年第2期40卷 192-196页

作者：李明范项占琴吕福在浙江大学现代制造工程研究所浙江杭州310027

为优化超磁致伸缩换能器的电磁性能,研究了线圈的几何尺寸和磁路元件的选择对换能器磁场特性和输出位移的影响,并进行了磁路损耗和气隙磁导分析.给出了合理的线圈结构参数,提出了在超磁致伸缩材料(GMM)棒两端安装高磁导率的软磁体和减少... 详细信息

为优化超磁致伸缩换能器的电磁性能,研究了线圈的几何尺寸和磁路元件的选择对换能器磁场特性和输出位移的影响,并进行了磁路损耗和气隙磁导分析.给出了合理的线圈结构参数,提出了在超磁致伸缩材料(GMM)棒两端安装高磁导率的软磁体和减少GMM棒涡流损耗的设计方案,并忽略了气隙的影响.采用有限元方法仿真了不同磁路设计方案对换能器性能的影响,并进行了试验分析.结果表明,在GMM棒两端安装电工软铁能够提高工作磁场强度,减少磁通泄漏,增加换能器输出位移并降低驱动电流,改善换能器的发热情况,从而整体改善超磁致伸缩换能器的性能.

关键词：超磁致伸缩换能器磁路线圈 Terfenol—D

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Imaging characteristics and surgical management of orbital neurilemmomas

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International Journal of Ophthalmology(English edition) 2019年第7期12卷 1108-1115页

作者： ming-Hao Chen Jian-Hua Yan The State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University

AIM: To review imaging characteristics and surgical outcomes of orbital neurilemmoma. METHODS: Retrospective review of 21 patients with orbital neurilemmoma managed at the Zhongshan Ophthalmic Center of sun Yat-sen University from June 2005 to December 2016. All patients underwent surgical excision following preoperative imaging including ultrasonography, computed tomography(CT) and magnetic resonance imaging(MRI).RESULTS: Among these patients, 11 were male and 10 were female, with age ranging from 12 to 75y(average, 40.3 y). Ultrasound of the orbit showed a roundish well-demarcated orbital mass with low or middle internal reflectivity in each case. Dark inner liquid fields were detected in 28.6% of these cases. Doppler ultrasound demonstrated blood flow signals in these masses. CT showed that the tumors were either homogeneous or heterogeneous. MRI of T1 WI revealed isointense or hypointense tumors, while the T2 WI indicated heterogeneous hyperintense lesions. Gd contrast MRI demonstrated heterogenous or homogeneous enhancement initiating from the wide area of the lesion. Six patients underwent lateral orbitotomy and 15 anterior orbitotomy. All tumors were completely removed. After a mean followup of 1.8 y, 3 patients experienced reduced vision while the remaining 10 patients showed improved vision after surgery. One patient experienced a mild limitation of upward motility. No recurrence occurred. CONCLUSION: Orbital neurilemmoma is a relatively rare, benign orbital tumor. Effective diagnosis requires a combination of ultrasonography, CT and/or MRI. These imaging techniques are also vital to differentiate neurilemmomas from other orbital masses like that of cavernous hemangiomas and *** treatment requires complete resection of the neurilemmomas as performed either by lateral or anterior orbitotomy. Recurrence is rare after complete removal.

关键词： neurilemmoma orbital tumor imaging orbitotomy orbital surgery

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