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HOXA11-AS aggravates microglia-induced neuroinflammation after traumatic brain injury

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Neural Regeneration Research 2022年第5期17卷 1096-1105页

作者： xiang-long li Bin Wang Fu-Bing Yang li-Gang Chen Jian You Department of Neurosurgery the Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan ProvinceChina Neurosurgical Clinical Research Center and Academician(Expert)Workstation of Sichuan Province LuzhouSichuan ProvinceChina Laboratory of Neurological Diseases and Brain Functions the Affiliated Hospital of Southwest Medical UniversityLuzhouSichuan ProvinceChina

long noncoding RNAs(lnc RNAs)participate in many pathophysiological processes after traumatic brain injury by mediating neuroinflammation and *** A11 antisense RNA(HOXA11-AS)is a member of the lnc RNA family that has been reported to participate in many inflammatory reactions;however,its role in traumatic brain injury remains *** this study,we established rat models of traumatic brain injury using a weight-drop hitting device and injected LV-HOXA11-AS into the right lateral ventricle 2 weeks before *** results revealed that overexpression of HOXA11-AS aggravated neurological deficits in traumatic brain injury rats,increased brain edema and apoptosis,promoted the secretion of proinflammatory factors interleukin-1β,interleukin-6,and tumor necrosis factorα,and promoted the activation of astrocytes and *** were treated with 100 ng/m L lipopolysaccharide for 24 hours to establish in vitro cell models,and then transfected with pc DNA-HOXA11-AS,mi R-124-3 p mimic,or *** results revealed that HOXA11-AS inhibited mi R-124-3 p expression and boosted MDK expression and TLR4-nuclear factor-κB pathway ***,lipopolysaccharide enhanced potent microglia-induced inflammatory responses in *** overexpression of mi R-124-3 p or downregulating MDK repressed microglial activation and the inflammatory response of ***,the mi R-124-3 p-mediated anti-inflammatory effects were reversed by *** findings suggest that HOXA11-AS can aggravate neuroinflammation after traumatic brain injury by modulating the mi R-124-3 p-MDK *** study was approved by the Animal Protection and Use Committee of Southwest Medical University(approval ***-2019-042)on February 4,2019.

关键词： astrocyte competitive endogenous RNA HOXA11-AS microglia midkine miR-124-3p neuroinflammation traumatic brain injury

Physical and numerical investigation on fluid flow and inclusion removal behavior in a single-strand tundish

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Journal of Iron and Steel Research International 2023年第6期30卷 1182-1198页

作者： Qi Quan Zhi-xiao Zhang Tian-peng Qu xiang-long li Jun Tian De-yong Wang School of Iron and Steel Soochow UniversitySuzhou 215137JiangsuChina

Aiming at the problem that the existence of inclusions in the tundish continuous casting process can easily lead to quality defects of the slab,the stainless steel continuous casting tundish was taken as the research *** effects of flow control device,inclusion density and inclusion size on the mixing characteristics of molten steel and inclusion behavior in tundish were *** results showed that compared with the tundish without flow control device,the average residence time of molten steel was prolonged by about 49 s,the dead zone volume fraction was reduced by 8.93%,and the piston fluid integral rate was increased by 12.68%.In the turbulence inhibitor(TI)tundish with weir-dam combination,the removal rate of inclusions with a density of 2700 kg m^(-3) and a particle size of 5 lm is 63.32%,while the removal rate of large inclusions with a density of 150μm could reach 89.04%.When the inclusion particle size was 10-50μm and the density was 2700-4500 kg m^(-3),the effect of inclusion density on inclusion removal rate was *** the same time,when weir-dam combination TI tundish was set,the inclusions were mainly limited to the slag-metal interface of the first and second chambers of the *** removal rate of inclusions in the first chamber was generally improved,with 10μm inclusions accounting for 47.67% and 150μm inclusions accounting for 60.69%.Furthermore,it has the best effect on the removal of small-size inclusions,especially those less than 70μm.

关键词： Non-metallic inclusion Flow control device Residence time distribution curve Removal behavior Discrete particle model

Mechanical properties and microstructure of Mg-treated and Catreated industrial H13 steel after quenching and tempering

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Journal of Iron and Steel Research International 2024年第8期31卷 1987-2001页

作者： Jun-ying Yue Dong Hou De-yong Wang Tian-peng Qu xiang-long li Jun Tian School of Iron and Steel Soochow UniversitySuzhou 215021JiangsuChina

The effect of magnesium treatment and calcium treatment on the microstructure and mechanical properties of industrial H13 steel after quenching and tempering was *** impact toughness and tensile tests were mainly carried out,and the microstructure was observed by scanning electron microscopy,electron backscattered diffraction,and X-ray *** results show that magnesium treatment is still feasible in industrial *** is mainly manifested in the refinement of lath martensite and *** with calcium treatment,the prior austenite grains and carbides size of industrial H13 steel treated with magnesium decreased by 3.17μm after *** quenching and tempering,the carbides(especially V-rich carbides)in Mg treatment obviously spheroidized and distributed uniformly and increased in quantity *** lath martensite size is reduced from 2.45 to 2.31μ*** suggests that magnesium treatment was able to yield smaller grains and more evenly distributed ***,the impact toughness,yield strength,and ultimate tensile strength of industrial H13 steel with magnesium treatment increased by 28%,65.5 MPa and 123.7 MPa,*** increment of strength mainly comes from dislocation strengthening,grain refinement strengthening,and precipitation strengthening,among which precipitation strengthening accounts for the largest proportion.

关键词： Industrial H13 steel Mg treatment Heat treatment Carbide-Mechanical property

Effects of Mg–Ca treatment and Ca treatment on impact toughness and morphology of sulfides in 45MnVS non-quenched and tempered steel

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Journal of Iron and Steel Research International 2024年第11期31卷 2755-2773页

作者： Tian-yin Zhan Jun Tian xiang-long li li-juan Su Dong Hou Tian-peng Qu De-yong Wang Shagang School of Iron and Steel Soochow UniversitySuzhou215137JiangsuChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina

An industrial experiment was conducted at a certain steel plant in China to compare and analyze the effects of Ca treatment and Mg–Ca treatment on inclusions in 45MnVS non-quenched and tempered steel. Through scanning electron microscopy-energy dispersive scanning analysis of the morphology and composition of inclusions, as well as Aspex quantitative analysis of their quantity, type and size, the formation mechanism of MnS–oxide (MnS inclusions with oxide cores) was intensively studied. The influence of sulfide morphology on the impact properties of steel was also analyzed. The results show that the quantity percentage of spindle-shaped sulfides in Ca-treated steel is 19.99%, and that in Mg–Ca-treated steel is 35.38%. Compared with Ca-treated steel, there are more MnS–oxide inclusions in Mg–Ca-treated steel. Controlling the content of Ca and Mg in the oxide core of MnS–oxide inclusion above 10 wt.% and the area ratio below 5 would contribute to the formation of spindle-shaped inclusions after rolling. The mismatch between MnS and oxides decreases with the increase in MgO content in the oxides, which is beneficial to nucleation and precipitation of MnS with this type of oxides as the core. Under the same deformation conditions, the size of sulfide does not affect its aspect ratio. Under the experimental conditions, the inclusion containing a certain amount of MgO can enhance its sulfur capacity, facilitating the formation of composite sulfides. The transverse impact energy of Ca-treated steel is 25.785 J, and that of Mg–Ca-treated steel is 32.119 J. Compared with the traditional Ca-treatment, Mg–Ca treatment can increase the number of spindle-shaped sulfides in the steel, thereby improving the transverse impact toughness of the steel and reducing the anisotropy of the mechanical properties of the material.

关键词： Non-quenched and tempered steel Calcium treatment Magnesium-calcium treatment Sulfide Impact toughness Morphology

Evaluating the thermal environment of urban land surfaces in Yakutsk,a city located in a region of continuous permafrost

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Advances in Climate Change Research 2024年第1期15卷 113-123页

作者： xiang-long li Ze ZHANG Jin-Xin LU Anatoli BROUCHKOV Qing-Kai YAN Qi-Hao YU Sheng-Rong ZHANG Andrey MELNIKOV School of Civil Engineering and Transportation Institute of Cold Regions Science and EngineeringPermafrost InstituteNortheast Forestry UniversityHarbin150040China China Railway Qinghai-Tibet Group Company Xining 810000China Department of Geocryology Faculty of GeologyLomonosov Moscow State UniversityMoscow 119234Russian Federation State Key Laboratory of Frozen Soil Engineering Northwest Institute of Eco Envi ronment and Re sourcesChinese Academy of SciencesLanzhou 730000China Melnikov Permafrost Institute Siberian BranchRussian Academy of ScienceYakutsk 677010Russian Federation

Rapid urbanization has led to changes in the urban land surface thermal ***,there are still much unknown about the urban land surface thermal conditions in permafrost *** is a unique geological environment,changes in the urban land surface thermal environment may trigger geological disasters caused by permafrost *** study utilized remote sensing data and geographic de-tectors to identify the dynamic changes in land surface temperature(LST)and land use/land cover(LU/LC)in Yakutsk,as well as the potential factors contributing to LST *** 1992 and 2020,the built-up area in Yakutsk increased by 36%,and the annual average LST in Yakutsk has risen by 6.67℃,accompanied by an expansion of high-temperature *** ongoing greening efforts,rapid urbanization poses a threat to these green *** in the normalized difference built-up index(NDBI)and land use transfer(LDT)were identified as the primary drivers of urban LST *** integrating geographic detector technology and artificial neural network models,we optimized the selection of input factors in the prediction model and used it to explore the future changes in LST in *** average LST in Yakutsk is expected to reach 23.4℃ and 25.1℃ in 2030 and 2040,respectively,with a further increase in high-temperature *** study provides a reference for ecological,hydrological,and geological assessments of cities in permafrost regions.

关键词： Remote sensing Land surface temperature Land use/Land cover Permafrost Yakutsk

Efficient and genotype independent maize transformation using pollen transfected by DNA-coated magnetic nanoparticles

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Journal of Integrative Plant Biology 2022年第6期64卷 1145-1156页

作者： Zuo-Ping Wang Zhong-Bao Zhang Deng-Yu Zheng Tong-Tong Zhang xiang-long li Chun Zhang Rong Yu Jian-Hua Wei Zhong-Yi Wu Beijing Key Laboratory of Agricultural Genetic Resources and Biotechnology Institute of BiotechnologyBeijing Academy of Agriculture and Forestry SciencesBeijing 100097China College of life Sciences Capital Normal UniversityBeijing 100048China

Current gene delivery methods for maize are limited to specific genotypes and depend on timeconsuming and labor-intensive tissue culture ***,we report a new method to transfect maize that is culture-free and genotype *** enhance efficiency of DNA entry and maintain high pollen viability of 32%-55%,transfection was performed at cool temperature using pollen pretreated to open the germination aperture(40%–55%).Magnetic nanoparticles(MNPs)coated with DNA encoding either red fluorescent protein(RFP),β-glucuronidase gene(GUS),enhanced green fluorescent protein(EGFP)or bialaphos resistance(bar)was delivered into pollen grains,and female florets of maize inbred lines were *** fluorescence was detected in 22%transfected pollen grains,and GUS stained 55%embryos at 18 d after *** fluorescence was detected in both silk filaments and immature *** T1 generation of six inbred lines showed considerable EGFP or GUS transcripts(29%–74%)quantitated by polymerase chain reaction,and 5%–16%of the T1 seedlings showed immunologically active EGFP or GUS ***,1.41%of the bar transfected T1 plants were glufosinate resistant,and heritable bar gene was integrated into the maize genome effectively as verified by DNA *** results demonstrate that exogenous DNA could be delivered efficiently into elite maize inbred lines recalcitrant to tissue culture-mediated transformation and expressed normally through our genotype-independent pollen transfection system.

关键词： exogenous genes genotype independence magnetic nanoparticles maize inbred lines pollen transfection pollen aperture

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石墨烯化聚合物的合成和应用

高分子学报 2014年第6期24卷 737-751页

作者：宋琪李祥龙郝龙智林杰国家纳米科学中心北京100190

石墨烯是由纯粹的sp2碳组成的二维蜂窝状结构,具有良好的导电导热性;聚合物是由某些小分子结构单元组成的链状或网状大分子,包含大量氢,氧,氮等杂原子或大量功能基团.由于石墨烯具有超大比表面积和优异的电学性能,国内外学者投入了大量... 详细信息

石墨烯是由纯粹的sp2碳组成的二维蜂窝状结构,具有良好的导电导热性;聚合物是由某些小分子结构单元组成的链状或网状大分子,包含大量氢,氧,氮等杂原子或大量功能基团.由于石墨烯具有超大比表面积和优异的电学性能,国内外学者投入了大量精力开发基于石墨烯的高性能储能器件,包括锂离子电池和超级电容器.同时,由于微孔聚合物具有高度可控的结构和超大比表面积,这种新型的聚合物可望广泛应用于气体存储、催化及传感领域.近年来,结构介于石墨烯和聚合物之间的一系列过渡型材料受到广泛关注,迅速成为能源等领域特别是储存领域的研究热点.这类材料同时具有石墨烯单元结构和聚合物片段及功能.但与传统的石墨烯/聚合物复合材料比较,这类材料中的石墨烯结构是由聚合物前驱体及聚合物本身在较高的温度下经过脱氢、重构、稠环化等苯环化学的成键反应逐渐长大而形成的;或者通过石墨烯的化学打孔、化学功能化、化学片段化逐渐形成的石墨烯与聚合物共存的独特结构.这些形成的石墨烯单元被有机链或片段相互连接,形成各式各样的带有化学功能的多孔结构与网络结构,这种独特的结构同时拥的良好的电子传输通道和离子传输通道,是二者的有机结合体,在能源储存等领域表现出极大的应用潜力.本文将这种具有独特结构的石墨烯片段与聚合物片段共同组成的结合体称之为石墨烯化聚合物(graphenal polymer),名称的准确与否还要聚合物界前辈与同仁一起决定.本文结合本课题组这几年来在这一领域的工作思路以及其他的部分本领域同行报道的一些工作进展,集中讨论石墨烯化聚合物的合成方法及其在储能领域的潜在应用.

关键词：石墨烯聚合物石墨烯化聚合物自下而上自上而下

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活性炭催化还原三价钴氨络合物反应过程

化学工程 2008年第8期36卷 32-35页

作者：陈华龙湘犁华东理工大学化学工程联合国家重点实验室上海200237

用活性炭作催化剂,水作还原剂,实现钴氨脱硝法中的关键组分[Co(NH3)6]2+离子的再生,保持[Co(NH3)6]2+溶液长时高效地脱除废气中的NO。在消除扩散影响的条件下,在搅拌釜中对活性炭催化还原[Co(NH3)6]3+的反应过程进行了研究,结果表明:活... 详细信息

用活性炭作催化剂,水作还原剂,实现钴氨脱硝法中的关键组分[Co(NH3)6]2+离子的再生,保持[Co(NH3)6]2+溶液长时高效地脱除废气中的NO。在消除扩散影响的条件下,在搅拌釜中对活性炭催化还原[Co(NH3)6]3+的反应过程进行了研究,结果表明:活性炭能催化还原[Co(NH3)6]3+的反应,而且活性炭加入量增加,反应速率也随之加快;反应速率随[Co(NH3)6]3+浓度的提高而加快;pH值是影响反应速度的一个重要因素,最佳pH值为2.74;反应温度的升高,明显地加快了反应速率。根据实验数据对该反应的本征动力学方程进行拟合,得该反应对[Co(NH3)6]3+为一级反应,反应活化能Ea=(64.62±2.06)kJ/mol。

关键词：活性炭钴氨络离子催化脱硝还原

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NO与乙二胺合钴离子气液反应动力学研究

化学工程 2005年第3期33卷 21-24页

作者：龙湘犁肖文德袁渭康华东理工大学联合化学反应工程研究所上海200237

用乙二胺合钴水溶液实现NO的液相催化氧化,乙二胺合钴离子作氧化催化剂,废气中残存的氧气作氧化剂,使NO的氧化和吸收同时进行。采用搅拌反应器分别在有氧和无氧时,对NO与乙二胺合钴离子气液反应动力学进行研究,结果表明当乙二胺合钴浓... 详细信息

用乙二胺合钴水溶液实现NO的液相催化氧化,乙二胺合钴离子作氧化催化剂,废气中残存的氧气作氧化剂,使NO的氧化和吸收同时进行。采用搅拌反应器分别在有氧和无氧时,对NO与乙二胺合钴离子气液反应动力学进行研究,结果表明当乙二胺合钴浓度大于0.02mol/L时,过程为气膜控制。氧的存在有利于NO的吸收,其分压越大,越有利于NO的氧化和脱除。气体中有氧存在时,最佳NO脱除温度为50℃,并推得吸收反应动力学方程。

关键词：动力学吸收气液反应一氧化氮