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World Journal of Clinical Cases 2022年第1期10卷 23-34页

作者： Fang Huang Wan-Yuan Chen Jie Ma xiang-lei he Jian-Wei Wang Department of Pathology Laboratory Medicine CenterZhejiang Provincial Peoples’HospitalPeoples’Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Key Laboratory of Endocrine Gland Diseases of Zhejiang Province Peoples’Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

Colorectal cancer(CRC)is presently the second most prevalent global mortalityinducing *** carcinogenesis is a multifactorial process involving internal genetic mutations and the external *** addition,non-neoplastic cell activities within tumor microenvironments for CRC development have been ***,interleukin(IL)-33,secreted by such cell types,plays a pivotal role in cancer progression due to interaction with cellular constituents within the tumor-inflammation ***-33 belongs to the IL-1 cytokine family and acts as binding attachments for the suppressor of tumorigenicity(ST)2 ***,how to coordinate tumor microenvironment,design and optimize treatment strategies suitable for CRC,based on IL-33/ST2 signal is a *** though it has established influences upon immunitylinked conditions,IL-33 effects on CRC progression and prevention and related mechanisms are still *** review depicts controversial activities for IL-33/ST2 within carcinogenesis and cancer ***,IL-33/ST2 signaling is a potential therapeutic target for CRC.

关键词： Interleukin 33 Suppressor of tumorigenicity 2 signaling Tumor microenvironment Conventional therapies Colorectal cancer

Association of p53 codon 72 polymorphism with liver metastases of colorectal cancers positive for p53 overexpression

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第11期9卷 847-852页

作者： Zhong-zheng ZHU Bing LIU Ai-zhong WANG Hang-ruo JIA Xia-xiang JIN xiang-lei he Li-fang HOU Guan-shan ZHU Department of Pathology No. 113 Hospital of People＇s Liberation Army Ningbo 315040 China Department of Urology Changhai Hospital the Second Military Medical University Shanghai 200433 China Department of Pathology Lihuili Hospital Ningbo 315041 China Department of Preventive Medicine Feinberg School of Medicine Northwestern University Chicago IL 60611 USA Innovation Center China AstraZeneca Global R ＆ D Shanghai201203 China

Objective： To evaluate the association between p53 codon 72 polymorphism （R72P） and the risk ofcolorectal liver metastases. Methods： The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer. Results： The R allele of the p53 R72P polymorphism was more frequently found in metastatic cases than in nonmetastatic cases （P=0.075）. Carriers of the 72R allele had a 2.25-fold （95% CI （confidence interval）=1.05-4.83） increased risk of liver metastases. On the stratification analysis, 72R-carrying genotype conferred a 3.46-fold （95% CI=1.02-11.72） and a 1.05-fold （95% CI=0.36-3.08） increased risk of liver metastases for p53 overexpression-positive and negative colorectal cancers, respectively. Conclusion： These results demonstrate for the first time that the 72R allele of the p53 polymorphism has an increased risk for liver metastases in colorectal cancers positive for p53 overexpression.

关键词： Colorectal cancer p53 Genetic polymorphism Liver metastases Overexpression

Understanding the molecular pathogenesis and prognostics of bladder cancer： an overview

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Chinese Journal of Cancer Research 2016年第1期28卷 92-98页

作者： Ming Zhao xiang-lei he Xiao-Dong Teng Department of Pathology Zhejiang Provincial People's Hospital Hangzhou 310014 China Department of Pathology The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 China

The knowledge of cellular mechanisms in malignances of the bladder has grown exponentially. Molecular technologies have led to the discovery of the molecular pathways distinguishing low-and high- grade urothelial neoplasms. This trend portends the future in which the classification and diagnosis of the bladder tumors through morphologic analysis will be supported by molecular information correlating with prognosis and targeted therapy. This article oudines tumor molecular pathology of bladder cancer with an emphasis on several promising candidate biomarkers that may soon make their transition to the realm of clinical management of bladder cancer.

关键词： Biomarkers molecular pathology prognosis bladder cancer

Zirconia quantum dots for a nonvolatile resistive random access memory device

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Frontiers of Information Technology & Electronic Engineering 2019年第12期20卷 1698-1705页

作者： xiang-lei he Rui-jie TANG Feng YANG Mayameen SKADHIM Jie-xin WANG Yuan PU Dan WANG State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China MoE Key Laboratory of Advanced Technology of Materials School of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

We propose a nonvolatile resistive random access memory device by employing nanodispersion of zirconia(ZrO2) quantum dots(QDs) for the formation of an active layer. The memory devices comprising a typical sandwich structure of Ag(top)/ZrO2(active layer)/Ti(bottom) are fabricated using a facile spin-coating method. The optimized device exhibits a high resistance state/low resistance state resistance difference(about 10 Ω), a good cycle performance(the number of cycles larger than 100), and a relatively low conversion current(about 1 μA). Atomic force microscopy and scanning electron microscope are used to observe the surface morphology and stacking state of the ZrO2 active layer. Experimental results show that the ZrO2 active layer is stacked compactly and has a low roughness(Ra=4.49 nm) due to the uniform distribution of the ZrO2 QDs. The conductive mechanism of the Ag/ZrO2/Ti device is analyzed and studied, and the conductive filaments of Ag ions and oxygen vacancies are focused on to clarify the resistive switching memory behavior. This study offers a facile approach of memristors for future electronic applications.

关键词： Zirconia quantum dot Resistive switching Memory device Spin coating

Three-dimensional magnetic reconnection in complex multiple X-point configurations in an ancient solar-lunar terrestrial system

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Chinese Physics B 2024年第3期33卷 488-495页

作者：何向磊毛傲华孙萌萌邹继同王晓钢 School of Physics Harbin Institute of TechnologyHarbin 150001China Laboratory for Space Environment and Materials Science Harbin Institute of TechnologyHarbin 150001China

Magnetic reconnection processes in three-dimensional(3D)complex field configurations have been investigated in different magneto-plasma systems in space,laboratory,and astrophysical ***-dimensional(2D)features of magnetic reconnection have been well developed and applied successfully to systems with symmetrical property,such as toroidal fusion plasmas and laboratory experiments with an axial *** in asymmetric systems,the 3D features are inevitably different from those in the 2D *** reconnection structures in multiple celestial body systems,particularly star-planet-Moon systems,bring fresh insights to the understanding of the 3D geometry of ***,we take magnetic reconnection in an ancient solar-lunar terrestrial magneto-plasma system as an example by using its crucial parameters approximately estimated already and also some specific applications in pathways for energy and matter transports among Earth,ancient Moon,and the interplanetary magnetic field(IMF).Then,magnetic reconnection of the ancient lunar-terrestrial magnetospheres with the IMF is investigated numerically in this *** a 3D simulation for the Earth-Moon-IMF system,topological features of complex magnetic reconnection configurations and dynamical characteristics of magnetic reconnection processes are *** is found that a coupled lunar-terrestrial magnetosphere is formed,and under various IMF orientations,multiple X-points emerge at distinct locations,showing three typical magnetic reconnection structures in such a geometry,i.e.,the X-line,the triple current sheets,and the A-B null *** results can conduce to further understanding of reconnection physics in 3D for plasmas in complex magnetic configurations,and also a possible mechanism for energy and matters transport in evolutions of similar astrophysical systems.

关键词： magnetic reconnection multiple X-points complex magneto-plasma system

Myxoid solitary fibrous tumor:clinicopathologic,immunohistochemical,and molecular analysis of five cases

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Myxoid solitary fibrous tumor:clinicopathologic,immunohistoc...

A case of secondary B-cell lymphoma diagnosed by fine-needle aspiration cytology and flow cytometry after penile carcinoma

2019年浙江省病理学术大会

作者： Ming Zhao Qi-le Tang Xin Zhang Yu-bin Wang Guo-qing Ru xiang-lei he Department of Pathology Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical College

Backgrounds Focal myxoid areas are not uncommon observed in solitary fibrous tumors (SFTs),but SFTs with extensive myxoid change are considered rare and has only been reported *** SFT is defined as exhibiting myxoid changes in 50%or more of the tumor examined,thus obscuring typical diagnostic features and may cause considerable diagnostic problems.

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A case of secondary B-cell lymphoma diagnosed by fine-needle...

Anastomosing hemangioma of the liver:reporting of three cases of an unusual variant of hemangioma arising from uncommon site,with an emphasis on diagnostic challenges

2015浙江省检验医学学术年会

作者：王欢 LIAN-NV QIU MAO WU WAN-YUAN CheN LI-GANG REN xiang-lei he YONG-LIE ZHOU Department of Laboratory Medicine People’s Hospital of Zhejiang Province Department of Pathology People’s Hospital of Zhejiang Province Department of Urinary Surgery People’s Hospital of Zhejiang Province

In recent years,case reports on lymphoma as secondary tumor increased ***,there were few reports on lymphoma as the secondary tumor after penile carcinoma treatment,especially on the lymphoma diagnosed by fine-needle aspiration cytology and flow ***,we reported such a case on a 62-year-old male patient who had been troubled with frequent urination and repeated chest tightness for five *** admission diagnosis identified as the penile *** months after the tumor remove operation,enlarged lymph nodes were taken with fine-needle biopsy for light microscopy examination and flow *** results showed a large number of abnormal cells scattered in the right axillary lymph *** cytometry immunophenotyping in fine-needle aspiration showed increased expressions of CD79 a,CD19,CD20,CD38,kappa chain and HLA-DR,which supported the diagnosis of B-cell *** patient was eventually diagnosed with B-cell lymphoma by both fine-needle aspiration biopsy and flow *** further discussed the diagnosis method and causes of the therapy-related leukemia.

关键词： Fine-needle aspiration biopsy flow cytometry penile carcinoma lymphoma

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Anastomosing hemangioma of the liver:reporting of three case...

Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

2019年浙江省病理学术大会

作者： Ming Zhao Ming-Xin Xu Li-li Yu Yuan Chen Xin Zhang Yu-bin Wang Guo-qing Ru xiang-lei he Department of Pathology Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical College

[Backgrounds] Anastomosing hemangioma (AH) is a newly recognized benign vascular neoplasm histologically simulating angiosarcoma and has often been described primarily in the genitourinary tract and adrenal gland *** involving the digestive system,such as liver and and gastrointestinal tract,is very uncommon,where it can be diagnostically challenging and may be mistaken for well-differentiated angiosarcoma,especially in core biopsy.

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu xiang Renrui Niu Xiaodong he Wenqi Luo Wanguo Liu Rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

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幽门螺杆菌耐药性及三种耐药检测方法的比较

世界华人消化杂志 2018年第18期26卷 1111-1118页

作者：孙婷陈泽鑫李鹏何向蕾浙江省人民医院/杭州医学院附属人民医院病理科浙江省杭州市310014 浙江大学附属第二医院科教科浙江省杭州市310009 浙江省人民医院/杭州医学院附属人民医院消化内科浙江省杭州市310014

目的分析浙江地区幽门螺杆菌(helicobacter pylori,***)耐药情况,并比较不同耐药检测方法的一致性.方法选择2017-06/2017-09进行胃镜检查的305例患者,取胃黏膜组织进行***菌株分离鉴定,对分离的127个菌株进行6种抗生素的药敏实验,提取... 详细信息

目的分析浙江地区幽门螺杆菌(helicobacter pylori,***)耐药情况,并比较不同耐药检测方法的一致性.方法选择2017-06/2017-09进行胃镜检查的305例患者,取胃黏膜组织进行***菌株分离鉴定,对分离的127个菌株进行6种抗生素的药敏实验,提取菌株的DNA,以荧光定量PCR法和测序法对克拉霉素耐药相关基因23S rRNA和左氧氟沙星耐药相关基因gyrA进行扩增和测序.结果在305份胃黏膜活检标本中,分离出*** 127株.127株***中124株为耐药菌株,3株为敏感菌株.阿莫西林、盐酸四环素、呋喃唑酮无耐药菌株;克拉霉素、左氧氟沙星、甲硝唑耐药率分别为33.86%(43/127)、44.88%(57/127)、91.34%(116/127)、三重耐药率为18.90%(24/127);克拉霉素和左氧氟沙星相关的主要耐药基因及其突变位点分别为23S rRNA(A2143G)、gyrA(C261A/G),突变频率分别为42.5%(54/127)和15.0%(19/127).不同耐药检测方法的一致性比较:荧光定量PCR法与测序法检测耐药突变一致性较高,与药敏培养法一致性相对较差.结论浙江地区对克拉霉素、左氧氟沙星耐药率均达到很高,在临床应用这些抗生素需结合耐药性,选择敏感的抗生素个体化地用药,提高根除效率.

关键词：幽门螺杆菌耐药性耐药基因