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Chemical Research in Chinese Universities 2001年第3期17卷 334-337页

作者： WANG li-qun TU Ke-hua WANG Yan-bing li xiang-rong Department of Polymer Science and Engineering College of Medicine of Zhejiang University Hangzhuo 310027P.R.China Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200433P.R.China

Starch is the second largest natural biopolymer. Its unique biodegradable and biocompatible properties make it be increasingly applied to the field of biomedicine. As one kind of polysaccharide, starch is easily degraded into small organic molecules by amylase in the alimentary canal. The fact that the activity of amylase is restrained in the high acid environment in stomach provides an opportunity to prepare an intestinal-specific delivery carrier with

关键词： Acryloyloxystarch PLA macromonomer Graft copolymerization

Theoretical Studies on the Hydrogen Bond Transfer and Proton Transfer between Anamorphoses of the Dihydrated Glycine Complex

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Chinese Journal of Structural Chemistry 2007年第5期26卷 580-586页

作者： WANG Ke-Cheng MENG xiang-Jun SHI Jin li bing-Huan Department of Chemistry Tangshan Teacher＇s College Tangshan 063000 China

The conversion between anamorphoses of the dihydrated glycine complex was studied by means of B3LYP/6-31＋＋G^＊＊. It was found that proton transfer was accompanied by hydrogen bond transfer in the process of conversion between different kinds of anamorphoses. With proton transfer, the electrostatic action was notably increased and the hydrogen-bonding action was evidently strengthened when the dihydrated neutral glycine complex converts into dihydrated zwitterionic glycine complex. The activation energy required for hydrogen bond transfer between dihydrated neutral glycine complexes is very low （6.32 kJ·mol^-1）; however, the hydrogen bond transfer between dihydrated zwitterionic glycine complexes is rather difficult with the required activation energy of 13.52 kJ·mol^-1 due to the relatively strong electrostatic action. The activation energy required by proton transfer is at least 27.33 kJ·mol^-1, higher than that needed for hydrogen bond transfer. The activation energy for either hydrogen bond transfer or proton transfer is in the bond-energy scope of medium-strong hydrogen bond, so the four kinds of anamorphoses of the dihydrated glycine complex could convert mutually.

关键词： intermolecular interaction B3LYP glycine,hydrogen bond transfer proton transfer

CO2-mediated bicarbonate conversion to concentrated formate in a CEM-based electrolyzer

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Journal of Energy Chemistry 2025年第1期100卷 605-611页

作者： Haocheng Xiong Donghuan Wu Haonan li Andrew li Qikun Hu Siyao Song bingjun Xu Qi Lu State Key Laboratory of Chemical Engineering Department of Chemical Engineering Tsinghua University College of Chemistry and Molecular Engineering Peking University Ordos Laboratory

Renewable energy-driven bicarbonate conversion to valuable chemicals presents an attractive strategy for mitigating CO2emissions,as bicarbonate can be efficiently generated from the capture of atmospheric CO2using alkaline solutions with reactive *** this work,we present a CO2-mediated bicarbonate conversion to pure formate using a cation exchange membrane-based electrolyzer with a 25 cm2electrode *** electrolysis achieved selectivities exceeding 75%for formate at a total current of 2.5 A,achieving formate concentrations up to 1.2 M and yields as high as 95%over extended *** techno-economic assessment confirmed the economic viability of the process,highlighting the potential for bicarbonate electrolysis as a sustainable method for producing valuable chemicals.

关键词： Electrocatalysis Techno-economic assessments Electrochemistry Flow electrolyzer

Chiral Phosphoric Acid Catalyzed Asymmetric Synthesis of Axially Chiral Compounds

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Chinese Journal of Chemistry 2021年第7期39卷 1787-1796页

作者： bing-Chao Da Shao-Hua xiang Shaoyu li Bin Tan Department of Chemistry and Shenzhen Grubbs Institute Southern University of Science and TechnologyShenzhenGuangdong 518055China Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhenGuangdong 518055China

The well-defined conformational properties of axially chiral compounds bring extraordinary values to an assortment of bioactive molecules,advanced materials,organocatalysts as well as chiral ligands in asymmetric *** demonstrated usefulness and untapped potential of axially chiral structural motifs stimulate increasing efforts to develop novel and efficient approaches for their *** this regard,the chiral phosphoric acids broadly used in asymmetric Brønsted acid catalysis have shown high relevance for atroposelective synthesis as *** strong interest in reaction chemistry of atropisomers has established a rewarding research programme in our *** course of studies will be recounted in this account,with discussion focused on the use of chiral phosphoric acids to catalyze construction of several key axially chiral structures such as BINAM,BINOL,NOBIN,arylquinones,SPINOL,arylpyrrole analogues and axially chiral alkenes.

关键词： Axial chirality Organocatalysis Chiral phosphoric acid Biaryls Asymmetric synthesis

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： li Xu Huiming Xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

Trap Characteristics and Their Temperature-dependence of Silicone Gel for Encapsulation in IGBT Power Modules

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CSEE Journal of Power and Energy Systems 2021年第3期7卷 614-621页

作者： Jiayu Xu Xuebao li xiang Cui Zhibin Zhao Shenyang Mo bing Ji State Key Laboratory of Alternate Electrical Power System with Renewable Energy Sources North China Electric Power UniversityBeijing 102206China School of Engineering University of LeicesterLeicester LE17RHUK

Silicone gel is a prevailing material for encapsulation in insulated gate bipolar transistor(IGBT)power *** space charge transport behavior in silicone gel is significant to evaluate the electrical insulation *** paper focuses on the trap characteristics and electrical properties of the silicone gel,which were rarely studied *** experiments are performed on the surface potential decay of silicone gel after the charge ***,the energy distributions of electron or hole traps are determined by a double-trap energy level model,which can be fitted by the Gaussian *** addition,the mobilities of positive and negative charges are determined,which are 1.38×10^(-12) m^(2)·V^(-1)·s^(-1) and 1.74×10^(12) m^(2)·V^(-1)·s^(-1),***,considering the heat as a byproduct resulting in thermal issues,the temperature-dependence of surface potential decay characteristics are also studied in this *** temperature rises,the decay rate of surface potential increases,especially when the temperature is higher than 80℃.Finally,the contrastive analysis illustrates that the trap characteristics of silicone gel are between the trap characteristics in liquid-state material and solid-state material,which supports the phenomenon that silicone gel is more resistive to the sharp edges in power *** work can provide a useful reference for the design of encapsulation in high-voltage IGBT power modules.

关键词： Charge mobility IGBT power modules silicone gel temperature-dependence trap characteristic

Local magnetic moment oscillation around an Anderson impurity on graphene

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 192-201页

作者： Shuai li Zhen Ma Jin-Hua Gao School of Science Hebei University of Science and Technology School of Electronics and Information Zhengzhou University of Light Industry School of Physics and Wuhan National High Magnetic Field Center Huazhong University of Science and Technology

We theoretically investigate the spin resolved Friedel oscillation （FO） and quasiparticle interference （QPI） in graphene induced by an Anderson *** the impurity becomes magnetic,the resulted FO becomes spin dependent,which gives rise to a local magnetic moment oscillation with an envelop decaying as r-2in real space in the doping ***,at half filling,the electron density and local magnetic moment will not oscillate but decay as *** spin resolved FO has both sublattice and spin ***,the local magnetic moment decay at half filling only occurs at one sublattice of graphene,which is quite like the phenomenon observed in the STM experiment (***ález-Herrero et al.,Science 352,437 （2016）).We further give an analytic formula about such spin dependent FO based on the stationary phase ***,we study the interference of quasiparticles around the magnetic impurity by calculating the spin dependent Fourier-transformed local density of states （FT-LDOS）.Our work gives a comprehensive understanding about the local magnetic moment oscillation around an Anderson impurity on graphene.

关键词： Friedel oscillation local magnetic moment graphene Anderson impurity

Self-propelled swimming of a flexible fllament driven by coupled plunging and pitching motions

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Journal of Hydrodynamics 2021年第1期33卷 157-169页

作者： bing-lin li Yi-wei Wang Bo Yin xiang Zhang Xing Zhang The State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

This paper numerically investigates the self-propelled swimming of a flexible filament driven by coupled pitching and plunging motions at the leading *** influences of bending rigidity and some actuation parameters(including the phase offset between pitching and plunging,and the amplitudes of pitching and plunging motions)on the swimming performance are *** is found that with increasing rigidity,the swimming style gradually transits from the undulatory mode to the oscillatory *** plunging-pitching actuation is found to be superior to the plunging-only actuation,in the sense that it prevents the decrease of speed at high rigidity and achieves a higher efficiency across a wide range of *** comparison of the body kinematics with those of animal swimmers,and the classification of the wake structures are *** results of this study provide some novel insights for the bio-inspired design of autonomous underwater vehicles.

关键词： Self-propelled swimming flexible filament fluid-structure interaction(FSI) vortex structures immersed boundary method

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： Jia Fang Zhuangzhuang li Pengjun Wang Xiaoxu Zhang Song Mao Yini li Dongzhen Yu Xiaoyan li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

再次宫颈锥切术在处理残留或复发宫颈上皮内瘤变中的应用

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中国癌症杂志 2013年第5期23卷 370-374页

作者：向礼兵蔡祎品徐晓丽杨文涛吴小华王华英李子庭杨慧娟复旦大学附属肿瘤医院妇瘤科复旦大学上海医学院肿瘤学系上海200032 复旦大学附属肿瘤医院病理科复旦大学上海医学院肿瘤学系上海200032

背景与目的：再次宫颈锥切可作为宫颈上皮内瘤变（cervical intraepithelial neoplasia，CIN）初次锥切后治疗失败患者的主要治疗手段之一，但很少有临床研究证实其有效性和安全性。本研究旨在评估再次宫颈锥切术在处理初次锥切术后切... 详细信息

背景与目的：再次宫颈锥切可作为宫颈上皮内瘤变（cervical intraepithelial neoplasia，CIN）初次锥切后治疗失败患者的主要治疗手段之一，但很少有临床研究证实其有效性和安全性。本研究旨在评估再次宫颈锥切术在处理初次锥切术后切缘阳性患者或随访再次发现宫颈病变患者中的诊治价值。方法：2003年9月-2010年7月在复旦大学附属肿瘤医院妇瘤科因高级别CIN接受2次宫颈锥切术的患者共65g0，包括50例首次手术切缘阳性患者和15例随访中再次发现宫颈病变患者。分析65例患者再次锥切标本的组织病理及切缘情况，随访观察再次术后并发症、术后妊娠以及病变复发情况。结果：50例首次手术切缘阳性的患者经再次锥切后，2例（4．0％）被证实为浸润性宫颈癌（腺癌ⅠB1期和鳞癌ⅠA1期各1例），23例（46．0％）标本中存在残留的CIN病变。15例随访中再次发现宫颈病变的患者，11例（73．3％）被证实存在CIN病变。再次锥切后58例患者切缘阴性（89．2％），7例（10．8％）患者切缘阳性（包括1例宫颈腺癌和6例CIN）。5例患者因发现宫颈浸润癌或2次锥切切缘阳性或术后并发症而补充行子宫切除术。另有2例发生严重并发症（1例术中大出血，1例术后宫颈创面大出血）的患者经保守处理后好转。在保留子宫的60例患者中，中位随访时间为41个月（25-87个月），4例（6．7％）患者被发现有CIN病变复发。结论：再次锥切术可以切除残留或复发的宫颈病变组织而保留生育功能，并有可能发现首次手术未被发现的浸润性癌；严重的手术并发症很少见，但需要积极预防。

关键词：宫颈上皮内瘤变再次锥切术残留复发