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Self-assembled liquid crystal architectures for soft matter photonics

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light(Science & Applications) 2022年第12期11卷 2849-2872页

作者： ling-ling Ma Chao-Yi li Jin-Tao Pan Yue-E.Ji Chang Jiang Ren Zheng Ze-Yu Wang Yu Wang bing-xiang li Yan-Qing Lu National Laboratory of Solid State Microstructures Key Laboratory of Intelligent Optical Sensing and ManipulationCollege of Engineering and Applied Sciencesand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023China College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China

Self-assembled architectures of soft matter have fascinated scientists for centuries due to their unique physical properties originated from controllable orientational and/or positional orders,and diverse optic and photonic *** one could know how to design,fabricate,and manipulate these optical microstructures in soft matter systems,such as liquid crystals(LCs),that would open new opportunities in both scientific research and practical applications,such as the interaction between light and soft matter,the intrinsic assembly of the topological patterns,and the multidimensional control of the light(polarization,phase,spatial distribution,propagation direction).Here,we summarize recent progresses in self-assembled optical architectures in typical thermotropic LCs and bio-based lyotropic *** briefly introducing the basic definitions and properties of the materials,we present the manipulation schemes of various LC microstructures,especially the topological and topographic *** work further illustrates external-stimuli-enabled dynamic controllability of self-assembled optical structures of these soft materials,and demonstrates several emerging ***,we discuss the challenges and opportunities of these materials towards soft matter photonics,and envision future perspectives in this field.

关键词： architectures topological originated

Proteome analysis of round-headed and normal spermatozoa by 2-D fluorescence difference gel electrophoresis and mass spectrometry

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Asian Journal of Andrology 2009年第6期11卷 683-694页

作者： Ting-Ting liao Zhen xiang Wen-bing Zhu li-Qing Fan Institute of Human Reproduction and Stem Cell Engineering Central South University Changsha 410078 China

Globozoospermia is a severe form of teratozoospermia characterized by round-headed spermatozoa with an absent acrosome, an aberrant nuclear membrane and midpiece defects. Globozoospermia is diagnosed by the presence of 100% round-headed spermatozoa on semen analysis, and patients with this condition are absolutely infertile. The objective of this study was to investigate the differences in protein expression between human round- headed and normal spermatozoa. Two-dimensional （2-D） fluorescence difference gel electrophoresis （DIGE） coupled with mass spectrometry （MS） was used in this study. Over 61 protein spots were analysed in each paired normal/round-headed comparison, using DIGE technology along with an internal standard. In total, 35 protein spots identified by tandem mass spectrometry （MS/MS） exhibited significant changes （paired t-test, P 〈 0.05） in the expression level between normal and round-headed spermatozoa. A total of nine proteins were found to be upregulated and 26 proteins were found to be downregulated in round-headed spermatozoa compared with normal spermatozoa. The differentially expressed proteins that we identified may have important roles in a variety of cellular processes and structures, including spermatogenesis, cell skeleton, metabolism and spermatozoa motility.

关键词： differential protein globozoospermia mass spectrometry (MS) two-dimensional difference gel electrophoresis (2-D DIGE)

Role of tissue factor in hepatocellular carcinoma genesis, invasion and metastasis

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Chinese Medical Journal 2011年第22期124卷 3746-3751页

作者： ZHOU Qi HUANG Tao WANG Ya-feng ZHOU xiang-bing liANG li-jian PENG Bao-gang Department of Hepatobiliary Surgery First Affiliated Hospital of Sun Yat-Sen University Guangzhou Guangdong 510080 China

Background Numerous studies indicate that tissue factor （TF）, namely tissue thromboplastin, has a close relationship with malignant tumor genesis and progress. It contributes to blood coagulation as well as the regulation of cellular differentiation, the formation of blood vessels, and also tumor recurrence and metastasis. The present study aimed to detect TF expression in hepatocellular carcinoma （HCC） patients and to elucidate its association with prognosis and clinical features of the disease. Methods The plasma TF levels of 50 HCC patients and 30 controls were assayed by EliSA. The expressions of TF mRNA and protein in HCC tissues, adjacent tissues and normal tissues were detected by reverse transcription- polymerase chain reaction （RT-PCR） and Western blotting. The acquired data were analyzed with related clinic-pathological documents. The patients were followed up for five years, and the relationship between TF and prognosis was analyzed. Results The plasma TF levels were significantly increased in HCC compared to the controls （P 〈0.05）, presenting a close relationship with differentiation level, tumor size and hepatocirrhosis occurrence （P 〈0.05）. There were remarkably higher values in cases of lymphatic metastasis, extrahepatic metastasis and portal tumor thrombus （PTT）（P 〈0.05） compared to non-metastasis or non-tumor thrombus, but no significant difference with different focus number or envelope （P 〉0.05）. The positive rates and the relative expression of TF mRNA in HCC tissue were 63.0% （17/27） and 0.567±0.268, respectively, significantly higher than that in adjacent tissues or normal tissues （P 〈0.05）. In the patients with positive results, the relative expression intensity varied significantly with different tumor size and index of local invasion and metastasis （P 〈0.05）. The positive rates and the relative expression intensities of TF protein in HCC tissue were 74.1% （20/27） and 4.093±1.256, respectively, significantly higher than those in adjacent tis

关键词： hepatocellular carcinoma tissue factor invasion and metastasis

经理层管理防御、股权激励与企业外源融资结构

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商业研究 2017年第8期 116-128页

作者：惠祥李秉祥李明敏西安理工大学经济与管理学院西安710054

企业外源融资结构主要取决于对经营决策具有决定作用的经理层的主观能动性,而经理层能动性受到客观存在的融资风险引发的自身利益损失和职位被替换等防御动机的影响。本文以GONE理论为基础分析了经理层管理防御影响企业外源融资结构的机... 详细信息

企业外源融资结构主要取决于对经营决策具有决定作用的经理层的主观能动性,而经理层能动性受到客观存在的融资风险引发的自身利益损失和职位被替换等防御动机的影响。本文以GONE理论为基础分析了经理层管理防御影响企业外源融资结构的机理,并以我国上市公司为研究对象实证研究经理层管理防御水平强弱与企业外源融资结构的内在关系,进一步考察股权激励对两者关系的调节作用。研究发现:经理层管理防御是企业外源融资结构的主要影响因素,而股权激励能够弱化经理层管理防御对企业外源融资结构的不利影响,发挥对债权融资比向上的调节作用和对股权融资比、长期债务比向下的调节作用。因此,企业应重视运用经理层股权激励对经理层管理防御动机下外源融资结构偏好的调节作用。研究结论可为企业外源融资结构设计提供参考,为弱化经理层管理防御强度以形成合理的外源融资结构提供借鉴。

关键词：经理层管理防御外源融资结构股权激励 GONE理论

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基于对称交互熵的多属性决策排序法

数学杂志 2016年第6期36卷 1253-1260页

作者：卢国祥李冰清中南财经政法大学统计与数学学院南开大学金融学院南开大学经济学院

本义研究了多属性决策的排序问题.利用信息熵理论提出了对称交互熵概念,定义了一种新的与理想方案的贴近度,由此给出了基于对称交互熵的排序方法.最后通过算例将新方法与传统的TOPSIS法、夹角度量法和正交投影法作对比,获得了新方法能... 详细信息

本义研究了多属性决策的排序问题.利用信息熵理论提出了对称交互熵概念,定义了一种新的与理想方案的贴近度,由此给出了基于对称交互熵的排序方法.最后通过算例将新方法与传统的TOPSIS法、夹角度量法和正交投影法作对比,获得了新方法能够更加精确地判断方案优劣的结果.

关键词：多属性决策对称交互熵 TOPSIS法相对贴近度

Dielectric anisotropy in liquid crystal mixtures with nematic and smectic phases

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Chinese Physics B 2024年第8期33卷 519-524页

作者：汤星舟叶家耀王子烨姜皓译尚小虎杨朝雁李炳祥 Nanjing University of Posts and Telecommunications College of Electronic and Optical Engineering&College of Flexible Electronics(Future Technology)Nanjing 210023China National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesNanjing UniversityNanjing 210023China

The modulation of dielectric anisotropy(△ε)is pivotal for elucidating molecular interactions and directing the alignment of liquid *** this study,we combine liquid crystals with opposing dielectric anisotropies to explore the impact of varying concentrations on their *** report the sign-reversal of△εin both the nematic and smectic A phases of these mixed liquid crystals,alongside a dual-frequency behaviour across a broad temperature *** research further quantifies the influence of mixture ratios under various temperatures and electric field *** exploration may pave the way for the discovery of new physical phenomena.

关键词： mixed liquid crystal dielectric anisotropy tunable nematic smectic

Observation of acoustic hybrid topological phases induced by the p-d orbital interactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 132-139页

作者： Xiao xiang Feng Gao Yu-Gui Peng Peng Wu Zong-lin li Xue-Feng Zhu School of Physics and Innovation Institute Huazhong University of Science and Technology

In spinless systems,growing attention has recently been attracted to synthetic gauge fields,which redefine the fundamental crystal symmetries by utilizing the projective algebraic ***,synthetic gauge fields have been commonly investigated in single orbital systems,and explorations on hybrid orbitals remain elusive in ***,we report the experimental observation of hybrid topological phases induced by hybrid synthetic gauge flux,which is formed by the interaction between p and d orbitals embedded in acoustic *** breaking the translation symmetries of Lxand/or Ly,we unambiguously demonstrate the first-order M?bius edge states and higher-order corner *** work establishes a platform for seeking exotic topological phases induced by hybrid-orbitals interactions and initializing the framework of hybrid-orbitalsrelated topological *** applications can be anticipated in scenarios such as high-quality sensing and robust wave trapping due to the stepwise energy distribution of the hybrid topological phase.

关键词： topological insulator synthetic gauge field projective symmetry corner states

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang bing Zhang Lanfang li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang liu Youming Lu Xinyan li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin Chen Jinghong Xu Bin Jiang Lei li Yawei li Yuliang Dai bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury