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Diagnostic and prognostic role of liNC01767 in hepatocellular carcinoma

World Journal of Hepatology 2024年第6期16卷 932-950页

作者： li Zhang Tong-Xing Cui xiang-zhi li Chong liu Wen-Qin Wang Department of Thyroid and Breast Surgery The Affiliated People Hospital of Second Medical UniversityWeifang 266010Shandong ProvinceChina Department of General Surgery Qingdao Municipal Hospital GroupQingdao 266237Shandong ProvinceChina School of life Sciences Shandong University(Qingdao)Qingdao 26637Shandong ProvinceChina School of Medicine Tsinghua UniversityBeijing 100084China

BACKGROUND Hepatocellular carcinoma(HCC)is a primary contributor to cancer-related mortality on a global ***,the underlying molecular mechanisms are still poorly *** noncoding RNAs are emerging markers for HCC diagnosis,prognosis,and therapeutic *** study of liNC01767 in HCC was *** To conduct a multi-omics analysis to explore the roles of liNC01767 in HCC for the first *** DESeq2 Package was used to analyze different gene *** operating characteristic curves assessed the diagnostic ***-Meier univariate and Cox multivariate analyses were used to perform survival *** least absolute shrinkage and selection operator(LASSO)-Cox was used to identify the prediction *** to the validation of liNC01767 expression in HCC fresh frozen tissues through quantitative real time polymerase chain reaction,next generation sequencing was performed following liNC01767 over expression(GSE243371),and Gene Ontology/Kyoto Encyclopedia of Genes and Genomes/Gene Set Enrichment Analysis/ingenuity pathway analysis was carried *** vitro experiment in Huh7 cell was carried *** liNC01767 was down-regulated in HCC with a log fold change=1.575 and was positively correlated with the cancer ***01767 was a good diagnostic marker with area under the curve(AUC)[0.801,95% confidence interval(CI):0.751-0.852,P=0.0106]and an independent predictor for overall survival(OS)with hazard ratio=1.899(95%CI:1.01-3.58,P=0.048).liNC01767 nomogram model showed a satisfied *** top-ranked regulatory network analysis of liNC01767 showed the regulation of genes participating various *** regression identified the 9-genes model showing a more satisfied performance than 5-genes model to predict the OS with AUC>***01767 was down-expressed obviously in tumor than para-tumor tissues in our cohort as well as in cancer cell line;the over expression of liNC01767 inhibit cell prolifer

关键词： Hepatocellular carcinoma liNC01767 Multi-omics analysis GSE243371 Cell proliferation Clone formation

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The Global Attractor of a Non-Local PDE Model with Delay for Population Dynamics in Rn

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Acta Mathematica Sinica,English Series 2011年第6期27卷 1121-1136页

作者： xiang li zhi xiang li Department of Mathematics and Systems Science College of ScienceNational University of Defense Technology Changsha 410073 P. R. China

In this paper, we consider a non-local PDE model with delay for population dynamics in Rn. First, we prove the existence and uniqueness of weak solutions under some suitable decayed assumptions on non-local term at infinity. Then, we obtain the global attractor by proving w-limit compactness property of the solution operator semigroup.

关键词： Non-local PDE model w-limit compact global attractor

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Oxidation resistant low-alloyed Ti alloys with good ductility

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Rare Metals 2024年第8期43卷 3921-3936页

作者： Meng li Zhang-zhi Shi Jun-Yi Xu Fu-zhi Dai xiang-Min li Zi-lin li Lu-Ning Wang Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advance Metals and MaterialsSchool of Materials Science and Engineering University of Science and Technology Beijing Institute of Materials Intelligent Technology Liaoning Academy of Materials

Oxidation resistance enhancement of pure Ti often comes at the cost of reduced ductility,which is frequently the problem through alloying with sole Al,Si,W,Mo and *** overcome the short coming of single element alloying,this paper proposes a multi-element low-alloying strategy to take advantage of synergistic effects and resolve the conflict between oxidation resistance and *** demonstrates that the addition of a small quantity of Ta（0.51wt%） can boost both oxidation resistance and ductility in comparison to pure ***,the combined addition of a small amount（0.54 wt%） of Ta,Nb and Si not only preserves good ductility of pure Ti,but also reduces mass gains to 14%-67% of pure Ti during 100 h oxidation at 650-850℃ in *** indicates even better oxidation resistance than that obtained through the use of Ta,Nb,or Nb+Ta *** Ta+Nb+Si alloying creates an oxide layer that is less porous and more resistant to stratification and ***,a 3-μm N-rich layer can form in the Ti substrate beneath the oxide scale,in which phase transformation generates coherent Ti2N with（0001）Tias the habit plane,with N atoms prefers to diffuse along ■ than along [0001]*** completely transformed Ti2N region or partially transformed Ti+Ti2N region can effectively impede oxygen ***,the multielement low-alloying strategy is promising for enhancing both oxidation resistance and mechanical properties of metallic materials in the future.

关键词： Ti alloys Multi-element Co-alloying Oxidation resistance Mechanical properties

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Iron–doped bismuth oxybromides as visible-light-responsive Fenton catalysts for the degradation of atrazine in aqueous phases

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Journal of Environmental Sciences 2024年第3期137卷 321-332页

作者： Yong-li Cai Yu-Hang Xu Ji-Zun xiang zhi-Qiang Zhang Qiu-xiang He Ya-Feng li Jian Lü Fujian Provincial Key Laboratory of Soil Environmental Health and Regulation College of Resources and EnvironmentFujian Agriculture and Forestry UniversityFuzhou 350002China State Key Laboratory of Photocatalysis on Energy and Environment Fuzhou UniversityFuzhou 350116China

Pesticides and its degradation products,being well–known residues in soil,have recently been detected in many water bodies as pollutants of emerging concerns,and thus there is a contemporary demand to develop viable and cost–effective techniques for the removal of related organic pollutants in aqueous ***,a visible-light-responsive Fenton system was constructed with iron–doped bismuth oxybromides(Fe–BiOBr)as the *** the advantage of sustainable Fe(Ⅲ)/Fe(Ⅱ)conversion and optimized H_(2)O_(2)utilization,the optimal Fe–BiOBr–2 catalyst showed an excellent atrazine removal efficiency of 97.61%in 120 min,which is superior than the traditional homogeneous Fenton and the majority of heterogeneous processes documented in the *** this photo–Fenton system,hydroxyl(·OH)and superoxide(·O_(2)^(-))radicals were dominant active species contributed to the oxidative degradation of *** to the production of various active radicals,five degradation pathways were proposed based on the identification of intermediates and degradation ***,this work not only demonstrates a fundamental insight into creating highly efficient and atom economic photo-Fenton systems,but also provides a complementary strategy for the treatment of organic pollutants in water.

关键词： Bismuth oxybromide Photo–Fenton Atrazine Catalytic degradation

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Miniaturized power detection module operating in millimeter wave band

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Journal of Electronic Science and Technology 2024年第2期22卷 69-76页

作者： xiang Zhou zhi-Yong Zhong School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China

The miniaturized broadband detection module can be embedded into the microwave application system such as the front end of the transmitter to detect the power or other parameters in real *** is highly prospective in military and scientific *** this paper,a broadband power detection module operating at 26.5 GHz-40.0 GHz is designed by using low-barrier Schottky diode as the detector and a comparator for threshold *** module can dynamically detect the power range between-10 dBm and 10 dBm with the detection accuracy of 0.1 ***,the temperature compensation circuit is also applied to improve the measurement *** a result,the resulted error low to±1 dB in the temperature range of -55℃ to +85℃ is *** designed module is encapsulated by a Kovar alloy with a small volume of 9 mm×6 mm×3 *** endows the designed module the advantages of small size,easy integration,and low cost,and even it is applicable to high-reliability environments such as satellites.

关键词： Diode Miniaturization Power detection Temperature compensation

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Synergistic effect of Zr and Mo on precipitation and high-temperature properties of Al-Si-Cu-Mg alloys

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China Foundry 2024年第1期21卷 71-81页

作者： Chao Gao Bing-rong Zhang Yin-ming li zhi-ming Wang xiang-bin Meng Faculty of Mechanical Engineering Qilu University of Technology(Shandong Academy of Sciences)Jinan 250353China Hebei Ounai Machinery Mould Co.Ltd. Xingtai 054500HebeiChina

This study focuses on finding a solution to the sharp decline in mechanical properties of Al-Si-Cu-Mg alloys due to rapid coarsening of traditional intermediate phases at high temperature.A new type of modified al oy,to be used in automobile engines at high temperatures,was prepared by adding Zr and Mo into Al-Si-Cu-Mg *** synergistic effects of Zr and Mo on the microstructure evolution and high-temperature mechanical properties were *** show that the addition of Zr and Mo generates a series of intermetallic phases dispersed in the *** can improve the strength of the alloy by hindering dislocation movement and crack *** addition,some nano-strengthened phases show coherent interfaces with the matrix and improve grain *** addition of Mo greatly improves the heat resistance of the *** extremely low diffusivity of Mo enables it to improve the thermal stability of the intermetallic phases,inhibit precipitation during aging,reduce the size of the precipitates,and improve the heat resistance of the alloy.

关键词： Al-Si-Cu-Mg alloy high-temperature properties Zr-Mo-rich intermetallics nano-strengthening phases

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Ballistic performances of the hourglass lattice sandwich structures under high-velocity fragments

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Defence Technology（防务技术） 2024年第1期31卷 312-325页

作者： He-xiang Wu Jia Qu lin-zhi Wu Key Laboratory of Advanced Ship Materials and Mechanics College of Aerospace and Civil EngineeringHarbin Engineering UniversityHarbin150001China School of Civil Engineering Northeast Forestry UniversityHarbin150040China

In this paper,the numerical simulation method is used to study the ballistic performances of hourglass lattice sandwich structures with the same mass under the vertical incidence of *** is paid to elucidating the influences of rod cross-section dimensions,structure height,structure layer,and rod inclination angle on the deformation mode,ballistic performances,and ability to change the ballistic direction of *** results show that the ballistic performances of hourglass lattice sandwich structures are mainly affected by their structural *** this respect,structural parameters optimization of the hourglass lattice sandwich structures enable one to effectively improve their ballistic limit velocity and,consequently,ballistic performances.

关键词： Hourglass lattice sandwich structures Ballistic performances high-velocity Finite element analysis

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Morphological Classification of Infrared Galaxies Based on WISE

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Research in Astronomy and Astrophysics 2024年第4期24卷 222-236页

作者： zhi-Ren Pan Bo Qiu Cui-xiang liu A-li Luo Xia Jiang Xiao-Yu Guo School of Electronic and Information Engineering Hebei University of TechnologyTianjin 300401China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

This study introduces a novel convolutional neural network,the WISE Galaxy Classification Network(WGC),for classifying spiral and elliptical galaxies using Wide-field Infrared Survey Explorer(WISE)*** attains an accuracy of 89.03%,surpassing the combined use of K-means or SVM with the Color-Color method in more accurately identifying galaxy *** enhanced variant,WGC_mag,integrates magnitude parameters with image features,further boosting the accuracy to 89.89%.The research also delves into the criteria for galaxy classification,discovering that WGC primarily categorizes dust-rich images as elliptical galaxies,corresponding to their lower star formation rates,and classifies less dusty images as spiral *** paper explores the consistency and complementarity of WISE infrared images with SDSS optical images in galaxy morphology *** SDSS Galaxy Classification Network(SGC),trained on SDSS images,achieved an accuracy of 94.64%.The accuracy reached 99.30% when predictions from SGC and WGC were *** the complementarity of features in WISE and SDSS images,a novel variant of a classifier,namely the Multi-band Galaxy Morphology Integrated Classifier,has been *** classifier elevates the overall prediction accuracy to 95.39%.Lastly,the versatility of WGC was validated in other data *** the HyperLEDA data set,the distinction between elliptical galaxies and Sc,Scd and Sd spiral galaxies was most pronounced,achieving an accuracy of 90%,surpassing the classification results of the Galaxy Zoo 2 labeled WISE data *** research not only demonstrates the effectiveness of WISE images in galaxy morphology classification but also represents an attempt to integrate multi-band astronomical data to enhance understanding of galaxy structures and evolution.

关键词： methods:data analysis infrared:galaxies galaxies:spiral galaxies:elliptical and lenticular cD

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Oscillation for a Class of Diffusive Hematopoiesis Model with Several Arguments

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Acta Mathematica Sinica,English Series 2012年第11期28卷 2345-2354页

作者： Xiao WANG Hao ZHANG zhi xiang li Department of Mathematics and System Science College of ScienceNational University of Defense Technology

By considering solution curve＇s or surface＇s composition of the functions of several variables and constructing the suitable lower-upper solution pair for the following special diffusive Hematopoiesis modelunder Neumann boundary condition, sufficient conditions are provided for the oscillation of the positive equilibrium for （0.1）. Moreover, these results extend or complement existing results.

关键词： Partial functional differential equations lower-upper solution pair oscillation

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Improvement of impact properties of Al-Si-Mg alloy via solution treatment and joint modification with Sr and La

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Rare Metals 2024年第7期43卷 3301-3313页

作者： Xiong-ling Zheng Shao-xiang li Jia-Le Ma Qing-Yan Xu Hai-Dong Zhao zhi-Qiang Han Key Laboratory for Advanced Materials Processing Technology Ministry of EducationSchool of Materials Science and EngineeringTsinghua University National Engineering Research Center of Near-Net Shape Forming for Metallic Materials South China University of Technology

An effort to obtain superior impact properties for Al-7Si-0.35 Mg alloy is presented,where modification with 0.02 wt% Sr and 0.1 wt% La as well as solution treatment was jointly *** samples were solution treated at 535℃ for 15 min to 12 *** microstructure,fracture mechanism,and their correlation with the impact properties of the alloy were studied in detail mainly through optical microscopy（OM）,scanning electron microscopy（SEM） and oscillography impact *** results show that the addition of Sr and La refined the eutectic Si particles significantly from～ 2.05 μm（modified with Sr alone） to～ 0.75 μm in as-cast microstructure,leading to a very homogeneous distribution of spheroidized Si particles in the alloy solution treated at 535℃ for 8 *** alloy exhibits excellent impact toughness up to 75 J·cm-2,which is much higher than the maximum impact toughness of the alloys modified by Sr alone(～ 46 J·cm-2).The major reason for this remarkable increase in the impact property is the dramatic increase in crack initiation *** dispersoid-free zones（DFZs）near the eutectic regions mainly consist of the ductile Al-matrix,which exhibits excellent *** ductile Al-matrix of the DFZs hinders the crack propagation,resulting in a significant increase in crack propagation energy.

关键词： Aluminum alloys Modification Solution treatment Microstructure Impact properties Fracture mechanism

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