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Journal of Mountain Science 2024年第8期21卷 2844-2854页

作者： CHEN Wenhua xiang tian School of Civil Engineering Beijing Jiaotong UniversityBeijing 202303China

Water freezing in rock fractures causes volumetric expansion and fracture development through frost *** study introduces a novel analytical model to investigate how uneven freezing force and surrounding rock pressure influence fracture initiation,based on mass conservation,elasticity,and water-ice phase transition principles.A model for rock fracture initiation considering freezing temperature,uneven freezing expansion,in-situ stress,and lateral pressure was proposed based on fracture *** for stress intensity factors were developed and validated using the phase field *** effects of rock elastic modulus anisotropy and critical fracture energy density on fracture initiation were also *** results show that the values of KI and KII exhibit an upward trend as the freezing temperature,uneven expansion,in-situ stress,and lateral pressure *** uneven freezing expansion has the most significant influence on KI and KII values among these *** the uneven freezing expansion coefficient increases to 0.5,the fracture initiation mode shifts from tensile fracture to shear *** the lateral pressure coefficient increases to 1,the fracture initiation mode shifts from tensile fracture to shear *** elastic modulus anisotropy causes fractures to propagate in a clockwise direction,forming a'butterfly'*** fracture energy density an isotropy causes counterclockwise deviation in propagation direction,resulting in branching paths and an'H'-shaped pattern.

关键词： Rock fractures Fracture water Uneven freezing expansion Phase field method Initiation angle Anisotropy

New insights into disruption of iron homeostasis by environmental pollutants

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Journal of Environmental Sciences 2015年第8期27卷 256-258页

作者： xiang Wang tian Xia Department of Medicine Division of Nano Medicine University of California California Nano Systems Institute University of California

Among the numerous health conditions environmental pollutants can cause, chronic exposure to pollutants including persistent organic pollutants（POPs） and heavy metals has been shown to disturb a specific biological homeostatic process, the iron metabolism in human body. Disorders of iron metabolism are among the common diseases of humans and encompass a broad spectrum of diseases with different clinical manifestations, ranging from anemia to iron overload, and possibly to neurodegenerative diseases and ***–ferroportin（FPN） signaling is one of the key mechanisms responsible for iron supply, utilization, recycling, and storage, and recent studies demonstrated that exposure to environmental pollutants including POPs and heavy metals could lead to disruption of the hepcidin–FPN axis along with disordered systemic iron homeostasis and diseases. This article introduces and highlights the accompanying review article by Drs. Xu and Liu in this journal, which elaborates in detail the adverse effects of environmental pollutants on iron metabolism, and the mechanisms responsible for these toxicological outcomes. It also points out the knowledge gaps still existing in this subject matter. Research that will fill these gaps will improve our understanding of the issue and provide useful information to prevent or treat diseases induced by environmental pollutants.

关键词： Environmental pollution Persistent organic pollutants Heavy metals Iron homeostasis Hepcidin Ferroportin

Effects of magnetic fields on Fe–Si composite electrodeposition

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International Journal of Minerals,Metallurgy and Materials 2014年第12期21卷 1175-1186页

作者： Qiong long Yun-bo Zhong Huai Wang tian-xiang Zheng Jun-feng Zhou Zhong-ming Ren Shanghai Key Laboratory of Modern Metallurgy and Material Processing Shanghai University

Coatings containing Fe-Si particles were electrodeposited on 3.0wt% Si steel sheets under magnetic fields. The effects of magnetic flux density （MFD）, electrode arrangement and current density on the surface morphology, the silicon content in the coatings and the cathode current efficiency were investigated. When a magnetic field was applied parallel to the current and when the MFD was less than 0.5 T, numerous needle-like structures appeared on the coating surface. With increasing MFD, the needle-like structures weakened and were transformed into dome-shaped structures. Meanwhile, compared to results obtained in the absence of a magnetic field, the silicon content in the coatings significantly increased as the MFD was increased for all of the samples obtained using a vertical electrode system. However, in the case of an aclinic electrode system, the silicon content decreased. Furthermore, the cathode current efficiency was considerably diminished when a magnetic field was applied. A possible mechanism for these phenomena was discussed.

关键词： composite coatings electrodeposition silicon steel magnetic field surface morphology silicon content magnetohydrodynamics

Cisplatin pretreatment enhances anti-tumor activity of cytokine-induced killer cells

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World Journal of Gastroenterology 2011年第25期17卷 3002-3011页

作者： xiang Huang Yi-tian Chen Hai-Zhu Song Gui-Chun Huang long-Bang Chen Department of Medical Oncology MedicalSchool of Nanjing University Jinling Hospital 305 ZhongshanEast Road Nanjing 210002 Jiangsu Province China

AIM： To investigate whether cisplatin （DDP） enhances the anti-tumor activity of cytokine- induced killer （CIK） cells in a murine colon adenocarcinoma model. METHODS： Tumor size and weight served as indicators of therapeutic response. Immunohistochemistry was performed to observe intratumoral lymphocyte infiltration and tumor microvessel density. Changes in the percentage of regulatory T （Treg） cells within the spleens of tumor-bearing mice preconditioned with DDP were monitored using flow cytometry. RESULTS： A marked T cell-dependent, synergistic anti- tumor effect of the combined therapy was observed （1968 ± 491 mm3 ys 3872 ＋ 216 mm3; P = 0,003）, Preconditioning chemotherapy with DDP augmented the infiltration of CD3＋ T lymphocytes into the tumor mass and reduced the percentage of both intratumoral and splenic Treg cells. CONCLUSION： Preconditioning with DDP markedly enhances the efficacy of adoptively transferred CIK cells, providing a potential clinical modality for the treatment of patients with colorectal cancer.

关键词： Colorectal cancer Preconditioning chemo-therapy Cytokine-induced killer cells Regulatory Tcells Immunomodulation

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai Chai Meng tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

Ultra‑High Sensitivity Anisotropic Piezoelectric Sensors for Structural Health Monitoring and Robotic Perception

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Nano-Micro Letters 2025年第2期17卷 432-446页

作者： Hao Yin Yanting Li Zhiying tian Qichao Li Chenhui Jiang Enfu Liang Yiping Guo State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Beijing Vacuum Electronics Research Institute Beijing 100015People’s Republic of China Fundamental Science On Vibration Shock and Noise LaboratoryState Key Laboratory of Mechanical System and VibrationSchool of Mechanical EngineeringShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Monitoring minuscule mechanical signals,both in magnitude and direction,is imperative in many application scenarios,e.g.,structural health monitoring and robotic sensing ***,the piezoelectric sensor struggles to satisfy the requirements for directional recognition due to the limited piezoelectric coefficient matrix,and achieving sensitivity for detecting micrometer-scale deformations is also ***,we develop a vector sensor composed of lead zirconate titanate-electronic grade glass fiber composite filaments with oriented arrangement,capable of detecting minute anisotropic *** as-prepared vector sensor can identify the deformation directions even when subjected to an unprecedented nominal strain of 0.06%,thereby enabling its utility in accurately discerning the 5μm-height wrinkles in thin films and in monitoring human pulse *** ultra-high sensitivity is attributed to the formation of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate ***,when integrated with machine learning techniques,the sensor’s capability to recognize multi-signals enables it to differentiate between 10 types of fine textures with 100%*** structural design in piezoelectric devices enables a more comprehensive perception of mechanical stimuli,offering a novel perspective for enhancing recognition accuracy.

关键词： Flexible piezoelectric filaments Anisotropic Ultra-high sensitivity Structural health detection Texture recognition

Characterization of thermal-shock cracks in ceramic bars

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Science China(Physics,Mechanics & Astronomy) 2014年第12期57卷 2205-2208页

作者： XU xiang Hong tian Cheng SHENG Shi long LIN Zhong Kang SONG Fan State Key Laboratory of Nonlinear Mechanics (LNM) Institute of Mechanics Chinese Academy of Sciences

Experimental analysis of the cracking in the ceramics subsequent to water quenching have been conducted to clarify the uncertainties of cracking in the ceramics when subjected to thermal *** results here indicate that at the critical point of quench temperature,the crack density and the depth reached the minimum and the maximum limits,*** increase of the quench temperature,the crack density increased rapidly before reaching its saturation point,while the crack depth initially decreased rapidly and then increased gradually before reaching its saturation point.

关键词： thermal-shock crack ceramics

Mainchain conformation ordering self-assembly tailored room temperature phosphorescence emission

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Science China Chemistry 2025年第1期 329-336页

作者： Yuzhu Li Yumeng Gao Feng tian Yu Wang Yuan Yao Shaoliang Lin xiang Ma Binbin Xu Shanghai Key Laboratory of Advanced Polymeric Materials Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute Chinese Academy of Sciences Key Laboratory for Advance Materials and Feringa Noble Prize Scientist Joint Research Centre Frontiers Science for Materiobiology and Dynamic Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology

Developing organic room-temperature phosphorescence （RTP） materials with a wide range of tunable-emission is significant in expanding the applications of RTP ***,we rationally designed amphiphilic alternating copolymers poly(1,2-bis（4-alkoxyphenyl）ethane-1,2-dione-alt-（ethylene glycol）x)(P（Bz-alt-EGx）) that combined the advantage of alternating benzil and EGxskeleton,and tunable mainchain *** a mainchain conformation ordering assembly （COA） process,P（Bz-alt-EGx） self-assembled into well-defined platelets,and such assemblies emitted blue RTP at ca.425 nm due to the ordered folded-chain conformation and confined *** contrast,traditional self-assembly （TA） of P（Bz-alt-EGx） obtained less ordered aggregates,such as asymmetric worms,vesicles,and rod-like *** resultant less ordered aggregates exhibited yellow-green RTP at ca.550 *** wide-tuning RTP emission in solution （between blue and yellow-green,over125 nm） is realized using the P（Bz-alt-EGx） alternating copolymers under the treatment of different self-assembly *** study uncovers a new strategy to tailor the RTP emission through different self-assembly pathways and holds great promise for the fabrication of advanced optical materials.

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Energy and carbon performance of urban buildings using metamodeling variable importance techniques

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Building Simulation 2021年第3期14卷 535-547页

作者： Yunliang Liu Wei tian xiang Zhou School of Mechanical Engineering Tongji UniversityShanghai 200092China tianjin Key Laboratory of Integrated Design and On-line Monitoring for Light Industry&Food Machinery and Equipment College of Mechanical EngineeringTianjin University of Science and TechnologyTianjin 300222China tianjin International Joint Research and Development Center of Low-Carbon Green Process Equipment Tianjin 300222China

Global urbanization causes more environmental stresses in cities and energy efficiency is one of major concerns for urban *** variable importance techniques have been widely used in building energy analysis to determine key factors influencing building energy *** of these applications,however,use only one type of variable importance ***,this paper proposes a procedure of conducting two types of variable importance analysis(predictive and variance-based)to determine robust and effective energy saving measures in urban *** two variable importance methods belong to metamodeling techniques,which can significantly reduce computational cost of building energy simulation models for urban *** predictive importance analysis is based on the prediction errors of metamodels to obtain importance rankings of inputs,while the variance-based variable importance can explore non-linear effects and interactions among input variables based on variance *** campus buildings are used to demonstrate the application of the method proposed to explore characteristic of heating energy,cooling energy,electricity,and carbon emissions of *** results indicate that the combination of two types of metamodeling variable importance analysis can provide fast and robust analysis to improve energy efficiency of urban *** carbon emissions can be reduced approximately 30%after using a few of effective energy efficiency measures and more aggressive measures can lead to the 60%of reduction of carbon ***,this research demonstrates the application of parallel computing to expedite building energy analysis in urban environment since more multi-core computers become increasingly available.

关键词： urban buildings variable importance metamodeling energy performance carbon emissions

Reflection and operationalization of the common but differentiated responsibilities and respective capabilities principle in the transparency framework under the international climate change regime

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Advances in Climate Change Research 2018年第4期9卷 253-263页

作者： WANG tian GAO xiang National Center for Climate Change Strategy and International Cooperation Ministry of Ecology and Environment Beijing 100038 China Energy Research Institute National Development and Reform Commission Beijing 100038 China

“Common but differentiated responsibilities and respective capabilities”(CBDRRC) is the most significant guiding principle in the international climate change regime, created by the United Nations Framework Convention on Climate Change in 1992 and inherited by the Paris Agreement 24 years later. This paper examines the operationalization of the CBDRRC principle in one of the cornerstone rules of the regimedits transparency provisions, both in existing practice under the convention and possible evolvement in negotiations under the Paris Agreement, from the perspectives of both international rule-making and domestic implementation. The authors have found a continuous enhancement of the transparency framework since the 1990s, and gradual consolidation of a bifurcated system between developed and developing countries into a common one. The authors argue that the transparency framework, as part of the procedural rules, should be designed to facilitate transparent information sharing in accordance with substantive commitments under international climate change laws. Thus, it indirectly reflects historical responsibilities for climate change, while the framework should also be designed as feasible and reflective of the respective capabilities of nations. Finally, the evolution of the transparency framework will aim to enact common and enhanced provisions while differentiating between developed and developing countries in the near term, and greater transparency-related capacity-building for developing countries.

关键词： International climate change law UNFCCC Paris agreement Transparency Common but differentiated responsibilities and respective capabilities principle