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Overexpression of vascular endothelial growth factor enhances the neuroprotective effects of bone marrow mesenchymal stem cell transplantation in ischemic stroke

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Neural Regeneration Research 2023年第6期18卷 1286-1292页

作者： Cui Liu Zhi-xiang yang Si-Qi Zhou Ding Ding Yu-Ting Hu Hong-Ning yang Dong Han Shu-qun Hu Xue-Mei Zong Institute of Emergency Rescue Medicine Emergency Centerthe Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Emergency Department of Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People’s Hospital of Lianyungang LianyungangLianyungangJiangsu ProvinceChina Laboratory of Emergency Medicine Second Clinical Medical College of Xuzhou Medical UniversityXuzhou Medical UniversityXuzhouJiangsu ProvinceChina Key Laboratory of Brain Diseases Bioinformation Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina

Although bone marrow mesenchymal stem cells(BMSCs)might have therapeutic potency in ischemic stroke,the benefits are *** current study investigated the effects of BMSCs engineered to overexpress vascular endothelial growth factor(VEGF)on behavioral defects in a rat model of transient cerebral ischemia,which was induced by middle cerebral artery ***-BMSCs or control grafts were injected into the left striatum of the infarcted hemisphere 24 hours after *** found that compared with the stroke-only group and the vehicle-and BMSCs-control groups,the VEGF-BMSCs treated animals displayed the largest benefits,as evidenced by attenuated behavioral defects and smaller infarct volume 7 days after ***,VEGF-BMSCs greatly inhibited destruction of the blood-brain barrier,increased the regeneration of blood vessels in the region of ischemic penumbra,and reducedneuronal degeneration surrounding the infarct *** mechanistic studies showed that among all transplant groups,VEGF-BMSCs transplantation induced the highest level of brain-derived neurotrophic *** results suggest that BMSCs transplantation with vascular endothelial growth factor has the potential to treat ischemic stroke with better results than are currently available.

关键词： bone marrow mesenchymal stem cell brain-derived neurotrophic factor CD31 microtubule associated protein 2 middle cerebral artery occlusion stroke transplantation vascular endothelial growth factor

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Clinical andTransmission Characteristics of COVID-19-A Retrospective Study of 25 Cases from a Single Thoracic Surgery Department

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Current Medical Science 2020年第2期40卷 295-300页

作者： yang-kai LI Shu PENG Le-qun LI Qi WANG Wei PING Ni ZHANG xiang-ning FU Deparnent of Thoracic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWiuhan 430030China

The outbreak of corona virus disease 2019(COVID-19)imposes a major challenge in managing patients undergoing surgical *** this study,we analyzed clinical and transmission features of 25 cases of COVID-19 from a single thoracic department,including 13 patients and 12 health care *** were 13 males and 12 *** median age of the patients was 61(range:51 to 69)*** median age of the health care staff was 35(range:22 to 51)*** the end of follow-up date(Mar.3,2020),there were 16 non-severe cases(64%)and 9 severe cases(36%),5 cases were dead(20%).Nineteen(76%)of the infected cases were confirmed by SARS-CoV-2 nucleic acid test,the rest were clinically diagnosed as suspected COVID-19 cases,and 19(76%)of the infected cases had positive exposure *** found that COPD was significantly associated with severity and death(P-0.040,and P=0.038,respectively),and chest operation was significantly associated with death for COVID-19 patients(P-0.039).A potential“super spreader"may be the source of the transmission before the implementation of quarantine and comprehensive *** was concluded that COVID-19 is associated with poor prognosis for patients undergoing thoracic operation,especially for those with *** of comprehensive protective measures is important to control nosocomial infection.

关键词： corona virus disease 2019 SARS-CoV-2 nosocomial infection

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Controlled low central venous pressure reduces blood loss and transfusion requirements in hepatectomy

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World Journal of Gastroenterology 2014年第1期20卷 303-309页

作者： Zhi Li Yu-Ming Sun Fei-xiang Wu Li-qun yang Zhi-Jie Lu Wei-Feng Yu Department of Anesthesiology Eastern Hepatobiliary Surgery Hospitalthe Second Military Medical University

AIM: To evaluate the effect of low central venous pressure (LCVP) on blood loss and blood transfusion in patients undergoing hepatectomy.

关键词： Low central venous pressure Hepatectomy Blood loss Blood transfusion

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角蛋白19在肉芽组织中的表达及意义

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实用预防医学 2003年第4期10卷 468-470页

作者：周鹏翔罗成群杨军贺全勇李高峰彭长缨彭浩中南大学湘雅三医院中国湖南长沙410013

目的　通过对度烧伤创面原位再生修复过程中肉芽组织中角蛋白 19(K19)表达特征的研究 ,旨在探索度烧伤创面原位再生修复的可能机制。　方法　选择有度烧伤创面的青年患者 10例 ,在原位再生修复过程中的不同时期分别切取肉芽组织 ... 详细信息

目的　通过对度烧伤创面原位再生修复过程中肉芽组织中角蛋白 19(K19)表达特征的研究 ,旨在探索度烧伤创面原位再生修复的可能机制。　方法　选择有度烧伤创面的青年患者 10例 ,在原位再生修复过程中的不同时期分别切取肉芽组织 ,应用过氧化酶标记的链霉卵白素 (SP)免疫组化法 ,以 K19单抗检测 K19表达阳性细胞的分布和形态特征 ;同时取供皮区的正常皮肤组织作对照。　结果　 1正常皮肤组织只有表皮基底细胞层和附属器的部分细胞表达K19;2早期肉芽样组织有部分细胞表达 K19,呈散在分布 ;中期肉芽样组织中 K19表达阳性细胞数较前明显增多 ,大多数阳性细胞形似血管内皮细胞和成纤维细胞 ;晚期肉芽样组织 K19表达阳性细胞数达峰值 ,分布排列类似表皮。　结论　在度烧伤创面原位再生修复过程中 ,血管内皮细胞、成纤维细胞于伤后 18～ 32 d表达

关键词：烧伤角蛋白肉芽组织

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Multi-objective strategy to optimize dithering technique for high-quality three-dimensional shape measurement

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Chinese Physics B 2019年第10期28卷 381-386页

作者： Ning Cai Zhe-Bo Chen xiang-qun Cao Bin Lin State Key Laboratory of Modern Optical Instrumentation CNERC for Optical InstrumentsZhejiang UniversityHangzhou 310027China Research Institute of Zhejiang University-Taizhou Taizhou 318000China

Dithering optimization techniques can be divided into the phase-optimized technique and the intensity-optimized technique. The problem with the former is the poor sensitivity to various defocusing amounts, and the problem with the latter is that it cannot enhance phase quality directly nor efficiently. In this paper, we present a multi-objective optimization framework for three-dimensional(3D) measurement by utilizing binary defocusing technique. Moreover, a binary patch optimization technique is used to solve the time-consuming issue of genetic algorithm. It is demonstrated that the presented technique consistently obtains significant phase performance improvement under various defocusing amounts.

关键词： three-dimensional(3D) shape measurement multi-objective dithering genetic algorithm

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Graft Polymerization of Acryloyloxystarch with Poly (D, L-lactide) Macromonomer——A Potential Drug Delivery Carrier for Oral Administration

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Chemical Research in Chinese Universities 2001年第3期17卷 334-337页

作者： WANG Li-qun TU Ke-hua WANG Yan-bing LI xiang-rong Department of Polymer Science and Engineering College of Medicine of Zhejiang University Hangzhuo 310027P.R.China Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai 200433P.R.China

Starch is the second largest natural biopolymer. Its unique biodegradable and biocompatible properties make it be increasingly applied to the field of biomedicine. As one kind of polysaccharide, starch is easily degraded into small organic molecules by amylase in the alimentary canal. The fact that the activity of amylase is restrained in the high acid environment in stomach provides an opportunity to prepare an intestinal-specific delivery carrier with

关键词： Acryloyloxystarch PLA macromonomer Graft copolymerization

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Humidity Sensing Properties of Pre-irradiation Grafted HDPE Membranes

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稀有金属材料与工程 2006年第A3期35卷 357-360页

作者： Zheng Jiao qun Fu xiang Geng Zhen Li Haijian Zhong Shanghai Applied Radiation Institute Shanghai University Shanghai 201800 China

Grafted high density polyethylene (HDPE) films have been prepared by grafting sodium styrene sulfonate (SSS) and acrylic acid (AA) onto HDPE using preirradiation *** structure and surface morphology of both grafted and ungrafted HDPE films were observed by FTIR spectroscopy and scanning electron microscope (SEM),*** humidity sensing properties of grafted HDPE films were *** results show that the impedance of the film decreases with increasing of relative humidity (RH).The films display high sensitivity with nearly three orders of magnitude change in the resistance during the relative humidity variation from 5% to 98%.Grafted HDPE films exhibit excellent properties as humidity sensors.

关键词： humidity sensors grafted HDPE films pre-irrsdistion

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Numerical study on variation characteristics of the unsteady bearing forces of a propeller with an external transverse excitation

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Journal of Hydrodynamics 2019年第2期31卷 400-412页

作者： Min-hua Shu Ke Chen Yun-xiang You Tian-qun Hu Remfeng Wang State Key Laboratory of Ocean Engineering Collaboration Innovation Center for Advanced Ship and Deep-Sea Exploitation EquipmentShanghai JiaoTong UniversityShanghai 200240China

The unsteady bearing forces of a propeller can be significantly affected by external transverse *** paper numerically studies the unsteady variation characteristics of the bearing forces of a three-blade conventional propeller with external transverse excitations or without *** dynamic mesh method combined with the RANS turbulence model is *** numerical simulation shows the frequency response in the frequency domain of KT,Kq under external transverse *** frequency of the response is found always equal to twice of the excitation *** the amplitude of the external transverse excitation keeps constant,the amplitude of the response increases with the in crease of the excitation *** the excitation frequency keeps constant,the amplitude of the response increases with the increase of the excitation amplitude,in a power-law *** pressure distribution can be significantly affected by the external transverse excitation,leading to a high irregularity of the flow field.

关键词： External transverse excitation unsteady bearing forces excitation frequency propeller dynamic mesh method

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The Study on the Gas Sensitivity of the One-Dimensional ZnO

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稀有金属材料与工程 2006年第A3期35卷 170-172页

作者： qun xiang Rongli Liu Liyi Shi Zhiyin Ni Qingyi Pan Department of Chemistry Shanghai University Shanghai 200444 China

One-dimensional (1D) ZnO was prepared through hydrothermal synthesis by cetyltrimethylammonium bromide (CTAB) controling its *** products were characterized by X-ray diffraction (XRD),transmission electron microscopy (TEM) and scanning electron microscopy (SEM).The sintered gas sensor was prepared using ZnO nanorods and its gas sensitivity was measured in static gas *** result showed that the ZnO nanorods had lower working temperature than granulated ZnO and had very good sensitivity to 10μg/g trimethylamine (TMA),methanol,ammonia, acetone and ethanol at the working temperature of 170℃.SEM picture revealed that there were many multi-pores in the surface of the *** multi-pores might help to absorb gases and improve the gas sensitivity.

关键词： gas sensitivity one-dimensional Zn hydrothermal synthesis

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Optimized dithering technique in frequency domain for high-quality three-dimensional depth data acquisition

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Chinese Physics B 2019年第8期28卷 124-131页

On the basis of the objective functions,dithering optimization techniques can be divided into the intensity-based optimization technique and the phase-based optimization ***,both types of techniques are spatial-domain optimization techniques,while their measurement performances are essentially determined by the harmonic components in the frequency *** this paper,a novel genetic optimization technique in the frequency domain is proposed for highquality fringe *** addition,to handle the time-consuming difficulty of genetic algorithm(GA),we first optimize a binary patch,then join the optimal binary patches together according to periodicity and symmetry so as to generate a full-size *** is verified that the proposed technique can significantly enhance the measured performance and ensure the robustness to various amounts of defocusing.

关键词： fringe generation genetic algorithm frequency domain 3D shape measurement

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