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Local Solvability of Cauchy Problem for Kaup-Kupershmidt Equation

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Journal of Mathematical Research and Exposition 2010年第3期30卷 543-551页

作者： xiang qing zhao Shen Ming GU School of Mathematics Physics and Information Science Zhejiang Ocean University Zhejiang 316000 P. R. China

This paper deals with the local solvability of initial value problem for Kaup-Kupershmidt equations. Indeed, using Bourgain method, we prove that the Cauchy problem of Kaup-Kupershmidt equation is local well-posed in ... 详细信息

关键词： Kaup-Kupershmidt equation initial value problem local well-posed.

How to interpret low human chorionic gonadotropin levels in cerebrospinal fluid of patients with intracranial germinoma？

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Chinese Medical Journal 2013年第24期126卷 4809-4810页

作者： CONG Lu TIAN Cheng-lin WANG xiang-qing DONG zhao ZHANG Jia-tang YU Sheng-yuan Department of Neurology Chinese People's Liberation Anny General Hospital Beijing 100853 China

Human chorionic gonadotropin （hCG） level in cerebrospinal fluid （CSF hCG） is very useful for thediagnosis of intracranial germinoma. We have previously reported on two patients with germinoma located in the basal ganglia. Their CSF hCG levels were extremely low upon presentation.1 However, significantly increased CSF hCG levels were detected when these two patients had a relapse. The experience acquired in these two cases is helpful to appropriately interpret the CSF hCG levels that are used to detect intracranial germinoma, evaluate the effectiveness of treatment and monitor recurrence.

关键词： germinoma, human chorionic gonadotropin cerebrospinal fluid

Preparation of FeCoNi medium entropy alloy from Fe^(3+)-Co^(2+)-Ni^(2+)solution system

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 92-101页

作者： Zongyou Cheng qing zhao Mengjie Tao Jijun Du Xingxi Huang Chengjun Liu Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-carbon Steelmaking(Ministry of Education) Shenyang 110819China

In recent years,medium entropy alloys have become a research hotspot due to their excellent physical and chemical *** controlling reasonable elemental composition and processing parameters,the medium entropy alloys can exhibit similar properties to high entropy alloys and have lower *** this paper,a FeCoNi medium entropy alloy precursor was prepared via sol-gel and coprecipitation methods,respectively,and FeCoNi medium entropy alloys were prepared by carbothermal and hydrogen *** phases and magnetic properties of FeCoNi medium entropy alloy were *** showed that FeCoNi medium entropy alloy was produced by carbothermal and hydrogen reduction at 1500℃.Some carbon was detected in the FeCoNi medium entropy alloy prepared by carbothermal *** alloy prepared by hydrogen reduction was uniform and showed a relatively high ***,the hydrogen reduction product exhibited better saturation magnetization and lower coercivity.

关键词： medium entropy alloy sol-gel co-precipitation carbothermal hydrogen reduction

Modular assembly of Co4-thiacalix[4]arene units and Keggin-type SiW12O40 for visible-light photothermal conversion

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Tungsten 2025年第1期7卷 112-119页

作者： Jia-Hui Li qing zhao Dong-Ao Mao Kun Zhou Bao-Kuan Chen Yan-Feng Bi School of Petrochemical Engineering Liaoning Petrochemical University

The construction of metal-organic coordination clusters（MCCs） using modular secondary building units is an important method for preparing functional *** this study,two new MCCs modularly assembled from Keggin-type {SiW12O40}H4TC4A=p-tert-Butylthiacalix[4]arene(SiW12) units and thiacalixarene-supported Co4-thiacalix[4]arene(Co4-TC4A polynuclear second-building units（PSBUs,H4TC4A=p-tert-Butylthiacalix[4]arene） are *** two MCCs,abbreviated as Co4-SiW12and Co8-SiW12,were structurally characterized by single-crystal X-ray *** Co4-SiW12is a supramolecular structure involving cation-anion interactions between Co4-TC4A PSBUs and ***8-SiW12features "barbell-like" shapes with two Co4-TC4A coordinatively linked to a Keggin-type SiW12unit on opposite via W-O_t-Co *** coordination of Co4-TC4A to SiW12in Co8-SiW12resulted in significantly improved photothermal conversion performances compared with Co4-SiW12and pure SiW12or ***-gap determination and photophysical analysis combined with density functional theory calculations indicated the binding mode between Co4-TC4A PSBUs and SiW12,which considerably influences the way of electron transport and the conversion ability of visible light to heat.

关键词： Modular construction Photothermal conversion Polyoxometalate Thiacalixarene

Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin Long Chuanhua Ge Yueyang zhao Yuanjie Liu qinghua Zeng qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina Department of Anatomy Chongqing Medical UniversityChongqingChina Department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child Development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

开腹胆囊切除术中胆管损伤的原因分析及预防对策

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中华肝胆外科杂志 2008年第4期14卷 278-279页

作者：向清召龙山县人民医院普外科湖南省416800

胆囊切除术是治疗胆囊疾病的主要手段，在农村基层医院仍以开腹胆囊切除术（OC）为主，随着胆囊切除术的普及，医源性胆管损伤的发生率有明显增高趋势。龙山县人民医院1995年9月至2005年9月间共行OC1268例，发生胆管损伤4例，外院转入1... 详细信息

胆囊切除术是治疗胆囊疾病的主要手段，在农村基层医院仍以开腹胆囊切除术（OC）为主，随着胆囊切除术的普及，医源性胆管损伤的发生率有明显增高趋势。龙山县人民医院1995年9月至2005年9月间共行OC1268例，发生胆管损伤4例，外院转入1例，现作回顾性分析，报告如下。

关键词：开腹胆囊切除术医源性胆管损伤原因分预防农村基层医院县人民医院胆囊疾病发生率

The complex roles of m^(6)A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases

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Neural Regeneration Research 2025年第6期20卷 1582-1598页

作者： Yanxi Li Jing Xue Yuejia Ma Ke Ye Xue zhao Fangliang Ge Feifei Zheng Lulu Liu Xu Gao Dayong Wang qing Xia Department of Biochemistry and Molecular Biology College of Basic Medical SciencesHarbin Medical UniversityHarbinHeilongjiang ProvinceChina College of Basic Medical Sciences Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Basic Medical Institute Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Key Laboratory of Heilongjiang Province for Genetically Modified Animals Harbin Medical UniversityHarbinHeilongjiang ProvinceChina Translational Medicine Research and Cooperation Center of Northern China Heilongjiang Academy of Medical SciencesHarbinHeilongjiang ProvinceChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

N6-methyladenosine(m^(6)A), the most prevalent and conserved RNA modification in eukaryotic cells, profoundly influences virtually all aspects of mRNA metabolism. mRNA plays crucial roles in neural stem cell genesis and neural regeneration, where it is highly concentrated and actively involved in these processes. Changes in m^(6)A modification levels and the expression levels of related enzymatic proteins can lead to neurological dysfunction and contribute to the development of neurological diseases. Furthermore, the proliferation and differentiation of neural stem cells, as well as nerve regeneration, are intimately linked to memory function and neurodegenerative diseases. This paper presents a comprehensive review of the roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, as well as its implications in memory and neurodegenerative diseases. m^(6)A has demonstrated divergent effects on the proliferation and differentiation of neural stem cells. These observed contradictions may arise from the time-specific nature of m^(6)A and its differential impact on neural stem cells across various stages of development. Similarly, the diverse effects of m^(6)A on distinct types of memory could be attributed to the involvement of specific brain regions in memory formation and recall. Inconsistencies in m^(6)A levels across different models of neurodegenerative disease, particularly Alzheimer's disease and Parkinson's disease, suggest that these disparities are linked to variations in the affected brain regions. Notably, the opposing changes in m^(6)A levels observed in Parkinson's disease models exposed to manganese compared to normal Parkinson's disease models further underscore the complexity of m^(6)A's role in neurodegenerative processes. The roles of m^(6)A in neural stem cell proliferation, differentiation, and self-renewal, and its implications in memory and neurodegenerative diseases, appear contradictory. These inconsistencies may be a

关键词： Alzheimer's disease cell self-renewal central nervous system memory microglia nerve regeneration neurodegenerative diseases neurogenesis RNA methylation

MGL联合玻璃体腔注射Ranibizumab治疗CRVO并发黄斑水肿的临床疗效

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延安大学学报（医学科学版） 2016年第3期14卷 12-16页

作者：马庆祥赵源榆林市第一医院眼科陕西榆林719000 子洲县疾病预防控制中心陕西子洲718400

目的探讨黄斑格栅光凝（MGL）联合玻璃体腔注射雷珠单抗（Ranibizumab）治疗视网膜中央静脉阻塞（CRVO）并发黄斑水肿的临床效果和安全性。方法选取榆林市第一医院在2015-01~2015-12期间收治的46例视网膜中央静脉阻塞（CRVO）并发黄斑... 详细信息

目的探讨黄斑格栅光凝（MGL）联合玻璃体腔注射雷珠单抗（Ranibizumab）治疗视网膜中央静脉阻塞（CRVO）并发黄斑水肿的临床效果和安全性。方法选取榆林市第一医院在2015-01~2015-12期间收治的46例视网膜中央静脉阻塞（CRVO）并发黄斑水肿患者,共46眼,随机分为雷珠单抗组和曲安奈德组,各23例（23眼）,前者给予黄斑格栅光凝联合玻璃体腔注射雷珠单抗治疗,后者给予黄斑格栅光凝联合玻璃体腔注射曲安奈德进行治疗。结果治疗后1周、1月、3月、6月,两组患者的BCVA值较治疗前均显著升高,而CMT值较治疗前均显著降低（P〈0.05或P〈0.01）。治疗后1周、1月、3月、6月,雷珠单抗组患者的眼压值较为稳定（P〉0.05）。治疗后1月,曲安奈德组患者的眼压值显著高于雷珠单抗组（P〈0.05）。结论黄斑格栅光凝（MGL）联合玻璃体腔注射雷珠单抗进行治疗视网膜中央静脉阻塞并发黄斑水肿是一种安全、有效的治疗方案,能够提高患者的最佳矫正视力水平,降低黄斑水肿程度,由于手术操作严格内眼手术规范完成治疗,还可降低眼压升高及全身并发症的发生,值得临床推广应用。

关键词：黄斑水肿视网膜中央静脉阻塞玻璃体腔注射雷珠单抗

Scattering Characteristics of Metallic Plates in Radial Waveguide

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Journal of Southwest Jiaotong University(English Edition) 2010年第3期18卷 244-249页

作者：李相强刘庆想赵柳张健穹 School of Physical Science and Technology Southwest Jiaotong University

Mode matching is a useful method to analyze the mode characteristics during the section change of a waveguide. By applying this method to the radial waveguide, and solving specific problems due to the radial transmission of electromagnetic wave, this presents a calculating method in radial waveguide based on mode matching. The scattering characteristics of metallic plates in the radial waveguide are calculated, and verified qualitatively using an electromagnetic simulator, which confirmed the validity of this method.

关键词： Mode matching method Radial waveguide Metallic plate Scattering characteristics