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Inetetamab combined with pyrotinib and oral vinorelbine for patients with human epidermal growth factor receptor 2 positive advanced breast cancer:A single-arm phase 2 clinical trial

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Cancer Pathogenesis and Therapy 2024年第1期2卷 31-37页

作者： Nan Jin Yi Xu Siqi Wang Chunxiao Sun Xueqi Yan Fan Yang Yan Liang Weiwei Chen xiang huang Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Pathology The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Radiology Department The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Oncology Affiliated Jinling HospitalMedical School of Nanjing UniversityNanjingJiangsu 210000China

Background Human epidermal growth factor receptor 2(HER2)-targeted agents have significantly improved the outcomes of patients with HER2-positive breast cancer;however,a large proportion of patients still develop resistance to *** this study,we investigated the efficacy and safety of inetetamab,another anti-HER2 antibody,combined with pyrotinib and oral vinorelbine in patients with HER2-positive advanced breast cancer so as to provide new ideas for the *** In this prospective,single-arm,phase 2 trial,patients with HER2-positive advanced breast cancer with disease progression after trastuzumab were *** received a combination of inetetamab(loading dose of 8 mg/kg and subsequent doses of 6 mg/kg intravenously once every 3 weeks),pyrotinib(400 mg orally once daily),and vinorelbine(60 mg/m^(2)orally once weekly)until disease progression or intolerable *** primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),overall survival(OS),disease control rate(DCR),and *** Between February 13,2022 and December 25,2022,30 patients were screened and enrolled in this *** median age of the patients at enrollment was 54 years,12 patients(40.0%)had hormone-receptor-positive disease and 23 patients(76.7%)had visceral *** median PFS was 8.63 months(95%confidence interval[CI]4.15-13.12 months).The median OS was not *** ORR was 53.3%(16/30)and the DCR was 96.7%(29/30).The most common Grade III/IV adverse events were leukopenia(n=5,16.7%),neutropenia(n=4,13.3%),and diarrhea(n=3,10%).No treatment-related serious adverse events or deaths *** The combination regimen of inetetamab,pyrotinib,and oral vinorelbine showed encouraging efficacy and favorable safety in patients with HER2-positive advanced breast cancer and could be considered as an alternative treatment option for the patients.

关键词： Human epidermal growth factor receptor 2 Breast cancer Inetetamab Pyrotinib Vinorelbine

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SENP3 Promotes Mantle Cell Lymphoma Development through Regulating Wnt10a Expression

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Current Medical Science 2024年第1期44卷 134-143页

作者： Yan-ni MA Yun-ding ZOU Zhi-long LIU Gui-xian WU Yuan-ze ZHOU Cheng-xin LUO xiang-tao huang Ming-ling XIE Shuang-nian XU Xi LI Department of Hematology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Department of Hematology the Third Affiliated Hospital(Daping Hospital)Third Military Medical University(Army Medical University)Chongqing 400042China

Objective SUMO-specific protease 3(SENP3),a member of the SUMO-specific protease family,reverses the SUMOylation of SUMO-2/3 *** of SENP3 has been proven to be involved in the development of various ***,its role in mantle cell lymphoma(MCL),a highly aggressive lymphoma,remains *** study was aimed to elucidate the effect of SENP3 in *** The expression of SENP3 in MCL cells and tissue samples was detected by RT-qPCR,Western blotting or *** cells with stable SENP3 knockdown were constructed using short hairpin *** proliferation was assessed by CCK-8 assay,and cell apoptosis was determined by flow *** sequencing(mRNA-seq)was used to investigate the underlying mechanism of SENP3 knockdown on MCL development.A xenograft nude mouse model was established to evaluate the effect of SENP3 on MCL growth in *** SENP3 was upregulated in MCL patient samples and *** of SENP3 in MCL cells inhibited cell proliferation and promoted cell ***,the canonical Wnt signaling pathway and the expression of Wnt10a were suppressed after SENP3 ***,the growth of MCL cells in vivo was significantly inhibited after SENP3 knockdown in a xenograft nude mouse *** SENP3 participants in the development of MCL and may serve as a therapeutic target for MCL.

关键词： mantle cell lymphoma SENP3 cell proliferation apoptosis

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基于图像识别估算碎裂岩崩体积方法研究

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水文地质工程地质 2024年第3期51卷 140-148页

作者：黄祥黄健贺子城王豪中国建筑西南勘察设计研究院有限公司四川成都610052 地质灾害防治与地质环境保护国家重点实验室(成都理工大学) 四川成都610059 中国电建集团西北勘测设计研究院陕西西安710065

西南山区碎裂岩崩灾害频发,为了准确模拟岩崩运动过程,量化岩崩风险大小,必须明确崩塌体体积,但目前尚无一种有效且可靠的碎裂岩崩体积估算方法。基于此,提出一种基于图像识别技术的碎裂岩崩体积精细估算方法,并以2020年雅西高速石棉姚... 详细信息

西南山区碎裂岩崩灾害频发,为了准确模拟岩崩运动过程,量化岩崩风险大小,必须明确崩塌体体积,但目前尚无一种有效且可靠的碎裂岩崩体积估算方法。基于此,提出一种基于图像识别技术的碎裂岩崩体积精细估算方法,并以2020年雅西高速石棉姚河坝崩塌为例进行应用与验证。通过现场实测与无人机贴近摄影测量方法,确定岩崩堆积区分区及采样区;利用图像处理开源软件(ImagePy),建立块体快速识别步骤,提取块体等效粒径、周长和面积等特征参数;构建基于块体体积分布的碎裂岩崩体积估算方法;以岩崩实例进行方法应用与验证。研究结果表明:(1)ImagePy软件对块体图像识别速度快、精度高;(2)获取的块体体积分布曲线与现场实测体积分布规律近一致;(3)姚河坝岩崩体积估算值占三维点云数据差分法获取体积近80%。综上,利用图像识别技术进行碎裂岩崩块体体积提取与体积估算的方法是可行的,并具有高效率与准确性优势,可应用于碎裂岩崩灾害快速评估与风险量化评价,统计的块体体积分布可为碎裂研究提供数据支撑。

关键词：岩崩堆积体图像识别粒径分布精细估算

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Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

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Signal Transduction and Targeted Therapy 2024年第1期9卷 259-270页

作者： Yan Sun Xiu-Na Yang Shuang-Shuang Yang Yi-Zhu Lyu Bing Zhang Kai-Wen Liu Na Li Jia-Chen Cui Guang-xiang huang Cheng-Lin Liu Jie Xu Jian-Qing Mi Zhu Chen Xiao-Hu Fan Sai-Juan Chen Shuo Chen Shanghai Institute of Hematology National Research Center for Translational MedicineState Key Laboratory of Medical GenomicsRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Department of Hematology Second Hospital of Dalian Medical UniversityDalian 116023China National Facility for Protein Science Shanghai Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China Legend Biotech China Nanjing 211112China Shanghai Immune Therapy Institute Shanghai Cancer InstituteState Key Laboratory of Oncogenes and Related GenesRenji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Wondercel Biotechnology Shenzhen 518052China

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity,safeguarding receptor activation,and facilitating amplification of signal transduction across the cellular ***,cell-surface antigeninduced multimerization(dubbed AIM herein)has not yet been consciously leveraged in chimeric antigen receptor(CAR)engineering for enriching T cell-based *** co-developed ciltacabtagene autoleucel(cilta-cel),whose CAR incorporates two B-cell maturation antigen(BCMA)-targeted nanobodies in tandem,for treating multiple *** we elucidated a structural and functional model in which BCMA-induced cilta-cel CAR multimerization amplifies myeloma-targeted T cell-mediated *** analysis of BCMA–nanobody complexes revealed atomic details of antigen–antibody hetero-multimerization whilst analytical ultracentrifugation and small-angle X-ray scattering characterized interdependent BCMA apposition and CAR juxtaposition in ***-induced nanobody CAR multimerization enhanced cytotoxicity,alongside elevated immune synapse formation and cytotoxicity-mediating cytokine release,towards myeloma-derived *** results provide a framework for contemplating the AIM approach in designing next-generation CARs.

关键词： cytotoxicity Antigen elevated

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Rastall gravity:accretion disk image in the context of radiation fields and visual transformations compared to Reissner-Nordström black hole

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Chinese Physics C 2024年第4期48卷 174-182页

作者：黄宇翔郭森梁宇崔宇昊蒋青权林恺 School of Physics and Astronomy China West Normal UniversityNanchong 637000China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China Hubei Subsurface Multi-scale Imaging Key Laboratory Institute of Geophysics and GeomaticsChina University of GeosciencesWuhan 430074China

In this study,we investigated the astronomical implications of Rastall gravity,particularly its behavior amidst a radiation field compared to Reissner-Nordström(RN)black *** found a crucial correlation between the dynamics of the accretion disk and the parameters Q and Nr,which properly reflect the influence of spacetime metrics on the disk’s *** electric charge Q causes contraction in the disk’s orbit due to enhanced gravitational effects,while higher Nr values lead to outward expansion,influenced by the attributes of the radiation ***,the charged black holes surrounded by radiation fields exhibit distinct visual disparities from RN black *** decreases and expansion occurs within the innermost stable circular orbit of the accretion disk with rising Nr *** study also reveals the process by which the accretion disk transitions from a conventional disk-like structure to a hat-like form at different observation angles,with the redshift effect gradually ***,the results of the considered Rastall gravity radiation field are consistent with the constraints of the gravitational lensing of the host galaxy on Rastall gravity parameters,thereby enhancing the consistency between theoretical predictions and actual observations.

关键词： Rastall theory optical appearance thin accretion disk

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聚合物挤出成型过程狭缝组合流道出口流动平衡系数解析解

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机械工程学报 2024年第12期60卷 259-267页

作者：张广冬黄翔盐城工学院机械工程学院盐城224051 南京航空航天大学机电学院南京210016

对于薄壁类塑料异型材挤出制品,其挤出模具成型段流道为狭缝组合流道。在挤出成型过程中,模具出口处的流动平衡状态直接影响着挤出制品的成型质量。狭缝组合流道出口处流动平衡系数通常依赖于数值模拟求解,技术门槛高,求解难度大,应用... 详细信息

对于薄壁类塑料异型材挤出制品,其挤出模具成型段流道为狭缝组合流道。在挤出成型过程中,模具出口处的流动平衡状态直接影响着挤出制品的成型质量。狭缝组合流道出口处流动平衡系数通常依赖于数值模拟求解,技术门槛高,求解难度大,应用范围受限。针对上述问题,提出狭缝组合流道出口流动平衡系数的解析模型。首先,对流动平衡系数理论公式进行完全平方公式展开,得到流动平衡系数的速度相关项和无关项。然后,假定幂律流体在狭缝流道中充分发展流动,通过理论推导,得到狭缝流道出口处流动平衡系数的解析式。接着,基于狭缝组合流道的区域划分,根据不同狭缝流道子区域的速度比公式,建立狭缝组合流道出口流动平衡系数的理论模型。最后,针对典型的狭缝组合流道,采用数值模拟方法对流动平衡系数的解析值进行验证。结果表明,在各个子区域的宽高比大于10时,流动平衡系数的解析解和数值解的误差小于5%,满足实际应用需要。

关键词：挤出模具流动平衡狭缝组合流道解析解数值解

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傅科摆在中国

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中国科技史杂志 2024年第1期45卷 107-119页

作者：胡树铎黄翔河西学院物理与机电工程学院复旦大学哲学学院

傅科摆是世界著名科普仪器，通过文献查询，本文对其在我国的传播历程进行了梳理，并在此基础上做了相关研究，内容分为四个部分：(1)简要回顾了傅科摆发明之前科学界对地球自转的实验探索历程和傅科摆发明过程；(2)概述了傅科摆在我国... 详细信息

傅科摆是世界著名科普仪器，通过文献查询，本文对其在我国的传播历程进行了梳理，并在此基础上做了相关研究，内容分为四个部分：(1)简要回顾了傅科摆发明之前科学界对地球自转的实验探索历程和傅科摆发明过程；(2)概述了傅科摆在我国的传播过程；(3)研究了傅科摆在教材中的应用情况；(4)分析了我国物理学家利用傅科摆测量本地重力加速度的实验个案。

关键词：傅科摆地球自转重力加速度

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基于周期特征提取的DLnet预测模型研究

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传感器与微系统 2024年第10期43卷 46-49,54页

作者：廖雪超黄相武汉科技大学计算机科学与技术学院湖北武汉430065 智能信息处理与实时工业系统重点实验室湖北武汉430065

现有的预测方法很少独立分析能源消耗的周期性特征。本文提出了一个短期办公建筑能耗预测模型(DLnet),以解决周期性能耗数据利用效率低下的问题。首先,利用STL对能耗数据的周期成分进行分解,通过网格搜索算法寻找能耗数据的最优周期;然... 详细信息

现有的预测方法很少独立分析能源消耗的周期性特征。本文提出了一个短期办公建筑能耗预测模型(DLnet),以解决周期性能耗数据利用效率低下的问题。首先,利用STL对能耗数据的周期成分进行分解,通过网格搜索算法寻找能耗数据的最优周期;然后,根据最优周期构建周期块;再根据周期块的数据形状构建时间序列块数据;之后,利用长短期记忆(LSTM)对时间序列块数据和周期块数据进行训练和学习;最后,通过线性回归将时间序列块数据和周期块数据的预测结果进行融合。事实证明,所提出的模型的4个预测精度指标分别比LSTM模型高7%,21%,25%和26%。

关键词：时序块周期块最佳周期 STL 长短期记忆

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Dt1 inhibits SWEET-mediated sucrose transport to regulate photoperiod-dependent seed weight in soybean

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Molecular Plant 2024年第3期17卷 496-508页

作者： Xiaoming Li Zhonghui Chen Haiyang Li Lin Yue Cuirong Tan Hongjie Liu Yilong Hu Yuhua Yang Xiani Yao Lingping Kong xiang huangi Bin Yu Chunyu Zhang Yuefeng Guan Baohui Liu Fanjiang Kong Xingliang Hou Guangdong Provincial Key Laboratory of Applied Botany&State Key Laboratory of Plant Diversity and Specialty Crops South China Botanical GardenChinese Academyof SciencesGuangzhou510650China Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design Guangzhou Key Laboratory of Crop Gene EditingInnovative Center of Molecular Genetics and EvolutionSchool of Life SciencesGuangzhou UniversityGuangzhou 510006China University of Chinese Academy of Sciences Beijing 100049China College of Agronomy and Biotechnology China Agricultural UniversityBeijing 100193China

Soybean is a photoperiod-sensitive short-day crop whose reproductive period and yield are markedly affected by day-length *** weight is one of the key traits determining the soybean yield;how-ever,the prominent genes that control the final seed weight of soybean and the mechanisms underlying the photoperiod's effect on this trait remain poorly *** this study,we identify SwW19 as a major locus controlling soybean seed weight by QTL mapping and determine Dt1,an orthologous gene of Arabidopsis TFL1 that is known to govern the soybean growth habit,as the causal gene of the SW19 *** showed that Dt1 is highly expressed in developing seeds and regulates photoperiod-dependent seed weight in *** analyses revealed that the Dt1 protein physically interacts with the sucrose transporter GmSWEET10a to negatively regulate the import of sucrose from seed coat to the embryo,thus modulating seed weight under long ***,Dt1 does not function in seed development under short days due to its very low ***,we discovered a novel natural allelic variant of Dt1(H4 haplotype)that decouples its pleiotropic effects on seed size and growth habit;i.e.,this variant remains functional in seed development but fails to regulate the stem growth habit of ***,our findings provide new insights into how soybean seed development responds to photoperiod at different latitudes,offering an ideal genetic component for improving soybean's yield by manipulating its seed weightandgrowth habit.

关键词： soybean seed weight photoperiod dt1 sucrose transport

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视觉传达方法论在产品设计中的应用研究

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玩具世界 2024年第3期 197-199页

作者：黄翔广西职业技术学院

随着科技的飞速发展和全球化的推动，产品设计不再仅仅关注功能的实现，也越发重视用户体验和品牌形象的塑造。视觉传达是产品设计中的重要一环，直接传递产品信息并影响着用户第一印象。文章首先说明视觉传达相关概念，阐述视觉传达方... 详细信息

随着科技的飞速发展和全球化的推动，产品设计不再仅仅关注功能的实现，也越发重视用户体验和品牌形象的塑造。视觉传达是产品设计中的重要一环，直接传递产品信息并影响着用户第一印象。文章首先说明视觉传达相关概念，阐述视觉传达方法论在产品设计中的应用价值，以及如何运用这一方法论创造更具吸引力、用户友好且具有独特品牌形象的产品，旨在通过视觉传达方法论的精妙运用，传递产品信息、引发用户情感共鸣，使产品在市场竞争中脱颖而出。

关键词：视觉传达方法论产品设计应用研究

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