检索结果-南通市图书馆

Seco-cyclic phorbol derivatives and their anti-HIV-1 activities

Chinese Journal of Natural Medicines 2024年第4期22卷 365-374页

作者： HUANG Xiaolei HUANG Xusheng LI qirun MA Mengdi CUI Yadong yang Liumeng WANG Haibo LUO Ronghua chen Jinglei yang Jingxuan lin Jinrong LI Duxin ZHENG Yongtang ZHANG Jian College of Pharmaceutical Science Soochow UniversitySuzhou 215123China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650204China College of Traditional Chinese Medicine Yunnan University of Chinese MedicineKunming 650500China

Phorbol esters are recognized for their dual role as anti-HIV-1 agents and as activators of protein kinase C(PKC).The efficacy of phorbol esters in binding with PKC is attributed to the presence of oxygen groups at positions C20,C3/C4,and C9 of ***,the lipids located at positions C12/C13 are essential for both the anti-HIV-1 activity and the formation of the PKC-ligand *** influence of the cyclopropane ring at positions C13 and C14 in phorbol derivatives on their anti-HIV-1 activity requires further *** research entailed the hydrolysis of phorbol,producing seco-cyclic phorbol *** anti-HIV-1 efficacy of these derivatives was assessed,and the affinity constant(Kd)for PKC-δprotein of selected seco-cyclic phorbol derivatives was determined through isothermal titration *** findings suggest that the chemical modification of cyclopropanols could affect both the anti-HIV-1 activity and the PKC binding ***,compound S11,with an EC_(50) of 0.27μmol·L^(−1) and a CC_(50) of 153.92μmol·L^(−1),demonstrated a potent inhibitory effect on the intermediate products of HIV-1 reverse transcription(ssDNA and 2LTR),likely acting at the viral entry stage,yet showed no affinity for the PKC-δ*** results position compound S11 as a potential candidate for further preclinical investigation and for studies aimed at elucidating the pharmacological mechanism underlying its anti-HIV-1 activity.

关键词： seco-Cyclic phorbol derivatives Hydrolysis reaction Cyclopropane ring Esterification Anti-HIV-1 agent

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Wind power forecasting error-based dispatch method for wind farm cluster

引用

Journal of Modern Power Systems and Clean Energy 2013年第1期1卷 65-72页

作者： Ning chen qi WANG Liangzhong YAO lingzhi ZHU Yi TANG Fubao WU Mei chen Ningbo WANG China Electric Power Research Institute Nanjing 210003China Southeast University Nanjing 210096China China Electric Power Research Institute Beijing 100192China Gansu Electric Power Company Lanzhou 730050China

With the technical development of wind power forecasting,making wind power generation schedule in power systems become an inevitable *** paper proposes a new dispatch method for wind farm(WF)cluster by considering wind power forecasting errors.A probability distribution model of wind power forecasting errors and a mathematic expectation of the power shortage caused by forecasting errors are ***,the total mathematic expectation of power shortage from all WFs is *** study with respect to power dispatch in a WF cluster is conducted using forecasting and actual wind power data within 30 days from sites located at Gansu *** with the variable proportion method,the power shortage of the WF cluster caused by wind power forecasting errors is *** with the increment of wind power integrated into power systems,the method positively influences future wind power operation.

关键词： Wind power Dispatch Forecasting error Probabilistic distribution

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical treatment of bipolar segmental clavicle fracture:A case report

引用

World Journal of Clinical Cases 2022年第29期10卷 10529-10534页

作者： lin Liang Xin-Lei chen Ye chen Nian-Nian Zhang Department of Orthopedics Shangyu People’s Hospital of Shaoxing CityShaoxing 312000Zhejiang ProvinceChina Department of Orthopedics Haimen People’s HospitalNantong 226000Jiangsu ProvinceChina

BACKGROUND Shoulder injuries caused by trauma are common,including clavicle *** so,bipolar segmental fracture of the clavicle is extremely rare and seldom ***,there is still a controversial issue about how to treat these bipolar segmental clavicle *** SUMMARY A 56-year-old security guard arrived at our emergency room after falling on his electric *** was no loss of consciousness or other *** had no numbness in his fingers.X-rays and 3D computed tomography revealed that the patient’s right shoulder had a bipolar segmental clavicle *** surgical procedure included both open reduction and internal *** the 1-year follow-up,he had a full range of motion and minimal discomfort in the injured *** We provide a rare case of bipolar clavicle facture in the right *** hold the opinion that such patients would get better clinical and radiological outcomes by early and correct operation.

关键词： Bipolar segmental clavicle fracture Arm sling Open reduction and internal fixation Acromioclavicular hook plate Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improvement of visual acuity in children with anisometropic amblyopia treated with rotated prisms combined with near activity

引用

International Journal of Ophthalmology(English edition) 2013年第4期6卷 487-491页

作者： Chao-Chyun lin Po-Liang chen Amblyopia Training Cnter 2F No.143Sec.1Chongqing S.RdTaipei 100TaiwanChina Hau-Ming Eye Clinic Center No.199Zhongxing Rd.New Taipei City221TaiwanChina

·AIM: To evaluate the efficacy of a new modality for improving visual acuity (VA) in pediatric patients with anisometropic amblyopia. · METHODS: Retrospective and interventional case series. Medical records of 360 children with anisometropic amblyopia treated with a modality that included rotated prisms, lenses, and near activities from January 2008 to January 2012 were analyzed. Characteristics such as improvement of VA and contrast sensitivity in amblyopic eyes and resolution of amblyopia (VA ≤ 0.1logMAR or a difference of ≤ 2 lines in logMAR between the eyes) were assessed. ·RESULTS: Among the patients, the mean VA of the amblyopic eyes improved from 0.48logMAR (SD=0.16) to 0.12logMAR (SD =0.16) and the mean VA improvement was 0.36logMAR (SD =0.10, Pline VA may be related to success and shorten the time to amblyopic resolution. ·CONCLUSION: VA and contrast sensitivity improved with rotated prisms, correcting lenses, and near activities in children with anisometropic amblyopia. The VA improvement by this modality was comparable to other methods. However, the time to resolution of amblyopia was shorter with this method than with other modalities. Rotated prisms combined with near acuity could provide an alternative treatment in children with anisometropic amblyopia who can’t tolerant traditional therapy method like patching.

关键词： amblyopia near activity perceptual learning rotated prism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrated neural tracing and in-situ barcoded sequencing reveals the logic of SCN efferent circuits in regulating circadian behaviors

引用

Science China(Life Sciences) 2024年第3期67卷 518-528页

作者： Meimei Liao Xinwei Gao chen chen qi Li qingchun Guo He Huang Erquan Zhang Dapeng Ju College of Biological Sciences China Agriculture UniversityBeijing 100193China National Institute of Biological Sciences(NIBS) Beijing 102206China Chinese Institute for Brain Research Beijing 102206China School of Biomedical Engineering Capital Medical UniversityBeijing 100069China Department of Anesthesiology The Second Affiliated HospitalChongqing Medical UniversityChongqing 401336China Tsinghua Institute of Multidisciplinary Biomedical Research Tsinghua UniversityBeijing 102206China

The circadian clock coordinates rhythms in numerous physiological processes to maintain organismal homeostasis. Since the suprachiasmatic nucleus(SCN) is widely accepted as the circadian pacemaker, it is critical to understand the neural mechanisms by which rhythmic information is transferred from the SCN to peripheral clocks. Here, we present the first comprehensive map of SCN efferent connections and suggest a molecular logic underlying these projections. The SCN projects broadly to most major regions of the brain, rather than solely to the hypothalamus and thalamus. The efferent projections from different subtypes of SCN neurons vary in distance and intensity, and blocking synaptic transmission of these circuits affects circadian rhythms in locomotion and feeding to different extents. We also developed a barcoding system to integrate retrograde tracing with in-situ sequencing, allowing us to link circuit anatomy and spatial patterns of gene expression. Analyses using this system revealed that brain regions functioning downstream of the SCN receive input from multiple neuropeptidergic cell types within the SCN, and that individual SCN neurons generally project to a single downstream brain *** map of SCN efferent connections provides a critical foundation for future investigations into the neural circuits underlying SCNmediated rhythms in physiology. Further, our new barcoded tracing method provides a tool for revealing the molecular logic of neuronal circuits within heterogeneous brain regions.

关键词： circadian rhythms SCN output circuit neural tracing barcoded GFP in situ sequencing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A new diterpenoid alkaloid isolated from Delphinium caeruleum

引用

Chinese Journal of Natural Medicines 2017年第1期15卷 45-48页

作者： lin Chao-Zhan LIU Zhu-Jie BAIRI Zeren-Dawa ZHU chen-chen Institute of Clinical Pharmacology Guangzhou University of Chinese MedicineGuangzhou 510405China Tibetan Traditional Medical College Lasa 850000China

The present study was designed to determine the chemical constituents of Delphinium caeruleum Jacq. ex Camb.. The chemical constituents were isolated and purified by column chromatography with silica gel, ODS, and Sephadex LH-20. Their structures were elucidated by IR, MS, and NMR. Ten compounds were obtained and identified as caerudelphinine A(1), lycoctonine(2), talitine B(3), talitine A(4), talitine C(5), tatsienine-V(6), d-magnoflorine(7), 2-trimethyl-ammonio-3-(3-indolyl) propionate(8), vakhmatine(9), and delatisine(10). Compound 1 was a new lycoctonine-type C19-diterpenoid alkaloid, and compounds 4-10 were isolated from this plant for the first time.

关键词： Delphinium caeruleum Alkaloids Caerudelphinine A

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Serum Total Bilirubin and Risk of Progressing Diabetes:A Prospective Cohort Study

引用

Biomedical and Environmental Sciences 2021年第8期34卷 632-636页

作者： ZHANG Jie ZHANG Yin Fei HU Chun Yan ZHANG Yi qi Hong Yan lin lin XU Yu XU Min LU Jie Li BI Yu Fang WANG Wei qing NING Guang chen Yu Hong Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai National Center for Translational MedicineRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of Endocrinology Jiading Central HospitalShanghai University of Medicine&Health SciencesShanghai 201800China

Diabetes has become a serious public health concern worldwide,and China is the epidemic *** China,the prevalence of type 2 diabetes(T2D)was 11.6%among adults aged≥18 years[1].Cardiovascular disease(CVD)occurs earlier and with greater severity in patients with T2D than in individuals without T2D[2].Thus,potential risk factors for screening T2D are needed to prevent such poor clinical outcomes.

关键词： Diabetes Serum clinical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Pangenome of water caltrop reveals structural variations and asymmetric subgenome divergence after allopolyploidization

引用

Horticulture Research 2023年第11期10卷 168-179页

作者： Xinyi Zhang yang chen lingyun Wang Ye Yuan Mingya Fang lin Shi Ruisen Lu Hans Peter Comes Yazhen Ma Yuanyuan chen Guizhou Huang Yongfeng Zhou Zhaisheng Zheng Yingxiong qiu Systematic and Evolutionary Botany and Biodiversity Laboratory College of Life SciencesZhejiang UniversityHangzhou310058ZhejiangChina CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Wuhan Botanical GardenChinese Academy of SciencesWuhan430074HubeiChina Provincial Key Laboratory of Characteristic Aquatic Vegetable Breeding and Cultivation Jinhua Academy of Agricultural Sciences(Zhejiang Institute of Agricultural Machinery)Jinhua321000ZhejiangChina Jiaxing Academy of Agricultural Sciences Jiaxing314016ZhejiangChina Institute of Botany Jiangsu Province and Chinese Academy of SciencesNanjing 210014JiangsuChina Department of Environment&Biodiversity Salzburg UniversitySalzburg5020Austria State Key Laboratory of Tropical Crop Breeding Shenzhen BranchGuangdong Laboratory of Lingnan Modern AgricultureKey Laboratory of Synthetic BiologyMinistry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518124GuangdongChina

Water caltrop(Trapa spp.,Lythraceae)is a traditional but currently underutilized non-cereal ***,we generated chromosome-level genome assemblies for the two diploid progenitors of allotetraploid ***(4x,AABB),i.e.,diploid ***(2x,AA)and Trapa incisa(2x,BB).In conjunction with four published(sub)genomes of Trapa,we used gene-based and graph-based pangenomic approaches and a pangenomic transposable element(TE)library to develop Trapa genomic *** pangenome displayed substantial gene-content variationwith dispensable and private gene clusters occupying a large proportion(51.95%)of the total cluster sets in the six(sub)*** of presence-absence variation(PAVs)identified 40453 PAVs associated with 2570 genes specific to A-or B-lineages,of which 1428were differentially expressed,andwere enriched in organ development process,organic substancemetabolic process and response to *** genome analyses showed that the allotetraploid *** underwent asymmetric subgenome divergence,with the B-subgenome being more dominant than the *** factors,including PAVs,asymmetrical amplification of TEs,homeologous exchanges(HEs),and homeolog expression divergence,together affected genome evolution after ***,this study sheds lights on the genome architecture and evolution of Trapa,and facilitates its functional genomic studies and breeding program.

关键词： divergence evolution structural

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

S vacancy modulated Zn_(x)Cd_(1-x)S/CoP quantum dots for efficient H_(2) evolution from water splitting under visible light

引用

Journal of Energy Chemistry 2021年第10期30卷 210-218,I0007页

作者： qi Xie Min Wang Yong Xu Xiaoke Li Xin Zhou Liang Hong Luhua Jiang Wen-Feng lin Nanomaterials and Electrocatalysis Laboratory College of Materials and EngineeringQingdao University of Science and TechnologyQingdao 266042ShandongChina College of Environment and Chemical Engineering Dalian UniversityDalian Economic Technological Development ZoneDalian 116622LiaoningChina Department of Chemical Engineering Loughborough UniversityLoughborough LE113TULeicestershireUK

Energy band structure and interfacial compatibility of heterojunctions are crucial for photocatalysts in promoting photogene rated charge separation and ***,a combined strategy of vacancy engineering and quantum effect via a facile phosphating process is reported,for the first time,to modulate the energy band structure and the interface of Zn_(x)Cd_(1-x)S/CoP quantum dots(ZCS_(v)/CoP QDs)*** combined experimental and theoretical investigation revealed that phosphating process transformed CoO_(x) QDs to CoP QDs,and more importantly,generated considerable amount of sulfur vacancies in ZCS_(v).As a result,a TypeⅡZCS_(v)/CoP QDs heterojunction with compatible interfaces was constructed via in-situ generated P-Zn,P-Cd and S-Co bonds,which facilitated the separation and transfer of the photogenerated charge and thus resulted in a high ability towards hydrogen evolution under visible light(17.53 mmol g^(-1) h^(-1)).This work provides an effective and adaptable strategy to modulate band structure and interfacial compatibility of heterojunctions via vacancy engineering and quantum effect.

关键词： Visible light excited photocatalyst Heterojunction Zn_(x)Cd_(1-x)S/CoP quantum dot S vacancy engineering Photocatalytic hydrogen evolution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The chromosome-level genome of double-petal phenotype jasmine provides insights into the biosynthesis of floral scent

引用

Horticultural Plant Journal 2024年第1期10卷 259-272页

作者： xiangyu qi Huadi Wang Shuyun Liu Shuangshuang chen Jing Feng Huijie chen Ziyi qin Quanming chen Ikram Blilou Yanming Deng Jiangsu Key Laboratory for Horticultural Crop Genetic Improvement Institute of Leisure AgricultureJiangsu Academy of Agricultural SciencesNanjingJiangsu 210014China School of Life Sciences Jiangsu UniversityZhenjiangJiangsu 212013China College of Horticulture Nanjing Agricultural UniversityNanjingJiangsu 210014China Shanghai Personal Biotechnology Company Limited Shanghai 200231China Biological and Environmental Sciences and Engineering King Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia

Jasmine(Jasminum sambac Aiton)is a well-known cultivated plant species for its fragrant flowers used in the perfume industry and ***,the genetic basis of its floral scent is largely *** this study,using PacBio,Illumina,10×Genomics and highthroughput chromosome conformation capture(Hi-C)sequencing technologies,a high-quality chromosome-level reference genome for *** was obtained,exploiting a double-petal phenotype cultivar‘Shuangbanmoli’(JSSB).The results showed that the final assembled genome of JSSB is 580.33 Mb in size(contig N50=1.05 Mb;scaffold N50=45.07 Mb)with a total of 39618 predicted protein-coding *** analyses revealed that the JSSB genome has undergone an ancient whole-genome duplication(WGD)event at 91.68 million years ago(Mya).It was estimated that *** diverged from the lineage leading to Olea europaea and Osmanthus fragrans about 28.8 *** the basis of a combination of genomic,transcriptomic and metabolomic analyses,a range of floral scent volatiles and genes were identified involved in the benzenoid/phenylpropanoid and terpenoid biosynthesis *** results provide new insights into the molecular mechanism of its fragrance biosynthesis in jasmine.

关键词： Jasminum sambac Aiton Oleaceae Genome evolution Floral scent Terpene synthase

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：