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Mesenchymal stem cells and their derived exosomes for the treatment of COVID-19

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World Journal of Stem Cells 2024年第4期16卷 353-374页

作者： xiang-Yi hou La-Mu Danzeng Yi-Lin Wu Qian-Hui Ma Zheng Yu Mei-Ying Li Li-Sha Li The Key Laboratory of Pathobiology Ministry of EducationCollege of Basic Medical SciencesJilin UniversityChangchun 130021Jilin ProvinceChina Department of Pharmacy Jilin UniversityChangchun 130021Jilin ProvinceChina The First Hospital of Jilin University Jilin UniversityChangchun 130021Jilin ProvinceChina

Coronavirus disease 2019(COVID-19)is an acute respiratory infection caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).SARS-CoV-2 infection typically presents with fever and respiratory symptoms,which can progress to severe respiratory distress syndrome and multiple organ failure.In severe cases,these complications may even lead to death.One of the causes of COVID-19 deaths is the cytokine storm caused by an overactive immune response.Therefore,suppressing the overactive immune response may be an effective strategy for treating COVID-19.Mesenchymal stem cells(MSCs)and their derived exosomes(MSCs-Exo)have potent homing abilities,immunomodulatory functions,regenerative repair,and antifibrotic effects,promising an effective tool in treating COVID-19.In this paper,we review the main mechanisms and potential roles of MSCs and MSCs-Exo in treating COVID-19.We also summarize relevant recent clinical trials,including the source of cells,the dosage and the efficacy,and the clinical value and problems in this field,providing more theoretical references for the clinical use of MSCs and MSCs-Exo in the treatment of COVID-19.

关键词： COVID-19 Cytokine storm Immunomodulation Mesenchymal stem cell Mesenchymal stem cell-derived exosomes

Anti-fertility effect of levonorgestrel and/or quinestrol on striped field mouse(Apodemus agrarius):evidence from both laboratory and field experiments

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Integrative Zoology 2022年第6期17卷 1041-1052页

作者： Xiaoning CHEN xiang hou Tuo FENG Ning HAN Jing WANG Gang CHANG Shaanxi Key Laboratory for Animal Conservation Shaanxi Institute of ZoologyXi’anChina College of Life Sciences Shaanxi Normal UniversityXi’anChina

The effect of combined levonorgestrel(P)and quinestrol(E)on the fertility of stripedﬁeld mouse(Apodemus agrarius)has not been evaluated.We performed a series of experiments in both the laboratory andﬁeld to assess the effect of P and/or E on the fertility of A.agrarius.In the laboratory,to test the time-dependent anti-fertility ef-fects of P and E,as well as their mixtures,90 male stripedﬁeld mice were randomly assigned to 6 treatment groups(n=60),and a control group(n=30).Mice in 3 treatment groups were administered 1 of the 3 compounds(1 mg�kg–1[body weight]EP-1,0.34 mg�kg–1 E,0.66 mg�kg–1 P)for 3 successive days(another half for 7 suc-cessive days)via oral gavage;mice were then sacriﬁced 15 and 45 days after initiating the gavage treatment.Ourﬁndings indicated that E and EP-1 treatment,but not P or control treatment,signiﬁcantly decreased the sperm count in the caudal epididymis,as well as the weight of the testes,epididymides,and seminal vesicles.Additionally,fer-tile female mice mated with E-and EP-1-treated males produced smaller pups.These data indicate that E and EP-1 can induce infertility in male A.agrarius.In theﬁeld,the population density of A.agrarius was signiﬁcantly inﬂu-enced by EP-1,and the rodent density in the treatment group was lower than that in the control group.Overall,our results indicate that EP-1 is an effective contraceptive in A.agrarius,a dominant rodent species in the farmland.

关键词： Apodemus agrarius fertility control levonorgestrel quinestrol

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高管中“她力量”对企业风险承担的影响研究

产经评论 2024年第1期15卷 80-98页

作者：徐斯旸蔡丹仪项后军广东金融学院金融与投资学院中国工商银行股份有限公司广州分行

高管团队中“她力量”的企业治理效应受到越来越多关注。基于2003—2021年中国A股上市公司数据,实证分析女性高管参与对企业风险承担的影响及董事会会议效率在二者关系中的调节效应。结果显示:女性高管参与能够显著降低企业的风险承担水... 详细信息

高管团队中“她力量”的企业治理效应受到越来越多关注。基于2003—2021年中国A股上市公司数据,实证分析女性高管参与对企业风险承担的影响及董事会会议效率在二者关系中的调节效应。结果显示:女性高管参与能够显著降低企业的风险承担水平,且董事会会议效率强化了女性高管对企业风险承担的影响。进一步的异质性分析表明,女性高管对企业风险承担的抑制作用仅存在于高风险承担的企业中,且只有当女性高管拥有一定话语权时,其对企业风险承担的抑制作用才得以体现。基于此,企业可适当打破女性高管晋升途径中的隐形天花板,灵活运用女性高管的特质和能力,并充分重视董事会会议在企业发展过程中的治理效应,提高会议效率,使之发挥实质性作用。

关键词：女性高管企业风险承担董事会会议效率风险偏好

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Seed traits and rodent community interact to determine seed fate:evidence from both enclosure and field experiments

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Integrative Zoology 2021年第6期16卷 939-954页

作者： xiang hou Bo ZHANG Michael A.STEELE Ning HAN Tuo FENG Jing WANG Xiaoning CHEN Xiaolei AN Gang CHANG Shaanxi Key Laboratory for Animal Conservation Shaanxi Institute of ZoologyXi’anChina School of Biomedicine and Food Engineering Shangluo UniversityShangluoChina Department of Biology Wilkes UniversityWilkes-BarrePennsylvaniaUSA

Animal-mediated seed dispersal is an important ecological process in which a strong mutualism between animals and plants can arise.However,few studies have examined how a community of potential seed dispersers interacts with sympatric seed trees.We employed a series of experiments in the Qinling Mountains in both semi-natural enclosure and the field to assess the interactions among 3 sympatric rodent species and 3 Fagaceae tree seeds.Seed traits all showed similar tannin levels but markedly different physical traits and nutritional contents.We found that seeds with heavy weight,thick coat,and high nutritional contents were less likely to be eaten in situ but more often to be eaten after dispersal or hoarded by rodents.These results support both the handling time hypothesis and the high nutrition hypothesis.Surprisingly,we also found that rodents,maybe,preferred to consume seeds with low levels of crude fiber in situ,and to harvest and hoard those with high levels of crude fiber for later consumption.The sympatric rodent species,Cansumys canus,the largest rodent in our study,harvested and hoarded more Quercus variabilis seeds with high physical and nutritional traits,while Apodemus draco,the smallest rodent,harvested more Q.serrata seeds with low physical and nutritional traits,and Niviventer confucianus harvested and hoarded more Q.aliena seeds with medium physical and nutritional traits.Our study demonstrates that different seed traits play different roles in influencing the seed fate and the shaping of mutualism and predation interactions within a community of rodent species.

关键词： hoarding behavior seed dispersal seed fate seed traits semi-natural enclosure

Erratum to: Tannic acid coated single-wall carbon nanotube membranes for the recovery of Au from trace-level solutions

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Nano Research 2024年第4期17卷 3426-3426页

作者： Chunmei Wang Peng-xiang hou Yiming Zhao Chao Shi Jiangang Zhang An-Ping Wu Chang Liu Hui-Ming Cheng Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Analysis and Test Center Shenyang University of Chemical TechnologyShenyang 110142China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China School of Materials Science and Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Erratum to Nano Research,2023,16(8):11350–11357 https://***/10.1007/s12274-023-5803-y The article"Tannic acid coated single-wall carbon nanotube membranes for the recovery of Au from trace-level solutions",written by Chunmei Wang et al.,was erroneously originally published electronically on the publisher’s internet portal(currently SpringerLink)on 27 June 2023 with Fig.3(a).In Fig.3(a),the rejection of MWCNT is 38.9%instead of 98.3%.

关键词： carbon solutions coated

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地铁上盖匝道桥施工技术研究

建筑技术开发 2024年第6期51卷 110-112页

作者：王廷高达侯向阳济南轨道交通集团有限公司济南250000 中铁一局集团有限公司西安710000

在城市中修建地铁线路时,经常会面临复杂的地形和交通环境,盖匝道桥的施工技术研究旨在解决在城市复杂环境下地铁线路施工中的技术难题,提高施工质量和效率,保证地铁线路的正常运营。为保证匝道桥的安全性,需要严格把控施工质量,并尽量... 详细信息

在城市中修建地铁线路时,经常会面临复杂的地形和交通环境,盖匝道桥的施工技术研究旨在解决在城市复杂环境下地铁线路施工中的技术难题,提高施工质量和效率,保证地铁线路的正常运营。为保证匝道桥的安全性,需要严格把控施工质量,并尽量简化施工程序。结合某市地铁工程,对地铁车辆段上盖匝道桥预应力整体张拉施工技术展开分析,重点探讨预应力施工深化设计程序、预应力孔道摩阻试验以及预应力施工关键技术3个层面,旨在为同类型工程施工提供有益参考。

关键词：地铁车辆段预应力

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One-dimensional π-d conjugated coordination polymers: synthesis and their improved memory performance

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Science China Chemistry 2019年第6期62卷 753-760页

作者： Xue-Feng Cheng Jie Li xiang hou Jin Zhou Jing-Hui He Hua Li Qing-Feng Xu Na-Jun Li Dong-Yun Chen Jian-Mei Lu College of Chemistry Chemical Engineering and Materials Science Soochow University Shanghai Institute of Measurement and Testing Technology

Multilevel resistance random access memories(RRAMs) are intensively studied due to their potential applications in high density information storage. However, the low ternary device yields and high threshold voltages based on current materials cannot meet the requirement for applications. Improvement via material innovation remains desirable and challenging. Herein,five one-dimensional conjugated coordination polymers were synthesized via the reaction between metal ions(Zn^(2+), Cu^(2+), Ni^(2+),Pt^(2+) and Pd^(2+)) and 2,5-diaminobenzene-1,4-dithiol(DABDT) and fabricated into RRAM devices. The as-fabricated ternary memories have relatively low threshold voltages(V_(th1):-1 to-1.4 V, V_(th2):-1.8 to-2.2 V). Their ternary device yields were improved from 24% to 56%. The first and the second resistance switches are interpreted by the space charge limited current(SCLC) and grain boundary depletion limited current(GBLC) modes, respectively. The Pd-DABDT, which is of planar structure,smaller band gap and better crystallinity than others, shows the best performance among these five polymers. Our work paves a simple and efficient way to optimize the performance of ternary RRAM devices employing one-dimensional hybrid materials.

关键词： one-dimensional coordination polymer resistive random access memory ternary device yield low threshold voltages d-π conjugation

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边缘智能与协同计算:前沿与进展

控制与决策 2024年第7期39卷 2385-2404页

作者：侯祥鹏兰兰陶长乐寇小勇丛佩金邓庆绪周俊龙南京理工大学计算机科学与工程学院东北大学计算机科学与工程学院东南大学移动通信全国重点实验室

随着万物互联时代的到来,边缘设备规模急剧增加,海量数据在网络边缘产生,人工智能技术的飞速发展为分析和处理这些数据提供了强大的支撑.然而,传统云计算的集中处理模式难以满足用户对任务低时延和设备低功耗的需求,并带来数据隐私泄露... 详细信息

随着万物互联时代的到来,边缘设备规模急剧增加,海量数据在网络边缘产生,人工智能技术的飞速发展为分析和处理这些数据提供了强大的支撑.然而,传统云计算的集中处理模式难以满足用户对任务低时延和设备低功耗的需求,并带来数据隐私泄露的潜在隐患.与此同时,嵌入式高性能芯片的发展显著提升了边缘设备的计算能力,使其能够在边缘侧实时处理部分计算密集型任务.在此背景下,边缘计算和人工智能有机融合,孕育了一种新的计算范式:边缘智能.鉴于此,聚焦边缘智能与协同计算的前沿与进展,首先概述边缘计算、人工智能和边缘智能的相关背景、基本原理与发展趋势;然后从训练、推理和缓存3个方面回顾面向单个设备的边缘智能方法;接着从架构、技术和功能3个维度介绍多个设备合作实现边缘智能协同的相关工作;最后总结边缘智能在工业物联网、智慧城市和虚拟现实等领域的广泛应用.

关键词：边缘智能边缘设备边缘训练边缘推理边缘缓存协同计算

A Photoelectric-Stimulated MoS_(2) Transistor for Neuromorphic Engineering

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Research 2019年第1期2019卷 273-282页

作者： Shuiyuan Wang xiang hou Lan Liu Jingyu Li Yuwei Shan Shiwei Wu David Wei Zhang Peng Zhou ASIC&System State Key Lab. School of MicroelectronicsFudan UniversityShanghai 200433China Department of Physics State Key Laboratory of Surface PhysicsKey Laboratory of Micro and Nano Photonic Structures(Ministry of Education)and Institute for Nanoelectronic Devices and Quantum ComputingFudan UniversityShanghai 200433China

The von Neumann bottleneck has spawned the rapid expansion of neuromorphic engineering and brain-like networks.Synapses serve as bridges for information transmission and connection in the biological nervous system.The direct implementation of neural networks may depend on novel materials and devices that mimic natural neuronal and synaptic behavior.By exploiting the interfacial effects between MoS_(2) and AlOx,we demonstrate that an h-BN-encapsulated MoS_(2) artificial synapse transistor can mimic the basic synaptic behaviors,including EPSC,PPF,LTP,and LTD.Efficient optoelectronic spikes enable simulation of synaptic gain,frequency,and weight plasticity.The Pavlov classical conditioning experiment was successfully simulated by electrical tuning,showing associated learning behavior.In addition,h-BN encapsulation effectively improves the environmental time stability of our devices.Our h-BN-encapsulated MoS_(2) artificial synapse provides a new paradigm for hardware implementation of neuromorphic engineering.

关键词： tuning optoelectronic artificial