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中国循环杂志 2016年第Z1期31卷 -页

作者： Wengen zhu kui Hong The second af iliated hospitalto Nanchang University Jiangxi china

Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants

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Science China(Life Sciences) 2016年第8期59卷 825-831页

作者： Yue Jiao Yuzhou Zhang Yu-xian zhu State Key Laboratory of Protein and Plant Gene Research College of Life Sciences Peking University Center for Science and Technology Development Ministry of Agriculture

BARD1(BRCA1 associated RING domain protein 1), as an important animal tumor suppressor gene associated with many kinds of cancers, has been intensively studied for decades. Surprisingly, homolog of BARD1 was found in plants and it was renamed At ROW1(repressor of Wuschel-1) according to its extremely important function with regard to plant stem cell homeostasis. Although great advances have been made in human BARD1, the function of this animal tumor-suppressor like gene in plant is not well studied and need to be further elucidated. Here, we review and summarize past and present work regarding this protein. Apart from its previously proposed role in DNA repair, recently it is found essential for shoot and root stem cell development and differentiation in plants. The study of At ROW1 in plant may provide an ideal model for further elucidating the functional mechanism of BARD1 in mammals.

关键词： repressor of Wuschel-1 DNA repair stem cell niche

Single-Nucleotide Resolution Mapping of the Gossypium raimondii Transcriptome Reveals a New Mechanism for Alternative Splicing of Introns

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Molecular Plant 2014年第5期7卷 829-840页

作者： Qin Li Guanghui Xiao Yu-xian zhu State Key Laboratory of Protein and Plant Gene Research College of Life Sciences Peking University Beijing 100871 China National Center for Plant Gene Research (Beijing) Beijing 100101 China

Alternative splicing （AS） is a vital genetic mechanism that enhances the diversity of eukaryotic transcriptomes. Here, we generated 8.3 Gb high-quality RNA-sequencing data from cotton （Gossypium raimondii） and performed a systematic, comparative analysis of AS events. We mapped 85% of the RNA-sequencing data onto the reference genome and identified 154 368 splice junctions with 16 437 as events in 10197 genes. I ntron retention constituted the majority （40%） of all AS events in G. raimondii. Comparison across 11 eukaryote species showed that intron retention is the most common AS type in higher plants. Although transposable elements （TEs） were found in only 2.9% of all G. raimondii introns, they are present in 43% of the retained introns, suggesting that TE-insertion may be an important mechanism for intron retention during AS. The majority of the TE insertions are concentrated 0-40 nt upstream of the 3＇-splice site, substantially altering the distribution of branch points from preferred positions and reducing the efficiency of intron splicing by decreasing RNA secondary structure flexibility. Our data suggest that TE-insertion-induced changes in branch point-site distribution are important for intron retention-type AS. Our findings may help explain the vast differences in intron-retention frequencies between vertebrates and higher plants.

关键词： cotton RNA-seq alternative splicing transposable element intron retention.

Identification and Analyses of miRNA Genes in Allotetraploid Gossypium hirsutum Fiber Cells Based on the Sequenced Diploid *** Genome

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Journal of Genetics and Genomics 2012年第7期39卷 351-360页

作者： Qin Li xiang Jin Yu-xian zhu The State Key Laboratory of Protein and Plant Gene Research College of Life SciencesPeking UniversityBeijing 100871China National Center for Plant Gene Research(Beijing) Beijing 100101China

The plant genome possesses a large number of microRNAs （miRNAs） mainly 21-24 nucleotides in length. They play a vital role in regulation of target gene expression at various stages throughout the whole plant life cycle. Here we sequenced and analyzed ~ 10 million non-coding RNAs （ncRNAs） derived from fiber tissue of the allotetraploid cotton （Gossypium hirsutum） 7 days post-anthesis using ncRNA-seq technology. In terms of distinct reads, 24 nt ncRNA is by far the dominant species, followed by 21 nt and 23 nt ncRNAs. Using ab initio prediction, we identified and characterized a total of 562 candidate miRNA gene loci on the recently assembled D5 genome of the diploid cotton G. raimondii. Of all the 562 predicted miRNAs, 22 were previously discovered in cotton species and 187 had sequence conservation and homology to homologous miRNAs of other plant species. Nucleotide bias analysis showed that the 9th and 1st positions were significantly conserved among different types of miRNA genes. Among the 463 putative miRNA target genes, most significant up/down-regulation occurred in 10-20 days post-anthesis, indicating that miRNAs played an important role during the elongation and secondary cell wall synthesis stages of cotton fiber development. The discovery of new miRNA genes will help understand the mechanisms of miRNA generation and regulation in cotton.

关键词： Cotton Genome Micro RNA Deep sequencing Microarray

Long-term prognosis of low-risk neuroblastoma treated by surgery alone: an experience from a single institution of China

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World Journal of Pediatrics 2019年第2期15卷 148-152页

作者： Wei Yao Kai Li kui-Ran Dong Shan Zheng xian-Min Xiao Department of Pediatric Surgery Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China National Children's Medical Center 399 Wanyuan RoadShanghai 201102China

Background Low-risk neuroblastomas have favorable biologic *** Oncology Group (COG) proposed that surgical resection of the primary tumor was *** evaluated the long-term prognosis of surgery alone for patients with low-risk neuroblastoma in *** A total of 34 patients with low-risk neuroblastoma were treated in our center between Jan 2009 and Dec *** medical records of these patients were *** The primary lesion was located in the adrenal gland in 19 patients,the retroperitoneum in 5,the posterior mediastinum in 9 and the neck in *** tumor diameters and volumes were 1.80-10.0 cm (average 5.5 ±2.3 cm) and 1.28-424.10 cm3 (average 58.81 ± 92.00 cm3),*** stages of the patients were as follows:stage Ⅰ in 25,stage Ⅱ in 7,and stage Ⅳs in *** patients were in the low-risk group according to COG risk stratification *** patients showed MYCN *** primary tumors of all patients were completely *** adrenal tumors were completely resected by *** patients were successfully followed for 66-115 (average 89.71 ± 16.17) *** was observed in 4 *** addition to one local recurrence,another three recurrences were *** lesions were effectively controlled in all patients with *** patients survived,including 28 cases of tumor-free survival;the 4-year overall and event-free survival rates were both 100%.Conclusions Surgery alone is a safe and effective treatment strategy for low-risk *** lesions may be controlled and treated by rescue chemotherapy and surgery.

关键词： Low-risk Neuroblastoma Outcome Surgery

Release Behavior of Sulfur during Fluidized Bed Gasification

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Journal of Thermal Science 2021年第5期30卷 1731-1740页

作者： xian Shengxian ZHANG Haixia CHAI Zhen JIANG Denghao zhu Zhiping Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China

During fluidized bed gasification,sulfur in coal will be released,which will lead to environmental *** release behavior of sulfur in fluidized bed gasification has not been fully studied,although fluidized bed gasification technology has a promising *** the release behaviors of sulfur during fluidized bed gasification were investigated comprehensively through two aspects:temperature and reaction *** air gasification,the main gaseous sulfur is H_(2)S,followed by COS,and the yield of SO_(2)and CS_(2)is *** the increase of temperature,both of the released sulfur and the percentage of inorganic sulfur in gas phase *** the same working condition,the distributions of sulfur forms in gasification residues are *** sulfur is the dominate sulfur forms in the gasification *** in residues increases while organic sulfur decreases with increasing *** three reaction atmospheres(CO_(2)/steam/air)studied,the yield of H_(2)S is the most among the above four kinds of gaseous *** percentage of H_(2)S in gaseous sulfur(H_(2)S/Sg)is the highest in the process of steam gasification,while most sulfur is released during air *** sequencing of H_(2)/CO is the same as that of H_(2)S/Sg,while the trend of sulfur release rate is consistent with that of carbon conversion *** distributions of sulfur species in the fly ash of CO_(2)gasification and steam gasification are similar,while the sulfate content in the fly ash of air gasification is the highest.

关键词： released sulfur fluidized bed gasification temperature reaction atmosphere

New-onset diabetes secondary to acute pancreatitis:An update

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World Journal of Clinical Cases 2022年第30期10卷 10862-10866页

作者： xian-Qiang Yu Qian zhu Department of General Surgery Women's and Children’s Hospital Affiliated to Qingdao UniversityQingdao 266034Shandong ProvinceChina Department of Hepatobiliary and Pancreatic Surgery Zhongnan Hospital of Wuhan UniversityWuhan 430071Hubei ProvinceChina

Diabetes is a condition of persistent hyperglycemia caused by the endocrine disorder of the ***,all pancreatic diseases have the risk of *** particular,increasing attention has been paid recently to new-onset diabetes secondary to acute pancreatitis(AP).The complications of secondary diabetes have caused a lot of trouble for patients and have garnered increasing *** present,the pathophysiological mechanism of new-onset diabetes caused by AP is not *** review summarizes the current understanding of new-onset diabetes secondary to AP.

关键词： Acute pancreatitis New-onset diabetes β-cell Hyperglycemia

Plant polyploidy and evolution

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Journal of Integrative Plant Biology 2019年第1期61卷 4-6页

作者： Gai Huang Yu-xian zhu Institute for Advanced Studies Wuhan University

Polyploidy refers to two or more complete sets of chromosomes that are combined within a nucleus,and includes both autopolyploidy and allopolyploidy(Otto 2007).Polyploidy is a recurring theme in the evolutionary history of plants and it has been considered an important mechanism for speciation and also for adaptability to changing environments(Shimizu-Inatsugi et al.2017).In nature,about one-third of flowering plants are polyploids,and a great majority of them are *** are many cultivated allopolyploid species,such as cotton,Brassica and potato,the possible evolutionary history of which can be inferred with high certainty.

关键词： Polyploidy history

Research trends in electron-doped cuprate superconductors

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Science China(Physics,Mechanics & Astronomy) 2015年第10期58卷 1-11页

作者： YUAN Jie HE Ge YANG Hua SHI YuJun zhu BeiYi JIN kui Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences

In this review, we look back on some intriguing and puzzling issues in electron-doped cuprate superconductors, such as electron-hole asymmetry, two types of carriers, quantum critical points, order-parameter symmetry, etc. The necessity of study on this family is invoked in comparison with the hole-doped counterparts from several aspects. The related progress, especially in last few years, has been outlined point to point, as well as other hot topics like the discovery of ambipolar superconductors, the applications in superconducting electronics, and the emergency of superconductivity in parent compounds. In perspective, the utilization of blooming advanced techniques, electric double layer transistor and combinatorial film deposition, will bring some new insights into the mechanism such as electron-doped cuprate superconductors.

关键词： electron-doped electronic structure quantum critical phenomena

ACPA-CD147 axis in the NLRP3 inflammasome of RA macrophages

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Cellular & Molecular Immunology 2022年第8期19卷 957-959页

作者： kui Zhang Yan Zheng Zhaohui Zheng Ping zhu Department of Clinical Immunology Xijing HospitalFourth Military Medical UniversityXi'anShaanxiPR China National Translational Science Center for Molecular Medicine Xi'anShaanxiPR China

In a recent publication in Cellular and Molecular Immunology,DONG et *** new data from rheumatoid arthritis(RA)patients with or without anti-citrullinated peptide/protein antibodies(ACPAs),linking the ACPA-CD147 axis in macrophages to the inflammasome-related pathogenesis of this disease[1].In this commentary,the findings regarding the ACPA-CD147 axis will be discussed,with accumulating evidence for the important roles of macrophage inflammasomes in RA pathogenesis.

关键词： NLRP3 inflam CD147