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Science China(Life Sciences) 2024年第5期67卷 1027-1034页

作者： Xiaolong Qi Lu Zhang Qiulin Zhao Peng Zhou Sai xian Zhang jingjin Li Zhuqing Zheng Yue xiang Xueting Dai Zhe jin Yaobang Jian Xinyun Li Liangliang Fu Shuhong Zhao Key Lab of Agricultural Animal Genetics Breeding and Reproduction of Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of AgricultureCollege of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China The Cooperative Innovation Center for Sustainable Pig Production Wuhan 430070China Hubei Hongshan Laboratory Frontiers Science Center for Animal Breeding and Sustainable ProductionWuhan 430070China

Protein-mediated chromatin interactions can be revealed by coupling proximity-based ligation with chromatin ***,these techniques require complex experimental procedures and millions of cells per experiment,which limits their widespread application in life science ***,we develop a novel method,Hi-Tag,that identifies high-resolution,long-range chromatin interactions through transposase tagmentation and chromatin proximity ligation(with a phosphorothioate-modified linker).Hi-Tag can be implemented using as few as 100,000 cells,involving simple experimental procedures that can be completed within 1.5 ***,Hi-Tag is capable of using its own data to identify the binding sites of specific proteins,based on which,it can acquire accurate interaction *** results suggest that Hi-Tag has great potential for advancing chromatin interaction studies,particularly in the context of limited cell availability.

关键词： Hi-Tag chromatin interactions transposase tagmentation chromatin proximity ligation low cell numbers

Application of UiO-66 and its composites for remediation and resource recovery of typical environmental contaminants:a review

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Rare Metals 2024年第6期43卷 2498-2526页

作者： Hui-Min Zhang Yun-Long Wang Xin-Feng Zhu Zhen-Zhen Huang Dan-Dan Pang Kai Wang Chao-Hai Wang Zhong-xian Song Shi-Qiang Yin Lin-Lin Chang jin-Hui Zhang School Infirmary Henan University of Urban ConstructionPingdingshan 467036China Faculty of Environmental and Municipal Engineering Henan Key Laboratory of Water Pollution Control and Rehabilitation TechnologyKey Laboratory of Carbon Emission Reduction and Combined Air Pollution Control TechnologyHenan University of Urban ConstructionPingdingshan 467036China School of Resources&Environment Collaborative Innovation Center of Coalbed Methane and Shale Gas for Central Plains Economic RegionHenan Polytechnic UniversityJiaozuo 454003China The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters Ministry of EducationGuangzhou Higher Education Mega CentreSouth China University of TechnologyGuangzhou 510006China

UiO-66 series metal-organic framework materials(MOFs)are typical porous materials assembled by Zr^(4+) with a large mass-to-nucleus ratio and terephthalic acid ligands,which form tetrahedral and octahedral cages arranged in a periodic triangular window *** to the strong interaction between Zr and O,UiO-66 series MOFs exhibit high thermal stability,structural stability,and chemical *** article mainly reviews the applications of UiO-66 and its composites in adsorption,photocatalysis,and resource utilization,while exploring the harm of pollutants to human health and the *** the first part,the differences in adsorption and removal mechanisms of liquid organic pollutants,heavy metals,and volatile organic compounds(VOCs)are *** results show that organic pollutants are mainly removed by physical adsorption,electrostatic interactions,hydrogen bonding,andπ-πinteractions,while heavy metals are mainly removed by chemical adsorption,electrostatic interactions,reduction,and *** are mainly removed by the pore volume and pore size structure of the *** catalysis can achieve non-toxic treatment of pollutants,and this study mainly focuses on UiO-based composite materials constructed by strategies such as semiconductor composites,ion doping,and metal/dye *** the second part,the synergistic effect between the components of UiO-based composite materials promotes the oriented and rapid separation and transfer of earriers at the material interface,thereby promoting the generation of active species such as h^(+),·O_(2)^(-) and·OH,and achieving rapid degradation of pollutants and detoxification of heavy *** the third part,heterojunctions can realize the resource utilization of pollutants in water and air,producing energy-type substances such as hydrogen and methanol while solving environmental *** addition,this article also summarizes the harm of common typical pollutants to the environment

关键词： UiO Adsorption Photocatalysis Environmental pollution Resource recovery

Diagnostic performance of intravascular ultrasound-based fractional flow reserve in evaluating of intermediate left main stenosis

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Journal of Geriatric Cardiology 2024年第1期21卷 34-43页

作者： Yong-Gang SUI Cheng yang Chang-Dong GUAN Yan-Lu XU Na-Qiong WU Wei-xian yang Yong-Jian WU Ke-Fei DOU Yue-jin yang Shu-Bin QIAO Wei YU Bo XU Sheng-xian TU Jie QIAN Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Catheterization Laboratories Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Biomedical Instrument Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina National Clinical Research Center for Cardiovascular Diseases BeijingChina

BACKGROUND The recently introduced ultrasonic flow ratio(UFR),is a novel fast computational method to derive fractional flow reserve(FFR)from intravascular ultrasound(IVUS)*** the present study,we evaluate the diagnostic performance of UFR in patients with intermediate left main(LM)*** This is a prospective,single center study enrolling consecutive patients with presence of intermediated LM lesions(diameter stenosis of 30%-80%by visual estimation)underwent IVUS and FFR *** independent core laboratory assessed offline UFR and IVUS-derived minimal lumen area(MLA)in a blinded *** Both UFR and FFR were successfully achieved in 41 LM patients(mean age,62.0±9.9 years,46.3%diabetes).An acceptable correlation between UFR and FFR was identified(r=0.688,P50%(AUC=0.66,P<0.001)and numerically higher than IVUS-derived MLA(AUC=0.82;P=0.09).Patient level diagnostic accuracy,sensitivity and specificity for UFR to identify FFR≤0.80 was 82.9%(95%CI:70.2-95.7),93.1%(95%CI:82.2-100.0),58.3%(95%CI:26.3-90.4),*** In patients with intermediate LM diseases,UFR was proved to be associated with acceptable correlation and high accuracy with pressure wire-based FFR as standard *** present study supports the use of UFR for functional evaluation of intermediate LM stenosis.

关键词： stenosis flow fractional

FDX1 as a novel biomarker and treatment target for stomach adenocarcinoma

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1803-1824页

作者： xian-Ze Xie Lei Zuo Wei Huang Qiao-Mei Fan Ya-Yun Weng Wen-Dong Yao Jia-Li Jiang Jia-Qi jin Department of Pharmacy The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Chinese Medicine)Hangzhou 310018Zhejiang ProvinceChina Anhui Province Huainan City Shou County Agricultural Machinery Affairs Management Center Huainan 232200Anhui ProvinceChina

BACKGROUND Stomach adenocarcinoma(STAD)is one of the main reasons for cancer-related deaths *** investigation aimed to define the connection between STAD and Cuproptosis-related genes(CRGs).Cuproptosis is a newly identified form of mitochondrial cell death triggered by *** To explore the identification of potential biomarkers for STAD disease based on *** A predictive model using Gene Ontology(GO),Least Absolute Shrinkage and Selection Operator(LASSO),Kyoto Encyclopedia of Genes and Genomes(KEGG),Gene Set Variation Analysis(GSVA),and Gene Set Enrichment Analysis analyzed gene interconnections,focusing on 3 copper-related genes and their expression in The Cancer Genome *** for mRNA-miRNA and mRNA-transcription factor interactions were *** prognostic significance of CRG scores was evaluated using time-receiver operating characteristic,Kaplan-Meier curves,and COX regression *** was conducted with datasets GSE26942,GSE54129,and *** of copper-related differ-entially expressed genes was also analyzed in various human tissues and gastric cancer subpopulations using the human protein *** Three significant genes(FDX1,LIAS,MTF1)were identified and selected via LASSO analysis to predict and classify individuals with STAD into high and low CRG score *** genes were down-regulated in both risk *** and KEGG analyses highlighted their involvement mainly in the electron transport *** validating their differential expression,FDX1 emerged as the most accurate diagnostic marker for gastric ***,the RCircos package localized FDX1 on chromosome *** Our study revealed that FDX1 could be a potential biomarker and treatment target for gastric malignancy,providing new ideas for further scientific research.

关键词： Stomach adenocarcinoma disease Copper death FDX1 prognostic biomarkers Cuproptosis-related genes

Characterization and Quantum Chemistry Calculation of Fluorinating Activity of N-F Reagents

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Characterization and Quantum Chemistry Calculation of Fluori...

Assessment of perianal fistulizing Crohn’s disease activity with endoanal ultrasound: A retrospective cohort study

中国化学会第十二届全国氟化学会议

作者： Qing-yang Hu Yan Zhang Fu-Li Chen xian-jin yang~* Key Laboratory for Advanced Materials and Institute of Fine Chemicals East China University of Science and Technology 130 Meilong Road Shanghai 200237 China Key Laboratory for Advanced Materials and Institute of Fine Chemicals East China University of Science and Technology 130 Meilong Road Shanghai 200237 China

＜正＞N-F electrophilic fluorinating agents has had a more and more application because of their good selectivity and strong fluorinating ***,we have synthesized several NFSI analogues（1-9） and tested their fluorinating reactivity by cyclic voltammetry according to the literature,the results indicated that their reduction potentials display positive

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2494-2502页

作者： Na Hong Wei-Yong Liu jin-Long Zhang Kai Qian Jie Liu xian-Jun Ye Fei-Yan Zeng Yue Yu Kai-Guang Zhang Cheeloo College of Medicine Shandong UniversityJinan 250012ShandongChina Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Division of Life Sciences and Medicine University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Ultrasound Medicine The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Rehabilitation Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina

BACKGROUND Perianal fistulas pose dual challenges to Crohn's disease(CD)*** patient compliance due to the complexity of existing examination methods plagues the treatment and follow-up management of perianal *** To determine the accuracy of endoanal ultrasound(EUS)and shear wave elastography(SWE)for evaluating perianal fistulizing CD(PFCD)*** This was a retrospective cohort study.A total of 67 patients from August 2022 to December 2023 diagnosed with CD were divided into three groups:Non-anal fistula group(n=23),low-activity perianal fistulas[n=19,perianal disease activity index(PDAI)≤4],high-activity perianal fistulas(n=25,PDAI>4)based on the *** patients underwent assessments including EUS+SWE,pelvic magnetic resonance[pelvic magnetic resonance imaging(MRI)],C-reactive protein,fecal calprotectin,CD activity index,*** The percentage of fistulas indicated by pelvic MRI and EUS was consistent at 82%,and there was good consistency in the classification of perianal fistulas(Kappa=0.752,P<0.001).Significant differences were observed in the blood flow Limberg score(χ^(2)=8.903,P<0.05)and shear wave velocity(t=2.467,P<0.05)between group 2 and *** wave velocity showed a strong negative correlation with magnetic resonance novel index for fistula imaging in CD(Magnifi-CD)score(r=-0.676,P<0.001),a weak negative correlation with the PDAI score(r=-0.386,P<0.05),and a weak correlation between the Limberg score and the PDAI score(r=0.368,P<0.05).CONCLUSION EUS combined with SWE offers a superior method for detecting and quantitating the activity of perianal fistulas in CD *** may be the ideal tool to assess PFCD activity objectively for management strategies.

关键词： Endoanal ultrasound Shear wave elastography Perianal fistulizing Crohn’s disease Perianal disease activity index

Optical facet coatings for high-performance LWIR quantum cascade lasers atλ∼8.5μm

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红外与毫米波学报 2024年第4期43卷 497-502页

作者： MA Yuan LIN Yu-Zhe WAN Chen-yang WANG Zi-xian ZHOU Xu-Yan ZHANG jin-Chuan LIU Feng-Qi ZHENG Wan-Hua Laboratory of Solid-State Optoelectronics Information Technology Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Weifang Academy of Advanced Opto-Electronic Circuits Weifang 261021China

We report on the performance improvement of long-wave infrared quantum cascade lasers(LWIR QCLs)by studying and optimizing the anti-reflection(AR)optical facet *** to the Al2O3 AR coat⁃ing,the Y_(2)O_(3)AR coating exhibits higher catastrophic optical mirror damage(COMD)level,and the optical facet coatings of both material systems have no beam steering effect.A 3-mm-long,9.5-μm-wide buried-heterostruc⁃ture(BH)LWIR QCL ofλ~8.5μm with Y_(2)O_(3)metallic high-reflection(HR)and AR of~0.2%reflectivity coating demonstrates a maximum pulsed peak power of 2.19 W at 298 K,which is 149%higher than that of the uncoated *** continuous-wave(CW)operation,by optimizing the reflectivity of the Y_(2)O_(3)AR coating,the maximum output power reaches 0.73 W,which is 91%higher than that of the uncoated device.

关键词： quantum cascade lasers long-wave infrared optical facet coatings catastrophic optical mirror damage

Effect of combination of ultraviolet radiation and biocide on fungal-induced corrosion of high-strength 7075 aluminum alloy

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Transactions of Nonferrous Metals Society of China 2024年第9期34卷 2787-2799页

作者： Zheng-yu jin Chao WANG Hai-xian LIU Hong-wei LIU School of Chemical Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China

The effect of ultraviolet(UV)radiation and biocide benzalkonium chloride(BKC)on fungal-induced corrosion of AA7075 induced by Aspergillus terreus(***)was deeply studied using analysis of biological activity,surface analysis,and electrochemical *** demonstrated that the planktonic and sessile spore concentrations decline by more than two orders of magnitude when UV radiation and BKC are combinedly used compared with the *** radiation can inhibit the biological activity of *** and influence the stability of passive film of *** for direct disinfection,the physical adsorption of BKC on the specimen can effectively inhibit the attachment of *** combination of UV radiation and BKC can much more effectively inhibit the corrosion of AA,especially pitting corrosion,due to their synergistic *** combined application of UV radiation and BKC can be a good method to effectively inhibit fungal-induced corrosion.

关键词： fungal-induced corrosion Aspergillus terreus 7075 aluminum alloy ultraviolet radiation benzalkonium chloride

演艺业与科技产业融合能否提升演艺业生产效率?——基于中国省域数据的实证研究

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经济问题 2024年第6期 91-98页

作者：武金爽杨敏娴张涛山西财经大学文化旅游与新闻艺术学院山西太原030032 中国海洋大学管理学院山东青岛266100 四川大学物理学院四川成都610064 中共汕头市委党校管理学教研室广东汕头515071

演艺业与科技产业融合是解决演艺业“成本病”的重要抓手。基于我国省域数据,对演艺业与科技产业融合能否提升演艺业生产效率进行了实证检验。结果表明:演艺业与科技产业融合对演艺业生产效率具有提升效应,且主要是通过促进技术效率来... 详细信息

演艺业与科技产业融合是解决演艺业“成本病”的重要抓手。基于我国省域数据,对演艺业与科技产业融合能否提升演艺业生产效率进行了实证检验。结果表明:演艺业与科技产业融合对演艺业生产效率具有提升效应,且主要是通过促进技术效率来提升演艺业生产效率;演艺业与科技产业融合对国有与非国有演艺组织生产效率均具有正向影响,但是对于国有演艺组织的正向影响更为显著;分地区来看,东部地区演艺业与科技产业融合对演艺业生产效率的提升效应最强,中部次之,西部最弱。为此,我国可进一步完善促进演艺业与科技产业融合的政策及其保障措施,积极培育演艺企业集团,推进跨区域合作,使演艺业与科技产业融合联动发展。

关键词：产业融合生产效率演艺业成本病

A tectono-thermal perspective on the petroleum generation,accumulation and preservation in the southern Ordos Basin, North China

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Petroleum Science 2024年第3期21卷 1459-1473页

作者： Peng yang Zhan-Li Ren jin-Hua Fu Hong-Ping Bao Hui Xiao Zheng Shi Kun Wang Yuan-Yuan Zhang Wen-Hui Liu Wen-Hou Li State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an710069ShanxiChina National Engineering Laboratory for Exploration and Development of Low-Permeability Oil and Gas Fields Exploration and Development Research Institute of PetroChina Changqing Oilfield CompanyXi'an710018ShaanxiChina Shaanxi Key Lab of Petroleum Accumulation Geology School of Earth Science and EngineeringXi'an Shiyou UniversityXian710065ShaanxiChina Wuxi Research Institute of Petroleum Geology Petroleum Exploration and Production Research InstituteSINOPECWuxi214126JiangsuChina

The southern Ordos Basin has excellent petroleum exploration ***,the tectono-thermal history and the controls on petroleum generation,accumulation and preservation conditions in southern basin are *** this study,we analyzed the present geothermal field,paleo-geothermal gradient,maturity of the hydrocarbon source rocks,uplift and cooling process and tectono-thermal evolution *** the study area,for the Ordovician,Permain and the Triassic strata,the present temperature is low(3070℃)in the southeastern area but high(80140℃)in the northwestern *** paleogeothermal gradient varied from 24℃/km to 30℃/km with a heat flow of 58—69 m W/m^(2)(i.e.,a medium-temperature basin).The paleo-temperatures are higher than the present temperatures and the maximum paleo-temperatures controlled the thermal maturity of the source *** vitrinite reflectance(Ro)values of the Triassic strata are>0.7%and the thermal maturity reached the middlemature oil generation *** Rovalues of the Permian-Ordovician strata are>1.8%and the thermal maturity reached the over-mature gas generation *** southern Ordos Basin has experienced the multiple tectonic events at the Late Ordovician Caledonian(452 Ma),Late Triassic(215 Ma),Late Jurassic(165160 Ma),End-Early Cretaceous(110100 Ma)and Cenozoic(since 40 Ma).A large-scale tectonothermal event occurred at the End-Early Cretaceous(110100 Ma),which was controlled by lithospheric extension,destruction and *** event led to the highest paleo-temperatures and thermal maturities and coeval with the peak period of petroleum generation and *** southern Ordos Basin has undergone rapid and large-scale uplift since the Late Cretaceous due to expansion of the northeastern margin of the Tibetan Plateau,uplift of the Qinling orogenic belt and thrust faulting in the Liupanshan tectonic *** southern Ordos Basin experienced tectonic overprinting that was strong in the south and weak in the *** str

关键词： Fission-track dating Vitrinitereflectance Geothermal field Tectono-thermal evolution Petroleum geology Ordos Basin