检索结果-南通市图书馆

A Comprehensive Study of the Association between LEPR Gene rs1137101 Variant and Risk of Digestive System Cancers

Biomedical and Environmental Sciences 2024年第5期37卷 445-456页

作者： hu Wei Qiong ZHOU Wei Guang ZHOU Guang Wei LIAO Jia Xi SHI Jia Xing XIE FengYang LI Shou Heng WANG Yong FENG xian Hong GU Xiu Li CHEN Bi Feng Department of Biological Science and Technology School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430070HubeiChina Institute of WUT-AMU Wuhan University of TechnologyWuhan 430070HubeiChina Department of Clinical Laboratory Wuhan Xinzhou District People’s HospitalWuhan 430499HubeiChina Department of Reproductive Genetics Wuhan Huake Reproductive HospitalWuhan 430013HubeiChina

Objective The leptin receptor,encoded by the LEPR gene,is involved in tumorigenesis.A potential functional variant of LEPR,rs1137101(Gln223Arg),has been extensively investigated for its contribution to the risk of digestive system(DS)cancers,but results remain conflicting rather than ***,we performed a case–control study and subsequent meta-analysis to examine the association between rs1137101 and DS cancer *** A total of 1,727 patients with cancer(gastric/liver/colorectal:460/480/787)and 800 healthy controls were *** of rs1137101 was conducted using a polymerase chain reactionrestriction fragment length polymorphism(PCR-RFLP)assay and confirmed using Sanger ***-four eligible studies were included in the *** After Bonferroni correction,the case–control study revealed that rs1137101 was significantly associated with the risk of liver cancer in the hubei Chinese *** meta-analysis suggested that rs1137101 is significantly associated with the risk of overall DS,gastric,and liver cancer in the Chinese *** The LEPR rs1137101 variant may be a genetic biomarker for susceptibility to DS cancers(especially liver and gastric cancer)in the Chinese population.

关键词： LEPR gene rs1137101 Digestive system cancers Genetic susceptibility Meta-analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The prognostic value of collateral circulation in coronary chronic total occlusion underwent percutaneous coronary intervention

引用

Journal of Geriatric Cardiology 2024年第2期21卷 232-241页

作者： Xiao-Ying hu Wei-xian YANG Chang-Dong GUAN Li-hua XIE Ke-Fei DOU Yong-Jian WU Jin-Qing YUAN Jie QIAN Yue-Jin YANG Shu-Bin QIAO Lei SONG Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina National Clinical Research Center for Cardiovascular Diseases BeijingChina Catheterization Laboratories Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

BACKGROUND The prognostic value of coronary collateral circulation(CC)in patients undergoing chronic total occlusion(CTO)percutaneous coronary intervention(PCI)is *** purpose of the study was to assess the prognostic value of current two CC grading systems and their association with long-term outcomes in patients with CTO underwent *** We consecutively enrolled patients with single-vessel CTO underwent PCI between January 2010 and *** patients were categorized into well-developed or poor-developed collaterals group according to angiographic Werner's CC(grade 2 *** 0–1)or Rentrop(grade 3 *** 0–2)grading *** primary endpoint was 5-year cardiac *** Of 2452 enrolled patients,the overall technical success rate was 74.1%.Well-developed collaterals were present in686 patients(28.0%)defined by Werner's CC grade 2,and in 1145 patients(46.7%)by Rentrop grade *** to Werner's CC grading system,patients with well-developed collaterals had a lower rate of 5-year cardiac death compared with those with poordeveloped collaterals(1.6%vs.3.3%,P=0.02),those with suboptimal recanalization was associated with higher rate of 5-year cardiac death compared with optimal recanalization(4.7%vs.0.8%,P=0.01)and failure patients(4.7%vs.1.6%,P=0.12).However,the similar effect was not shown in Rentrop grading *** In patients with the single-vessel CTO underwent PCI,well-developed collaterals by Werner's CC definition were associated with lower rate of 5-year cardiac ***'s CC grading system had a greater prognostic value than Rentrop grading system in patients with CTO underwent PCI.

关键词： coronary collateral occlusion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Severe pediatric COVID‑19:a review from the clinical and immunopathophysiological perspectives

引用

World Journal of Pediatrics 2024年第4期20卷 307-324页

作者： Yi‑Kan Sun Can Wang Pei‑Quan Lin Lei hu Jing Ye Zhi‑gang Gao Ru Lin Hao‑Min Li Qiang Shu Li‑Su huang Lin‑hua Tan Children's Hospital Zhejiang University School of MedicineHangzhou 310052China The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310030China Surgical Intensive Care Unit Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of General Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Cardiopulmonary and Extracorporeal Life Support Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Clinical Data Center Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Cardiac Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310052China National Clinical Research Center for Child Health Children’s HospitalZhejiang University School of MedicineHangzhou 310052China Department of Infectious Diseases Children’s HospitalZhejiang University School of MedicineHangzhou 310052China

Background Coronavirus disease 2019(COVID-19)tends to have mild presentations in ***,severe and critical cases do arise in the pediatric population with debilitating systemic impacts and can be fatal at times,meriting further attention from ***,the intricate interactions between the pathogen virulence factors and host defense mechanisms are believed to play indispensable roles in severe COVID-19 pathophysiology but remain incompletely *** sources A comprehensive literature review was conducted for pertinent publications by reviewers independently using the PubMed,Embase,and Wanfang *** keywords included“COVID-19 in children”,“severe pediatric COVID-19”,and“critical illness in children with COVID-19”.Results Risks of developing severe COVID-19 in children escalate with increasing numbers of co-morbidities and an unvaccinated *** respiratory distress stress and necrotizing pneumonia are prominent pulmonary manifestations,while various forms of cardiovascular and neurological involvement may also be *** immunological processes are implicated in the host response to COVID-19 including the type I interferon and inflammasome pathways,whose dysregulation in severe and critical diseases translates into adverse clinical *** inflammatory syndrome in children(MIS-C),a potentially life-threatening immune-mediated condition chronologically associated with COVID-19 exposure,denotes another scientific and clinical conundrum that exemplifies the complexity of pediatric *** the considerable dissimilarities between the pediatric and adult immune systems,clinical trials dedicated to children are lacking and current management recommendations are largely adapted from adult *** Severe pediatric COVID-19 can affect multiple organ *** dysregulated immune pathways in severe COVID-19 shape the disease course,epitomize the vast functional diversity of the

关键词： Immunopathophysiology MIS-C Pediatric critical care Severe pediatric COVID-19

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Survey Study of Kindergarten Teachers’Use of ChatGPT to Support Instructional Design

引用

教育技术与创新 2024年第3期6卷 47-55页

作者： Wanlin Chen Yali Wang Lailin hu gang Yang School of Education Wenzhou UniversityChina

With the rapid development of information technology,Artificial Intelligence(AI)is gradually applied to a wide range of fields,especially the powerful ability of ChatGPT to bring infinite possibilities for education,but teachers’attitudes toward using it are not yet *** study investigates the use of ChatGPT by kindergarten teachers to support instructional design using questionnaires and interviews to explore the attitudes and perceptions of kindergarten teachers toward its *** results indicate that kindergarten teachers hold positive preferences for technology acceptance,perceived self-efficacy,and learning attitudes toward using ChatGPT for instructional ***,the study argues that more research is needed in the future to focus on how kindergarten teachers can aptly use ChatGPT to improve the quality of instruction in realistic instructionenvironments.

关键词： Kindergarten Teachers ChatGPT Instructional Design Survey Study STEM

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of Nonbreaking Wave-Induced Mixing Parameterization Schemes Based on a One-Dimensional Ocean Model

引用

Journal of Ocean University of China 2024年第3期23卷 567-576页

作者： TANG Ran huANG Chuanjiang DAI Dejun WANG gang The First Institute of Oceanography Ministry of Natural ResourcesQingdao 266061China Laboratory for Regional Oceanography and Numerical Modeling Laoshan LaboratoryQingdao 266237China Shandong Key Laboratory of Marine Science and Numerical Modeling Qingdao 266061China

Surface waves have a considerable effect on vertical mixing in the upper *** the past two decades,the vertical mixing induced through nonbreaking surface waves has been used in ocean and climate models to improve the simulation of the upper *** far,several nonbreaking wave-induced mixing parameterization schemes have been proposed;however,no quantitative comparison has been performed among *** this paper,a one-dimensional ocean model was used to compare the performances of five schemes,including those of Qiao et al.(Q),hu and Wang(HW),huang and Qiao(HQ),Pleskachevsky et al.(P),and Ghantous and Babanin(GB).Similar to previous studies,all of these schemes can decrease the simulated sea surface temperature(SST),increase the subsurface temperature,and deepen the mixed layer,thereby alleviating the common thermal deviation problem of the ocean model for upper ocean *** these schemes,the HQ scheme exhibited the weakest wave-induced mixing effect,and the HW scheme exhibited the strongest effect;the other three schemes exhibited roughly the same *** particular,the Q and P schemes exhibited nearly the same *** the simulation based on observations from the Ocean Weather Station Papa,the HQ scheme exhibited the best performance,followed by the Q *** the experiment with the HQ scheme,the root-mean-square deviation of the simulated SST from the observations was 0.43℃,and the mixed layer depth(MLD)was 2.0 *** a contrast,the deviations of the SST and MLD reached 1.25℃ and 8.4 m,respectively,in the experiment without wave-induced mixing.

关键词： wave-induced mixing surface waves sea surface temperature mixed layer depth General Ocean Turbulence Model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dissection of molecular mechanisms of liver injury induced by microcystin-leucine arginine via single-cell RNA-sequencing

引用

Journal of Environmental Sciences 2024年第11期145卷 164-179页

作者： Yunmeng Bai Yali Song Miaoran Li Jinhuan Ou Hong hu Nan Xu Min Cao SiyuWang Lin Chen Guangqing Cheng Zhijie Li gang Liu Jigang Wang Wei Zhang Chuanbin Yang Dongguan Maternal and Child Health Care Hospital Postdoctoral Innovation Practice Base of Southern Medical UniversityDongguan 523125China Department of Rehabilitation Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Division of Thyroid and Breast Surgery Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China Faculty of Brain Sciences University College LondonWC1E 6BTUK State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China

The occurrence of poisoning incidents caused by cyanobacterial blooms has aroused wide public ***-leucine arginine(MC-LR)is a well-established toxin produced by cyanobacterial blooms,which is widely distributed in eutrophic ***-LR is not only hazardous to the water environment but also exerts multiple toxic effects including liver toxicity in both humans and ***,the underlying mechanisms of MCLR-induced liver toxicity are ***,we used advanced single-cell RNA sequencing technology to characterize MC-LR-induced liver injury in *** established the first single-cell atlas ofmouse livers in response to *** results showed that the differentially expressed genes and pathways in diverse cell types of liver tissues of mice treatedwith MC-LR are highly *** analysis showed that MC-LR induced an increase in a subpopulation of hepatocytes that highly express Gstm3,which potentially contributed to hepatocyte apoptosis in response to ***,MC-LR increased the proportion and multiple subtypes of Kupffer cells with M1 phenotypes and highly expressed proinflammatory ***,the MC-LR increased several subtypes of CD8+T cells with highly expressed multiple cytokines and ***,apart from directly inducing hepatocytes apoptosis,MC-LR activated proinflammatory Kupffer cell and CD8+T cells,and their interaction may constitute a hostile microenvironment that contributes to liver *** findings not only present novel insight into underlying molecular mechanisms but also provide a valuable resource and foundation for additional discovery of MC-LR-induced liver toxicity.

关键词： MC-LR Liver toxicity Single-cell RNA sequencing Immune response Inflammatory responses

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

On-chip spiking neural networks based on add-drop ring microresonators and electrically reconfigurable phase-change material photonic switches

引用

Photonics Research 2024年第4期12卷 755-766页

作者： QIANG ZHANG NING JIANG YIQUN ZHANG ANRAN LI huANhuAN XIONG gang hu YONGSHENG CAO KUN QIU School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

We propose and numerically demonstrate a photonic computing primitive designed for integrated spiking neural networks (SNNs) based on add-drop ring microresonators (ADRMRs) and electrically reconfigurable phasechange material (PCM) photonic switches. In this neuromorphic system, the passive silicon-based ADRMR,equipped with a power-tunable auxiliary light, effectively demonstrates nonlinearity-induced dual neural dynamics encompassing spiking response and synaptic plasticity that can generate single-wavelength optical neural spikes with synaptic weight. By cascading these ADRMRs with different resonant wavelengths, weighted multiple-wavelength spikes can be feasibly output from the ADRMR-based hardware arrays when external wavelengthaddressable optical pulses are injected;subsequently, the cumulative power of these weighted output spikes is utilized to ascertain the activation status of the reconfigurable PCM photonic switches. Moreover, the reconfigurable mechanism driving the interconversion of the PCMs between the resonant-bonded crystalline states and the covalent-bonded amorphous states is achieved through precise thermal modulation. Drawing from the thermal properties, an innovative thermodynamic leaky integrate-and-firing (TLIF) neuron system is proposed. With the TLIF neuron system as the fundamental unit, a fully connected SNN is constructed to complete a classic deep learning task:the recognition of handwritten digit patterns. The simulation results reveal that the exemplary SNN can effectively recognize 10 numbers directly in the optical domain by employing the surrogate gradient algorithm. The theoretical verification of our architecture paves a whole new path for integrated photonic SNNs, with the potential to advance the field of neuromorphic photonic systems and enable more efficient spiking information processing.

关键词： neural networks precise

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中国式农业农村农民现代化独特道路

引用

甘肃社会科学 2024年第3期 178-190页

作者：胡鞍钢清华大学国情研究院北京100084 清华大学国家治理与全球治理研究院北京100084 清华大学公共管理学院北京100084

中国式现代化特点之一是创新了中国式农业农村农民现代化独特道路。经过70多年持续努力,长期不断推进农业现代化,农业增加值跃居世界前列,谷物和粮食生产总量一直居世界首位,农业综合生产能力显著增长,农业劳动生产率持续提高,农业水利... 详细信息

中国式现代化特点之一是创新了中国式农业农村农民现代化独特道路。经过70多年持续努力,长期不断推进农业现代化,农业增加值跃居世界前列,谷物和粮食生产总量一直居世界首位,农业综合生产能力显著增长,农业劳动生产率持续提高,农业水利现代化取得重要进展,长期持续的良种革命,农业科技进步率不断提高;长期不断推进农村现代化,农村各类现代化要素持续投入和普及,初步实现现代化生产生活方式;长期不断推进农民现代化,农村人口向城镇超大规模转移,农村脱贫人口收入持续增长,农民健康人力资本水平持续提高,农民教育人力资本持续提高,农村居民居住条件明显改善,农村成为国内旅游大市场;成功地开辟了中国独特的农业现代化、农村现代化、农民现代化的新道路,成为中国式“三农”现代化长期目标与长期主义最好实践。

关键词：农业现代化农村现代化农民现代化长期主义

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Opinion consensus incorporating higher-order interactions in individual-collective networks

引用

Chinese Physics B 2024年第7期33卷 105-115页

作者：叶顺涂俐兰王先甲胡佳王薏潮 hubei Province Key Laboratory of Systems Science in Metallurgical Process Wuhan University of Science and TechnologyWuhan 430065China College of Science Wuhan University of Science and TechnologyWuhan 430065China Economics and Management School of Wuhan University Wuhan UniversityWuhan 430065China

In the current information society, the dissemination mechanisms and evolution laws of individual or collective opinions and their behaviors are the research hot topics in the field of opinion dynamics. First, in this paper, a two-layer network consisting of an individual-opinion layer and a collective-opinion layer is constructed, and a dissemination model of opinions incorporating higher-order interactions(i.e. OIHOI dissemination model) is proposed. Furthermore, the dynamic equations of opinion dissemination for both individuals and groups are presented. Using Lyapunov's first method,two equilibrium points, including the negative consensus point and positive consensus point, and the dynamic equations obtained for opinion dissemination, are analyzed theoretically. In addition, for individual opinions and collective opinions,some conditions for reaching negative consensus and positive consensus as well as the theoretical expression for the dissemination threshold are put forward. Numerical simulations are carried to verify the feasibility and effectiveness of the proposed theoretical results, as well as the influence of the intra-structure, inter-connections, and higher-order interactions on the dissemination and evolution of individual opinions. The main results are as follows.(i) When the intra-structure of the collective-opinion layer meets certain characteristics, then a negative or positive consensus is easier to reach for individuals.(ii) Both negative consensus and positive consensus perform best in mixed type of inter-connections in the two-layer network.(iii) Higher-order interactions can quickly eliminate differences in individual opinions, thereby enabling individuals to reach consensus faster.

关键词： two-layer social networks individual and collective opinions higher-order interactions consensus Lyapunov's first method

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

谢林与康德论有机体的偶然性

引用

山西大学学报(哲学社会科学版) 2024年第2期47卷 19-26页

作者：常文琦先刚北京大学哲学系

康德和谢林对有机体有着类似的刻画，有机体的偶然性特征使他们面临类似的二律背反。康德和谢林对有机体的偶然性给出了不同的处理方案，这使得他们的有机体理论最终呈现出不同的面貌：康德为消除偶然性为有机体找到的目的论原则必然会... 详细信息

康德和谢林对有机体有着类似的刻画，有机体的偶然性特征使他们面临类似的二律背反。康德和谢林对有机体的偶然性给出了不同的处理方案，这使得他们的有机体理论最终呈现出不同的面貌：康德为消除偶然性为有机体找到的目的论原则必然会与机械论原则陷入冲突，而其采取的“目的-手段”式的统一方案无法实现二者的真正统一；谢林为保证偶然性而赋予有机体的独特的肯定性本原与代表必然性的否定性本原同样会构成冲突，但谢林通过维持这个冲突的方式来化解冲突，不仅捍卫了有机体的偶然性特征，而且保证了整个有机世界内部的发展进程，实现了相互冲突的本原之间真正意义上的统一。

关键词：谢林康德有机体偶然性

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：