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Correlations of β-catenin,Ki67 and Her-2/neu with gastric cancer

Asian Pacific Journal of Tropical Medicine 2014年第4期7卷 257-261页

作者： Hong-Wen Wu Cheng-Yong Qin Ji-Lai Huang xian-yi kong Wen-Ji Wang Wen-Kun Bai School of Medicine Shandong University Digestive Internal Medicine The First Hospital of Zibo City Digestive Internal Medicine Shandong Provincial Hospital Digestive Internal Medicine Shandong Qianfoshan Hospital

Objective:To study the clinical pathologic characteristics ofβ-catenin,Ki67 and Her-2/neu in gastric cancer and the correlation ofβ-catenin and Ki67 to the protein expression and gene conditions of Her-2/***:The protein expression ofβ-catenin,Ki67 and Her-2/Neu was detected by immunohistochemistry in 101 cases of gastric cancer and the gene conditions of Her-2/Neu by fluorescence in situ hybridization(FISH).Results:The protein expression ofβ-catenin,Ki67 and Her-2/Neu had close relationship with the clinical pathologic characteristics of gastric ***β-catenin and Ki67 had obvious correlation to the differentiation,infiltration and lymphatic metastasis of the gastric cancer(P<0.05).The Ki67 had close relationship with the tumor-node-metastasis staging staging of gastric cancer(P<0.05).Her-2/Neu had close relationship with the differentiation and tumor-node-metastasis staging of gastric cancer(P<0.05)but had no relationship with the infiltration and lymphatic metastasis of the gastric cancer(P<0.05).The protein expression of Ki67 had significantly positive correlation to the protein expression and gene amplification conditions of Her-2/Neu(r=0.567,P<0.05 for protein;r=0.304,P<0.05 for gene).Conclusions:Combined detection ofβ-catenin,Ki67 and Her-2/Neu can be used as a reliable method to help the observation of biological behavior,diagnosis and prognosis of gastric cancer,and Ki67 can be used to serve the preliminary screening of Her-2/Neu gene state.

关键词： Gastric cancer β-catenin Ki67 Her-2/neu Immunohistochemistry Fluorescence in situ hybridization Tumor marker

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Competition of Composition Fluctuation Modes in Weakly Segregated Salt-doped Symmetric Diblock Copolymers

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Chinese Journal of Polymer Science 2024年第9期42卷 1375-1385,I0008页

作者： Yuan-Xin Zhou xian kong South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou510640China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou510640China

Salt-doped block copolymers have widespread applications in batteries,fuel cells,semiconductors,and various industries,where their properties crucially depend on phase separation ***,investigations into salt-doped diblock copolymers have predominantly focused on microphase separation,overlooking the segregation between ionic and polymeric *** study employs weak segregation theory to explore the interplay between phase separation dominated by the polymer-modulated mode and the salt-out-modulated mode,corresponding to microscopic and macroscopic phase separations,*** comparing diblock copolymers doped with salts to those doped with neutral solvents,we elucidate the significant role of charged species in modulating phase *** phase separation mode exhibits a transition between the polymer-modulated and salt-out-modulated modes at different *** systems doped with neutral solvents,this transition is stepwise,while in salt-ion-doped systems,it is *** a sufficiently large Flory-Huggins parameter between ions and polymers,the salt-out-modulated mode becomes dominant,promoting macrophase *** to the solvation effect of salt ions,salt-doped systems are more inclined to undergo microphase ***,we explore factors influencing the critical wavenumber of phase separation,including doping level and the Flory-Huggins parameters between two blocks and between ions and polymeric *** findings reveal that in a neutral solvent environment,these factors alter only the boundary between micro-and macro-phase separations,leaving the critical wavenumber unchanged in microphase separation ***,in a salt-doped environment,the critical wavenumber of microphase separation varies with these *** provides valuable insights into the pivotal role of electrostatics in the phase separation of salt-doped block copolymers.

关键词： Block copolymer Phase separation Field theory Salt-doped

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High-temperature Thermo-oxidative Aging of Vulcanized Natural Rubber Nanocomposites:Evolution of Microstructure and Mechanical Properties

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Chinese Journal of Polymer Science 2023年第8期41卷 1287-1297,I0010页

作者： Zhou-xian Li yi-Ran kong xiang-Fei Chen Ya-Jiang Huang Ya-Dong Lv Guang-xian Li College of polymer science and engineering State key laboratory of polymer materials engineering of ChinaSichuan UniversityChengdu 610065China

The aging of natural rubber(NR)at high temperatures will seriously affect its service lifetime in many key *** the present work,the changes in microstructure and mechanical properties of semi-efficient vulcanized NR/carbon black(CB)vulcanizates during thermooxidative aging at high temperatures(150-200℃)and a moderate temperature(95℃)were *** high temperatures,a two-stage aging behavior,which was characteristic of a first rapid decline and then a continuous rise in the crosslinking density(ve),was identified and was found to be closely related to the depletion behavior of *** surface cracking behavior observed in the second stage of high-temperature aging was discussed in terms of the grafting reaction of macromolecular radicals on CB particles and thermal *** contrast,the aging of NR at moderate temperatures was much mild,which featured a continuous increase in ve and an oxidation mechanism dominated by peroxy radicals attacking double *** general,the mechanical properties of NR vulcanizates during high-temperature aging depended on the competition effects of structural evolution in the crosslinked network and oxidation-induced chain scission.

关键词： Natural rubber nanocomposites High-temperature Thermo-oxidative aging

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Type B polycyclic polyprenylated acylphloroglucinols from the roots of Hypericum beanii

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Chinese Journal of Natural Medicines 2021年第5期19卷 385-390页

作者： LI Wei-xian XU Wen-Jun LUO Jun YANG Lei kong Ling-yi Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China

Two new type B polycyclic polyprenylated acylphloroglucinols(PPAPs)(1 and 2)and a known biogenetic precursor hyperbeanol Q(3)were isolated from the root extract of Hypericum beanii,a medicinal plant widespread in southwest *** chemical structures were elucidated by 1 D/2 D NMR and HRESIMS data analysis,and absolute configurations were determined through detailed electric circular dichroism(ECD)analysis including ECD exciton chirality,Mo2(OAc)4-induced ECD,and ECD *** these compounds,hyperbeone A(1)is a typical[3.3.1]-type B PPAP with an unusual C-1 geranyl side chain,and hyperberin C(2)possesses a rare bicyclo[5.3.1]hendecane *** compound 3 as a starting point,a plausible biosynthetic pathway to the bicyclic type B frameworks of 1 and 2 was proposed.

关键词： Polyprenylated acylphloroglucinol Hypericum beanii Hyperbeone A ECD

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Informational uncertainties of risk assessment about accidents of chemicals

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Journal of Environmental Sciences 2001年第1期13卷 69-74页

作者： ZHANG yi-xian Suzhou Institute of Urban Construction and Environmental Protection Suzhou 215011China

An analysis system of informational uncertainties for accidental risk assessment of chemicals is introduced. Statistical test methods and fuzzy sets method can do the quantitative analysis of the input parameters. The uncerainties of the model can be used by quantitative compared method for the leakage accidents of chemicals. The estimation of the leaking time is important for discussing accidental source term. The uncertain analyses of the release accident for pipeline gas (CO) liquid chlorine and liquid propane gas (LPG) have been discussed.

关键词： uncertainty risk assessment accident chemicals pipeline gas liquid chlorine LPG

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Science Letters:Average SNR of maximum ratio transmission with selection combining

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第12期10卷 1683-1687页

作者： xian-yi RUI School of Electronic and Information Engineering Soochow University Suzhou 215006 China

Two kinds of selection combining schemes including generalized selection combining (GSC) and generalized order selection combining (GOSC) are investigated. In the GSC scheme, L strongest diversity branches from a total of R diversity branches are selected and coherently combined by maximal ratio combining. GOSC means that the Lth strongest diversity branch from R diversity branches is selected for reception. Closed-form expressions for the average signal-to-noise ratios of maximum ratio transmission with GSC and GOSC are derived in Rayleigh fading channels.

关键词： Maximum ratio transmission (MRT) Generalized selection combining (GSC) Generalized order selection combining (GOSC) Average signal-to-noise ratio Rayleigh fading

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Magnifying chromoendoscopy combined with immunohistochemical staining for early diagnosis of gastric cancer

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World Journal of Gastroenterology 2013年第3期19卷 404-410页

作者： xian-Mei Meng yi Zhou Tong Dang Xu-Yang Tian Jie kong Department of Gastroenterology The Second Affiliated Hospital of Baotou Medical College Institute of Digestive Diseases of Inner Mongolia Autonomous Region Department of Pathology The Second Affiliated Hospital of Baotou Medical College

AIM:To assess the diagnostic value of using magnifying chromoendoscopy combined with immunohisto-chemical staining of proliferating cell nuclear antigen (PCNA)and p53 in the detection of gastric precancerous lesions. METHODS:Ninety-five patients who were treated for abdominal discomfort,abdominal pain,bloating,and acid reflux at our hospital from January 2010 to December 2011 were included in the *** ordinary gastroscopic procedure was initially performed to select the *** subjects underwent magnifying chromo-endoscopy to observe morphological changes of gastric *** were then taken from each area of interest and sent for pathological examination and detection of PCNA and p53 expression by immunohistochemistry. An immunoreactivity score for each lesion was *** on immunoreactivity scores,immunohisto-chemical staining was then considered. RESULTS:Compared to intestinal metaplasia,gastric pits were more diverse in size,more irregular in shape, and more disorderly in arrangement in moderate and severe *** and p53 expression was sig-nificantly higher in precancerous lesions(intestinal metaplasia and dysplasia)than in chronic gastritis. PCNA expression showed an upward trend in types A-F *** number of cases that showed strong PCNA positivity increased significantly with an increase in the severity of *** sum test for independent samples showed that p53 expression was significantly higher in types E and F pits than in types A-D pits(H =33.068,P=0.000).Rank sum test for independent samples showed that PCNA expression was significantly higher in types E and F pits than in types A-D pits(H =31.791,P=0.001). CONCLUSION:The presence of types E and F pits,in which p53 and PCNA are highly expressed,is highly sug- gestive of the occurrence of early cancer,and patients developing these changes should be closely followed.

关键词： Magnifying chromoendoscopy Gastric precancerous lesions p53 Proliferating cell nuclear antigen Early gastric cancer

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Precision measurement and compensation of kinematic errors for industrial robots using artifact and machine learning

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Advances in Manufacturing 2022年第3期10卷 397-410页

作者： Ling-Bao kong yi Yu Shanghai Engineering Research Center of Ultra-precision Optical Manufacturing Department of Optical Science and EngineeringFudan UniversityShanghai 200438People's Republic of China

Industrial robots are widely used in various areas owing to their greater degrees of freedom(DOFs)and larger operation space compared with traditional frame movement systems involving sliding and rotational ***,the geometrical transfer of joint kinematic errors and the relatively weak rigidity of industrial robots compared with frame movement systems decrease their absolute kinematic accuracy,thereby limiting their further application in ultraprecision *** imposes a stringent requirement for improving the absolute kinematic accuracy of industrial robots in terms of the position and orientation of the robot arm *** measurement and compensation methods for industrial robots either require expensive measuring systems,producing positioning or orientation errors,or offer low measurement ***,a kinematic calibration method for an industrial robot using an artifact with a hybrid spherical and ellipsoid surface is proposed.A system with submicrometric precision for measuring the position and orientation of the robot arm end is developed using laser displacement ***,a novel kinematic error compensating method involving both a residual learning algorithm and a neural network is proposed to compensate for nonlinear errors.A six-layer recurrent neural network(RNN)is designed to compensate for the kinematic nonlinear errors of a six-DOF industrial *** results validate the feasibility of the proposed method for measuring the kinematic errors of industrial robots,and the compensation method based on the RNN improves the accuracy via parameter *** studies show that the measuring system and compensation method can reduce motion errors by more than 30%.The present study provides a feasible and economic approach for measuring and improving the motion accuracy of an industrial robot at the submicrometric measurement level.

关键词： Industrial robot Kinematic error Calibration Machine learning Recurrent neural network(RNN)

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Neurons-system-like structured SnS_(2)/CNTs composite for high-performance sodium-ion battery anode

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Rare Metals 2021年第6期40卷 1383-1390页

作者： Ling Zhu Xue-xian Yang Yan-Hong xiang Peng kong xian-Wen Wu School of Physics and Electromechanical Engineering Jishou UniversityJishou 416000China School of Chemistry and Chemical Engineering Jishou UniversityJishou 416000China

Sodium-ion batteries(SIBs)have attracted significant attention with respect to renewable energy power generation systems because of the abundant reserves of sodium on ***,anode materials are presently limited by low energy density,poor rate performance and inferior cycling *** recent years,tin disulfide(SnS_(2))with a particular layered structure has been considered as a promising anode material for SIBs due to its high theoretical capacity and low ***,a nervoussystem-like structured SnS_(2)/CNTs composite was successfully synthesized via a hydrothermal *** SnS_(2)sheets were strung with carbon nanotubes(CNTs)to form a hierarchical porous structure,which is effective for electrolyte diffusion and electronic *** large distance of the(001)plane(0.5899 nm)of SnS_(2)favors Na+insertion-extraction *** from these structural characteristics,SnS_(2)/CNTs electrodes exhibit high specific capacity,excellent rate performance and superior cycling stability.A high charge capacity of 642 mAh·g^(-1)was released at 0.2 A·g^(-1),and then,a high reversible capacity of 427 mAh·g^(-1)was retained after 100 *** charged at 2 A·g^(-1),the SnS_(2)/CNTS electrode maintained a capacity of 282 mAh·g^(-1).The nervous-system-like structure of the SnS_(2)/CNTs composite provides a novel strategy for the development of SIBs with high electrochemical performance.

关键词： SnS_(2)/CNTs Sodium-ion batteries Anode Composite Rate capability

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Global asymptotical stability in a rational difference equation

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Applied Mathematics(A Journal of Chinese Universities) 2021年第1期36卷 51-59页

作者： LI xian-yi LI Wei Institute of Nonlinear Analysis and Department of Big Data Science Zhejiang University of Science and TechnologyHangzhou 310023China

In this paper we prove a global attractivity result for the unique positive equilibrium point of a difference equation,which improves and generalizes some known ones in the existing ***,our results completely solve an... 详细信息

关键词： global asymptotic stability global attractivity Open problem and conjecture Schwartzian derivative,rational difference equation

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