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Growth differentiation factor-15 is a prognostic marker in patients with intermediate coronary artery disease

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Journal of Geriatric Cardiology 2020年第4期17卷 210-216页

作者： Wei WANG xian-Tao SONG yun-Dai CHEN Fei yuAN Feng XU Min ZHANG Kai TAN Xing-Sheng YANG xian-peng yu Kong-Yong CUI Shu-Zheng Lyu Department of Cardiology Beijing Anzhen HospitalCapital Medical University and Beijing Institute of HeartLung and Blood Vessel DiseasesBeijingChina Department of Cardiology the First Medical Center of Chinese PLA General HospitalBeijingChina

Background Growth differentiation factor-15(GDF-15)is involved in multiple processes that are associated with coronary artery disease(CAD).However,little is known about the association between GDF-15 and the future ischemic events in patients with intermediate *** study was conducted to investigate whether plasma GDF-15 constituted risk biomarkers for future cardiovascular events in patients with intermediate *** A prospective study was performed based on 541 patients with intermediate CAD(20%–70%).GDF-15 of each patient was determined in a blinded *** primary endpoint was major adverse cardiac event(MACE),which was defined as a composite of all-cause death,nonfatal myocardial infarction,revascularization and readmission due to angina *** After a median follow-up of 64 months,504 patients(93.2%)completed the ***,the combined endpoint of MACE appeared in 134 patients(26.6%)in the overall population:26 patients died,11 patients suffered a nonfatal myocardial infarction,51 patients underwent revascularization,and 46 patients were readmitted for angina *** plasma levels of GDF-15(median:1172.02 vs.965.25 pg/m L,P=0.014)were higher in patients with ischemic events than those without *** adjusting for traditional risk factors,higher GDF-15 levels were significantly associated with higher incidence of the composite endpoint of MACE(HR=1.244,95%CI:1.048–1.478,Quartile 4 *** 1,P=0.013).Conclusions The higher level of GDF-15 was an independent predictor of long-term adverse cardiovascular events in patients with intermediate CAD.

关键词： Growth differentiation factor-15 Intermediate coronary artery disease Prognosis

Long-term outcomes of PCI vs. CABG for ostial/midshafl lesions in unprotected left main coronary artery

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Journal of Geriatric Cardiology 2017年第4期14卷 254-260页

作者： Cheng-Long GUO xian-peng yu Bang-Guo YANG Meng-Meng LI Ji-Qiang HE Quan LI Cheng-Xiong GU Shu-Zheng Lyu Jian-Zeng DONG Department of Cardiology Beijing Anzhen Hospital Capital Medical University Beijing China Department of Cardiac Surgery Beijing Anzhen Hospital Capital Medical University Beijing China

Background There are limited data on long-term （〉 5 years） outcomes of drug-eluting stent （DES） implantation compared with coro- nary artery bypass grafting （CABG） for ostial/rnidshaft left main coronary artery （LMCA） lesions. Methods Of the 259 consecutive pa- tients in Beijing Anzhen Hospital with ostial/midshaff LMCA lesions, 149 were treated with percutaneous coronary intervention （PCI） with DES and 110 were with CABG. The endpoints of the study were death, repeat revascularization, myocardial infarction （MI）, stroke, the composite of cardiac death, and major adverse cardiac and cerebrovascular events （MACCE, the composite of cardiac death, MI, stroke or repeat revascularization）.The duration of follow-up is 7.1 years （interquartile range 5.3 to 8.2 years）. Results There is no significant differ- ence between the PCI and CABG group during the median follow-up of 7.1 years （interquartile range： 5.3-8.2 years） in the occurrence of death （HR： 0.727, 95% CI： 0.335-1.578; P = 0.421）, the composite endpoint of cardiac death, MI or stroke （HR： 0.730, 95% CI： 0.375-1.421; P = 0.354）, MACCE （HR： 1.066, 95% CI： 0.648-1.753; P = 0.801）, MI （HR： 1.112, 95% CI： 0.414-2.987; P = 0.833）, stroke （HR： 1.875, 95% CI： 0.528-6.659; P = 0.331）, and repeat revascularization （HR： 1.590, 95% CI： 0.800-3.161; P = 0.186）. These results remained after multivariable adjusting. Conclusion During a follow-up up to 8.2 years, we found that DES implantation had similar endpoint outcomes compared with CABG.

关键词： Coronary artery bypass graft Drug-eluting stent Percutaneous coronary intervention

Impact of prior cerebrovascular events on patients with unprotected left main coronary artery disease treated with coronary artery bypass grafting or percutaneous coronary intervention

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Chinese Medical Journal 2021年第16期134卷 1988-1990页

作者： yu Pan yu Mu Ze-Sen Liu yu-Chen Zhang Ji-Qiang He xian-peng yu Qi Qiu Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Department of Pharmacy Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China Department of Cardiology Beijing Luhe HospitalCapital Medical UniversityBeijing 101100China.

Treatment of unprotected left main coronary artery(ULMCA)disease with coronary artery bypass grafting(CABG)or percutaneous coronary intervention(PCI)has developed rapidly during the past *** optimal revascularization strategy has been a subject of debate,with several randomized controlled trials and metaanalyses comparing outcomes of CABG and PCI.

关键词： coronary bypass artery

SOS Calculation of Nonlinear Optical Propertiesof Synthesized ASPBPh_4

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Chemical Research in Chinese Universities 2001年第2期17卷 207-211页

作者： ZHAO xian, TIAN yu-peng, ZHOU yu-fang and JIANG Min-hua (State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, P. R. China) LIU Yong-jun and HU Hai-quan (Institute of Theoretical Chemistry, Shandong University, Jinan 250100) 山东大学晶体材料国家重点实验室山东济南 250100 山东大学山东济南 250100

The two-photon absorption induced lasing spectrum shows that the synthesized ASPBPh4, trans-4- [p- (N-methyl-N- (hydroxyethyl)amino) styryl]-N-methylpyridinium, has a distinct ef- ficiency of laser frequency up-conversion. This nonlinear optical property of such a kind of com- pounds is related to two-photon absorption (TPA). In our work, we used the intermediate ne- glect of differential overlap (INDO) plus single-excitation configuration interaction (SCI) method to get the basic properties of the molecule, and calculated the second hyperpolarizability and the cross section of two-photon absorption by means of sum-over-state (SOS) expression. The rela- tionship between the structure and the properties is discussed.

关键词： Two-photon absorption Semiempirical method Sum-over-state

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圆锥滚子轴承筐形保持架的设计改进

轴承 2010年第12期 8-9页

作者：县鹏宇甘肃海林中科科技股份有限公司技术中心甘肃天水741018

针对圆锥滚子轴承筐形保持架进行了设计改进。该类型保持架大端口部采用收口设计,底部折角设计为10°～20,°压坡角设计为20°和22°30′。改进后的保持架不仅强度得到增加,而且旋转灵活性也有大幅提高。

关键词：圆锥滚子轴承筐形保持架改进

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载重卡车车桥主减速器轴承的技术发展

轴承 2010年第10期 56-59页

作者：县鹏宇甘肃海林中科科技股份有限公司技术中心甘肃天水741018

从功能和结构特征等方面论述了载重卡车车桥主减速器轴承的发展过程,并重点介绍了结构优化的单元轴承。

关键词：滚动轴承车桥主减速器卡车发展

Predictive Ability of the SYNergy Between Percutaneous Coronary Intervention with TAXus and Cardiac Surgery Score Ⅱ for Long-term Mortality in Patients with Three-vessel Coronary Artery Disease Undergoing Percutaneous Coronary Intervention Treated

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Chinese Medical Journal 2015年第16期128卷 2176-2182页

作者： Ji-Qiang He xian-peng yu Cheng peng Quan Li Ya-Wei Luo yue-Chun Gao Xiao-Ling Zhang Chang-Yan Wu Hua Zhao yu-Chen Zhang Jing-Hua Liu Shu-Zheng Lyu Fang Chen Department of Cardiology Beijing Anzhen Hospital Capital Medical University and Institution of Beijing Heart Lung and Vascular Disease Beijing 100029 China

Background：The SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery Score Ⅱ （SS-Ⅱ） can well predict 4-year mortality in patients with complex coronary artery disease （CAD）,and guide decision-making between coronary artery bypass graft surgery and percutaneous coronary intervention （PCI）.However,there is lack of data regarding the utility of the SS-Ⅱ in patients with three-vessel CAD undergoing PCI treated with second-generation drug-eluting stents （DES）.The purpose of the present study was to evaluate the ability of the SS-Ⅱ to predict long-term mortality in patients with three-vessel CAD undergoing PCI with second-generation ***：Totally,573 consecutive patients with de novo three-vessel CAD who underwent PCI with second-generation DES were retrospectively *** to the tertiles of the SS-Ⅱ,the patients were divided into three groups：The lowest SS-Ⅱ tertile （SS-Ⅱ ≤20）,intermediate SS-Ⅱ tertile （SS-Ⅱ of 21-31）,and the highest SS-Ⅱ tertile （SS-Ⅱ ≥32）.The survival curves of the different groups were estimated by the Kaplan-Meier *** and multivariate Cox proportional hazard regression analyses were performed to evaluate the relationship between the SS-Ⅱ and 5-year *** performance of the SS-Ⅱ with respect to predicting the rate of mortality was studied by calculating the area under the receiver operator characteristic （ROC） *** predictive ability of the SS-Ⅱ for 5-year mortality was evaluated and compared with the SS ***：The overall SS-Ⅱ was 27.6 ± *** patients in the lowest,intermediate and the highest SS-Ⅱ tertiles,the 5-year rates of mortality were 1.6%,3.2%,and 8.6%,respectively （P =0.003）;the cardiac mortality rates were 0.5%,1.9%,and 5.2%,respectively （P =0.014）.By multivariable analysis,adjusting for the potential confounders,the SS-Ⅱ was an independent predictor of 5-year mortality （hazard ratio：2.45,95% confidence interval：1.38-4.36;P=0.002）.The SS-Ⅱ demonstrated a high

关键词： Mortality Percutaneous Coronary Intervention Predictive Ability Second-generation Drug-eluting Stents SYNTAX Score II Three-vessel Coronary Artery Disease

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圆锥滚子轴承小挡边锁量的验算公式

轴承 2011年第1期 13-14页

作者：刘锋县鹏宇甘肃海林中科科技股份有限公司技术中心甘肃天水741018

对圆锥滚子轴承小挡边锁量进行验算,通过对最大内复圆直径的形成过程进行分析,最终推出了小挡边锁量的验算公式。

关键词：圆锥滚子轴承筐形保持架小挡边锁量内复圆直径

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配对圆锥滚子轴承轴向游隙的设计与测量

轴承 2010年第9期 45-47页

作者：县鹏宇刘锋甘肃海林中科科技股份有限公司技术中心甘肃天水741018

对面对面和背对背两种结构的配对圆锥滚子轴承轴向游隙的设计思路及方法进行了探讨,并介绍了其测量方法,有助于轴承设计时隔圈公差的确定。

关键词：配对圆锥滚子轴承结构轴向游隙尺寸链测量