检索结果-南通市图书馆

In situ generated thrombin in the protein corona of zeolites： Relevance of the functional proteins to its biological impact

在线全文

学校读者我要写书评

暂无评论

Nano Research 2014年第10期7卷 1457-1465页

作者： Yunlong Li Xiaofeng Liao Xiaoxi zhang Guicen Ma Shuai Zuo Liping Xiao Galen D. Stucky Zhugang Wang xian Chen Xiaoqiang Shang Jie Fan Key Lab of Applied Chemistry of Zhejiang Province Zhejiang University Hangzhou 310027 China Department of Chemistry Fudan University Shanghai 200433 China Department of Chemistry and Biochemistry University of California San ta Barbara CA 93106 USA Department of Medical Genetics Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Biochemistry and Biophysics School of Medicine University of North Carolina-Chapel Hill NC 27599 USA

Adsorption of plasma proteins to nanomaterial surfaces has a great influence on their bio-functionality. However, there is limited understanding of the relationship between the functional proteins in the protein corona and the biological identity of the materials. Here we show that the in situ generated thrombin in the protein corona of a Ca-zeolite surface displays a calcium-dependent, unusually high （-3,000 NIH U/mg） procoagulant activity, which is even stable against antithrombin deactivation. Removing the encapsulated Ca^2＋ in the zeolites leads to deactivation by antithrombin. Our observations suggest that the thrombin activity can be regulated by the inorganic surface and cations. Most importantly, our discovery indicates the link between the biomolecules in the protein corona and the procoagulant activity of the materials, providing a new molecular basis for the procoagulant mechanism for zeolite hemostatics.

关键词： protein corona zeolite thrombin activity procoagulant activity calcium

Significance of vulnerability assessment in establishment of Hainan provincal disaster medical system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2011年第8期4卷 594-596页

作者： min Li Chuanzhu Lu Wei Son Junhong Miao Yipeng Ding Longhe Li Leilei zhang Nin Zhao Bijiang Hu Yunjun zhang Hainan People's Hospital Hainan Medical College Hainan Normal University

Hainan is an island province in south China with a high frequency of unconventional emergencies due to its special geographic location and national military defense *** the limited transportation route from Hainan to the outside world,self-rescue is more important to Hainan Province than other provinces in China and it is therefore imperative to establish an independent, scientific as well as efficient provincal disaster medical system in *** regulatory role for vulnerability analysis/assessment has been demonstrated in establisment of disaster medical system in varoius countries and or *** this paper,we attempt to describe/propose how to adopt vulnerability assessment through mathematical modeling of major biophysical social vulnerability factors to establish an independent,scientific,effieicnt and comprehensive provincial disaster medical system in Hainan.

关键词： Vunlerability analysis Disasters medical Emergency medical rescue

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

网络外部性下零售商市场策略演化博弈分析

系统工程理论与实践 2015年第9期35卷 2251-2261页

作者：易余胤张显玲暨南大学管理学院广州510632

运用演化博弈理论,构建了网络外部性环境下的不对称双群体演化博弈模型,分析了具有有限理性的零售商在长期的市场演化中,会如何选择最适合其生存的市场策略的问题.首先,假设零售商有两种市场策略:数量策略和价格策略,并在网络外部性环... 详细信息

运用演化博弈理论,构建了网络外部性环境下的不对称双群体演化博弈模型,分析了具有有限理性的零售商在长期的市场演化中,会如何选择最适合其生存的市场策略的问题.首先,假设零售商有两种市场策略:数量策略和价格策略,并在网络外部性环境下建立了零售商在不同市场策略下的演化博弈模型.其次,在产品具有替代互补性和网络外部性下讨论了动态系统的稳定性,发现在一定的条件下,价格策略和数量策略均可以成为系统的演化稳定点.再次,分析了网络外部性、产品的替代/互补性和市场规模对演化稳定点的吸引域的影响,发现网络外部性、产品替代/互补性和市场规模的变化均会影响到系统的演化路径.最后,通过数值算例,进一步验证和分析了所取得的理论成果.

关键词：网络外部性市场策略演化博弈

EFFECT OF ERYTHROMYCIN ON GASTRIC DYSMOTILITY AND NEUROENDOCRINE PEPTIDES IN RATS WITH DIABETES MELLITUS

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Sciences Journal 2005年第3期20卷 176-180页

作者： Lin Lin min Ji Hong-jie zhang Zheng Lin Zhi-quan Zhao Department of Gastroenterology the First Affiliated Hospital of Nanjing Medical University Nanjing 210029

Objective To investigate the effect of erythromycin on the contractive activity of the isolated gastric antrum smooth muscle and somatostatin （SS）, vasoactive intestinal peptide （VIP）, motilin （MTL）, and substance P （SP） in plasma and isolated gastric antrum tissue of diabetes mellitus （DM） rat models. Methods Thirty male Sprague-Dawley rats were divided into three groups： control group （n = 10）, DM group （n = 10）, and erythromycin group （DM models with erythromycin treatment, n = 10）. A single dose of streptozotocin （100 mg/kg, dissolved in 0. I mol/L citric acid buffer, pH4.5） was injected intraperitoneally. After 48 to 72 hours, rats with blood glucose above 16.7 mmol/L and urine glucose level to be （＋＋＋） to （＋＋＋＋） over one week were considered successful DM models. The resting tension, mean contractile amplitude and fi＇equency of spontaneous change in isolated longitudinal and circular gastric antrum smooth muscle strips were measured. SS, VIP, MTL, and SP levels in plasma and gastric antrum tissue were measured using radioimmunoassay. Results （1） In the isolated gastric antrum smooth muscle strips, the gastric motility parameters were lower in DM group than those in control group except circular smooth muscle contractile amplitude and longitudinal smooth muscle contractile fi＇equency. The gastric motility parameters were significantly strengthened in erythromycin group, compared with DM group except longitudinal smooth muscle resting tension （P 〈 0.01 ）. （2） Plasma SS, VIP, and MTL concentrations in DM group were higher than those in control （P 〈 0.05）, while the SP level decreased （P 〈 0.05）. In the gastric antrum, SS of DM group was significantly higher than that of control group （P 〈 0.01 ）, while SP and MTL levels were lower than those of control group （P 〈 0.05 and P 〈 0.01, respectively）. However, the level of VIP in gastric antrum tissue did not change among three groups. The plasma level of SS in erythromycin group was higher than that of DM group （P

关键词： diabetes mellitus gastric dysmotility erythromycin somatostatin vasoactive intestinal peptide motilin substance P

Non-invasive ventilation improves hemorheology status in hypoxemic patients with acute myocardial infarction after PCI

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2017年第4期14卷 274-279页

作者： Xi-Fu WANG ming YE Dong YAN Hui-min zhang Ping JIA Xue-Jun REN Yu-Jie ZENG Department of Emergency and Critical Care Center Beij'ing Anzhen Hospital Capital Medical University Beijing China Department of Cardiology Peking University Shougang Hospital Beijing China Department of Cardiology Beifing Anzhen Hospital Capital Medical University Beijing China

Background Hypoxemia sometimes occurs in the emergency room in the patients with acute myocardial infarction （AMI） after percutaneous coronary intervention （PCI）, even in those with administration of conventional high-flow oxygen inhalation. The objective of the present study was to evaluate the effectiveness of non-invasive ventilation （NIV） in improving blood oxygen content and hemorheology in patients with AMI and hypoxemia. Methods This prospective study enrolled 50 consecutive eligible patients with AMI （aged 72.3 ± 9.5 years）, who had undergone PCI and been administered high-flow oxygen but still had hypoxemia. Blood was taken before NIV and at 0.5, 1, and 2 h after NIV. Blood gases, hemorheological variables including erythrocyte deformability, erythrocyte aggregation, erythrocyte osmotic fragility, membrane fluidity, and oxidative stress level were measured. Results Blood PaO2 increased to normal by 1 h after NIV. Assessed hemorheological variables had all improved and plasma malondialdehyde concentration decreased significantly after 2 h of NIV. Conclusions Our data suggest that NIV can help to improve blood oxygen content, hemorheological status, and minimize plasma lipid peroxidation injury in hypoxemic patients with AMI who have undergone PCI.

关键词： Acute myocardial infarction Hypoxemia Non-invasive ventilation Percutaneous coronary intervention

Analysis and design of steel-concrete composite sandwich systems subjected to extreme loads

在线全文

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2011年第3期5卷 278-293页

作者： Kazi Md Abu SOHEL Jat Yuen Richard LIEW min Hong zhang Department of Civil Engineering National University of Singapore Singapore

This paper presents the design guide based on analytical,numerical and experimental investigation of Steel-concrete-steel(SCS)sandwich structural members comprising a lightweight concrete core with density ranged from 1300 to 1445 kg/m3 subjected to static,impact and blast *** performance of lightweight sandwich members is also compared with similar members with normal weight concrete core and ultra high strength concrete core(fc=180 MPa).Novel J-hook shear connectors were invented to prevent the separation of face plates from the concrete core under extreme loads and their uses are not restricted by the concrete core *** and punching are the primary modes of failure under static point *** test results show that the SCS sandwich panels with the J-hook connectors are capable of resisting impact load with less damage in comparison than equivalent stiffened steel plate *** tests with 100 kg TNT were performed on SCS sandwich specimens to investigate the key parameters that affect the blast resistance of SCS sandwich *** yield line method is proposed to predict the plastic capacity and post peak large deflection of the sandwich ***,an energy balanced model is developed to analyze the global behavior of SCS sandwich panels subjected to dynamic load.

关键词： blast load composite structure impact load lightweight concrete sandwich plate J-hook connector

In vitro corrosion resistance of layer-by-layer assembled polyacrylic acid multilayers induced Ca–P coating on magnesium alloy AZ31

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioactive Materials 2020年第1期5卷 153-163页

作者： Lan-Yue Cui Shen-Cong Cheng Lu-xian Liang Jing-Chao zhang Shuo-Qi Li Zhen-Lin Wang Rong-Chang Zeng College of Materials Science and Engineering Shandong University of Science and TechnologyQingdao266590China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450002China College of Materials Science and Engineering Chongqing University of TechnologyChongqing400065China

Biodegradable magnesium(Mg)-based alloys have aroused great concern owing to their promising characteristics as temporary implants for orthopedic *** their undesirably rapid corrosion rate under physiological conditions has limited the actual clinical *** study reports the use of a novel biomimetic polyelectrolyte multilayer template,based on polyvinylpyrrolidone(PVP)and polyacrylic acid(PAA)via layerby-layer(LbL)assembly,to improve the corrosion resistance of the *** characterization techniques(field-emission scanning electron microscopy,Fourier transform infrared(FTIR)spectrophotometer and X-ray diffractometer)confirmed the formation of biomineralized Ca–P coating on AZ31 *** hydrogen evolution and electrochemical corrosion tests demonstrated that the corrosion protection of the polyelectrolyte-induced Ca–P coating on AZ31 *** formation mechanism of biomineralized Ca–P coating was proposed.

关键词： Magnesium alloy Layer-by-layer assembly Biomineralization Calcium phosphate Coating Corrosion

风荷载作用下大型柔性储液结构动态响应仿真方法研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

振动与冲击 2009年第5期28卷 115-118页

作者：张晓敏金先龙陈向东上海交通大学高性能计算中心上海200240

风荷载作用下柔性储液结构的动态响应属于典型的非线性流固耦合问题。采用多物质ALE有限元法,建立了大型柔性储液结构的有限元模型,数值模拟风荷载作用下柔性储液结构的动态响应,比较了不同风速对柔性结构的影响。仿真结果表明:风速越大... 详细信息

风荷载作用下柔性储液结构的动态响应属于典型的非线性流固耦合问题。采用多物质ALE有限元法,建立了大型柔性储液结构的有限元模型,数值模拟风荷载作用下柔性储液结构的动态响应,比较了不同风速对柔性结构的影响。仿真结果表明:风速越大,结构的最大主应力、质心偏移量也越大,当风速达到一定时,结构将会沿地面产生滑动。仿真结果为风荷载作用下柔性储液结构的抗风性研究提供参考依据。

关键词：柔性结构 ALE 流固耦合风荷载

A　NEW　METHOD　OF　JUDGING　THE　PHOTOSENSITIVITY　OF　WATER－SOLUBLE　PORPHYRINS　IN　THE　PHOTOSENSITIVE　SYSTEM

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 1995年第5期6卷 433-436页

作者： Guo Yu YANG Qing min WANG Jie zhang Lian xiang YU Xi zhang CAO (Department of Chemistry,Jilin University, Changchun 130023) Jilin Univ Dept Chem Changchun 130023 Peoples R China

The electron transfer between triethanolamine (TEOA) and methylviologen (MV2+) was photosensitized by water - soluble meso-tetrakis (4 -dimethylsulfonatopylanilino) porphyrins and meso-tetrakis (4-trimethylanilino)porphyrins excited in their triplet state by visible light in DMSO solution containing 20% V/V water at room *** kinetic parameter A,photo- inductive time ti and initial reaction rate Vo are applied to measuring the photosensitivity of photosensitizers.

关键词：