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Ceftriaxone,a selective GLT-1 activator,plays an anti-nociceptive role through up-regulating expression and glutamate uptake of spinal GLT-1 in chronic neuropathic pain model in rats

Ceftriaxone,a selective GLT-1 activator,plays an anti-nocice...

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中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Yu-Yan HU~1,Wen-Bin LI~(1,2,*),Li-Li LU~1,Jin-Song CAI~1,Xiao-Hui xian~1,min zhang~1,Qing-Jun LI~1 1 Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,China 2 Aging and Cognition Neuroscience Laboratory of Hebei Province,Shijiazhuang 050031,China

＜正＞We have found that accompanied by the up-regulation of spinal GLT-1 expression,intraperitoneal administration of Cef had a clear anti-nociceptive effect on chronic neuropathic pain model of rats induced by chronic constructive nerve injury of sciatic *** further demonstrate that the above anti-nociceptive effects of Cef result from the upregulation of spinal GLT-1 expression and its function,the present study was undertaken to observe the effects of intrathecal administration of Cef on pain behavior responses,expression and glutamate uptake of GLT-1 using the same *** was found that CCI induced significant thermal hyperalgesia and mechanical allodynia,which began from postoperative day 3 and lasted to day 21 *** long-term hyperalgesia was accompanied by significant downregulation of GLT-1 expression in L4-L6 segments of spinal dorsal horn revealed by immunohistochemistry and Western blotting *** intrathecal preventive and therapeutic administration of Cef（502 nmol/kg） once daily for 5 days effectively prevented or reversed,respectively,the development of thermal hyperalgesia and mechanical allodynia. Simultaneously,intrathecal administration of Cef led to specific up-regulation of GLT-1 expression and glutamate uptake （3H-glutamate） in spinal dorsal horn accompanied by the above anti-nociceptive *** above effects of Cef were all significantly inhibited by intrathecal administration of GLT-1 antisense *** results indicated that Cef plays an anti-nociceptive role by up-regulating spinal GLT-1 expression and its function.

关键词： ceftriaxone GLT-1 chronic constrictive nerve injury spinal cord rat

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Effects of Elemental Chemical State in NiFe2O4@TiO2 on the Photocatalytic Performance

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Journal of Wuhan University of Technology(Materials Science) 2020年第2期35卷 320-326页

作者： RAO Rui zhang xian SUN Xiao WANG min MA Yongqing Anhui Key Laboratory of Information Materials and Devices School of Physics and Materials ScienceAnhui UniversityHefei 230039China Institute of Physical Science and Information Technology Anhui UniversityHefei 230039China

The elemental chemical state of NiFe2O4@TiO2 was changed by the reduction in order to investigate its effects on the photocatalytic *** synthesized NiFe2O4@TiO2 samples were characterized by means of X-ray diffraction (XRD),high-resolution transmission electron microscopy (HRTEM),Fourier-transform infrared spectroscopy (FT-IR),X-ray photoelectron spectroscopy (XPS),magnetic and photocatalytic ***,the reduction reaction does not produce oxygen vacancies Ov and TiOx in the TiO2 *** optimal catalyst was obtained at the reducing temperature of 800℃,and its degradation efficiency De to the methylene blue and reaction rate constant Kapp are the highest,reaching 99.9% and 3×10^-2 min-1,*** reason could not be explained by both the visible light absorption and the appropriate amount of Ov and ***,the lowest ratios of TiOH and Ti-O-Fe(Ni) may be responsible for the optimum photocatalytic performance.

关键词： photocatalyst TiO2 self-doping NiFe2O4 photocatalytic performance

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Inhomogeneous Shadowing Effect in High-Energy p-A Drell-Yan Process:

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Communications in Theoretical Physics 2008年第7期50卷 175-179页

作者： WANG Hong-min SUN xian-Jing zhang Ben-Ai Physics Department Academy of Armored Forces Engineering of PLA Beijing 100072 China Institute of High Energy Physics the Chinese Academy of Sciences Beijing 100049 China Institute of Applied Physics and Computational Mathematics Beijing 100088 China

Having studied the initial state energy loss versus nuclear shadowing for the Drell-Yan dimuon pairproduction in the color string model,the inhomogeneous shadowing effect is considered in this *** find thatthe inhomogeneous shadowing effect does amend the rate of energy loss per unit path length,-dE/***,thetheoretical results for the Drell-Yan differential cross-section ratios are compared with the E772 and E866 *** isfound that the theoretical results are in good agreement with the experimental data.

关键词： inhomogeneous shadowing effect color string model Drell Yan process

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The role of glial glutamate transporter-la in the induction of brain ischemic tolerance in rats

The role of glial glutamate transporter-la in the induction ...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Yi-xian LIU~1,min zhang~1,Li-Zhe LIU~1,Xin CUI~1,Yu-Yan HU~1,Wen-Bin LI~(1,2,*) 1 Department of Pathophysiology,Hebei Medical University,361 Zhongshan East Road,Shijiazhuang 050017,China 2 Aging and Cognition Neuroscience Laboratory of Hebei Province,89 Donggang Road,Shijiazhuang 050031,China

＜正＞Objective This study was undertaken to determine the role of glial glutamate transporter（GLT）-1a,one of splice variants of GLT-1,in the induction of brain ischemic tolerance by cerebral ischemic preconditioning（CIP） in a rat global cerebral ischemic *** The expression of GLT-1 a protein and mRNA in the CAl hippocampus was observed by using western blotting analysis,immunohistochemistry and *** appearance of neuron and the glutamate concentration in the CAl hippocampus was studied by using neuropathological evaluation and in vivo brain microdialysis combined with ***（1） CIP induced a significant up-regulation of the GLT- 1a expression in the CA1 hippocampus in a time course corresponding to that of neuroprotection of CIP against brain *** brain ischemia for 8 min induced delayed down-regulation of GLT-1a,obvious increase in glutamate concentration and delayed neuronal death of the pyramidal neurons in the CAl *** the animals were pretreated with CIP before the severe ischemia,the above changes induced normally by the severe ischemia were effectively prevented.（2） The preventive effect of CIP on the above changes was significantly inhibited by intracerebroventricular administration of GLT-1 a AS-ODNs which has been proved to specifically inhibit the expression of GLT-1 a protein and mRNA.（3） The concentration of aspartate and GABA was also elevated after severe brain ischemic *** the CIP had no effect on the elevated aspartate concentration and induced a further elevation in the GABA *** GLT-1a participates in the acquirement of brain ischemic tolerance induced by CIP in rats.

关键词： cerebral ischemic preconditioning GLT-la AS-ODNs glutamate global cerebral ischemia rat

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PMN/CB/EP阻尼性能的力和频率特性

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武汉理工大学学报 2009年第1期31卷 8-11页

作者：黄志雄石敏先张联盟王雁冰魏涛武汉理工大学材料科学与工程学院武汉430070

采用动态力学热分析方法,研究了载荷应力和振动频率对铌镁锆钛酸铅(PMN)/导电炭黑(CB)/环氧树脂(EP)复合材料阻尼性能的影响。结果表明,随着动态应力的增大,复合材料的损耗因子峰值tanδmax增大,玻璃化转变温度Tg降低,而阻尼温域ΔT逐... 详细信息

采用动态力学热分析方法,研究了载荷应力和振动频率对铌镁锆钛酸铅(PMN)/导电炭黑(CB)/环氧树脂(EP)复合材料阻尼性能的影响。结果表明,随着动态应力的增大,复合材料的损耗因子峰值tanδmax增大,玻璃化转变温度Tg降低,而阻尼温域ΔT逐渐增加。当应力大于2000mN时,tanδmax、Tg变化的幅度较小,但ΔT有较大的增幅。动态应力对复合材料的模量有较大的影响,在T

关键词：铌镁锆钛酸铅环氧树脂阻尼性能动态应力

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沙眼衣原体被膜和细胞壁分离纯化及其结构的初步研究

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微生物学报 1980年第3期 323-327页

作者：胡朝彬张友逊孟宪敏张利华苏华中国科学院动物研究所北京市眼科研究所

通过强超声处理,酶水解和差速离心等步骤分离了纯化过的沙眼衣原体 TE-55细胞的被膜和细胞壁,并以5—50%泛影葡胺密度梯度离心加以纯化,区带界面清楚、稳定,重复性较好。对完整细胞和分离成份的超薄切片、冰冻断裂及蚀刻和负染标本进行... 详细信息

通过强超声处理,酶水解和差速离心等步骤分离了纯化过的沙眼衣原体 TE-55细胞的被膜和细胞壁,并以5—50%泛影葡胺密度梯度离心加以纯化,区带界面清楚、稳定,重复性较好。对完整细胞和分离成份的超薄切片、冰冻断裂及蚀刻和负染标本进行的电镜观察表明:被膜一般分为三层,负染的细胞壁中见到规则的、排列紧密的直径约28毫微米的亚单位,完整细胞经冰冻蚀刻后也有类似的六角形突起。初步对被膜和细胞壁的多肽组份进行了 SDS-聚丙烯酰胺凝胶电泳分析。对比并讨论了该种膜与革兰氏阴性细菌膜的异同。

关键词：细胞壁沙眼衣原体衣原体属被膜分离纯化

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An improved implementable process for the synthesis of zeolite 4A from bauxite tailings and its Cr^(3+) removal capacity

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International Journal of minerals,Metallurgy and Materials 2016年第7期23卷 850-857页

作者： Peng-cheng Lei xian-jiang Shen Yang Li min Guo Mei zhang School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

A simple and practical method for the synthesis of zeolite 4A from bauxite tailings is presented in this paper. Systematic investigations were carried out regarding the capacity of zeolite 4A to remove Cr（III） from aqueous solutions with relatively low initial concentrations of Cr（III）（5–100 mg·L^（-1））. It is found that the new method is extremely cost-effective and can significantly contribute in decreasing environmental pollution caused by the dumping of bauxite tailings. The Cr（III） removal capacity highly depends on the initial p H value and concentration of Cr（III） in the solution. The maximum removal capacity of Cr（III） was evaluated to be 85.1 mg×g^（-1） for zeolite 4A, measured at an initial p H value of 4 and an initial Cr（III） concentration of 5 mg·L^（-1）. This approach enables a higher removal capacity at lower concentrations of Cr（III）, which is a clear advantage over the chemical precipitation method. The removal mechanism of Cr（III） by zeolite 4A was examined. The results suggest that both ion exchange and the surface adsorption-crystallization reaction are critical steps. These two steps collectively resulted in the high removal capacity of zeolite 4A to remove Cr（III）.

关键词： bauxite tailings zeolite trivalent chromium wastewater treatment

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Numerical Simulation of Heat Transfer and Deformation of Initial Shell in Soft Contact Continuous Casting Mold Under High Frequency Electromagnetic Field

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Journal of Iron and Steel Research International 2007年第6期14卷 14-21页

作者： NA xian-zhao XUE min zhang Xing-zhong GAN Yong State Key Laboratory of Advanced Steel Processes and Materials Central Iron and Steel Research Institute Beijing 100081 China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China

Heat transfer and deformation of initial solidification shell in soft contact continuous casting mold under high frequency electromagnetic field were analyzed using numerical simulation method; the relative electromagnetic parameters were obtained from the previous studies. Owing to the induction heating of a high frequency electromagnetic field （20 kHz）, the thickness of initial solidification shell decreases, and the temperature of strand surface and slit copper mold increases when compared with the case without the electromagnetic filed. The viscosity of flux de- creases because of the induction heating of the high frequency electromagnetic field, and the dimension of the flux channel increases with electromagnetic pressure; thus, the deformation behavior of initial solidification shell was different before and after the action of high frequency electromagnetic field. Furthermore, the abatement mechanism of oscillation marks under high frequency electromagnetic field was explained.

关键词： soft contact electromagnetic continuous casting mold heat transfer ~ initial solidification~ elastic-plasticdeformation finite element method numerical simulation

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A novel active-passive protection strategy endows carbonyl iron with excellent intelligent anti-corrosion and microwave absorption dual functional characteristics

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Nano Research 2025年第1期18卷 487-500页

作者： Wei Tian Quanyuan Feng Linbo zhang Yinfan Liu xian Jian Longjiang Deng Institute of Microelectronics School of Information Science and TechnologySouthwest Jiaotong UniversityChengdu 611756China National Engineering Researching Centre of Electromagnetic Radiation Control Materials Key Laboratory of Multi-Spectral Absorbing Materials and Structures of Ministry of EducationState Key Laboratory of Electronic Thin Films and Integrated DevicesSchool of Electronic Science and EngineeringUniversity of Electronic Science and Technology of ChinaChengdu 611731China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China The Yangtze Delta Region Institute(Huzhou)&School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaHuzhou 313001China

Carbonyl iron absorbers(CI)face significant challenges in practical applications,such as corrosion,interface bonding failure,detachment,and high maintenance ***,we have developed intelligent self-healing technology based on proactive/passive mechanisms via in situ synthesis of self-healing factors(polydopamine/benzotriazole(PDA/BTA))and physical barrier layers(SiO_(2)/1,1,1,3,3,3-hexamethyl disilazane,SiO_(2)/HMDS)to enhance corrosion resistance,while also being compatible with efficient microwave absorption *** unique multiscale structure gives full play to the utilization of the roles of each functional layer,including the intelligent self-healing features of PDA/BTA,physical shielding and spatial confinement characteristics of SiO_(2)/HMDS,and magnetic-dielectric synergistic mechanism resulted from the good impedance matching characteristics,the conduction loss,the interfacial polarization loss and natural *** asfabricated composites achieved an exceptional minimum reflection loss value of-55.4 dB at 10.7 GHz and the effective absorption band of 7.6 ***,it still exhibits obvious self-healing and corrosion resistance characteristics after 360 h corrosion treatment,ascribed to the self-healing mechanism of PDA/BTA and the blocking intervention effect of SiO_(2)/*** work is considered to pave the way for the synthesis of high-performance magnetic absorbers,especially in enhancing their intelligent self-healing ability in corrosive environments.

关键词： microwave absorption intelligent self-healing technology carbonyl iron multiscale structure magneticdielectric synergistic mechanism

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Attraction of bruchid beetles Callosobruchus chinensis (L.) (Coleoptera: Bruchidae) to host plant volatiles

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Journal of Integrative Agriculture 2020年第12期19卷 3035-3044页

作者： WANG Hong-min BAI Peng-hua zhang Jing zhang Xue-min HUI Qin ZHENG Hai-xia zhang xian-hong College of Agricultural Economics and Management Shanxi Agricultural UniversityTaigu 030801P.R.China College of Plant Protection Shanxi Agricultural UniversityTaigu 030801P.R.China Institute of Plant Protection Tianjin Academy of Agricultural SciencesTianjin 300384P.R.China

Host-plant volatiles play an important role as cues for herbivores in search of resources, mates and oviposition sites in complex environments. Plant volatile-based attractants can be developed for pest monitoring and control. Previously, we indicated that mated female adults of Callosobruchus chinensis showed choice preference behavior toward 2-hexenal and benzaldehyde. Our objective here was to investigate the synergistic effect of host-derived attractive volatiles in attracting C. chinensis under laboratory and field conditions in Shanxi Province, China. We hypothesized that the ratio and concentration of volatiles derived from Vigna radiata play critical roles for C. chinensis in locating this host. Therefore, we collected and identified the volatiles of mungbean by using headspace collection and GC-MS. The effectiveness of different ratios and concentrations of two compounds (2-hexenal and benzaldehyde) that elicit C. chinensis searching behavior were examined in Y-tube olfactometer assays. The combination of 300 μg μL^–1 2-hexenal and 180 μg μL^–1 benzaldehyde loadings exhibited a synergistic effect on attracting C. chinensis (82.35%). Compared to control traps, the adults were significantly attracted to traps baited with blends, and more attraction to females than males was found for blend traps in the field experiments. Our results suggest that blends of this specific concentration and ratio of benzaldehyde and 2-hexenal can be used in traps as attractants for C. chinensis monitoring and control in the field.

关键词： Callosobruchus chinensis plant volatiles synergistic effect olfactometer attractant

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