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Well production optimization using streamline features-based objective function and Bayesian adaptive direct search algorithm

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Petroleum Science 2022年第6期19卷 2879-2894页

作者： Qi-Hong Feng Shan-Shan Li xian-min zhang Xiao-Fei Gao Ji-Hui Ni School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Shandong Institute of Petroleum and Chemical Technology Dongying257061ShandongChina CNOOC China Limited Shenzhen BranchShenzhen518000GuangdongChina

Well production optimization is a complex and time-consuming task in the oilfield *** combination of reservoir numerical simulator with optimization algorithms is usually used to optimize well *** method spends most of computing time in objective function evaluation by reservoir numerical simulator which limits its optimization *** improve optimization efficiency,a well production optimization method using streamline features-based objective function and Bayesian adaptive direct search optimization(BADS)algorithm is *** new objective function,which represents the water flooding potential,is extracted from streamline *** only needs to call the streamline simulator to run one time step,instead of calling the simulator to calculate the target value at the end of development,which greatly reduces the running time of the *** the well production optimization model is established and solved by the BADS *** feasibility of the new objective function and the efficiency of this optimization method are verified by three *** demonstrate that the new objective function is positively correlated with the cumulative oil *** the BADS algorithm is superior to other common algorithms in convergence speed,solution stability and optimization ***,this method can significantly accelerate the speed of well production optimization process compared with the objective function calculated by other conventional *** can provide a more effective basis for determining the optimal well production for actual oilfield development.

关键词： Well production Optimization efficiency Streamline simulation Streamline feature Objective function Bayesian adaptive direct search algorithm

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Cross-linking Copolymerization of Acrylic Acid and Multi-armed Cross-linkers

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Chinese Chemical Letters 2001年第11期12卷 1029-1032页

作者： Qiang CHEN Ying GUAN xian min zhang Yu Xing PENG Jian XU State Key Laboratory of Polymer Physics&Chemistry Center for Molecular ScienceInstitute of ChemistryChinese Academy of SciencesBeijing 100080 Chengdu Institute of Organic Chemistry Chinese Academy of SciencesChengdu 610041 Department of Information&Elctronic Engineering Zhejiang UniversityHangzhou 310027

The overall cross-linking copolymerization of acrylic acid and multi-armed cross-linkers are investigated by in situ interferometry. The results show that the more arms the cross-linkers have, the higher the polymerization rate is. However, they also mean the existence of less cross-linking efficiency and some defects in gel network.

关键词： multi-armed cross-linker acrylic acid in situ interferometry

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A NOVEL METHOD FOR CHARACTERIZING THE WHOLE PROCESS OF POLYMER GELATION

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Chinese Journal of Polymer Science 2001年第4期19卷 335-339页

作者： Qiang Chen xian-min zhang Guo-wei Wang Jian Xu State Key Laboratory of Polymer Physics & Chemistry, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences Beijing 100080, China Department of Information & Electronic Engineering Zhejiang University, Hangzhou 310027, China Tjanjin Polytechnic University,Tianjin 300160 Chinese Acad Sci Ctr Mol Sci State Key Lab Polymer Phys & Chem Beijing 100080 Peoples R China Zhejiang Univ Dept Informat & Elect Engn Hangzhou 310027 Peoples R China

A novel method was established to investigate the gelation process of polymers. The change of refractive index of a polymer system during gelation was determined in situ in a prismatic cell. It can give reliable information on the whole gelation process. The apparatus and the execution of this technique are illustrated and the error is also discussed.

关键词： gelation process in situ technique refractive index

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Dynamic response analysis of airport pavements during aircraft taxiing for evaluating pavement bearing capacity

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2021年第9期22卷 736-750页

作者： Qian DONG Jian-hua WANG xian-min zhang Hao WANG Jing-nan ZHAO School of Civil Engineering Tianjin UniversityTianjin 300072China College of Transportation Science and Engineering Civil Aviation University of ChinaTianjin 300300China Department of Civil and Environmental Engineering Rutgers UniversityPiscataway NJ 08854USA

In this paper,we propose a new method to analyze airport pavement bearing capacity using vibration in runways during aircraft *** new method overcomes shortcomings of existing tests,such as flight suspension and simulated *** aircraft take-off and landing,acceleration sensors are arranged on the surface of the pavement far from the centerline,and the in-situ responses of the pavement under aircraft loads are collected during aircraft *** fundamental frequencies of the pavement are obtained by fast Fourier transformation of the measured accelerations,and are used to modify the parameters of a pavement finite element model built according to a design *** comparing the fundamental frequencies of the measured and calculated signals,the soil modulus is *** implement this test method and ensure the accuracy of bearing capacity evaluation,aircraft dynamic loads are obtained by solving dynamic balance equations of the aircraft-pavement coupled system,and the vibration response of the pavement and sensitivity analysis of the fundamental frequencies are *** results show that the fundamental frequencies at the center of the pavement are basically the same as those at the far side on the cross section;the fundamental frequencies in the depth direction remain constant,but the amplitude of the frequency spectrum *** effect of the soil resilient modulus on the vibration frequency is most *** fundamental frequency increases from 6.02 to 10.55 Hz when the soil dynamic resilient modulus changes from 91 to 303 *** effects of surface thickness and base thickness on the vibration frequency are less significant,and there is minimal influence when changing the dynamic elastic moduli of the surface layer or base *** test results indicate the efficacy of the method of vibration measurement at the pavement surface to estimate the layer modulus of airport pavement.

关键词： Airport pavement Non-destructive test Aircraft-pavement coupling Fundamental frequency Acceleration Finite element model

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IN SITU INTERFEROMETRIC STUDY ON THE GELATION PROCESS OF POLYACRYLIC ACID GELS

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Chinese Journal of Polymer Science 2000年第4期18卷 373-377页

作者： Ying Guan Qiang Chen xian-min zhang Yu-xing Peng Jian Xu Polymer Physics Laboratory, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Department of Information & Electronic Engineering, Zhejiang University, Hangzhou 310027, China Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China Chinese Acad Sci Inst Chem Ctr Mol Sci Polymer Phys Lab Beijing 100080 Peoples R China Zhejiang Univ Dept Informat & Elect Engn Hangzhou 310027 Peoples R China Chinese Acad Sci Chengdu Inst Organ Chem Chengdu 610041 Peoples R China

In situ interferometry was used to investigate the gelation process of polyacrylic acid (PAA) gels. The basic principle of the in situ interferometry technique is illustrated. It can give sufficient information for non-destructive and successful investigation of the whole gelation process. The effect of initiator concentration on the gelation process was studied. The polymerization rate of AA increases with increasing initiator concentration. The error arising from the thermal effect in the gelation process can be neglected.

关键词： in situ interferometry gelation polyacrylic acid

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伏立康唑药物相互作用与处理对策

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中国新药与临床杂志 2009年第6期28卷 415-420页

作者：孟现民张莉复旦大学附属上海市公共卫生临床中心上海201508

伏立康唑是合成的第2代三唑类广谱抗真菌药,抗真菌作用强,主要用于各种真菌引起的严重感染以及免疫缺陷病人真菌感染的治疗。体外人肝微粒体实验表明,伏立康唑不仅是CYP2C19、CYP2C9和CYP3A4酶的底物,也是其抑制剂,而体内多数药物主要... 详细信息

伏立康唑是合成的第2代三唑类广谱抗真菌药,抗真菌作用强,主要用于各种真菌引起的严重感染以及免疫缺陷病人真菌感染的治疗。体外人肝微粒体实验表明,伏立康唑不仅是CYP2C19、CYP2C9和CYP3A4酶的底物,也是其抑制剂,而体内多数药物主要由这几种酶代谢。因此,伏立康唑与很多药物都存在潜在的相互作用,医生在应用此药时应引起注意。本文就已报告的伏立康唑药物相互作用作一综述并总结出相应的对策,以供临床参考。

关键词：抗真菌药细胞色素P450酶系统药物相互作用伏立康唑

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Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

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Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu Luo min Song Lulu An Xiao Huang Qian zhang Chenhao zhang Tao Shen Shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

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痛刺激或针刺时大鼠下丘脑弓状核区单位放电的变化

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生理学报 1984年第1期36卷 33-41页

作者：虞献民印其章苏州医学院生理教研室、电生理研究室苏州医学院生理教研室、电生理研究室研究生南京药学院生理教研室工作

在75只清醒麻痹大鼠身上,记录了下丘脑弓状核(ARC)区的166个单位放电。单位自发放电频率最幔的不到1次/s,最快的很少超过10次/s。所记录的单位放电的平均频率白天(1.83±0.2次/s,n=75)低于晚上(2.70±0.3次/s,n=91)。观察了129个单位对... 详细信息

在75只清醒麻痹大鼠身上,记录了下丘脑弓状核(ARC)区的166个单位放电。单位自发放电频率最幔的不到1次/s,最快的很少超过10次/s。所记录的单位放电的平均频率白天(1.83±0.2次/s,n=75)低于晚上(2.70±0.3次/s,n=91)。观察了129个单位对外周伤害性刺激的反应,其中发生兴奋反应的有56个(43.4%);抑制反应的有46个(35.7%);不发生反应的有27个(20.9%)。电针和电刺激中缝背核或中脑导水管周围灰质能改变 ARC 区单位的自发放电频率,并明显削弱 ARC 区单位对伤害性刺激的反应。结果提示,ARC 区神经元在痛觉整合过程和针刺镇痛中有重要作用。

关键词：弓状核伤害性刺激电针导水管周围灰质中缝背核镇痛

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu xiandeng Li Mi Li xian Wu Xiaohui Huang Ajing Xu Yan Liu Jian zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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流体中双自由度二维振动平板推进运动的非线性分析

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水动力学研究与进展（A辑） 1989年第4期4卷 69-82页

作者：庄礼贤贾明祥张剑峰中国科技大学近代力学系

本文提出了计算双自由度二维振动平板绕流的一种半解析非线性方法;讨论了非定常流Kutta条件的自洽处理问题;模拟了尾涡的脱泻、变形和配对过程;并对振动平板的推进运动方式进行了优化分析,给出了优化推进参数的选择范围。

关键词：流体自由度振动平板绕流

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