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LncRNA pol-lnc78 as a ceRNA regulates antibacterial responses via suppression of pol-miR-n199-3p-mediated SARM down-regulation in Paralichthys olivaceus

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Zoological Research 2024年第1期45卷 25-35页

作者： xian-hui ning Bing Han Ye Peng Shao-Wu Yin College of Marine Science and Engineering Nanjing Normal UniversityNanjingJiangsu 210023China CAS Key Laboratory of Experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdaoShandong 266071China Co-Innovation Center for Marine Bio-Industry Technology of Jiangsu Province LianyungangJiangsu 222005China

Long non-coding RNAs(lncRNAs)function as key modulators in mammalian immunity,particularly due to their involvement in lncRNA-mediated competitive endogenous RNA(ceRNA)*** their recognized significance in mammals,research on lncRNAs in lower vertebrates remains *** the present study,we characterized the first immune-related lncRNA(pol-lnc78)in the teleost Japanese flounder(Paralichthys olivaceus).Results indicated that pol-lnc78 acted as a ceRNA for pol-miR-n199-3p to target the sterile alpha and armadillo motif-containing protein(SARM),the fifth discovered member of the Toll/interleukin 1(IL-1)receptor(TIR)adaptor *** ceRNA network regulated the antibacterial responses of flounder via the Toll-like receptor(TLR)signaling ***,SARM acted as a negative regulator and exacerbated bacterial infection by inhibiting the expression of inflammatory cytokines IL-1βand tumor necrosis factor-α(TNF-α).Pol-miR-n199-3p reduced SARM expression by specifically interacting with the 3’untranslated region(UTR),thereby promoting SARM-dependent inflammatory cytokine expression and protecting the host against bacterial ***,pol-lnc78 sponged pol-miR-n199-3p to ameliorate the inhibition of SARM *** infection,the negative regulators pol-lnc78 and SARM were significantly down-regulated,while pol-miR-n199-3p was significantly up-regulated,thus favoring host antibacterial *** findings provide novel insights into the mechanisms underlying fish immunity and open new horizons to better understand ceRNA crosstalk in lower vertebrates.

关键词： LncRNA SARM miRNA ceRNA Antibacterial response

Consumers'willingness to pay for ethical consumption initiatives on e-commerce platforms

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Journal of Integrative Agriculture 2021年第4期20卷 1012-1020页

作者： WANG Er-peng AN ning GENG xian-hui Zhifeng GAO Emmanuel KIPROP School of Economics and Management Nanjing Tech UniversityNanjing 211816P.R.China College of Economics and Management Nanjing Agricultural UniversityNanjing 210095P.R.China Food and Resource Economics Department University of FloridaGainesvilleFL 32611-0240USA

Despite China's fast-growing e-commerce and its great achievement in promoting poverty alleviation through consumption,little is known about Chinese consumers'online ethical *** the payment card elicitation method,this paper designs a within-subject survey and a between-subject survey to investigate Chinese consumers'quality perception and preference for apples from poverty-stricken *** results show that before"information shock",emphasizing that taste and safety attributes of apples from poverty-stricken areas are the same as the conventional ones,Chinese consumers on average are willing to pay a 31%premium for apples from poverty-stricken ***"information shock",both the within-subject and between-subject designs show a minimal drop of the premium,implying that the ethical attribute is the main motivation for buying apples from poverty-stricken *** regression results show that quality perception of private attributes has significant effect on consumers'willingness to pay(WTP)for apples from poverty-stricken areas,and trust in government supervision of e-commerce plays an essential role in motivating online ethical consumption.

关键词： ethical consumption apples from poverty-stricken areas WTP interval regression

Biological object recognition approach using space variant resolution and pigeon-inspired optimization for UAV

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Science China(Technological Sciences) 2017年第10期60卷 1577-1584页

作者： XIN Long xian ning State Key Laboratory of 14rtual Reality Technology and Systems Beihang University Beijing 100191 China

Recognizing the target from a rotated and scaled image is an important and difficult task for computer vision. Visual system of humans has a unique space variant resolution mechanism(SVR) and log-polar transformations(LPT) is a mapping method that is invariant to rotation and scale. Motivated by biological vision, we propose a novel global LPT based template-matching algorithm(GLPT-TM) which is invariant to rotational and scale changes; and with pigeon-inspired optimization(PIO) used to optimize search strategy, a hybrid model of SVR and pigeon-inspired optimization(SVRPIO) is proposed to accomplish object recognition for unmanned aerial vehicles(UAV) with rotational and scale changes of the target. To demonstrate the efficiency, effectiveness and reliability of the proposed method, a series of experiments are carried out. By rotating and scaling the sample image randomly and recognizing the target with the method, the experimental results demonstrate that our proposed method is not only efficient due to the optimization, but effective and accurate in recognizing the target for UAV.

关键词： biological vision space variant resolution mechanism (SVR) log-polar transformations (LPT) pigeon-inspiredoptimization (PIO) object recognition

Effect of dissolved organic matter on the toxicity of chlorotoluron to Triticum aestivum

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Journal of Environmental Sciences 2006年第1期18卷 101-108页

作者： SONG ning-hui YANG Zhi-min ZHOU Li-xian WU Xin YANG Hong College of Science Nanjing Agricultural University Nanjing 210095 China College of Life Science Nanjing Agricultural University Nanjing 210095 China College of Resources and Environmental Sciences Nanjing Agricultural University Nanjing 210095 China

Response of two wheat cultivars （Triticum aestivum cv. YM 158 and NM 9） to the herbicide chlorotoluron and the effect of two forms of dissolved organic matter on the chlorotoluron toxicity to the plants were characterized. Treatment with chlorotoluron at 10-50 μg/ml inhibited the seed germination and a dose-response was observed. The inhibition of seed germination was correlated to the depression of a-amylase activities. To identify whether chlorotoluron induced oxidative damage to wheat plants, the malondlaldehyde （MDA） content and electrolyte leakage were measured. Results showed that both MDA content and electrolyte leakage in the chlorotoluron-treated roots significantly increased. Activities of several key enzymes were measured that operate in citric acid cycle and carbohydrate metabolic pathway. Inhibited activities of citrate synthase and NADP-isocitrate dehydrogenase were observed in the chlorotoluron-treated roots as compared to control plants. We also examined malate dehydrogenase and phosphoenolpyruvate carboxylase in wheat roots exposed to 30 μg/ml chlorotoluron, liowever, none of the enzymes showed significant changes in activities. Application of 160 μg/ml dissolved organic matter （DOM） extracted from non-treated sludge（NTS） and heat-expanded sludge （lIES） in the medium with 30 μg/ml chlorotoluron induced an additive inhibition of seed germination and plant growth. The inhibition of growth due to the DOM treatment was associated with the depression of activities of a-amylase, citrate synthase and NADP-isocitrate dehydrogenase, as well as the increase in malondlaldehyde content and electrolyte leakage. These results suggested that the presence of DOM might enhance the uptake and accumulation of chlorotoluron, and thus resulted in greater toxicity in wheat plants. The two forms of DOM exhibited differences in regulation of chlorotoluron toxicity to the wheat plants. Treatments with DOM-NTS induced greater toxicity to plants as compared to those with DOM-

关键词： dissolved organic matter chlorotoluron Triticum aestivum toxicity

Comparative study of swarm intelligence-based saliency computation

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International Journal of Intelligent Computing and Cybernetics 2017年第3期10卷 348-361页

作者： ning xian School of Automation Science and Electrical Engineering Beihang UniversityBeijingChina

Purpose–The purpose of this paper is to propose a new algorithm chaotic pigeon-inspired optimization(CPIO),which can effectively improve the computing efficiency of the basic Itti’s model for saliency-based *** CPIO algorithm and relevant applications are aimed at air surveillance for target ***/methodology/approach–To compare the improvements of the performance on Itti’s model,three bio-inspired algorithms including particle swarm optimization(PSO),brain storm optimization(BSO)and CPIO are applied to optimize the weight coefficients of each feature map in the saliency ***–According to the experimental results in optimized Itti’s model,CPIO outperforms PSO in terms of computing efficiency and is superior to BSO in terms of searching ***,CPIO provides the best overall properties among the three *** implications–The algorithm proposed in this paper can be extensively applied for fast,accurate and multi-target detections in aerial ***/value–CPIO algorithm is originally proposed,which is very promising in solving complicated optimization problems.

关键词： Visual attention Particle swarm optimization(PSO) Brain storm optimization(BSO) Chaotic pigeon-inspired optimization(CPIO) Saliency computation

Lipidomic Analysis Reveals the Importance of GIPCs in Arabidopsis Leaf Extracellular Vesicles

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Molecular Plant 2020年第10期13卷 1523-1532页

作者： ning-Jing Liu ning Wang Jing-Jing Bao hui-xian Zhu Ling-Jian Wang Xiao-Ya Chen State Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences/Shanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesFenglin Road 300Shanghai 200032China Key Laboratory of Plant Stress Biology State Key Laboratory of Cotton BiologySchool of Life SciencesHenan UniversityKaifeng 475004China University of Chinese Academy of Sciences Shanghai 200032China

Plant extracellular vesicles(EVs)are membrane-enclosed nanoparticles that play diverse roles in plant development and ***,impressive progress has been made in the isolation and identification of the proteins and RNAs carried in plant EVs;however,the analysis of EV lipid compositions remains ***,we performed lipidomic analysis of Arabidopsis rosette leaf EVs,revealing a high abundance of certain groups of lipids,in particular sphingolipids,in the ***,the EV sphingolipids are composed of nearly pure glycosylinositolphosphoceramides(GIPCs),which are green lineage abundant and negatively *** further showed that the Arabidopsis TETRASPANIN 8(TET8)knockout mutant has a lower amount of cellular GIPCs and secrets fewer EVs,companied with impaired reactive oxygen species(ROS)burst toward *** application of GIPCs promoted the secretion of EVs and ROS burst in both the WT and tet8 *** characteristic enrichment of sphingolipid GIPCs provides valuable insights into the biogenesis and function of plant EVs.

关键词： sphingolipids extracellular vesicles

SUPERCONVERGENCE AND A POSTERIORI ERROR ESTIMATES FOR BOUNDARY CONTROL GOVERNED BY STOKES EQUATIONS

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Journal of Computational Mathematics 2006年第3期24卷 343-356页

作者： hui-po Liu ning-ning Yan Institute of Systems Science Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100080 China

In this paper, the superconvergence results are derived for a class of boundary control problems governed by Stokes equations. We derive superconvergence results for both the control and the state approximation. Base ... 详细信息

关键词： Boundary control Finite element method Superconvergence A posteriori error estimates.

Exploring gut microbiota as a novel therapeutic target in Crohn’s disease: Insights and emerging strategies

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World Journal of Gastroenterology 2025年第2期31卷 147-156页

作者： Tong Qiao xian-hui Wen Department of Clinical Medicine Jinan UniversityGuangzhou 510632Guangdong ProvinceChina College of Life Science and Technology Jinan UniversityGuangzhou 510632Guangdong ProvinceChina

Extensive research has investigated the etiology of Crohn’s disease(CD),encompassing genetic predisposition,lifestyle factors,and environmental ***,the gut microbiome,recognized as the human body’s second-largest gene pool,has garnered significant attention for its crucial role in the patho-genesis of *** paper investigates the mechanisms underlying CD,focusing on the role of‘creeping fat’in disease progression and exploring emerging therapeutic strategies,including fecal microbiota transplantation,enteral nutri-tion,and therapeutic *** fat has been identified as a unique patho-logical feature of CD and has recently been found to be associated with dysbiosis of the gut *** characterize this dysbiotic state by identi-fying key microbiome-bacteria,fungi,viruses,and archaea,and their contributions to CD ***,this paper reviews contemporary therapies,empha-sizing the potential of biological therapies like fecal microbiota transplantation and dietary *** elucidating the complex interactions between host-microbiome dynamics and CD pathology,this article aims to advance our under-standing of the disease and guide the development of more effective therapeutic strategies for managing CD.

关键词： Crohn’s disease Gut microbiome Dysbiosis Creeping fat Fecal microbiota transplantation

Fatigue limit assessment of a 6061 aluminum alloy based on infrared thermography and steady ratcheting effect

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International Journal of Minerals,Metallurgy and Materials 2020年第9期27卷 1301-1308页

作者： Ru-yi Feng Wen-xian Wang Zhi-feng Yan Deng-hui Wang Shi-peng Wan ning Shi College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Interface Science and Engineering in Advanced Materials Ministry of EducationTaiyuan University of TechnologyTaiyuan 030024China Shanxi Key Laboratory of Advanced Magnesium-based Materials Taiyuan University of TechnologyTaiyuan 030024China

To quickly predict the fatigue limit of 6061 aluminum alloy,two assessment methods based on the temperature evolution and the steady ratcheting strain difference under cyclic loading,respectively,were *** temperature evolutions during static and cyclic loadings were both measured by infrared *** tests show that the temperature evolution was closely related to the cyclic loading,and the cyclic loading range can be divided into three sections according to the regular of temperature evolution in different *** mechanism of temperature evolution under different cyclic loadings was also analyzed due to the thermoelastic,viscous,and thermoplastic ***,ratcheting strain under cyclic loading was also measured,and the results show that the evolution of the ratcheting strain under cyclic loading above the fatigue limit undergone three stages:the first increasing stage,the second steady state,and the final abrupt increase *** fatigue limit of the 6061 aluminum alloy was quickly estimated based on transition point of linear fitting of temperature increase and the steady value of ratcheting strain ***,it is feasible and quick of the two methods by the proof of the traditional S-N curve.

关键词： 6061 Aluminum temperature evolution fatigue limit ratcheting strain