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Association of food intake with a risk of metabolic dysfunction-associated fatty liver disease:a cross-sectional study

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Gastroenterology Report 2023年第1期11卷 439-445页

作者： xian-hua huang He-Wei Peng Jing-Ru huang Rong Yu Zhi-Jian Hu xian-E Peng Department of Epidemiology and Health Statistics Fujian Provincial Key Laboratory of Environment Factors and CancerSchool of Public HealthFujian Medical UniversityFuzhouFujianP.R.China College of Integrated Chinese and Western Medicine Fujian University of Traditional Chinese MedicineFuzhouFujianP.R.China Key Laboratory of Gastrointestinal Cancer Ministry of EducationFujian Medical UniversityFuzhouFujianP.R.China

Background:Metabolic dysfunction-associated fatty liver disease(MAFLD)is a common liver disease,the risk of which can be increased by poor *** objective of this study was to evaluate the associations between food items and MAFLD,and to propose reasonable dietary recommendations for the prevention of ***:Physical examination data were collected from April 2015 through August 2017 at Nanping First Hospital(n=3,563).Dietary intakes were assessed using a semi-quantitative food frequency *** association between food intake and the risk of MAFLD was assessed by using the inverse probability weighted propensity ***:Beverages(soft drinks and sugar-sweetened beverages)and instant noodles were positively associated with MAFLD risk,adjusting for smoking,drinking,tea intake,and weekly hours of physical activity[adjusted odds ratio(ORadjusted):1.568;P=0.044;ORadjusted:4.363;P=0.001].Milk,tubers,and vegetables were negatively associated with MAFLD risk(ORadjusted:0.912;P=0.002;ORadjusted:0.633;P=0.007;ORadjusted:0.962;P=0.028).In subgroup analysis,the results showed that women[odds ratio(OR):0.341,95%confidence interval(CI):0.172–0.676]had a significantly lower risk of MAFLD through consuming more tubers than men(OR:0.732,95%CI:0.564–0.951).Conclusions:These findings suggest that reducing consumption of beverages(soft drinks and sugar-sweetened beverages)and instant noodles,and consuming more milk,vegetables,and tubers may reduce the risk of MAFLD.

关键词： metabolic dysfunction-associated fatty liver disease food intake cross-sectional study inverse probability of treatment weighting

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Complex structure of human Hsp90~N and a novel small inhibitor FS5

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Nuclear Science and Techniques 2020年第3期31卷 74-84页

作者： Rui Liu Xiao-Lu Lu xian-hua huang Wei He Jing-Jing Duan Jin Zhang Jian Li School of Basic Medical Sciences Nanchang UniversityNanchang 330031China College of Pharmaceutical Sciences Gannan Medical UniversityGanzhou 341000China Human Aging Research Institute(HARI) School of Life SciencesNanchang UniversityNanchang 330031China Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases Ministry of EducationGannan Medical UniversityGanzhou 341000China

Heat shock proteins(Hsps)are a family of abundantly expressed ATP-dependent chaperone ***90 is an eminent member of Hsp *** far,two primary functions have been described for Hsp90:first,as a regulator of conformational change of some protein kinases and nuclear hormone receptors,and the other as an indispensable factor in cellular stress ***90 has an essential number of interaction proteins since it participates in almost every biological process and its importance is ***90 has an inextricable relationship in the pathogenesis of cancer,especially in the proliferation and irradiation of cancer cells,thus being a notable cancer *** the discovery of geldanamycin,the first inhibitor of Hsp90,from the bacterial species Streptomyces hygroscopicus,even more attention has been focused toward *** structure-based inhibitors of Hsp90 have been designed to develop an innovative method to defeat ***,already designed inhibitors have various deficiencies,such as hepatotoxicity,poor aqueous solubility,instability,and non-ideal oral *** on the aforementioned reasons and to achieve an optimal performance and fewer side effects,we designed a novel inhibitor of Hsp90,called FS5,and resolved the crystal structure of the Hsp90^N-FS5 complex(1.65 A°,PDB code 5XRB).Furthermore,we compared the complexes Hsp90^N,Hsp90^N-GDM,and Hsp90^N-ATP and suggest that the inhibitor FS5 may compete with ATP for binding to Hsp90,which can be regarded as a potential strategy for the development of novel cancer drugs in the future.

关键词： Heat shock protein 90 Complex crystal structure Interactions Anti-tumor drugs X-ray diffraction

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Protective effects of imperatorin against cerebral ischemia/reperfusion-induced oxidative stress through Nrf2 signaling pathway in rats

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中国药理学与毒理学杂志 2017年第10期31卷 988-988页

作者： Wei HE Wei-wei CHEN xian-hua huang Yu-mei ZHOU Fang LIAO Department of Pharmacology Gannan Medical UniversityKey Laboratory of Cerebrovascular Pharmacology of Jiangxi Province

OBJECTIVE To investigates the effects of imperatorin on the oxidative stress in the cerebral cortex and hippocampus after focal cerebral ischemia/reperfusion *** Transient focal cerebral ischemia/reperfusion model in male Sprague-Dawley rats was induced by 2 h middle cerebral artery occlusion followed by 24 h ***(1.25 and 2.5 mg·kg-1)or vehicle were administered intraperitoneally at 1,5 and 9 h after the onset of *** 24 h after reperfusion,the biomarkers of oxidative stress such as the levels of reactive oxygen species(ROS),lipid peroxidation products malondialdehyde(MDA),nitric oxide(NO)and total antioxidant capacity(T-AOC),the activities of inducible nitric oxide synthase(iN OS),superoxide dismutase(SOD)and catalase(CAT)in the cerebral cortex and hippocampus were *** also assessed the nuclear factor erythroid 2-related factor 2(Nrf2),heme oxygenase-1(HO-1),and the NAD(P)H-quinone oxidoreductase 1(NQO-1)protein expression by Western *** As compared to vehicle-treated animals,imperatorin treatment significantly reduced the ROS,MDA,NO levels and i NOS activity,increased T-AOC and the activities of SOD and ***,imperatorin treatment also significantly induced the nuclear translocation of Nrf2,enhanced the protein expression of HO-1 and NQO-1 in the cerebral cortex and *** Our findings indicate that imperatorin can protect the brain against the excessive oxidative stress induced by cerebral ischemia/reperfusion through activation of Nrf2 signaling pathway.

关键词： imperatorin cerebral ischemia/reperfusion reactive oxygen species nuclear factor erythroid 2-related factor 2

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蜘蛛拖丝蛋白基因的构建及在大肠杆菌中的表达

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生物工程学报 2002年第3期18卷 331-334页

作者：李敏章文贤黄智华黄建坤福建师范大学生物工程学院福州350007

蜘蛛大壶腹线产生的拖丝是非常优良的纤维蛋白 ,具有独特的强度和弹性。基于拖丝蛋白高度重复序列和部分cDNA序列 ,合成蜘蛛拖丝蛋白基因单体 ,通过头尾相连的构建策略 ,得到拖丝蛋白多聚体 ,与原核高效表达载体pET30a(+)连接 ,转化大... 详细信息

蜘蛛大壶腹线产生的拖丝是非常优良的纤维蛋白 ,具有独特的强度和弹性。基于拖丝蛋白高度重复序列和部分cDNA序列 ,合成蜘蛛拖丝蛋白基因单体 ,通过头尾相连的构建策略 ,得到拖丝蛋白多聚体 ,与原核高效表达载体pET30a(+)连接 ,转化大肠杆菌BLR(DE3) ,用IPTG诱导表达。表达产物经His .Bind树脂金属螯合亲和层析一步纯化 ,纯度达 90 %以上 ,表达量为 2 0mg L。SDS PAGE和蛋白质印迹图谱显示表达产物分子量为 37kD 。

关键词：蜘蛛拖丝蛋白基因大肠杆菌表达

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基于d-型函数的具有最优周期部分汉明相关的跳频序列

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山东大学学报（理学版） 2017年第5期52卷 95-103页

作者：宁多彪牛宪华黄平王常远成都东软学院计算机科学与技术系四川成都611844 西华大学计算机与软件工程学院四川成都610039

基于d-型函数,提出了两类具有最优周期部分汉明相关的跳频序列的构造方法。研究表明,对于任意相关窗长,新构造的跳频序列都是最优的。

关键词： d-型函数跳频序列周期部分汉明相关严格最优

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu xiandeng Li Mi Li xian Wu Xiaohui huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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Deciphering the role of ultra-low-loaded rhodium in NiFe-MIL-53 for superior oxygen evolution reaction

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Journal of Energy Chemistry 2025年第1期100卷 77-86页

作者： Jinzhi Jia Jinhua Zhang Kailu Guo Lanyue Zhang Gening Du Hao You Junfeng huang Mudong Tu hua Li Yong Peng Wei Dou Cailing Xu State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering School of Materials and Energy Lanzhou University College of Chemistry and Chemical Engineering Luoyang Normal University

Designing highly active and stable electrocatalysts of oxygen evolution reaction （OER） is one of the crucial *** this study,a novel OER electrocatalyst,NiFe-MIL-53 modified with ultra-low rhodium（Rh@NiFe-MIL-53）,is successfully prepared via the hydrothermal ***-situ Raman spectroscopy and electrochemical impedance spectroscopy reveal that the doped Rh accelerates the phase transformation of NiFe-MIL-53 and the in-situ formed Rh@NiFeOOH is the actual active *** importantly,the enhanced reversibility of electrochemical reconstruction between NiFeOOH and NiFe（OH）2after doping Rh is beneficial for improving the electrochemical stability of the catalyst.X-ray photoelectron spectroscopy spectra show the strong electronic interaction between single-atom Rh and Ni/Fe in Rh@***,theoretical calculations confirm that the integration of single-atom Rh into the NiFeOOH successfully reduces the band gap,regulates the d-band center （εd）,accelerates the charge transfer,and optimizes the adsorption behavior of oxygen-containing intermediates,thereby lowering the energy barrier of rate-determining ***,the optimized Rh@NiFe-MIL-53 exhibits excellent OER activity （240 mV） with a small Tafel slope of 48.2 mV dec-1and long-term durability (over1270 h at 10 m A cm-2and 110 h at 200 mA cm-2).This work presents a new perspective on designing highly efficient OER electrocatalysts.

关键词： NiFe-MIL-53 Rh Electrochemical reconstruction Catalytic mechanism Oxygen evolution reaction

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网状色素性皮病1例

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中国皮肤性病学杂志 2016年第10期30卷 1052-1053页

作者：赵桓玉常莉金仙花黄洋陈溪高微张钰夏建新吉林大学第二医院皮肤科吉林长春130041

患者男,30岁。全身网状黑褐色色素沉着20余年。面颈、躯干及四肢可见网状黑褐色色素沉着,尤以颈部、躯干及上肢为重,头部毛发稀疏,发质干脆,双侧眉毛外1/3稀疏,掌跖点状角化过度、双手指甲萎缩、脱落,双手掌皮纹减少,拇指指纹消失。皮... 详细信息

患者男,30岁。全身网状黑褐色色素沉着20余年。面颈、躯干及四肢可见网状黑褐色色素沉着,尤以颈部、躯干及上肢为重,头部毛发稀疏,发质干脆,双侧眉毛外1/3稀疏,掌跖点状角化过度、双手指甲萎缩、脱落,双手掌皮纹减少,拇指指纹消失。皮损组织病理示:棘层萎缩变薄,真皮浅中层血管周围中等量淋巴细胞浸润并见大量嗜色素细胞。诊断:网状色素性皮病。

关键词：网状色素性皮病

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Advanced Functional Electromagnetic Shielding Materials:A Review Based on Micro‑Nano Structure Interface Control of Biomass Cell Walls

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Nano-Micro Letters 2025年第1期17卷 98-134页

作者： Yang Shi Mingjun Wu Shengbo Ge Jianzhang Li Anoud Saud Alshammari Jing Luo Mohammed A.Amin hua Qiu Jinxuan Jiang Yazeed M.Asiri Runzhou huang hua Hou Zeinhom M.El‑Bahy Zhanhu Guo Chong Jia Kaimeng Xu xiangmeng Chen Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources College of Materials Science and EngineeringNanjing Forestry UniversityNanjing 210037People’s Republic of China State Key Laboratory of Efficient Production of Forest Resourced Beijing Forestry UniversityQinghua East Road 35Haidian DistrictBeijing 100083People’s Republic of China Department of Physics Faculty of Sciences‑ArarNorthern Border UniversityArar 91431Saudi Arabia Department of Chemistry College of ScienceTaif UniversityP.O.Box 1109921944 TaifSaudi Arabia Shaanxi Key Laboratory of Macromolecular Science and Technology School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024People’s Republic of China Department of Chemistry Faculty of ScienceAl-Azhar UniversityNasr CityCairo 11884Egypt Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products International Joint Research Center for Biomass MaterialsSouthwest Forestry UniversityKunming 650224People’s Republic of China School of Science Henan Agricultural UniversityZhengzhou 450002People’s Republic of China

Research efforts on electromagnetic interference(EMI)shielding materials have begun to converge on green and sustainable biomass *** materials offer numerous advantages such as being lightweight,porous,and *** to their porous nature,interfacial compatibility,and electrical conductivity,biomass materials hold significant potential as EMI shielding *** concerted efforts on the EMI shielding of biomass materials have been reported,this research area is still relatively new compared to traditional EMI shielding *** particular,a more comprehensive study and summary of the factors influencing biomass EMI shielding materials including the pore structure adjustment,preparation process,and micro-control would be *** preparation methods and characteristics of wood,bamboo,cellulose and lignin in EMI shielding field are critically discussed in this paper,and similar biomass EMI materials are summarized and *** composite methods and fillers of various biomass materials were *** paper also highlights the mechanism of EMI shielding as well as existing prospects and challenges for development trends in this field.

关键词： Biomass materials Electromagnetic interference shielding Micro-nano structure interface control Conductivity

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A Convenient Synthesis of Diacyl Selenides by Selenium Transfer Reaction of Primary Selenoamides

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Chinese Chemical Letters 2001年第10期12卷 873-874页

作者： hua Rong ZHAO Xin Jian ZHAO xian huang Department of Chemistry Zhejiang UniversityHangzhou 310027 Zhejiang Institute of Calibaration and Testing for Technical Superision Hangzhou 310013

As a selenium transfer reagent, arylselenoamides react with acyl chlorides in chloroform to give diacyl selenides conveniently in good yield.

关键词： diacyl selenides selenium transfer reaction

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