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Role of moxibustion in inflammatory responses during treatment of rat ulcerative colitis

World Journal of Gastroenterology 2014年第32期20卷 11297-11304页

作者： Yang Han Tie-Ming ma mao-Lin Lu Lu Ren xian-de ma Zeng-Hua Bai department of Acupuncture and massage Liaoning University of Traditional Chinese Medicine Center for Photochemical Sciences Department of Chemistry Bowling Green State University Bowling Green OH 43403 United States

AIM: To investigate the efficacy of moxibustion in ulcerative colitis (UC) rats from morphological, immunological and molecular biological perspectives. METHODS: Thirty-two Sprague-Dawley rats were randomly assigned to a blank control group (normal rats, n = 6) and a model replication (MR) group (UC rats, n = 26). A UC model was established by 2,4,6-trinitrobenzenesulfonic acid/dextran sulfate sodium enema. Rats in the MR group were further randomly assigned to a 9-min moxibustion (9M) group (9 moxa-cone, n = 6), 6-min moxibustion (6M) group (6 moxa-cone, n = 6), 3-min moxibustion (3M) group (3 moxa-cone, n = 6), and a waiting list control (WLC) group (no moxibustion treatment, n = 6). Rats in the moxibustion treatment group were treated in 14 sessions over 28 d. Disease activity, local tissue morphology, serum level of interleukin (IL)-8 and IL-10, and expression of Toll-like receptor (TLR)9 as well as nuclear factor (NF)-kappa B p65 in colonic tissue were determined by disease activity index (DAI), hematoxylin and eosin staining, electron microscopy, enzyme-linked immunosorbent assay and Western blotting, respectively. RESULTS: DAI was lowest in the 9M group and highest in the WLC group. The differences in DAI between the moxibustion treatment (3M, 6M, 9M) and no treatment groups were significant for all one-to-one comparisons (0.60 +/- 0.54 vs 1.20 +/- 0.44, 0.60 +/- 0.54 vs 1.80 +/- 0.45, 0.60 +/- 0.54 vs 3.0 +/- 0.45, respectively, P decreased while IL-10 level increased from the WLC to 3M, 6M and 9M groups. The differences among these groups were significant for all comparisons (105.46 +/- 8.75 vs 76.61 +/- 3.58, 105.46 +/- 8.75 vs 69.78 +/- 1.87, 105.46 +/- 8.75 vs 67.41 +/- 1.84, respectively, P < 0.01 for IL-8; and 30.83 +/- 1.29 vs 75.64 +/- 1.90, 30.83 +/- 1.2

关键词： Moxibustion Ulcerative colitis Disease activity index Interleukin-8 Interleukin-10 Toll-like receptor 9 Nuclear factor-kappa B p65

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Moxibustion regulates inflammatory mediators and colonic mucosal barrier in ulcerative colitis rats

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World Journal of Gastroenterology 2016年第8期22卷 2566-2575页

作者： Tie-Ming ma Na Xu xian-de ma Zeng-Hua Bai Xing Tao Hong-Chi Yan Liaoning University of Traditional Chinese Medicine Shenyang 110847 Liaoning Province China

AIM: To observe the efficacy and mechanism of grain-sized moxibustion at different acupoints in a rat model of ulcerative colitis (UC). METHODS: Sprague-Dawley rats were randomly divided into control, UC model, grain-sized moxibustion at a single acupoint (CV 12), grain-sized moxibustion at two acupoints (CV 12 and CV 4), grain-sized moxibustion at three acupoints (CV 12, CV 4, and ST 36), and medication groups (n = 8/group). The UC model was established by enema of trinitrobenzene sulfonic acid. Direct moxibustion was used once a day for 7 d. Disease activity index (DAI) was evaluated before and after the treatment. Morphologic changes of intestinal tissue were observed under an optical microscope. The expression of tumor necrosis factor (TNF)-alpha and p38 mitogen-activated protein kinase (p38maPK) in colonic tissue was detected using Western blot, and the levels of occludin and zonula occludens-1 (ZO-1) mRNAs were detected using reverse transcription PCR. RESULTS: Compared with the control group, the intestinal mucosae were incomplete in the model group, glandular structures were irregular, and submucosae were edematous, hyperemic, and infiltrated with inflammatory cells. The DAI scores and expression of TNF-alpha and p38maPK were increased significantly in the model group compared to controls (Ps del group, colonic mucosa and the arrangement of glands were complete and regular in the treatment groups. DAI scores and the expression of TNF-alpha and p38maPK were reduced significantly in moxibustion groups compared to controls (Ps maPK and increased expre

关键词： Different acupoints Grain-sized moxibustion Inflammatory factors Intestinal mucosal barrier Ulcerative colitis

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电针治疗对完全性骶上脊髓损伤后神经源性膀胱大鼠尿流动力学和脊髓组织中CyclinD1、Ngn1的影响

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中国现代医学杂志 2021年第5期31卷 45-52页

作者：邓悦宁周达岸王卓马贤德锦州医科大学附属第三医院辽宁锦州121000 辽宁中医药大学教学实验中心辽宁沈阳110847

目的观察电针治疗完全性骶上脊髓损伤(SSCI)后神经源性膀胱(逼尿肌反射亢进)大鼠的效果,探讨电针基于Wnt/β-catenin信号通路调控脊髓组织中CyclinD1、Ngn1 mRNA及蛋白的表达及其促进模型大鼠排尿功能恢复的作用机制。方法SD雌性SPF级大... 详细信息

目的观察电针治疗完全性骶上脊髓损伤(SSCI)后神经源性膀胱(逼尿肌反射亢进)大鼠的效果,探讨电针基于Wnt/β-catenin信号通路调控脊髓组织中CyclinD1、Ngn1 mRNA及蛋白的表达及其促进模型大鼠排尿功能恢复的作用机制。方法SD雌性SPF级大鼠60只,随机分为假手术组12只和模型组48只。模型组大鼠手术致完全性SSCI,采用BBB评分和尿流动力学对大鼠模型进行评价。术后2周,将模型复制成功的大鼠再次随机分为模型对照组、电针组和电针对照组,每组12只。电针组在大椎穴、次髎穴(次髎穴隔日左右更替)用电针治疗;电针对照组亦于相同时间在大椎穴、次髎穴远脊柱侧(次髎穴用法同上)1 cm处为针刺点,进行电针治疗。电针参数采用疏密波(疏波10 Hz/9 s,密波50 Hz/5 s),留针20 min,强度以针刺处出现规律性抽动为宜,1次/d,连续1周。末次电针治疗后各组大鼠行尿流动力学检测,采用RT-PCR、Western blotting和免疫组织化学法检测大鼠脊髓组织中Cyclin D1、Ngn1 mRNA及蛋白表达。结果①尿流动力学:与假手术组比较,其他3组大鼠膀胱基础压力和膀胱最大压力升高,膀胱最大容量和膀胱顺应性降低;模型对照组和电针对照组大鼠膀胱漏尿点压力升高(P<0.05)。与模型对照组比较,电针组大鼠膀胱基础压力、膀胱最大压力和膀胱漏尿点压力降低,膀胱最大容量和膀胱顺应性升高(P<0.05)。与电针组比较,电针对照组大鼠膀胱基础压力、膀胱最大压力和膀胱漏尿点压力升高,膀胱最大容量和膀胱顺应性降低(P<0.05)。②Cyclin D1 mRNA及蛋白:与假手术组比较,其他3组Cyclin D1 mRNA及蛋白表达升高(P<0.05);与模型对照组比较,电针组Cyclin D1 mRNA及蛋白表达升高(P<0.05);与电针组比较,电针对照组Cyclin D1 mRNA及蛋白表达降低(P<0.05)。③Ngn1蛋白:与假手术组比较,模型对照组和电针对照组Ngn1蛋白表达降低(P<0.05);与模型对照组比较,电针组Ngn1蛋白表达升高(P<0.05);与电针组比较,电针对照组Ngn1蛋白表达降低(P<0.05)。④Ngn1 mRNA:与假手术组比较,其他3组Ngn1 mRNA表达下降(P<0.05);与模型对照组比较,电针组Ngn1 mRNA表达升高(P<0.05);与电针组比较,电针对照组Ngn1 mRNA表达降低(P<0.05)。结论电针大椎穴、次髎穴对完全性SSCI后神经源性膀胱(逼尿肌反射亢进)大鼠尿流动力学具有明显改善作用,其作用机制可能是通过Wnt/β-catenin信号通路调控Cyclin D1、Ngn1 mRNA及蛋白表达,促进脊髓内源性神经干细胞的增殖和活化而实现。

关键词：完全性骶上脊髓损伤电针神经源性膀胱 Wnt/β-catenin信号通路

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毛蕊异黄酮对肺腺癌SPC-A1细胞增殖和凋亡的影响

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中国现代医学杂志 2020年第11期30卷 1-6页

作者：周立霞关洪全马贤德王丹遵义医科大学第五附属(珠海)医院广东珠海519100 辽宁中医药大学基础医学院辽宁沈阳110847 锦州医科大学研究生学院辽宁锦州121001

目的探讨毛蕊异黄酮对肺腺癌SPC-A1细胞增殖与凋亡的影响。方法将25、50及100μg/ml毛蕊异黄酮分别作用SPC-A1细胞12、24、36及48 h后,用MTT法检测其对SPC-A1细胞增殖的抑制作用;Hoechst 33258染色观察SPC-A1细胞核变化,流式细胞术检测S... 详细信息

目的探讨毛蕊异黄酮对肺腺癌SPC-A1细胞增殖与凋亡的影响。方法将25、50及100μg/ml毛蕊异黄酮分别作用SPC-A1细胞12、24、36及48 h后,用MTT法检测其对SPC-A1细胞增殖的抑制作用;Hoechst 33258染色观察SPC-A1细胞核变化,流式细胞术检测SPC-A1细胞凋亡情况;不同浓度毛蕊异黄酮作用SPC-A1细胞48 h后,Western blotting及逆转录聚合酶链反应(RT-PCR)检测SPC-A1细胞Cyclin D1、CDK4、CDK6蛋白及mRNA的表达水平。结果毛蕊异黄酮能有效抑制SPC-A1细胞的增殖,且呈浓度和时间依赖性(P<0.05),100μg/ml毛蕊异黄酮作用SPC-A1细胞48 h后,细胞增殖抑制率可高达(81.26±0.05)%;毛蕊异黄酮能够诱导SPC-A1细胞凋亡,引起核固缩,形成凋亡小体,细胞凋亡率从(3.12±1.07)%升至(42.78±2.16)%(P<0.05);毛蕊异黄酮可以抑制SPC-A1细胞中Cyclin D1、CDK4、CDK6蛋白及mRNA的表达,组间比较差异有统计学意义(P<0.05)。结论毛蕊异黄酮可通过降低Cyclin D1、CDK4、CDK6蛋白及mRNA的表达抑制SPC-A1细胞的增殖,毛蕊异黄酮对SPC-A1细胞具有诱导凋亡作用。

关键词：肺癌毛蕊异黄酮增殖凋亡

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Direct numerical simulation of compressible turbulent flows

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Acta Mechanica Sinica 2010年第6期26卷 795-806页

作者： Xin-Liang Li de-Xun Fu Yan-Wen ma xian Liang LHD Institute of MechanicsChinese Academy of Sciences 100190 BeijingChina LNM Institute of MechanicsChinese Academy of Sciences 100190 BeijingChina

This paper reviews the authors＇ recent studies on compressible turbulence by using direct numerical simulation （DNS）,including DNS of isotropic（decaying） turbulence, turbulent mixing-layer,turbulent boundary-layer and shock/boundary-layer *** statistics, compressibility effects,turbulent kinetic energy budget and coherent structures are studied based on the DNS *** mechanism of sound source in turbulent flows is also analyzed. It shows that DNS is a powerful tool for the mechanistic study of compressible turbulence.

关键词： Direct numerical simulation Compressible turbulence Coherent structures Turbulent boundary-layer flow

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Static recrystallization behavior of 25CrMo4 mirror plate steel during two-pass hot deformation

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Journal of Iron and Steel Research International 2017年第2期24卷 222-228页

作者： Peng Zhou Qing-xian ma department of Mechanical Engineering Tsinghua University Beijing 100084 China Key Laboratory for Advanced materials Processing Technology of Ministry of Education Tsinghua University Beijing 100084 China

The static recrystallization behavior of 25CrMo4 mirror plate steel has been determined by hot compression testing on a Gleeble 1500 thermal mechanical simulation tester. Compression tests were performed using double hit schedules at temperatures of 950-- 1 150 ~C, strain rates of 0.01--0.5 s-1 , and recrystallization time of 1--100 s. Results show that the kinetics of static recrystallization and the microstructural evolution were greatly influenced by the deformation parameters （deformation temperature, strain rate and pre strain） and the initial austenite grain size. Based on the experimental results, the kinetics model of static recrystallization has been generated and the comparison between the experimental results and the predicted results has been carried out. It is shown that the predicted results were in good agreement with the experimental results.

关键词： Hot deformation Static recrystallization 25CrMo4 Kinetics equation Microstructure

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Adaptive modification of turbofan engine nonlinear model based on LSTM neural networks and hybrid optimization method

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Chinese Journal of Aeronautics 2022年第9期35卷 314-332页

作者： Yanhua ma xian DU Ximing SUN School of Microelectronics Dalian University of TechnologyDalian 116024China Key Laboratory of Intelligent Control and Optimization for Industrial Equipment Ministry of EducationDalian University of TechnologyDalian 116024China School of Control Science and Engineering Dalian University of TechnologyDalian 116024China

An accurate and reliable turbofan engine model which can describe its dynamic behavior within the full flight envelop and lifecycle plays a critical role in performance optimization, controller design and fault diagnosis. However, due to the performance differences caused by the tolerance of engine manufacturing and assembly, and performance degradation during continuously stringent environmental regulations, the model accuracy is severely reduced. In this paper, an adaptive modification method of turbofan engine nonlinear Component-Llevel Model(CLM) based on Long Short-Term Memory(LSTM) Neural Network(NN) and hybrid optimization algorithm is pro-posed. First, a dynamic compensator with a combined LSTM NN architecture is constructed to compensate for the initial error between the experimental data and CLM of a turbofan engine under health condition. Then, a sensitivity analysis approach based on the entropy coefficient and technique for order preference by similarity to an ideal solution integrated evaluation is developed to choose the unmeasurable health parameters to be adjusted. Finally, a parallel hybrid optimization algorithm is developed to complete the adaptive model modification when the performance degrades. The proposed method is verified on a military low-bypass twin-spool turbofan engine, and the experimental results show the effectiveness of the proposed method.

关键词： Hybrid optimization Long short-term memory Model modification and testing Sensitivity analysis Turbofan engines

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Dynamic Recrystallization Behavior and Processing map development of 25CrMo4 Mirror Plate Steel During Hot deformation

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Acta Metallurgica Sinica(English Letters) 2017年第9期30卷 907-920页

作者： Peng Zhou Qing.xian ma department of Mechanical Engineering TsinghuaUniversityBeijing 100084China Key Laboratory for Advanced materials ProcessingTechnology of Ministry of Education Tsinghua University Beijing 100084China

The dynamic recrystallization behavior of 25CrMo4 steel was systematically investigated by compression deformation at different temperatures and strain rates on a Gleeble 1500 thermal mechanical simulation tester. The flow curves under different deformation conditions were obtained, and the effects of deformation temperature and strain rate on the appearance of the flow curves were discussed. Based on the experimental flow curves, the activation energy determined by regression analysis was Q = 337 kJ/mol, and the constitutive model was constructed. All the characteristic points of the flow curves were identified from the work hardening rate curves （θ= dσ/dε vs σ）, which were derived from the flow curves. Then, the kinetics model of dynamic recrystallization was determined by combining the Avrami equation with the stress loss resulted from the dynamic recrystallization. With the aid of the kinetics model, the effect of strain on the efficiency of power dissipation was discussed. Furthermore, the optimum parameters for the forging process were determined based on the processing maps.

关键词： 25CrMo4 steel Dynamic recrystallization Kinetics model Processing map

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Effect of heat treatments on Charpy impact properties of 15Cr12MoVWN ferritic/martensitic steel

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Journal of Iron and Steel Research International 2022年第3期29卷 512-518页

作者： Ting-wei ma xian-chao Hao Ping Wang Key Laboratory of Electromagnetic Processing of materials Ministry of EducationNortheastern UniversityShenyang110819LiaoningChina Yingkou Institute of Technology Yingkou115014LiaoningChina CAS Key Laboratory of Nuclear materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016LiaoningChina

The Charpy impact properties of 15Cr12MoVWN ferritic/martensitic steel for sodium-cooled reactors with variation in heat treatment factors and parameters are *** results show that the ductile-to-brittle transition temperature(DBTT)increased and the upper shelf energy(USE)decreased with increase in normalizing ***,the variation tendency of DBTT and USE was the opposite with increase in tempering *** tempering temperature showed a greater influence on USE than the normalizing temperature,and normalizing and tempering temperatures had the equally significant effects on DBTT,but the cooling method was not a significant factor for DBTT and *** prior austenite grain and M_(23)C_(6) size were the main influences on DBTT,and the dislocation density was the main factor affecting the variation of *** heat-treatment regime recommended for 15Cr12MoVWN steel was composed of normalizing at 1000-1050℃ for 0.5 h followed by water quenching or air cooling and tempering at 760℃ for 1.5 h.

关键词： 15Cr12MoVWN steel Ductile-to-brittle transition temperature Prior austenite grain size M23C6-MX

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density fluctuations in intermediate-energy heavy-ion collisions

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Nuclear Science and Techniques 2022年第5期33卷 1-7页

作者： Cong Liu xian-Gai deng Yu-Gang ma Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China

Within the framework of the isospin-dependent quantum molecular dynamics model,we simulate^(129)Xe+^(119)Sn collisions in an incident energy range of 20 to 190MeV/nucleon and discuss the liquid-gas phase transition with density *** comparison,we also extract the effective Fisher parameter τ_(eff),multiplicity of intermediate-mass fragments(IMFs),and information *** is found that the Fisher parameter and maximum information entropy of collisions have peak values at E_(beam)=50-80 MeV/*** addition,the maximum multiplicity of IMFs has a plateau around 70 MeV/*** higher-order density moments in a larger central region of[-5,5]^(3) fm^(3) in the collision system,a maximum plateau also appears as function of beam energy at energies exceeding 70 MeV/*** observables,which are consistent with each other,indicate a liquid-gas phase transition around 70 MeV/nucleon for the^(129)Xe+^(119)Sn system.

关键词： Heavy-ioncollisions Liquid-gasphase transition IQMD density moment Intermediatemass fragment Informationentropy Fisher-lawparameter

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