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Comparative study of swarm intelligence-based saliency computation

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International Journal of Intelligent Computing and Cybernetics 2017年第3期10卷 348-361页

作者： ning xian School of Automation Science and Electrical Engineering Beihang UniversityBeijingChina

Purpose–The purpose of this paper is to propose a new algorithm chaotic pigeon-inspired optimization(CPIO),which can effectively improve the computing efficiency of the basic Itti’s model for saliency-based *** CPIO algorithm and relevant applications are aimed at air surveillance for target ***/methodology/approach–To compare the improvements of the performance on Itti’s model,three bio-inspired algorithms including particle swarm optimization(PSO),brain storm optimization(BSO)and CPIO are applied to optimize the weight coefficients of each feature map in the saliency ***–According to the experimental results in optimized Itti’s model,CPIO outperforms PSO in terms of computing efficiency and is superior to BSO in terms of searching ***,CPIO provides the best overall properties among the three *** implications–The algorithm proposed in this paper can be extensively applied for fast,accurate and multi-target detections in aerial ***/value–CPIO algorithm is originally proposed,which is very promising in solving complicated optimization problems.

关键词： Visual attention Particle swarm optimization(PSO) Brain storm optimization(BSO) Chaotic pigeon-inspired optimization(CPIO) Saliency computation

Emergence of higher-level neuron properties using a hierarchical statistical distribution model

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Science China(Technological Sciences) 2019年第4期62卷 628-634页

作者： xian ning DENG Yi Min DUAN HaiBin School of Automation Science and Electrical Engineering Beihang University

Essential to visual tasks such as object recognition is the formation of effective representations that generalize from specific instances of visual input. Neurons in primary visual cortex are typically hypothesized to efficiently encode image structures such as edge and textures from natural scenes. Here this paper proposed a novel hierarchical statistical distribution model to generalize higher-level neuron properties and encode distributed regularities that characterize local image regions. Two layers of our hierarchical model are presented to extract spiking activities of excitatory neurons decorrelated by inhibitory neurons and to construct the statistical patterns of input data, respectively. Trained on whitened natural images, parameters including neural connecting weights and distribution coding weights are estimated by their corresponding learning rules. To prove the feasibility and effectiveness of our model, several experiments on natural images are conducted. Adapting our model to natural scenes yields a distributed representation for higher-order statistical regularities. Comparison results provide insight into higher-level neurons which encode more abstract and invariant properties.

关键词： statistical distribution spiking activity object classification localization

A Quantum-behaved Pigeon-Inspired Optimization approach to Explicit Nonlinear Model Predictive Controller for quadrotor

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International Journal of Intelligent Computing and Cybernetics 2018年第1期11卷 47-63页

作者： ning xian Zhilong Chen Science and Technology on Aircraft Control Laboratory Beihang University(BUAA)BeijingChina

Purpose–The purpose of this paper is to simplify the Explicit Nonlinear Model Predictive Controller(ENMPC)by linearizing the trajectory with Quantum-behaved Pigeon-Inspired Optimization(QPIO).Design/methodology/approach–The paper deduces the nonlinear model of the quadrotor and uses the ENMPC to track the *** the ENMPC has high demand for the state equation,the trajectory needed to be differentiated many *** the trajectory is complicate or discontinuous,QPIO is proposed to linearize the *** the linearized trajectory will be used in the ***–Applying the QPIO algorithm allows the unequal distance sample points to be acquired to linearize the *** with the equidistant linear interpolation,the linear interpolation error will be *** implications–Small-sized quadrotors were adopted in this research to simplify the *** model is supposed to be accurate and differentiable to meet the requirements of ***/value–Traditionally,the quadrotor model was usually linearized in the *** this paper,the quadrotormodel waskept nonlinear and the trajectorywill be *** sample points were utilized to linearize the *** this way,the authors can get a smaller interpolation *** method can also be applied to discrete systems to construct the interpolation for trajectory tracking.

关键词： Explicit Nonlinear Model Predictive Controller Linearized trajectory Quantum-behaved Pigeon-Inspired Optimization

Short Review:Mitochondrion and its related disorders:Making a comeback

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第2期9卷 90-92页

作者： xian-ning ZHANG Ming QI Zhejiang University-Adinovo Center for Genetic and Genomic Medicine Zhejiang University Hangzhou 310058 China James D. Watson Institute of Genome Sciences Zhejiang University Hangzhou 310058 China National Education Base for Basic Medical Sciences Zhejiang University Hangzhou 310058 China

The great majority of genetic disorders are caused by defects in the nuclear genome. However, some significant diseases are the result of mitochondrial mutations. Because of the unique features of the mitochondria, these diseases display characteristic modes of inheritance and a large degree of phenotypic variability. Recent studies have suggested that mitochondrial dysfunction plays a central role in a wide range of age-related disorders and various forms of cancer.

关键词： Mitochondria Mitochondrial disorder Mutation

Analysis of prognostic factors in patients with emergency sepsis

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World Journal of Clinical Cases 2023年第25期11卷 5903-5909页

作者： xian-Li ning Min Shao Department of Emergency Anqing Municipal HospitalAnqing 246000Anhui ProvinceChina Department of Critical Care Medicine The First Affiliated Hospital of Anhui Medical UniversityHefei 230031Anhui ProvinceChina

BACKGROUND Emergency sepsis is a common and serious infectious disease,and its prognosis is influenced by a number of *** To analyse the factors influencing the prognosis of patients with emergency sepsis in order to provide a basis for individualised patient treatment and *** retrospectively analysing the clinical data collected,we conducted a comprehensive analysis of factors such as age,gender,underlying disease,etiology and site of infection,inflammatory indicators,multi-organ failure,cardiovascular function,therapeutic measures,immune status and severity of *** Data collection:Clinical data were collected from patients diagnosed with acute sepsis,including basic information,laboratory findings,medical history and treatment *** selection:Variables associated with prognosis were selected,including age,gender,underlying disease,etiology and site of infection,inflammatory indicators,multi-organ failure,cardiovascular function,treatment measures,immune status and severity of *** analysis:The data collected are analysed using appropriate statistical methods such as multiple regression analysis and survival *** impact of each factor on prognosis was assessed according to prognostic indicators,such as survival,length of stay and complication *** Descriptive statistics:Descriptive statistics were performed on the data collected from the patients,including their basic characteristics and clinical *** Type 2 diabetes mellitus were independent factors affecting the prognosis of patients with sepsis.

关键词： Platelet count Length of ICU stay Mechanical ventilation Abdominal infection Combined coronary artery disease

LncRNA pol-lnc78 as a ceRNA regulates antibacterial responses via suppression of pol-miR-n199-3p-mediated SARM down-regulation in Paralichthys olivaceus

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Zoological Research 2024年第1期45卷 25-35页

作者： xian-Hui ning Bing Han Ye Peng Shao-Wu Yin College of Marine Science and Engineering Nanjing Normal UniversityNanjingJiangsu 210023China CAS Key Laboratory of Experimental Marine Biology Center for Ocean Mega-ScienceInstitute of OceanologyChinese Academy of SciencesQingdaoShandong 266071China Co-Innovation Center for Marine Bio-Industry Technology of Jiangsu Province LianyungangJiangsu 222005China

Long non-coding RNAs(lncRNAs)function as key modulators in mammalian immunity,particularly due to their involvement in lncRNA-mediated competitive endogenous RNA(ceRNA)*** their recognized significance in mammals,research on lncRNAs in lower vertebrates remains *** the present study,we characterized the first immune-related lncRNA(pol-lnc78)in the teleost Japanese flounder(Paralichthys olivaceus).Results indicated that pol-lnc78 acted as a ceRNA for pol-miR-n199-3p to target the sterile alpha and armadillo motif-containing protein(SARM),the fifth discovered member of the Toll/interleukin 1(IL-1)receptor(TIR)adaptor *** ceRNA network regulated the antibacterial responses of flounder via the Toll-like receptor(TLR)signaling ***,SARM acted as a negative regulator and exacerbated bacterial infection by inhibiting the expression of inflammatory cytokines IL-1βand tumor necrosis factor-α(TNF-α).Pol-miR-n199-3p reduced SARM expression by specifically interacting with the 3’untranslated region(UTR),thereby promoting SARM-dependent inflammatory cytokine expression and protecting the host against bacterial ***,pol-lnc78 sponged pol-miR-n199-3p to ameliorate the inhibition of SARM *** infection,the negative regulators pol-lnc78 and SARM were significantly down-regulated,while pol-miR-n199-3p was significantly up-regulated,thus favoring host antibacterial *** findings provide novel insights into the mechanisms underlying fish immunity and open new horizons to better understand ceRNA crosstalk in lower vertebrates.

关键词： LncRNA SARM miRNA ceRNA Antibacterial response

Cu-Catalyzed Cascade Cyclization of Ketoxime Acetates and Alkynals Enabling Synthesis of Acylpyrroles

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Chinese Journal of Chemistry 2021年第5期39卷 1175-1180页

作者： Zhenhua Xu ning xian Hongbiao Chen Guo-Jun Deng Huawen Huang Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtanHunan 411105China

A facile copper-based catalytic system has been developed to enable efficient cyclization of methylketoximes and *** protocol provides a viable entry to synthetically and pharmaceutically useful 2-acylpyrroles with a broad range of compatible ***,a key acyl migration is probably involved that leads to the formation of N-acyl pyrroles or otherwise NH pyrroles by further *** importantly,the present reaction system also gives an opportunity to realize three-component pyrrole assembly by simple addition of carboxylic acid.

关键词： Copper catalysis Nitrogen heterocycles Cyclization Ketoximes Alkynals

Corneal stromal mesenchymal stem cells: reconstructing a bioactive cornea and repairing the corneal limbus and stromal microenvironment

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International Journal of Ophthalmology(English edition) 2021年第3期14卷 448-455页

作者： xian-ning Liu Sheng-Li Mi Yun Chen Yao Wang Department of Ophthalmology First Hospital of Xi'anShaanxi Institute of OphthalmologyShaanxi Provincial Key Lab of OphthalmologyClinical Research Center for Ophthalmology Diseases of Shaanxi Provincethe First Affiliated Hospital of Northwest UniversityXi'an 710002Shaanxi ProvinceChina Open FIESTA Center Graduate School at ShenzhenTsinghua UniversityShenzhen 518055Guangdong ProvinceChina Biomanufacturing Engineering Laboratory Graduate School at ShenzhenTsinghua UniversityShenzhen 518055Guangdong ProvinceChina

Corneal stroma-derived mesenchymal stem cells(CS-MSCs) are mainly distributed in the anterior part of the corneal stroma near the corneal limbal stem cells(LSCs). CS-MSCs are stem cells with self-renewal and multidirectional differentiation potential. A large amount of data confirmed that CS-MSCs can be induced to differentiate into functional keratocytes in vitro, which is the motive force for maintaining corneal transparency and producing a normal corneal stroma. CS-MSCs are also an important component of the limbal microenvironment. Furthermore, they are of great significance in the reconstruction of ocular surface tissue and tissue engineering for active biocornea construction. In this paper, the localization and biological characteristics of CS-MSCs, the use of CS-MSCs to reconstruct a tissue-engineered active biocornea, and the repair of the limbal and matrix microenvironment by CS-MSCs are reviewed, and their application prospects are discussed.

关键词： corneal stroma-derived mesenchymal stem cells bioactive cornea corneal limbus tissue-engineered active biocornea stromal microenvironment

Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第29期26卷 4240-4260页

作者： Zhao-Shan Niu Wen-Hong Wang xian-ning Dong Li-Mei-Li Tian Laboratory of Micromorphology School of Basic MedicineMedical Department of Qingdao UniversityQingdao 266071Shandong ProvinceChina Department of Pathology School of Basic MedicineMedical Department of Qingdao UniversityQingdao 266071Shandong ProvinceChina Department of Pathology the Affiliated Hospital of Qingdao UniversityQingdao 266061Shandong ProvinceChina School of Basic Medicine Medical Department of Qingdao UniversityQingdao 266071Shandong ProvinceChina

Long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) are noncodingRNAs (ncRNAs) that occupy over 90% of the human genome, and their mainfunction is to directly or indirectly regulate messenger RNA (mRNA) expressionand participate in the tumorigenesis and progression of malignances. Inparticular, some lncRNAs can interact with miRNAs as competing endogenousRNAs (ceRNAs) to modulate mRNA expression. Accordingly, these RNAmolecules are interrelated and coordinate to form a dynamic lncRNA-mediatedceRNA regulatory network. Mounting evidence has revealed that lncRNAs thatact as ceRNAs are closely related to tumorigenesis. To date, numerous studieshave established many different regulatory networks in hepatocellular carcinoma(HCC), and perturbations in these ceRNA interactions may result in the initiationand progression of HCC. Herein, we emphasize recent advances concerning thebiological function of lncRNAs as ceRNAs in HCC, with the aim of elucidating themolecular mechanism underlying these HCC-related RNA molecules andproviding novel insights into the diagnosis and treatment of HCC.

关键词： Hepatocellular carcinoma Long noncoding RNA MicroRNA Competing endogenous RNA Function Mechanism