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Intensifying electrified flow-through water treatment technologies via local environment modification

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Frontiers of Environmental Science & Engineering 2024年第6期18卷 17-25页

作者： Zheng-Yang Huo xiaoxiong Wang xia.huang Menachem Elimelech School of Environment and Natural Resources Institute of Ecological CivilizationRenmin University of ChinaBeijing 100872China Institute for Ocean Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Center of Double Helix Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Department of Chemical and Environmental Engineering Yale UniversityNew HavenCT 06520-8286USA

Removing high-risk and persistent contaminants from water is challenging,because they typically exist at low concentrations in complex water *** flow-through technologies are viable to overcome the limitations induced by mass transport for efficient contaminant *** the local environment of the flow-through electrodes offers opportunities to further improve the reaction kinetics and selectivity for achieving near-complete removal of these contaminants from ***,we present state-of-the-art local environment modification approaches that can be incorporated into electrified flow-through technologies to intensify water *** first show methods of nanospace incorporation,local geometry adjustment,and microporous structure optimization that can induce spatial confinement,enhanced local electric field,and microperiodic vortex,respectively,for local environment *** then discuss why local environment modification can complement the flow-through electrodes for improving the reaction rate and ***,we outline appropriate scenarios of intensifying electrified flow-through technologies through local environment modification for fit-for-purpose water treatment applications.

关键词： Point-of-use water treatment Electrified membrane Advection-enhanced mass transport Water decontamination and disinfection Emerging contaminants

A NEW GLOBAL OPTIMIZATION ALGORITHM FOR MIXED-INTEGER QUADRATICALLY CONSTRAINED QUADRATIC FRACTIONAL PROGRAMMING PROBLEM

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Journal of Computational Mathematics 2024年第3期42卷 784-813页

作者： Bo Zhang Yuelin Gao xia Liu xiaoli huang School of Civil and Hydraulic Engineering School of Mathematics and StatisticsNingxia UniversityYinchuan 750021China School of Mathematics and Information Science North Minzu UniversityYinchuan 750021China Ningxia Province Key Laboratory of Intelligent Information and Data Processing Yinchuan 750021China School of Mathematics and Statistics Ningxia UniversityYinchuan 750021China

The mixed-integer quadratically constrained quadratic fractional programming(MIQCQFP)problem often appears in various fields such as engineering practice,management science and network ***,most of the solutions to such problems are often designed for their unique *** paper puts forward a new global optimization algorithm for solving the problem *** first convert the MIQCQFP into an equivalent generalized bilinear fractional programming(EIGBFP)problem with integer ***,we linearly underestimate and linearly overestimate the quadratic functions in the numerator and the denominator respectively,and then give a linear fractional relaxation technique for EIGBFP on the basis of non-negative *** that,combining rectangular adjustment-segmentation technique and midpointsampling strategy with the branch-and-bound procedure,an efficient algorithm for solving MIQCQFP globally is ***,a series of test problems are given to illustrate the effectiveness,feasibility and other performance of this algorithm.

关键词： Global optimization Branch and bound Quadratic fractional programming Mixed integer programming

Engineering W/O/W pickering emulsion for the enhanced antigen delivery and immune responses

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Particuology 2024年第9期92卷 224-233页

作者： Sihua Wu xiaonan huang Yin Ma Naoki Asakawa Yufei xia State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100081China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China Division of Molecular Science Graduate School of Science and TechnologyGunma University1-5-1Tenjin-choKiryu376-8515Japan Sinovac Biotech Ltd. Beijing100085China School of Chemical Engineering Nanjing Tech UniversityNanjing211816China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Tumor immunotherapy,particularly cancer vaccines,holds promise for combating cancer by harnessing tailored immune responses against malignant ***,conventional approaches face challenges in efficiently delivering antigens for optimal immune *** adjuvants,like MF59,enhance cellular uptake but struggle to induce robust CD8^(+)T cell ***,we introduce a novel strategy employing a water-in-oil-in-water(W/O/W)multiple Pickering emulsion(mPE)for antigen *** mPE,utilizing biocompatible,pH-sensitive particles,encapsulates antigens within the inner water phase,ensuring enhanced intracellular processing and dictating the intracellular fate of antigens for improved *** vitro and in vivo studies demonstrated that mPEs induced robust dendritic cells activation and antigen cross-presentation,leading to a significantly enhanced immune ***,calcium phosphate-stabilized mPE(CaP-mPE)illustrated the more robust IFN-γ^(+)T cell *** comparison with traditional surfactant-stabilized multiple emulsions,CaP-mPE significantly inhibit tumor growth and effectively prolong the survival of tumor-bearing *** innovative approach offers a promising avenue for the development of effective cancer vaccines with potent cellular immune responses.

关键词： Cancer vaccine Multiple pickeringemulsion Adjuvant Antigen delivery Anti-tumor response

Starlet:Network defense resource allocation with multi-armed bandits for cloud-edge crowd sensing in IoT

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Digital Communications and Networks 2024年第3期10卷 586-596页

作者： Hui xia Ning huang Xuecai Feng Rui Zhang Chao Liu College of Computer Science and Technology Ocean University of ChinaQingdao266100China

The cloud platform has limited defense resources to fully protect the edge servers used to process crowd sensing data in Internet of *** guarantee the network's overall security,we present a network defense resource allocation with multi-armed bandits to maximize the network's overall ***,we propose the method for dynamic setting of node defense resource thresholds to obtain the defender(attacker)benefit function of edge servers(nodes)and ***,we design a defense resource sharing mechanism for neighboring nodes to obtain the defense capability of ***,we use the decomposability and Lipschitz conti-nuity of the defender's total expected utility to reduce the difference between the utility's discrete and continuous arms and analyze the difference ***,experimental results show that the method maximizes the defender's total expected utility and reduces the difference between the discrete and continuous arms of the utility.

关键词： Internet of things Defense resource sharing Multi-armed bandits Defense resource allocation

Drug repurposing for cancer therapy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1981-2013页

作者： Ying xia Ming Sun Hai huang Wei-Lin Jin Center for Clinical Laboratories The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550004PR China The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine Guiyang 550001PR China School of Clinical Laboratory Science Guizhou Medical UniversityGuiyang 550004PR China Division of Gastroenterology and Hepatology Department of Medicine andDepartment of OncologySidney Kimmel Comprehensive Cancer CenterJohns Hopkins University School of MedicineBaltimoreMD 21287USA Institute of Cancer Neuroscience Medical Frontier Innovation Research CenterThe First Hospital of Lanzhou UniversityThe First Clinical Medical College of Lanzhou UniversityLanzhou 730000PR China

Cancer,a complex and multifactorial disease,presents a significant challenge to global *** significant advances in surgical,radiotherapeutic and immunological approaches,which have improved cancer treatment outcomes,drug therapy continues to serve as a key therapeutic ***,the clinical efficacy of drug therapy is often constrained by drug resistance and severe toxic side effects,and thus there remains a critical need to develop novel cancer *** promising strategy that has received widespread attention in recent years is drug repurposing:the identification of new applications for existing,clinically approved *** repurposing possesses several inherent advantages in the context of cancer treatment since repurposed drugs are typically cost-effective,proven to be safe,and can significantly expedite the drug development process due to their already established safety *** light of this,the present review offers a comprehensive overview of the various methods employed in drug repurposing,specifically focusing on the repurposing of drugs to treat *** describe the antitumor properties of candidate drugs,and discuss in detail how they target both the hallmarks of cancer in tumor cells and the surrounding tumor *** addition,we examine the innovative strategy of integrating drug repurposing with nanotechnology to enhance topical drug *** also emphasize the critical role that repurposed drugs can play when used as part of a combination therapy *** conclude,we outline the challenges associated with repurposing drugs and consider the future prospects of these repurposed drugs transitioning into clinical application.

关键词： drugs integrating spite

Cyclic Pulsating Pressure Enhanced Segregating Structuration of Ultra-High Molecular Weight Polyethylene/Graphene Composites as High-performance Light-Weight EMI Shields

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Chinese Journal of Polymer Science 2024年第7期42卷 958-967,I0008页

作者： Yun-Zhi huang xiao-xiao Liu Lan-Wei Li Guang-Ming huang Zhao-xia.huang Jin-Ping Qu National Engineering Research Center of Novel Equipment for Polymer Processing Key Laboratory of Polymer Processing EngineeringMinistry of EducationGuangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced ManufacturingSchool of Mechanical and Automotive EngineeringSouth China University of TechnologyGuangzhou 510641China School of Advanced Manufacturing Technology Guangdong Mechanical&Electrical PolytechnicGuangzhou 510550China

Currently,the enhancement in electromagnetic interference(EMI)performance of polymeric composite generally relies on either improving electrical conductivity(σ)for stronger electromagnetic(EM)reflections or tailoring structure for higher EM ***,we proposed a novel technique called cyclic pulsating pressure enhanced segregating structuration(CPP-SS),which can reinforce these two factors *** structural information was supplied by optical microscopy(OM)and scanning electron microscopy(SEM),both of which confirmed the formation and evolution of segregate structured ultra-high molecular weight polyethylene(UHMWPE)/graphene ***,the result showed that CPP-SS can significantly improve theσof ***,advanced specific EMI shielding efficiency of 31.1 d B/mm was achieved for UHMWPE/graphene composite at 1-mm thickness and a low graphene loading of 5 wt%.Meanwhile,it also confirmed that the intrinsic disadvantage of poor mechanical properties of conventional segregated structure composites can be *** work is believed to provide a fundamental understanding of the structural and performance evolutions of segregated structured composites prepared under CPPSS,and to bring us a simple and efficient approach for fabricating high-performance,strong and light-weight polymeric EMI shields.

关键词： Cyclic pulsating pressure Segregated structure Ultra-high molecular weight polyethylene Graphene Electromagnetic interface

Dynamic Stability and Fuzzy Reliability Analysis of Toppling Perilous Rock Under Seismic Excitation

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Journal of Earth Science 2024年第1期35卷 248-262页

作者： Linfeng Wang Jixu Zhang Wanchun xia xiaoming huang Guojin Tan Key Laboratory of Geological Hazards Mitigation for Mountainous Highway and Waterway Chongqing Jiaotong UniversityChongqing 400074China School of Transportation Southeast UniversityNanjing 211189China College of Transportation Jilin UniversityChangchun 130012China

To predict the occurrence of the collapse disaster in toppling perilous rock under the action of bidirectional earthquakes,the dynamic stability and fuzzy reliability calculation method of toppling perilous rock under the action of bidirectional earthquakes is ***,the mass viscoelasticity model is used to simulate two main control surfaces of toppling perilous rock,the seismic dynamic response model and motion equation of toppling perilous rock are established based on the D'Alembert principle,and the Newmark-β method is used to solve the dynamic motion ***,the instability event of toppling perilous rock is considered a fuzzy event,the membership function expression of the stability coefficient of toppling perilous rock is determined based on the fuzzy failure criterion,the calculation equations of the toppling perilous rock dynamic stability coefficient and fuzzy reliability are established,and the fuzzy reliability evaluation method based on the probability distribution of reliability is ***,the influence of different superposition modes of seismic excitation on the fuzzy reliability of toppling perilous rock is *** calculation results of toppling perilous rock in the engineering case show that the fuzzy reliability calculated after considering the fuzzy failure criterion is reduced by 10.73% to 25.66% compared with the classical *** the bidirectional seismic excitation,the fuzzy reliability of toppling perilous rock is reduced by 5.46% to 14.89%.Compared with using the acceleration peak time encounter mode to superpose the seismic excitation,the fuzzy reliability of toppling perilous rock is reduced by 3.4% when the maximum action effect time encounter mode is adopted.

关键词： toppling perilous rock bidirectional earthquake fuzzy failure criterion dynamic stability fuzzy reliability Newmark-βmethod probability distribution function

A feedback control method for phase signal demodulation in fber-optic hydrophones

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Applied Mathematics and Mechanics(English Edition) 2024年第3期45卷 515-528页

作者： Zhiqiang LIU Lei xia Qiangfeng LYU Bin WU Ronghua HUAN Zhilong huang Department of Mechanics Key Laboratory of Soft Machines and Smart Devices of Zhejiang ProvinceZhejiang UniversityHangzhou 310000China Huanjiang Laboratory Zhuji 311899Zhejiang ProvinceChina Advanced Technology Research Institute Zhejiang UniversityHangzhou 310000China

In the realm of acoustic signal detection,the identification of weak signals,particularly in the presence of negative signal-to-noise ratios,poses a significant *** challenge is further heightened when signals are acquired through fiber-optic hydrophones,as these signals often lack physical significance and resist clear systematic *** processing methods,e.g.,low-pass filter(LPF),require a thorough understanding of the effective signal bandwidth for noise reduction,and may introduce undesirable time *** paper introduces an innovative feedback control method with dual Kalman filters for the demodulation of phase signals with noises in fiber-optic hydrophones.A mathematical model of the closed-loop system is established to guide the design of the feedback control,aiming to achieve a balance with the input phase *** dual Kalman filters are instrumental in mitigating the effects of signal noise,observation noise,and control execution noise,thereby enabling precise estimation for the input phase *** effectiveness of this feedback control method is demonstrated through examples,showcasing the restoration of low-noise signals,negative signal-to-noise ratio signals,and multi-frequency *** research contributes to the technical advancement of high-performance devices,including fiber-optic hydrophones and phase-locked amplifiers.

关键词： feedback control method fiber-optic hydrophone acoustic signal detection phase signal

Retrospective and prospective review of the generalized nonlinear strength theory for geomaterials

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International Journal of Minerals,Metallurgy and Materials 2024年第8期31卷 1767-1787页

作者： Shunchuan Wu Jiaxin Wang Shihuai Zhang Shigui huang Lei xia Qianping Zhao Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming 650093China Key Laboratory of Geohazard Forecast and Geoecological Restoration in Plateau Mountainous Area MNRKunming 650093China Yunnan Key Laboratory of Geohazard Forecast and Geoecological Restoration in Plateau Mountainous Area Kunming 650093China School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China

Strength theory is the basic theory for calculating and designing the strength of engineering materials in civil,hydraulic,mechanical,aerospace,military,and other engineering ***,the comprehensive study of the generalized nonlinear strength theory(GNST)of geomaterials has significance for the construction of engineering rock *** paper reviews the GNST of geomaterials to demonstrate the research status of nonlinear strength characteristics of geomaterials under complex stress ***,it systematically summarizes the research progress of GNST(classical and empirical criteria).Then,the latest research the authors conducted over the past five years on the GNST is introduced,and a generalized three-dimensional(3D)nonlinear Hoek‒Brown(HB)criterion(NGHB criterion)is proposed for practical *** criterion can be degenerated into the existing three modified HB criteria and has a better prediction *** strength prediction errors for six rocks and two in-situ rock masses are 2.0724%-3.5091%and 1.0144%-3.2321%,***,the development and outlook of the GNST are expounded,and a new topic about the building strength index of rock mass and determining the strength of in-situ engineering rock mass is *** summarization of the GNST provides theoretical traceability and optimization for constructing in-situ engineering rock mass strength.

关键词： rock mechanics rock mass strength strength theory failure criterion Hoek-Brown criterion intermediate principal stress deviatoric plane smoothness and convexity