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Minimum mass-entransy dissipation profile for one-way isothermal diffusive mass-transfer process with mass-resistance and massleakage

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Science China(Technological Sciences) 2024年第8期67卷 2427-2435页

作者： CHEN LinGen xia.shaojun Institute of Thermal Science and Power Engineering Wuhan Institute of TechnologyWuhan 430205China School of Mechanical Electrical EngineeringWuhan Institute of TechnologyWuhan 430205China School of Power Engineering Naval University of EngineeringWuhan 430033China

As a new concept,mass-entransy is one of the twins in the core of entransy *** can describe mass-transfer ability for masstransfer processes(MTPes),just as thermal-entransy for describing heat-transfer ***,mass-entransy dissipation can be utilized to evaluate the loss of mass-transfer *** mass-entransy dissipation(MMED) is utilized to optimize one-way isothermal diffusive MTPes with mass-leakage and mass-transfer law(g ∝ Δ(c),where c means concentration).For a given net amount of mass-transferred key components at the low-concentration side,optimality-condition for the MMED of isothermal diffusive MTPes is obtained by using the *** of the amount of mass-transferred and mass-leakage on optimal results are analyzed,and the obtained optimization profiles are compared with those for MTP profiles of constant-concentration-difference(c_1-c_2=const) and constant-concentration-ratio(c_1/c_2=const).The product of square of key-component-concentration(KCC) difference between high-and low-concentration sides and inert component concentration at high-concentration side for the MMED of the MTP with no mass-leakage is a constant,and the optimal relationship of the KCCs between high-and low-concentration sides with mass-leakage is significantly different from the *** mass-leakage is relatively small,the MTP with c_1-c_2=const strategy is superior to that with c_1/c_2=const strategy,and the latter is superior to the former with an increase in mass-leakage.A combination of mass-entransy concept,finite-time thermodynamics,and averaged-optimization-method is a meaningful tool for optimizing MTPes.

关键词： diffusive mass-transfer-law mass-leakage one-way isothermal mass-transfer minimum mass-entransy dissipation finite-time thermodynamics averaged-optimization-method

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Penpulimab,an anti-PD-1 antibody,for heavily pretreated metastatic nasopharyngeal carcinoma:a single-arm phase II study

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3056-3062页

作者： xiaozhong Chen Wei Wang Qingfeng Zou xiaodong Zhu Qin Lin Yi Jiang Yan Sun Liangfang Shen Lin Wang Guorong Zou xiaoyan Lin shaojun Lin Minying Li Ying Wang Ruilian Xu Rui Ao Rensheng Wang Haifeng Lin Shuang Huang Tingting Xu Wenting Li Mengying xia Yu xia Zhongmin Wang Baiyong Li Jingao Li Chaosu Hu Department of Radiation Oncology Cancer Hospital of the University of ChineseAcademy of Sciences(Zhejiang Cancer Hospital)HangzhouChina Gastroenterology and Urology Department II Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaChina Clinical Research Center for Gastrointestinal Cancer in Hunan Province ChangshaChina Department of Medical Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhouChina Department of Radiation Oncology Guangxi Medical University Affiliated Tumor Hospital&Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University)Ministry of Education&Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorGuangxi Medical UniversityNanningChina Department of Radiation Oncology Cancer CenterThe First Affiliated Hospital of Xiamen UniversityXiamenChina Department of Medical Oncology Cancer Hospital of Shantou University Medical CollegeShantouChina Department of Radiation Oncology Peking University Cancer Hospital&InstituteBeijingChina Department of Oncology Xiangya Hospital Central South UniversityChangshaChina Department of Medical Oncology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouChina Department of Oncology The Affiliated Panyu Central Hospital of Guangzhou Medical UniversityGuangzhouChina Department of Medical Oncology Fujian Medical University Union HospitalFuzhouChina Department of Radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina Department of Radiation Therapy for Thoracic Tumors Zhongshan City People’s HospitalZhongshanChina Tumor Radiotherapy Center Chongqing University Cancer HospitalChongqing Cancer HospitalChongqing Cancer InstituteChongqingChina Department of Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSo

Penpulimab is an anti-programmed cell death-1(PD-1)IgG1 antibody with no Fc gamma receptor(FcγR)binding activity,and thus theoretically reduced immune-related adverse events(irAEs)while maintaining *** single-arm,phase II trial conducted across 20 tertiary care centers in China enrolled adult patients with metastatic nasopharyngeal carcinoma(NPC)who had failed two or more lines of previous systemic *** received 200-mg penpulimab intravenously every 2 weeks(4 weeks per cycle)until disease progression or intolerable *** primary endpoint was objective response rate(ORR)per RECIST(version 1.1),as assessed by an independent radiological review *** secondary endpoints included progression-free survival(PFS)and overall survival(OS).One hundred thirty patients were enrolled and 125 were efficacy *** the data cutoff date(September 28,2022),1 patient achieved complete response and 34 patients attained partial *** ORR was 28.0%(95%CI 20.3–36.7%).The response was durable,with 66.8%still in response at 9 ***-three patients(26.4%)were still on *** median PFS and OS were 3.6 months(95%CI=1.9–7.3 months)and 22.8 months(95%CI=17.1 months to not reached),***(7.6%)patients experienced grade 3 or higher *** has promising anti-tumor activities and acceptable toxicities in heavily pretreated metastatic NPC patients,supporting further clinical development as third-line treatment of metastatic NPC.

关键词： metastatic nasopharyngeal supporting

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CO_(2)氢化合成低碳烯烃反应流程熵产率最小化

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热科学与技术 2024年第3期23卷 257-266页

作者：于亚杰夏少军赵明海军工程大学动力工程学院湖北武汉430033

CO_(2)氢化合成低碳烯烃是一种非石油原料合成烯烃路径,具有广阔的应用前景。以有限时间热力学理论为基础,对包含混合器、压缩机、换热器与CO_(2)氢化合成低碳烯烃反应器的反应流程进行建模及优化。在压缩机效率和癸烯(C10H20)产率均给... 详细信息

CO_(2)氢化合成低碳烯烃是一种非石油原料合成烯烃路径,具有广阔的应用前景。以有限时间热力学理论为基础,对包含混合器、压缩机、换热器与CO_(2)氢化合成低碳烯烃反应器的反应流程进行建模及优化。在压缩机效率和癸烯(C10H20)产率均给定以及换热器与反应器热源温度完全可控的条件下,以整个流程的熵产率最小为优化目标,对流程最小熵产率及换热器与反应器的热源温度分布最优构型进行数值求解,并将最优流程与反应器熵产率最小对应流程进行对比。结果表明:通过优化使反应流程熵产率相比参考反应流程下降7.77%;在优化范围内,选取较低的换热器出口温度、适当提高H2摩尔分数与降低CO_(2)摩尔分数可以降低反应流程的熵产率。研究结果对CO_(2)氢化合成低碳烯烃反应流程最优设计具有一定理论指导意义。

关键词：有限时间热力学合成低碳烯烃化学反应流程熵产率最小化

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不同吹扫模式下HI分解膜反应器多目标性能优化

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工程热物理学报 2024年第3期45卷 615-621页

作者：孔锐陈林根夏少军李鹏蕾戈延林海军工程大学动力工程学院武汉430033 武汉工程大学热科学与动力工程研究所武汉430205 武汉工程大学机电工程学院武汉430205 湖北省绿色化工装备工程技术研究中心武汉430205

建立了不同吹扫模式下碘化氢(HI)分解膜反应器有限时间热力学模型,将吹扫气流率、反应进口压力、渗透膜厚度、反应器长度作为决策变量,以HI转化率最大、H_(2)回收率最大、总熵产率最小为目标开展多目标优化。通过研究发现,在给定的决策... 详细信息

建立了不同吹扫模式下碘化氢(HI)分解膜反应器有限时间热力学模型,将吹扫气流率、反应进口压力、渗透膜厚度、反应器长度作为决策变量,以HI转化率最大、H_(2)回收率最大、总熵产率最小为目标开展多目标优化。通过研究发现,在给定的决策变量变化范围内HI转化率和H_(2)回收率最大两者具有一致性,但两者无法与总熵产率最小同时达到最优;相比顺流吹扫模式,逆流吹扫模式下Pareto前沿目标值均具有较高的HI转化率和H_(2)回收率。使用不同的决策方法选取最优解,顺流模式下的TOPSIS决策点和逆流模式下的LINMAP决策点具有较小的偏差因子可作为反应器参数设计最优解。

关键词：有限时间热力学 HI分解膜反应器 HI转化率 H_(2)回收率总熵产率多目标优化

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Entransy dissipation minimization for generalized heat exchange processes

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Science China(Technological Sciences) 2016年第10期59卷 1507-1516页

作者： xia.shaojun Institute of Thermal Science and Power Engineering Naval University of EngineeringWuhan 430033China Military Key Laboratory for Naval Ship Power Engineering Naval University of EngineeringWuhan 430033China College of Power Engineering Naval University of EngineeringWuhan 430033China

This paper investigates the MED （Minimum Entransy Dissipation） optimization of heat transfer processes with the generalized heat transfer law q ∝ （A（T^n））m. For the fixed amount of heat transfer, the optimal temperature paths for the MED are obtained The results show that the strategy of the MED with generalized convective law q ∝ （△T）^m is that the temperature difference keeps constant, which is in accordance with the famous temperature-difference-field uniformity principle, while the strategy of the MED with linear phenomenological law q ∝ A（T^-1） is that the temperature ratio keeps constant. For special cases with Dulong-Petit law q ∝ （△T）^1.25 and an imaginary complex law q ∝ （△（T^4））^1.25, numerical examples are provided and further compared with the strategies of the MEG （Minimum Entropy Generation）, CHF （Constant Heat Flux） and CRT （Constant Reservoir Temperature） operations. Besides, influences of the change of the heat transfer amount on the optimization results with various heat resistance models are discussed in detail.

关键词： entransy theory finite time thermodynamics heat exchange process optimal temperature path generalized heattransfer law generalized thermodynamic optimization

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Power output and efficiency optimization of endoreversible non-isothermal chemical engine via Lewis analogy

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中国科学:技术科学英文版 2023年第9期66卷 2651-2659页

作者： CHEN LinGen xia.shaojun Institute of Thermal Science and Power Engineering Wuhan Institute of TechnologyWuhan 430205China School of Mechanical&Electrical Engineering Wuhan Institute of TechnologyWuhan 430205China School of Power Engineering Naval University of EngineeringWuhan 430033China

Compared with endoreversible heat engine with pure heat transfer and endoreversible isothermal chemical engine with pure mass transfer,endoreversible non-isothermal chemical engine(ENICE)is a more reasonable model of practical mass exchanger,solid device and chemo-electric *** exists heat and mass transfer(HMT)simultaneously between working fluid and chemical potential reservoir in *** is coupled HMT effect that in ENICE should be *** are two ways to consider this coupled *** is based on Onsager equations,and another is based on Lewis *** the mathematical and physical description of the above HMT process,the model using Onsager equations are more appropriate in the linear HMT region not far from the equilibrium state,while that based on Lewis analogy is more appropriate in nonlinear HMT region far from the equilibrium *** from the previous research on the power optimization of ENICEs with Onsager equations,this paper optimizes power and efficiency of ENICE based on Lewis *** processes are assumed to obey Newtonian heat transfer law(q∝ΔT,and T is temperature)and Fick's diffusive mass transfer law(g∝Δc,and c is concentration),*** results of power output and corresponding vector efficiency(η_(T)andη_(μ))of ENICE are obtained,which provide important parallel results with those based on Onsager *** include special cases for endoreversible Carnot heat engine with q∝ΔT and endoreversible isothermal chemical engine with g∝Δ*** Lewis analogy in the modelling of ENICEs with simultaneous HMT is an important *** provides important analytical and numerical results different from those with Onsager equations obtained previously and enriches the research contents of *** research results in this paper have a certain guiding significance for the optimal designs of single irreversible NICEs,multistage NICE systems,practical mass exchangers,solid devices,chemo-electric syste

关键词： finite time thermodynamics endoreversible non-isothermal chemical engine Lewis analogy heat and mass transfer vector efficiency maximum power output

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Power-optimization of multistage non-isothermal chemical engine system via Onsager equations,Hamilton-Jacobi-Bellman theory and dynamic programming

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Science China(Technological Sciences) 2023年第3期66卷 841-852页

The research on the output rate performance limit of the multi-stage energy conversion system based on modern optimal control theory is one of the hot spots of finite time *** existing research mainly focuses on the multi-stage heat engine system with pure heat transfer and the multi-stage isothermal chemical engine(ICE)system with pure mass transfer,while the multi-stage non ICE system with heat and mass transfer coupling is less involved.A multistage endoreversible non-isothermal chemical engine(ENICE)system with a finite high-chemical-potential(HCP)source(driving fluid)and an infinite low-chemical-potential sink(environment)is *** multistage continuous system is treated as infinitesimal ENICEs located *** infinitesimal ENICE is assumed to be a single-stage ENICE with stationary *** single-stage results,the maximum power output(MPO)of the multistage system is *** and mass transfer processes between the reservoir and working fluid are assumed to obey Onsager *** the fixed initial time,fixed initial fluid temperature,and fixed initial concentration of key component(CKC)in the HCP source,continuous and discrete models of the multistage system are *** given initial reservoir temperature,initial CKC,and total process time,the MPO of the multistage ENICE system is optimized with fixed and free final temperature and final *** the final concentration and final temperature are free,there are optimal final temperature and optimal final concentration for the multistage ENICE system to achieve MPO;meanwhile,there are low limit values for final fluid temperature and final *** cases for multistage endoreversible Carnot heat engines and ICE systems are further *** the model in this paper,the minimum entropy generation objective is not equivalent to MPO objective.

关键词： endoreversible non-isothermal chemical engine multi-stage system linear irreversible thermodynamics maximum power output finite time thermodynamics optimal control

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Maximum work configurations of finite potential capacity reservoir chemical engines

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Science China Chemistry 2010年第5期53卷 1167-1175页

作者： xia, shaojun Chen, LinGen Sun, FengRui Postgraduate School Naval University of Engineering Wuhan 430033 China

An isothermal endoreversible chemical engine operating between the finite potential capacity high-chemical-potential reservoir and the infinite potential capacity low-chemical-potential reservoir has been studied in this *** control theory was applied to determine the optimal cycle configurations corresponding to the maximum work output per cycle for the fixed total cycle time and a universal mass transfer *** of special examples showed that the optimal cycle configuration with the mass transfer law g∝△μ,where△μis the chemical potential difference,is an isothermal endoreversible chemical engine cycle,in which the chemical potential(or the concentration) of the key component in the working substance of low-chemical-potential side is a constant,while the chemical potentials(or the concentrations) of the key component in the finite potential capacity high-chemical-potential reservoir and the corresponding side working substance change nonlinearly with time,and the difference of the chemical potentials(or the ratio of the concentrations) of the key component between the high-chemical-potential reservoir and the working substance is a *** the optimal cycle configuration with the mass transfer law g∝△μc,where △μc is the concentration difference,is different from that with the mass transfer law g∝△μ *** the high-chemical-potential reservoir is also an infinite potential capacity chemical potential reservoir,the optimal cycle configuration of the isothermal endoreversible chemical engine consists of two constant chemical potential branches and two instantaneous constant mass-flux branches,which is independent of the mass transfer *** object studied in this paper is general,and the results can provide some guidelines for optimal design and operation of real chemical engines.

关键词： isothermal endoreversible chemical engine maximum work output optimal control finite time thermodynamics generalized thermodynamic optimization

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The optimal path of piston motion for Otto cycle with linear phenomenological heat transfer law

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Science China(Physics,Mechanics & Astronomy) 2009年第5期52卷 708-719页

作者： xia.shaojun CHEN LinGen SUN FengRui Postgraduate School Naval University of EngineeringWuhan 430033China

An Otto cycle engine with internal and external irreversibilities of friction and heat leakage, in which the heat transfer between the working fluid and the environment obeys linear phenomenological heat transfer law [q ∝△(T -1)], is studied in this paper. The optimal piston motion trajectory for maximizing the work output per cycle is derived for the fixed total cycle time and fuel consumed per cycle. Optimal control theory is applied to determine the optimal piston trajectories for the cases of with and without piston acceleration constraint on each stroke and the optimal distribution of the total cycle time among the strokes. The optimal piston motion with acceleration constraint for each stroke consists of three segments, including initial maximum acceleration and final maximum deceleration boundary segments, respectively. Numerical examples for optimal configuration are provided, and the obtained results are compared with those obtained with Newton’s heat transfer law [q ∝△(T )]. The results also show that optimizing the piston motion can improve power and efficiency of the engine by more than 9%. This is primarily due to the decrease in heat leakage loss on the initial portion of the power stroke.

关键词： linear phenomenological heat transfer law Otto cycle maximum work output optimal piston trajectory finite time thermodynamics generalized thermodynamic optimization

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Entransy dissipation minimization for a class of one-way isothermal mass transfer processes

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Science China(Technological Sciences) 2011年第2期54卷 352-361页

作者： xia.shaojun CHEN LinGen SUN FengRui Postgraduate School Naval University of Engineering Wuhan 430033 China

A class of one-way isothermal mass transfer processes with Fick’s diffusive mass transfer law[g ∝Δ(c)]is investigated in this *** on the definition of the mass entransy,the entransy dissipation function which reflects the irreversibility of mass transfer ability loss is *** optimal concentration allocations of the key components corresponding to the highand low-concentration sides for the minimum entransy dissipation of the mass transfer process are obtained by applying opti- mal control theory and compared with the strategies of the minimum entropy generation,constant mass transfer flux(constant concentration difference),and constant concentration ratio(constant chemical potential difference).The results are as follows. For the optimal mass transfer strategy of the minimum entransy dissipation,the product of the square of the key component concentration difference between the high-and the low-concentration sides and the inert component concentration at the low-concentration side is a constant,while for that of the minimum entropy generation,the ratio of the square of the key com-ponent concentration difference between the high-and the low-concentration sides to the key component concentration at the low-concentration side is a constant;when the mass transfer process is not involved in energy conversion process,the optimi-zation principle should be the minimum entransy dissipation;the mass transfer strategy of constant concentration difference is superior to that of constant concentration *** results obtained in this paper can provide some theoretical guidelines for optimal designs and operations of practical mass transfer processes.

关键词： diffusive mass transfer law isothermal mass transfer entransy dissipation optimal control finite time thermodynamics

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