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SRY-Box transcription factor 9 triggers YAP nuclear entry via direct interaction in tumors

Signal Transduction and Targeted Therapy 2024年第5期9卷 2285-2297页

作者： Hui Qian Chen-hong Ding Fang Liu Shi-Jie Chen Chen-Kai Huang Meng-Chao xiao xia-lu hong Ming-Chen Wang Fang-Zhi Yan Kai Ding Ya-lu Cui Bai-Nan Zheng Jin Ding Cheng luo Xin Zhang Wei-Fen Xie Department of Gastroenterology Changzheng HospitalNaval Medical UniversityShanghaiChina Department of Gastroenterology Shanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Drug Discovery and Design Center CAS Key Laboratory of Receptor ResearchState Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina Department of Gastroenterology First Affiliated Hospital of Nanchang UniversityNanchangChina Clinical Cancer Institute Center for Translational MedicineNaval Medical UniversityShanghaiChina

The translocation of YAP from the cytoplasm to the nucleus is critical for its activation and plays a key role in tumor ***,the precise molecular mechanisms governing the nuclear import of YAP are not fully *** this study,we have uncovered a crucial role of SOX9 in the activation of ***9 promotes the nuclear translocation of YAP by direct ***,we have identified that the binding between Asp-125 of SOX9 and Arg-124 of YAP is essential for SOX9-YAP interaction and subsequent nuclear entry of ***,we have discovered a novel asymmetrical dimethylation of YAP at Arg-124(YAP-R124me2a)catalyzed by ***-R124me2a enhances the interaction between YAP and SOX9 and is associated with poor prognosis in multiple ***,we disrupted the interaction between SOX9 and YAP using a competitive peptide,S-A1,which mimics anα-helix of SOX9 containing Asp-125.S-A1 significantly inhibits YAP nuclear translocation and effectively suppresses tumor *** study provides the first evidence of SOX9 as a pivotal regulator driving YAP nuclear translocation and presents a potential therapeutic strategy for YAP-driven human cancers by targeting SOX9-YAP interaction.

关键词： interaction interaction precise

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船舶纵向构件疲劳评估的热点应力方法

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船海工程 2007年第4期36卷 15-19页

作者：詹志鹄夏洪禄中国船级社上海规范研究所上海200135

在中国船级社《船体结构疲劳强度指南》(2001版)提出的用名义应力计算船体结构疲劳强度的基础上,提出了一套对船体纵向构件用热点应力方法进行评估的方法,给出了热点应力的计算有限元模型、计算方法和对应的SN曲线选取的要求。

关键词：疲劳评估热点应力纵向构件

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Successful emergency surgical intervention in acute non-STsegment elevation myocardial infarction with rupture:A case report

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World Journal of Clinical Cases 2025年第4期13卷 41-47页

作者： Xing-Po Li Zi-Shan Wang hong-xia Yu Shan-Shan Wang Department of Cardiovascular Medicine Huantai County Hospital of Traditional Chinese MedicineZibo 256400Shandong ProvinceChina Department of Cardiovascular Medicine Zibo Hospital of Integrated Traditional Chinese and Western MedicineZibo 255500Shandong ProvinceChina

BACKGROUND The incidence of acute myocardial infarction(AMI)is rising,with cardiac rupture accounting for approximately 2%of deaths in patients with acute ST-segment elevation myocardial infarction(STEMI).Ventricular free wall rupture(FWR)occurs in approximately 2%of AMI patients and is notably rare in patients with *** of cardiac rupture include left ventricular FWR,ventricular septal rupture,and papillary muscle *** FWR usually leads to acute cardiac tamponade or electromechanical dissociation,where standard resuscitation efforts may not be *** septal rupture and papillary muscle rupture often result in refractory heart failure,with mortality rates over 50%,even with surgical or percutaneous repair *** SUMMARY We present a rare case of an acute non-STEMI patient who suffered sudden FWR causing cardiac tamponade and loss of consciousness immediate before undergoing coronary *** resuscitation and emergency open-heart repair along with coronary artery bypass grafting resulted in successful patient *** This case emphasizes the risks of AMI complications,shares a successful treatment scenario,and discusses measures to prevent such complications.

关键词： Acute non-ST segment elevation myocardial infarction Cardiac rupture Acute myocardial infarction Free wall rupture Case report

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Geometric Phases for Mixed States in Trapped Ions

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Communications in Theoretical Physics 2006年第3X期46卷 423-428页

作者： lu hong-xia Department of Physics and Electronics Huaiyin Teachers College Huaian 213001 China

The generalization of geometric phase from the pure states to the mixed states may have potential applications in constructing geometric quantum gates. We here investigate the mixed state geometric phases and visibilities of the trapped ion system in both non-degenerate and degenerate cases. In the proposed quantum system, the geometric phases are determined by the evolution time, the initial states of trapped ions, and the initial states of photons. Moreover, special periods are gained under which the geometric phases do not change with the initial states changing of photon parts in both non-degenerate and degenerate cases. The high detection efficiency in the ion trap system implies that the mixed state geometric phases proposed here can be easily tested.

关键词： geometric phase mixed state trapped ions

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Rock fracture mechanism of buffer blasting with cushion layer at the borehole bottom

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 325-334页

作者： Xinguang Zhu Chenxi Ding Zhe Sui hong Su Xu Guo School of Civil and Resources Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory for Mechanics in Fluid Solid Coupling Systems Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Mechanics and Civil Engineering China University of Mining and Technology(Beijing)Beijing 100083China School of Chemical and Blasting Engineering Anhui University of Science and TechnologyHuainan 232001China

This study primarily investigates the rock fracture mechanism of bottom cushion layer blasting and explores the effects of the bottom cushion layer on rock *** involves analyses of the evolution patterns of blasting stress,characteristics of crack distribution,and rock fracture features in the ***,blasting model experiments were carried out using the dynamic caustics principle to investigate the influence of bottom cushion layers and initiation methods on the integrity of the bottom rock *** experimental results indicate that the combined use of bottom cushion layers and inverse initiation effectively protects the integrity of the bottom rock ***,the process of stress wave propagation and dynamic crack propagation in rocks was simulated using the continuum-discontinuum element method(CDEM)and the Landau explosion source model,with varying thicknesses of bottom cushion *** numerical simulation results indicate that with increasing cushion thickness,the absorption of energy generated by the explosion becomes more pronounced,resulting in fewer cracks in the bottom rock *** illustrates the positive role of the cushion layer in protecting the integrity of the bottom rock mass.

关键词： bottom cushion layer blasting crack propagation continuum-discontinuum element method dynamic stress intensity factor

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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying hong Ximin Yuan Weicheng Kong Pengcheng xia Yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian Xie Yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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Combined Molecular Dynamics Simulation and Rouse Model Analysis of Static and Dynamic Properties of Unentangled Polymer Melts with Different Chain Architectures

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Chinese Journal of Polymer Science 2021年第4期39卷 512-524,I0008页

作者： Pu Yao lu-Kun Feng hong-xia Guo Beijing National Laboratory for Molecular Sciences Joint Laboratory of Polymer Sciences and MaterialsState Key Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Chain architecture effect on static and dynamic properties of unentangled polymers is explored by molecular dynamics simulation and Rouse mode analysis based on graph *** open chains,although they generally obey ideal scaling in chain dimensions,local structure exhibits nonideal behavior due to the incomplete excluded volume(EV)screening,the reduced mean square internal distance(MSID)can be well described by Wittmer'theory for linear chains and the resulting chain swelling is architecture dependent,i.e.,the more branches a bit stronger *** rings,unlike open chains they are compact in term of global *** to EV effect and nonconcatenated constraints their local structure exhibits a quite different non-Gaussian behavior from open chains,i.e.,reduced MSID curves do not collapse to a single master curve and fail to converge to a chain-length-independent constant,which makes the direct application of Wittmer's theory to rings quite *** from ideality is further evidenced by limited applicability of Rouse prediction to mode amplitude and relaxation time at high modes as well as the non-constant and mode-dependent scaled Rouse mode amplitudes,while the latter is architecture-dependent and even molecular weight dependent for *** chain relaxation time is architecture-dependent,but the same scaling dependence on chain dimensions does hold for all studied *** mode orthogonality at static state,the role of cross-correlation in orientation relaxation increases with time and the time-dependent coupling parameter rises faster for rings than open chains even at short time scales it is lower for rings.

关键词： Rouse model Unentangled chains Architecture Excluded volume effects

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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： xia-Jie Quan Hao Liang Yong-hong Tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

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慢性阻塞性肺疾病对心功能影响的研究

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临床肺科杂志 2017年第1期22卷 50-53页

作者：李晓霞陆霓虹方如意昆明市第三人民医院呼吸科云南昆明650000

目的探讨慢性阻塞性肺疾病(简称慢阻肺)患者异常肺功能对心脏结构、左心功能的影响,并分析其与运动耐力的关系。方法收集2012年1月至2013年11月在本院呼吸科门诊随访的慢阻肺稳定期患者70例,男性52例,女性18例,平均年龄69.14±7.40岁。... 详细信息

目的探讨慢性阻塞性肺疾病(简称慢阻肺)患者异常肺功能对心脏结构、左心功能的影响,并分析其与运动耐力的关系。方法收集2012年1月至2013年11月在本院呼吸科门诊随访的慢阻肺稳定期患者70例,男性52例,女性18例,平均年龄69.14±7.40岁。对照组50例为门诊健康体检者,男28例,女22例,平均70.93±6.44岁。70例患者分为Ⅰ、Ⅱ、Ⅲ级三个组。慢阻肺组及健康对照组通过超声心动图检测左右心腔内径大小、左心室舒张功能及肺动脉收缩压(SPAP)。三个组与健康对照组完成左右心腔大小、左心室舒张功能比较、慢阻肺三个组完成六分钟步行距离的比较,对检测结果进行统计学分析。结果 (1)三个组之间肺功能指标的差异均有统计学意义,P<0.05;(2)三个组的左右心腔大小均小于对照组,四个组之间的指标比较差异有统计学意义;三组功能残气量占预计值百分比(FRC%pre)和残气量占预计值百分比(RV%pre)与左心房内径(LAID)、右心房内径(RAID)、左心室舒张末期内径(LVEDD)、右心室内径(RVID)呈负相关性;第一秒用力呼气容积占预计值百分比(FEV1%pre)、深吸气量/肺总量(IC/TLC)、弥散量占预计值百分比(DLco%pre)与左心房内径(LAID)、右心房内径(RAID)、左心室舒张末期内径(LVEDD)、右心室内径(RVID)呈正相关;(3)深吸气量/肺总量(IC/TLC)及二尖瓣口舒张早期血流速度/二尖瓣口舒张晚期血流速度(E/A)均是患者运动耐力的独立影响因素。结论随着患者轻到中度分期增加,左右心腔大小逐渐缩小。静态肺过度充气的生理指标对患者心腔大小有重要的影响作用。

关键词：肺疾病慢性阻塞性心室功能

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Advance in the understanding of vasovagal syncope in children and adolescents

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World Journal of Pediatrics 2021年第1期17卷 58-62页

作者： hong-xia Li lu Gao Yue Yuan Department of Cardiology National Center for Children's HealthBeijing Children's HospitalCapital Medical UniversityBeijingChina

Background Vasovagal syncope(VVS)accounts for 60-80% of cases of neurally mediated *** results from acute orthostatic intolerance and recurrent syncopal attacks,which can seriously affect an individual's quality of *** addition,some children even experience trauma during ***,it is particularly important to clarify the pathogenesis of *** aim of our study is to reveal the latest research progress of *** sources Literature that involved the pathogenesis of VVS were selected from Cochrane Library(1990-2019),EMBASE(1991-2019)and PubMed(1968-2019)*** Hypovolemia,autonomic dysfunction,vasomotor dysfunction,baroreceptor reflex abnormalities,endothelial dys-function,serotonin surges,and gut microbiota were involved in the underlying mechanism of *** VVS is not always a benign *** aspects were involved in its ***-Jarish reflex,dysfunction of the autonomic nervous system,genetic factors and so on played important roles in VVS;however,the mecha-nism remains unclear.

关键词： Autonomic nervous system Bezold-Jarish reflex Children Genetic pathogenesis Vasovagal syncope

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