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Fluorescent Probes for Cysteine and Cysteine Oxidation Imaging

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Chemical Research in Chinese Universities 2024年第2期40卷 225-236页

作者： ZHANG xia li Guocheng PAN Wei li Na li Yanhua TANG Bo College of Chemistry Chemical Engineering and Materials ScienceKey Laboratory of Molecular and Nano ProbesMinistry of EducationCollaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of ShandongInstitute of Molecular and Nano ScienceShandong Normal UniversityJinan250014P.R.China Laoshan Laboratory Qingdao266237P.R.China

Cysteine is an important regulator of redox *** to the nucleophilic and oxidative sensitivity,cysteine residues in proteins can be oxidized by intracellular reactive oxygen species(ROS),which can lead to protein structural and functional ***,the development of fluorescent probes to image cysteine and cysteine oxidation is of great significance for the study of redox homeostasis in living *** this review,the development of fluorescent probes for imaging cysteine and cysteine oxidation was ***,we further analyzed defects of the reported fluorescent probes and made suggestions for the future development of fluorescent *** expect that this review can not only provide a deeper understanding of the role of cysteine and cysteine oxidation in oxidative stress,but also broaden the application of fluorescent probes in imaging cysteine and cysteine oxidation.

关键词： Cysteine Cysteine oxidation Fluorescent probe Oxidative stress

Energy release characteristics of PTFE/Al/TiH_(2) reactive jet with different TiH_2 content

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Defence Technology（防务技术） 2024年第9期39卷 168-176页

作者： Chunlan Jiang Jingbo Zhang rong Hu liang Mao Ming li State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

Titanium hydride(TiH_(2)), a promising high-energy additive, is doped into PTFE/Al to optimize the energy output structure of the reactive jet and strive for better aftereffect damage ability to the target. Six types of PTFE/Al/TiH_(2) reactive liners with different TiH_(2) content are prepared by the molding and sintering method. The energy release characteristics of PTFE/Al/TiH_(2) reactive jet are tested by the transient explosion energy test, and are characterized from pressure and temperature. The reaction delay time,pressure history, and temperature history of the energy release process are obtained, then the actual value of released energy and reaction efficiency of the reactive jet are calculated. The results show that the peak pressure and temperature of the PTFE/Al/TiH_(2) jet initially increase and then decrease with increasing TiH_(2) content. When the TiH_(2) content is 10%, the actual value of released energy and reaction efficiency increased by 24% and 6.4%, respectively, compared to the PTFE/Al jet. The reaction duration of the reactive material is significantly prolonged as the TiH_(2) content increased from 0% to 30%. Finally,combined with the energy release behaviors of PAT material and the dynamic deformation process of liner, the enhancement mechanism of TiH_(2) on energy release of the reactive jet is expounded.

关键词： PTFE/Al/TiH_(2) Reactive materials Shaped charge Impact energy release characteristics

Effects of fracture evolution and non-Darcy flow on the thermal performance of enhanced geothermal system in 3D complex fractured rock

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International Journal of Mining Science and Technology 2024年第4期34卷 443-459页

作者： Yachen Xie Jianxing liao Pengfei Zhao Kaiwen xia Cunbao li Department of Civil and Mineral Engineering University of TorontoToronto M5S1A4Canada College of Water Resources and Hydropower Sichuan UniversityChengdu 610225China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsWuhan 430071China College of Civil Engineering Guizhou UniversityGuiyang 550025China Institute of Geosafety School of Engineering and TechnologyChina University of GeosciencesBeijing 100083China State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering Shenzhen UniversityShenzhen 518060China

In fractured geothermal reservoirs,the fracture networks and internal fluid flow behaviors can significantly impact the thermal *** this study,we proposed a non-Darcy rough discrete fracture network(NR-DFN)model that can simultaneously consider the fracture evolution and non-Darcy flow dynamics in studying the thermo-hydro-mechanical(THM)coupling processes for heat extraction in geothermal *** further employed the model on the Habanero enhanced geothermal systems(EGS)project located in ***,our findings illustrate a clear spatial-temporal variation in the thermal stress and pressure perturbations,as well as uneven spatial distribution of shear failure in 3D fracture *** shear failure is mainly concentrated in the first fracture ***,channeling flow have also been observed in DFNs during heat extraction and are further intensified by the expansion of fractures driven by thermal ***,the combined effect of non-Darcy flow and fracture evolution triggers a rapid decline in the resulting heat rate and *** NR-DFN model framework and the Habanero EGS's results illustrate the importance of both fracture evolution and non-Darcy flow on the efficiency of EGS production and have the potential to promote the development of more sustainable and efficient EGS operations for stakeholders.

关键词： Coupled THM model Non-Darcy flow Deformable DFN Enhanced geothermal systems

Design of integral sliding mode guidance law based on disturbance observer

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Journal of Systems Engineering and Electronics 2024年第1期35卷 186-194页

作者： ZHOU Jianping ZHANG Wenjie ZHOU Hang li Qiang xia Qunli School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China School of Informatic Engineering Mianyang Techers’CollegeMianyang 62100China Beijing Institute of Electronic System Engineering Beijing 100854China Beijing Institute of Space Long March Vehicle Beijing 100076China

With the increasing precision of guidance,the impact of autopilot dynamic characteristics and target maneuvering abilities on precision guidance is becoming more and more *** order to reduce or even eliminate the autopilot dynamic operation and the target maneuvering influence,this paper suggests a guidance system model involving a novel integral sliding mode guidance law(ISMGL).The method utilizes the dynamic characteristics and the impact angle,combined with a sliding mode surface scheme that includes the desired line-ofsight angle,line-of-sight angular rate,and second-order differential of the angular *** the same time,the evaluation scenario considere the target maneuvering in the system as the external disturbance,and the non-homogeneous disturbance observer estimate the target maneuvering as a compensation of the guidance *** proposed system’s stability is proven based on the Lyapunov stability *** simulations reveale that ISMGL effectively intercepted large maneuvering targets and present a smaller miss-distance compared with traditional linear sliding mode guidance laws and trajectory shaping guidance ***,ISMGL has a more accurate impact angle and fast convergence speed.

关键词： disturbance observer pilot dynamics integral sliding mode impact angle constraint maneuvering target

Drainage of paddy terraces impacts structures and soil properties in the globally important agricultural heritage of Hani Paddy Terraces,China

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International Soil and Water Conservation Research 2024年第1期12卷 64-76页

作者： Ming Wang li rong Yanbo li Jiangcheng Huang Yuanmei Jiao xiaoyan Wei Institute of International Rivers and Eco-Security Kunming650500China Yunnan Key Laboratory of International Rivers and Transboundary Eco-Security Kunming650500China Power China Kunming Engineering Corporation limited Kunming650051China Department of Geography Yunnan Normal UniversityKunming650500China Yunnan Provincial Archives of Surveying and Mapping(Yunnan Provincial Geomatics Centre) Kunming650032China

Marginalization and abandonment of paddy terraces are widespread,but their effects on the sustainability of subsequent agricultural production are still *** Paddy Terraces,included in Globally Important Agriculture Heritage Systems,are threatened by paddy fields ***,changes in terrace structure,the productivity of topsoil(0-20 cm),and soil water holding capacity at 0-70 cm depth were determined in a case study of Hani Paddy Terraces in Amengkong River Basin in Yuanyang County in Southwestern China,which had been converted into dryland terraces for 2-14 *** results showed that:(1)The degree of terrace structures degradation exhibited a U-shaped curve with increasing time since draining,with those drained for 5-9 years having the best structure;(2)Soil productivity index decreased first and then increased with time after conversion;(3)Maximum water holding capacity at 0-70 cm soil depth dramatically decreased after conversion and such trend became increasingly obvious with increasing time since *** study revealed that drainage of paddy terraces along with associated changes in crop and field management led to an increase in soil productivity,but degradation of terrace structures and a decrease in water holding capacity will inhibit restoration to paddy *** findings enhance the understanding of the biophysical changes due to marginalization in paddy terraces.

关键词： Hani paddy terraces Terraces marginalization Terrace structure degradation Soil productivity Water holding capacity

A projected Newton algorithm based on chemically allowed interval for chemical equilibrium computations

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Frontiers of Chemical Science and Engineering 2024年第3期18卷 25-37页

作者： Hongbin Lu Shaohui Tao xiaoyan Sun li xia Shuguang xiang Institute of Process Systems Engineering College of Chemical EngineeringQingdao University of Science and TechnologyQingdao266042China

The chemical equilibrium equations utilized in reactive transport modeling are complex and nonlinear,and are typically solved using the Newton-Raphson *** this algorithm is known for its quadratic convergence near the solution,it is less effective far from the solution,especially for ill-conditioned *** such cases,the algorithm may fail to converge or require excessive *** address these limitations,a projected Newton method is introduced to incorporate the concept of *** method constrains the Newton step by utilizing a chemically allowed interval that generates feasible descending ***,we utilize the positive continuous fraction method as a preconditioning technique,providing reliable initial values for solving the *** numerical results are compared with those derived using the regular Newton-Raphson method,the Newton-Raphson method based on chemically allowed interval updating rules,and the bounded variable least squares method in six different test *** numerical results highlight the robustness and efficacy of the proposed algorithm.

关键词： chemical equilibrium reactive transport modeling numerical methods projected Newton method

Iridoids modulate inflammation in diabetic kidney disease: A review

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Journal of Integrative Medicine 2024年第3期22卷 210-222页

作者： Tong-yi Zhou Na Tian liu li rong Yu The First Clinical College of Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Hunan Provincial Key Laboratory of Translational Research in Traditional Chinese Medicine Prescriptions and Zheng Changsha 410208Hunan ProvinceChina

In recent years,preclinical research on diabetic kidney disease (DKD) has surged to the forefront of scientific and clinical *** has become a pervasive complication of type 2 *** the complexity of its etiology and pathological mechanisms,current interventions,including drugs,dietary modifications,exercise,hypoglycemic treatments and lipid-lowering methods,often fall short in achieving desired therapeutic ***,primarily derived from the potent components of traditional herbs,have been the subject of long-standing *** data suggest that iridoids possess notable renal protective properties;however,there has been no summary of the research on their efficacy in the management and treatment of *** article consolidates findings from in vivo and in vitro research on iridoids in the context of DKD and highlights their shared anti-inflammatory activities in treating this ***,it explores how certain iridoid components modify their chemical structures through the regulation of intestinal flora,potentially bolstering their therapeutic *** review provides a focused examination of the mechanisms through which iridoids may prevent or treat DKD,offering valuable insights for future research endeavors.

关键词： Diabetic kidney disease Iridoids Gut-kidney axis Traditional Chinese medicine monomer Inflammation

Intercultural Trust in Global Contexts:Synthesizing a Western Nomological Approach with a Chinese Systems Approach

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Journal of Systems Science and Systems Engineering 2024年第2期33卷 162-186页

作者： rong Du Mingqian li Shizhong Ai Cathal MacSwiney Brugha Uirike Reisach School of Economics and Management Xidian UniversityXi'an 710071China UCD School of Business University College DublinDublinIreland Information Management Department Neu-Ulm University of Applied SciencesBavariaGermany

Intercultural trust in global contexts plays a central role in helping people from different cultures to communicate comfortably,which is essential for *** to construct a framework that might foster international cooperation,and thus be helpful for coping with global emergencies,we relate a Western nomological approach to an Eastern systems approach to analyse intercultural trust in global *** cultural impacts on intercultural trust and the nomological framework of cultural differences,we propose an intercultural trust model to interpret how cultural differences influence trust.A qualitative study of Chinese-Irish interactions was conducted to interpret this *** organized 10 seminars on intercultural trust,and interviewed 16 people to further explore the respondents'deeper feelings and experiences about intercultural trust in global *** this study,we have identified factors impacting on intercultural trust,and found that intercultural trust can be developed and improved in various *** llustrate these ways,we have provided tactics and methods for building intercultural trust in global *** are highlighted for organizations to avoid cultural clashes and relevant political or economic risks.

关键词： Intercultural trust global contexts systems approach Western approach Chinese approach

Towards accurate mapping of loess waterworn gully by integrating google earth imagery and DEM using deep learning

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International Soil and Water Conservation Research 2024年第1期12卷 13-28页

作者： rong Chen Yi Zhou Zetao Wang Ying li Fan li Feng Yang School of Geography and Tourism Shaanxi Normal UniversityXi'an710119China National Experiment and Teaching Demonstration Center for Geography Xi'an710119China SuperMap Software Co. Ltd.Beijing100015China School of Environmental Science and Engineering Southern University of Science and TechnologyShenzhen518055China

Accurate mapping of loess waterworn gully(LWG)is essential to further study gully erosion and geomorphological evolution for the Chinese Loess Plateau(CLP).Due to the vertical joint and collapsibility of loess,LWGs have the characteristics of zigzag and unique slope abruptness under synthetic action of hydraulic force and *** forces existing LWG mapping methods to either focus on the improvement of mapping accuracy or center on the increase of mapping ***,simultaneously achieving accurate and efficient mapping of LWG is still in its infancy under complex topographic ***,we proposed a method that innovatively integrates the loess slope abruptness feature into an improved deep learning semantic segmentation framework for LWG mapping using 0.6 m Google imagery and 5 m DEM *** selected four study areas representing typical loess landforms to test the performance of our *** proposed method can achieve satisfactory mapping results,with the F1 score,mean Intersection-over-Union(mIoU),and overall accuracy of 90.5%,85.3%,and 92.3%,*** addition,the proposed model also showed significant accuracy improvement by inputting additional topographic information(especially the slope of slope).Compared with existing algorithms(Random forests,original DeepLabV3+,and Unet),the proposed approach in this study achieved a better accuracy-efficiency ***,the method can ensure high accuracy and efficiency of the LWG mapping for different loess landform types and can be extended to study various loess gully mapping and water and soil conservation.

关键词： Loess waterworn gully Topographic information Mapping Deep learning Soil erosion Loess plateau