检索结果-南通市图书馆

Comparison of outcomes between overlapping-spot and single-spot photodynamic therapy for circumscribed choroidal hemangioma

引用

International Journal of Ophthalmology(English edition) 2014年第1期7卷 66-70页

作者： Zhao-An Su xia-jing tang Li-xia Zhang xiao-Hong Su Eye Center the Second Affiliated Hospital of Zhejiang University School of Medicine

AIM: To compare the efficacy and safety of photodynamic therapy(PDT) with overlapping multiple spots and single spot for treating circumscribed choroidal hemangioma. · METHODS: Twenty-two patients(22 eyes) with symptomatic circumscribed choroidal hemangioma received PDT treatment. Fourteen patients received overlapping spots(two to three spots) PDT,whereas eight patients received single-spot PDT. Laser was used at 50J/cm2for 83s in the overlapping-spot group and 50J/cm2for 166s in the single-spot group. Clinical examination,funduscopy,fluorescein angiography,and ultrasonography were performed at baseline and after treatment. ·RESULTS: The mean follow-up time was 28.5 ±8.0 months in the overlapping-spot group and 27.0 ±5.0 months in the single-spot group. Nine patients(64.2%) had their vision improved over two lines on the Snellen chart,and five patients showed stable visual acuity in the overlapping-spot group. The mean thickness of tumor decreased from 2.7 ±0.8mm to 1.2±0.9mm,and the mean greatest tumor linear dimension decreased from 7.4 ± 1.5mm to 4.5 ±3.5mm after treatment. In the single-spot group,two patients(25%) had their vision improved over two lines on the Snellen chart,and six patients had unchanged stable vision. The mean tumor thickness in this group decreased from 2.5±0.7mm to 1.4±1.0mm,and the mean greatest tumor linear dimension decreased from 7.2±1.3mm to 4.7±3.6mm. No significant differences in visual improvement and tumor regression were found between the two groups. ·CONCLUSION:Overlapping-spotPDTunderappropriate treatment parameters and strategies is as effective andsafe as single-spot PDT for treating symptomatic circumscribed choroidal hemangioma. Improved or stabilized visual acuity was achieved as a result of tumor regression.

关键词： photodynamic therapy circumscribed choroidal hemangioma spot pattern

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The impact of GJA3 SNPs on susceptibility to age-related cataract

引用

International Journal of Ophthalmology(English edition) 2019年第6期12卷 1008-1011页

作者： xia-jing tang Xing-Chao Shentu Ye-Lei tang Xi-Yuan Ping xiao-Ning Yu Eye Center of the Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Zhejiang Provincial Key Lab of Ophthalmology Hangzhou 310009Zhejiang ProvinceChina The Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310009Zhejiang ProvinceChina

AIM: To determine the association of gap junction protein alpha 3(GJA3) gene tag single-nucleotide polymorphisms(SNPs) with susceptibility to age-related cataract(ARC).METHODS: In total, 486 ARC patients were matched with 500 healthy controls. All the participants underwent complete ophthalmic examinations. Haplotype-tagging SNPs of GJA3 gene were selected from the HapMap Beijing Han Chinese population. Genomic DNA was extracted from the peripheral blood leukocytes of all the *** three different genetic models: dominant, recessive,and additive, the association between SNPs and ARC was examined. After adjusting for age and sex, the genetic effects of the GJA3 SNPs were evaluated with logistic regression ***: Four tag GJA3 SNPs(rs6490519, rs9506430,rs9509053, and rs9552089) were included in the present study. None of the SNPs showed a significant relationship with an altered risk of total ARC under the dominant,recessive, or additive models. In the subgroup analysis,rs9506430 had a significant effect on the formation of a posterior subcapsular cataract(P=0.002, OR: 0.227, 95%CI:0.088-0.590) under the recessive ***: Our study indicates that GJA3 variants may influence the development of posterior subcapsular cataracts. Further studies need to be designed to confirm this possibility.

关键词： gap junction protein alpha 3 single-nucleotide polymorphisms age-related cataract

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hydrogen peroxide-induced apoptosis of human lens epithelial cells is inhibited by parthenolide

引用

International Journal of Ophthalmology(English edition) 2018年第1期11卷 12-17页

作者： Xing-Chao Shentu Xi-Yuan Ping Ya-Lan Cheng Xin Zhang Ye-Lei tang xia-jing tang Eye Center the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina The Second Affiliated Hospital of Zhejiang University the School of Medicine Hangzhou 310000Zhejiang ProvinceChina

AIM： To explore the effect of parthenolide on hydrogen peroxide（H_2O_2）-induced apoptosis in human lens epithelial（HLE） cells. METHODS： The morphology and number of apoptotic HLE cells were assessed using light microscopy and flow cytometry. Cell viability was tested by MTS assay. In addition, the expression of related proteins was measured by Western blot assay. RESULTS： Apoptosis of HLE cells was induced by 200 μmol/L H_2O_2, and the viability of these cells was similar to the half maximal inhibitory concentration（IC50）, as examined by MTS assay. In addition, cells were treated with either different concentrations（6.25, 12.5, 25 and 50 mol/L） of parthenolide along with 200 μmol/L H_2O_2 or only 50 μmol/L parthenolide or 200 mol/L H_2O_2 for 24 h. Following treatment with higher concentrations of parthenolide（50 μmol/L）, fewer HLE cells underwent H_2O_2-induced apoptosis, and cell viability was increased. Further, Western blot assay showed that the parthenolide treatment reduced the expression of caspase-3 and caspase-9, which are considered core apoptotic proteins, and decreased the levels of phosphorylated nuclear factor-κB（NF-κB）, ERK1/2 [a member of the mitogen-activated protein kinase（MAPK） family], and Akt proteins in HLE cells. CONCLUSION： Parthenolide may suppress H_2O_2-induced apoptosis in HLE cells by interfering with NF-κB, MAPKs, and Akt signaling.

关键词： parthenolide apoptosis human lens epithelial cells hydrogen peroxide

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dystrophia canthorum in Waardenburg syndrome with a novel MITF mutation

引用

International Journal of Ophthalmology(English edition) 2020年第7期13卷 1054-1059页

作者： xia-jing tang Xi-Yuan Ping Chen-Qi Luo xiao-Ning Yu Ye-Lei tang Xing-Chao Shentu Eye Center of the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina

AIM:To reveal a novel MITF gene mutation in Waardenburg syndrome(WS),which is an autosomal dominant inherited neurogenic disorder that consists of various degrees of sensorineural deafness and pigmentary abnormalities in the eyes,hair and ***:The genetic analysis of the Chinese family was conducted by whole-exome sequencing,then the results were confirmed by Sanger ***:WS is classified into type I to IV,which are identified by the W index,clinical characteristics and additional *** MITF gene mostly accounts for WS type *** this study,a de novo heterozygous mutation in the MITF gene,c.638 A>G in exon 7,was identified in the patient diagnosed with WS type I features,as the W index was 2.17(over 2.10),with dystrophia canthorum,congenital bilateral profound hearing loss,bilateral heterochromia irides,premature greying of the hair,and excessive freckling on the face at *** also underwent refractive errors and esotropia,reduced pigmentation of the choroid and visible choroid *** mutation was not found in previous studies or mutation ***:The novel mutation in the MITF gene,which altered the protein in amino acids 213 from the glutamic acid to glycine,is the genetic pathological cause for WS features in the *** characteristics of this family revealed a novel genetic heterogeneity of MITF in WS,which expanded the database of MITF mutations and offered a possible in correcting the W index value of WS in distinct ***,ocular symptoms should be emphasized in all types of WS patients.

关键词： Waardenburg syndrome gene MITF dystrophia canthorum whole-exome sequencing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ocular findings in syndromic gingival fibromatosis: a case study and electronic microscopic investigation of lens

引用

International Journal of Ophthalmology(English edition) 2014年第3期7卷 574-576页

作者： Ye-Lei tang Xing-Chao Shentu Su-Juan Zhao xia-jing tang Long He Fei-Yun Ping Department of Neurology Second Affiliated Hospital of the Medical College Zhejiang University Eye Center Second Affiliated Hospital of the Medical College Zhejiang University Department of Stomatology Second Affiliated Hospital of the Medical College Zhejiang University

We report a case of syndromic gingival fibromatosis with notable ocular lesions,bilateral congenital cataracts,esotropia,and high myopia of a 21-year-old male patient from *** patient was diagnosed with gingival fibromatosis based on his massive gingival overgrowth and histological findings that were consistent with gingival fibromatosis through a gingival *** opacity features were presented and phacoemulsificaion with intraocular lens(IOL)implantation was performed to manage the cataracts in both *** electronic microscopy was used to investigate the ultrastructure of the removed lens *** also review the literature on gingival fibromatosis and briefly summarize the ocular manifestations of this rare disease.

关键词： congenital cataract transmission electron microscopy gingival fibromatosis syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of IGF1R polymorphisms(rs1546713) with susceptibility to age-related cataract in a Han Chinese population

引用

International Journal of Ophthalmology(English edition) 2020年第3期13卷 374-381页

作者： Yi-Lei Cui xiao-Ning Yu Xin Zhang Ye-Lei tang xia-jing tang Hao Yang Xi-Yuan Ping jing Wu Qi-Chuan Yin Jia-Yue Zhou xia-Yan Xu Xing-Chao Shentu Eye Center the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina The Second Affiliated Hospital Zhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina

AIM:To explore the susceptible association between the insulin-like growth factor-1 receptor(IGF1 R)single nucleotide polymorphism(SNP)and age-related cataract(ARC),and investigate the underlying mechanisms in human lens epithelium(HLE)***:Totally 1190 unrelated participants,comprising 690 ARC patients and 500 healthy individuals in Han Chinese population were recruited and genotyped for target ***χ2-test was used to detect genotypic distribution between the patient and control groups and the logistic regression was performed to adjust the age and ***,different biological experimental methods,such as cell counting kit 8(CCK-8)assay,flow cytometry,quantitative real time polymerase chain reaction(Q-PCR)and Western blot,were used to detect cell viability,cell cycle progression and apoptosis in HLE cells or IGF1 R knockdown HLE ***:The rs1546713 in IGF1 R gene was identified(P=0.046,OR:1.606,95%CI:1.245-2.071),which shown a significant relevance with ARC risk under the dominant *** results demonstrated that IGF1 R knockdown inhibited cell proliferation by inducing cell cycle arrested at S phase and promoting ***,the cell cycle blocked at S phase was linked with the alterations of cyclin A,cyclin B,cyclin E and *** pro-apoptosis function of IGF1 R may related with stimulating the activation of Caspase-3 and altering the expression levels of apoptotic proteins,including Bcl-2,Bax and ***:This study first report that IGF1 R polymorphisms may affect susceptibility to ARCs in Han Chinese population and provide new clues to understand the pathogenic mechanism of ***,IGF1 R is likely a potential target for ARC prevention and treatment.

关键词： insulin-like growth factor-1 receptor age-related cataract single nucleotide polymorphism

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Novel mutation c.980_983delATTA compound with c.986C>A mutation of the FRMD7 gene in a Chinese family with X-linked idiopathic congenital nystagmus

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第6期14卷 479-486页

作者： Feng-wei SONG Bin-bin CHEN Zhao-hui SUN Li-ping WU Su-juan ZHAO Qi MIAO xia-jing tang Eye Center the Second Affiliated HospitalSchool of MedicineZhejiang University Department of Ophthalmology the First Affiliated Hospital of Huzhou Teachers College Department of Otolaryngology-Head and Neck Surgery the First Affiliated HospitalWenzhou Medical College

Objective:To screen mutations in FERM domain-containing protein 7(FRMD7) gene in two Chinese families with X-linked idiopathic congenital nystagmus(XLICN).Methods:Common ophthalmic data and peripheral blood of two Chinese XLICN families(families A and B) were collected after informed *** DNA was prepared from the peripheral blood of members of the two families and from 100 normal *** in the FRMD7 gene were determined by directly sequencing polymerase chain reaction(PCR) ***:We identified a novel mutation c.980_983delATTA compound with c.986C>A mutation in the 11th exon of FRMD7 in family B,and a previously reported splicing mutation c.782G>C(p.R261G) in family *** mutations were detected in patients and female carriers,while they were absent in other relatives or in the 100 normal ***:Our results expand the spectrum of FRMD7 mutations in association with XLICN,and further confirm that the mutations of FRMD7 are the underlying molecular mechanism for XLICN.

关键词： Mutation Idiopathic congenital nystagmus FERM domain-containing protein 7(FRMD7)

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Prospects on mangrove knowledge services in the smart era: From plant atlas to knowledge graphs

引用

Science China Earth Sciences 2025年第1期68卷 111-127页

作者： Zhi-Wei HOU Wenlong jing Cheng-Zhi QIN Ji YANG Qing xia xiaoling YIN Key Laboratory of Guangdong for Utilization of Remote Sensing and Geographical Information System Guangdong Open Laboratory of Geospatial Information Technology and Application Guangzhou Institute of Geography Guangdong Academy of Sciences Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) State Key Laboratory of Resources and Environmental Information System Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences College of Resources and Environment University of Chinese Academy of Sciences School of Traffic & Transportation Engineering Changsha University of Science and Technology

Mangroves are crucial to the ecological security of the Earth and human well-being. Their management, conservation, and restoration are of great importance and necessitate the support of spatio-temporal information and multidisciplinary knowledge such as biology and ecology. Traditional knowledge services such as plant atlas provide illustrated textual knowledge of mangroves. However, this kind of service is oriented to information retrieval and is incapable of effectively mining and utilizing fragmented knowledge from multi-source heterogeneous data, facing the problem of “massive data, rare knowledge”. Knowledge graphs are capable of extracting, organizing, and fusing the knowledge contained in massive data into semantic networks that can be understood and computed by computers. They provide a solution for the realization of intelligent knowledge services. Focusing on the urgent need for mangrove knowledge acquisition, formal representation, and intelligent services, this paper proposes a research prospect on mangrove knowledge graphs and knowledge services. We first analyze the similarities and differences between various domain-specific concepts of Tupu. On this basis, we define the mangrove knowledge graph as a large-scale knowledge base that integrates multi-disciplinary knowledge and spatio-temporal information with mangrove ecosystems as the core. Then, we propose a research framework for mangrove knowledge services that can realize the transformation from multi-modal data to intelligent knowledge services, including multiple research levels such as ubiquitous data sensing and aggregation, knowledge organization and graph construction, and intelligent mangrove knowledge services. Subsequently, the methods and workflow for constructing mangrove knowledge graphs are introduced. Finally, we discuss the challenges and possible future directions of mangrove knowledge services in the smart era, including the construction of a mangrove knowledge system that integra

关键词： Mangrove Tupu Knowledge graph Multi-modal Knowledge service

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Hydrogen peroxide(H2O2) and Methyl-β-cyclodextrin (MβCD) down regulate caveolin expression in human lens epithelial cells (HLECs)

Hydrogen peroxide(H2O2) and Methyl-β-cyclodextrin (MβCD) d...

引用

2007年浙江省眼科学术会议

作者： Hong-ying Jin Ke Yao Jin Ma Hong-wu Li xia-jing tang 浙江大学医学院附属第二医院眼科中心

Purpose:Oxidative stimulation induced by hydrogen peroxide(HO)on human epithelial cells (HLECs)was performed to observe the effects on cell proliferation,caveolin expression,and cholesterol depletion in HLECs caused by methyl-β-cyclodextrin(MβCD)was also studied. Methords:SRA01/04 HLECs were exposed to HO or MβCD of various concentrations and *** used a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrozolium bromide(MTT)assay to measure the effect of HO on the proliferation of SRA01/04 *** distributions of caveolins after oxidative stimulation were probed by fluorescence microscopy and laser scanning confocal *** was performed to analyze alterations of caveolins expression. Results:We observed that the proliferation of SRA01/04 HLECs under 0.1 mM HO for 10 min or longer was significantly reduced(p＜0.05,F=11.63).Laser scanning microscopy showed immunofluorescent caveolins in SRA01/04 HLECs under 0.1 mM HO for 10 min or longer,caveolins were largely confined to intracellular *** blots showed both membrane and total caveolin protein(22 kDa)levels in SRA01/04 HLECs treated with 0.1,0.2,0.5 or 1.0 mM HO for 30 min were significantly reduced,compared with the untreated(p＜0.05,F=6.149,or p＜0.05,F=14.489,respectively).In addition,the membrane and total caveolin protein level after treated with 0.1mM (p＜0.05,F=6.843,or p＜0.05,F=7.944,respectively) HO for different durations also down *** microscopy also showed that phosphorylated caveolin-1 was distributed near the focal adhesions of the cells. Conclusion:This study concludes that the responses of HLECs to oxidative stress may include down regulation of caveolin and phosphorylation of caveolin-1 on tyrosine 14,and that MβCD also down regulates caveolin while depleting cholesterol in HLECs.

关键词： caveolae caveolins hydrogen peroxide(H2O2) methyl-β-cyclodextrin(MβCD) cholesterol human lens epithelial cells(HLECs) cataract

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Hydrogen peroxide (H2O2) and Methyl-β-cyclodextrin (MβCD) down regulate caveolin expression in human lens epithelial cells(HLECs)

Hydrogen peroxide (H2O2) and Methyl-β-cyclodextrin (MβCD) ...

引用

中华医学会第十二届全国眼科学术大会

作者： Hong-ying Jin Ke Yao Jin Ma Hong-wu Li xia-jing tang 浙江大学医学院附属第二医院眼科中心

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：