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基于自组织映射神经网络的多目标调度研究

计算机集成制造系统 2008年第4期14卷 757-760,820页

作者：夏凌谷寒雨上海交通大学自动化系上海200240

为解决后验式场景下的多目标生产调度问题,提出一种基于自组织映射神经网络的策略来生成近似Pareto边界。该方法首先使用拉格朗日松弛法获得若干Pareto解,从而将搜索范围划分为若干区域。对于每一个区域,构造两个并发运行的自组织映射... 详细信息

为解决后验式场景下的多目标生产调度问题,提出一种基于自组织映射神经网络的策略来生成近似Pareto边界。该方法首先使用拉格朗日松弛法获得若干Pareto解,从而将搜索范围划分为若干区域。对于每一个区域,构造两个并发运行的自组织映射神经网络搜索区域中的Pareto解,在不增加求解时间的情况下提高了求解精度。另外,根据多目标调度问题的特点,改变了神经网络训练过程中邻域的定义,从而加快了求解速度。仿真实验验证了该算法的可行性与有效性。

关键词：多目标调度 Pareto边界自组织映射神经网络拉格朗日松弛法

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高流强RFQ质子加速器研制

原子能科学技术 2009年第B12期43卷 159-164页

作者：傅世年关遐令中国科学院高能物理研究所北京100049 中国原子能科学研究院北京102413

在国家"973"计划洁净核能项目的支持下,中国科学院高能物理研究所与中国原子能科学研究院合作,建成了我国首台强流质子加速器。它是1台四翼型结构的射频四极(radio-frequency qaudrupole,RFQ)加速器,这种先进加速结构可为来自离子源的... 详细信息

在国家"973"计划洁净核能项目的支持下,中国科学院高能物理研究所与中国原子能科学研究院合作,建成了我国首台强流质子加速器。它是1台四翼型结构的射频四极(radio-frequency qaudrupole,RFQ)加速器,这种先进加速结构可为来自离子源的低能强流束提供周期性强聚焦,并同时在纵向对束流进行聚束和加速。我国建成的这台RFQ加速器束流能量为3.5 MeV,脉冲流强达46 mA,束流工作比大于7%。本文将介绍这台RFQ加速器的物理设计、研制、调试和出束实验的结果。

关键词：强流质子束射频四极加速器加速器驱动的次临界系统

IVF/ICSI-ET术后早期妊娠丢失患者绒毛组织拷贝数变异异常的高危因素分析

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生殖医学杂志 2024年第1期33卷 29-34页

作者：黄蕾何蕊许晓雪闫慧赵君利哈灵侠刘春莲宁夏医科大学总医院生殖医学中心银川750004 宁夏医科大学银川750004

目的探讨体外受精(IVF)/卵胞浆内单精子注射(ICSI)后行新鲜胚胎移植(ET)的早期妊娠丢失(EPL)患者绒毛组织拷贝数变异(CNV)异常的高危因素,为遗传咨询提供依据。方法采用回顾性队列研究,选择2020年6月至2022年12月就诊宁夏医科大学总医... 详细信息

目的探讨体外受精(IVF)/卵胞浆内单精子注射(ICSI)后行新鲜胚胎移植(ET)的早期妊娠丢失(EPL)患者绒毛组织拷贝数变异(CNV)异常的高危因素,为遗传咨询提供依据。方法采用回顾性队列研究,选择2020年6月至2022年12月就诊宁夏医科大学总医院生殖医学中心接受IVF/ICSI助孕新鲜胚胎移植后EPL患者中绒毛组织CNV结果异常的周期作为病例组(n=29),随机抽选同期IVF/ICSI-ET术后正常活产的周期作为对照组(n=60)。比较两组患者的一般资料、临床及实验室指标,并对病例组流产绒毛组织CNV异常的构成及占比进行分析讨论。结果(1)病例组年龄[(33.45±3.78)岁]及自然流产次数[(0.41±0.73)次]显著高于对照组[分别为(29.52±4.27)岁、(0.05±0.22)次](P<0.05),抗苗勒管激素(AMH)水平显著低于对照组[(2.49±2.05)ng/ml vs.(4.03±2.67)ng/ml,P<0.05];(2)病例组促性腺激素(Gn)启动日FSH水平[(6.63±6.31)U/L]、Gn启动日LH水平[(2.28±1.85)U/L]、HCG日LH水平[(3.05±3.28)U/L]显著高于对照组[分别为(3.10±2.13)U/L、(1.26±0.79)U/L、(1.27±1.14)U/L](P<0.05);(3)病例组患者绒毛组织拷贝数变异测序(CNV-seq)结果中染色体数目异常占比72.41%、结构异常占比27.59%;常染色体三体占比55.17%,其中16-三体和22-三体最常见(分别占比17.24%、10.34%)。结论高龄、卵巢储备功能下降可能是导致EPL患者胚胎染色体核型异常的主要因素。

关键词： IVF/ICSI 绒毛染色体拷贝数变异非整倍体

Random Terpolymer Based on Simple Siloxane-functionalized Thiophene Unit Enabling High-performance Non-fullerene Organic Solar Cells

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Chinese Journal of Polymer Science 2024年第3期42卷 311-321,I0006页

作者： Fuliang Cheng Shiting Lai Yihan Zhang ling Xue Xinxin xia Peipei Zhu Xinhui Lu Xunfan Liao Yiwang Chen National Engineering Research Center for Carbohydrate Synthesis/Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education College of Chemistry and Chemical EngineeringJiangxi Normal UniversityNanchang 330022China Department of Physics Chinese University of Hong Kong New TerritoriesHong Kong 999077China Institute of Polymers and Energy Chemistry(IPEC)/Jiangxi Provincial Key Laboratory of New Energy Chemistry Nanchang UniversityNanchang 330031China

Incorporation of siloxane-functionalized units into polymers backbone has proven to be an efficient strategy to improve photovoltaic performance. In this work, a low-cost siloxane-containing unit was developed to construct a series of terpolymers, and the effects of siloxane on the polymer performance were systematically studied. Different contents of thiophene containing siloxane-functionalized side chain were introduced into PM6 to obtain a series of polymers(PM6, PM6-SiO-10, PM6-SiO-20 and PM6-SiO-30). The siloxane-functionalized side chains in polymers have only a slight effect on the absorption behavior and frontier molecular orbitals. However, when the siloxane content increased, the terpolymers' aggregation property decreased and the temperature-dependency increased, leading to improved donor-acceptor compatibility. The power conversion efficiency(PCE) based on PM6:Y6, PM6-SiO-20:Y6 and PM6-SiO-30:Y6 devices was 15.64%, 16.03% and 15.82%, respectively. In comparison, the active layer based on PM6-SiO-10:Y6 exhibits the most appropriate phase separation morphology, resulting in effective exciton dissociation, more balanced hole-electron transport and less recombination. Consequently, the highest PCE of 16.69% with an outstanding shortcircuit current density of 26.96 mA·cm^(-2) was obtained, which are one of the highest values for siloxane-functionalized polymer-based *** work demonstrates that finely controlling the content of siloxane-functionalized thiophene is beneficial for obtaining high-performance terpolymer donors and provides a novel and low-cost method to improve photovoltaic performance.

关键词： Organic solar cells Terpolymers Siloxane-functionalized unit Low-cost Morphology

Application of digital positioning guide plates for the surgical extraction of multiple impacted supernumerary teeth:A case report and review of literature

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World Journal of Clinical Cases 2022年第27期10卷 9886-9896页

作者： Zhi Wang Shu-Yi Zhao Wu-Shu He Fan Yu Shao-Jie Shi Xue-ling xia Xin-xiao Luo Yu-Hong xiao Department of Oral and Maxillofacial Surgery 920th Hospital of Joint Logistics Support ForcePLATeaching Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND An extra tooth in the normal tooth sequence in any region of the dental arch is regarded as a supernumerary tooth(SNT).Due to the large variation in location and morphology,the extraction of impacted SNTs is an extensive and complex procedure with high risks of several *** report presents a rare case of seven impacted SNTs in the bilateral upper and lower arch that were successfully extracted with the use of digital positioning guide *** SUMMARY In January 2022,a 21-year-old male was referred to our department with a chief complaint of pain in relation to tooth#*** examination showed a deep carious lesion with pulpal involvement in tooth#36 and lingual swelling of the bilateral mandibular posterior *** examination revealed seven deeply impacted SNTs in the bilateral posterior area and bilateral impacted mandibular third *** on these findings,the patient was diagnosed with bilateral,multiple impacted SNTs and tooth#36 chronic pulpitis.A root canal treatment and an all-ceramic crown restoration for tooth#36 were *** individualized digital positioning guide plate was designed by computer-aided design/computer-aided manufacturing technology and cone-beam computed tomography for extraction of the impacted *** the operation,the digital positioning guide plate allowed rapid positioning and exposure of the SNTs while avoiding adjacent important anatomical *** 3-month follow-up,regeneration of bone and soft tissues was *** The application of digital positioning guide plates is useful for the individualized and minimalized extraction of impacted supernumerary teeth.

关键词： Supernumerary teeth Computer aided design/computer aided manufacturing Digital Surgical guide Minimal invasion Case report

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具有荚膜的白色念珠菌转录组学分析

赣南医学院学报 2024年第8期44卷 795-799页

作者：唐晓媛陈亚运陈玲霞刘志平刘志春赣南医科大学第一附属医院呼吸与危重症医学科江西赣州341000 赣南医科大学基础医学院江西赣州341000

目的:探讨具有荚膜的白色念珠菌转录组学特征。方法:⑴采用feature Counts(1.5.0-p3)获得基因或转录本的表达量,通过DESeq2软件(1.20.0)筛选出具有荚膜的白色念珠菌的差异表达基因(Different Express Gene,DEG),使用“clusterProfiler”... 详细信息

目的:探讨具有荚膜的白色念珠菌转录组学特征。方法:⑴采用feature Counts(1.5.0-p3)获得基因或转录本的表达量,通过DESeq2软件(1.20.0)筛选出具有荚膜的白色念珠菌的差异表达基因(Different Express Gene,DEG),使用“clusterProfiler”R包对差异表达基因进行基因本体(Gene Ontology,GO)富集分析和基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)富集分析,并筛选关键基因。⑵RT-PCR验证白色念珠菌无荚膜菌株与荚膜菌株部分差异表达基因mRNA表达。结果:C1-1与SC5314相比,差异表达基因达到2586个,其中显著上调的有1184个,显著下调的有1402个。对差异表达基因进行GO富集分析发现,DEGs主要富集在蛋白质代谢过程、膜的构成和膜的固有成分及结构分子活性和核糖体结构性成分。对差异表达基因进行KEGG富集分析发现,DEGs富集在核糖体、丙酮酸盐代谢、过氧化物酶体、细胞周期、氨基糖和核苷酸糖代谢等通路。对新转录本进行GO、KEGG、Pfam等数据库注释,共预测关键基因113个,其中GO数据库注释关键基因1个,具有氧化还原酶活性,可能参与荚膜的生物代谢过程;KEGG数据库注释关键基因3个,参与白色念珠菌的氧代羧酸、柠檬酸盐循环、氨基酸等代谢活动。与白色念珠菌无荚膜菌株相比,荚膜菌株Efg1、Thr1 mRNA表达均降低。结论:白色念珠菌荚膜菌株与无荚膜菌株在基因表达总体水平和相关代谢通路基因表达水平上存在明显的差异。

关键词：白色念珠菌荚膜转录组学基因

Serum and cerebrospinal fluid tau protein level as biomarkers for evaluating acute spinal cord injury severity and motor function outcome

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Neural Regeneration Research 2019年第5期14卷 896-902页

作者： Ying Tang Hong-Liang Liu ling-xia Min Hao-Shi Yuan Lei Guo Peng-Bo Han Yu-Xin Lu Jian-Feng Zhong Dong-Lin Wang Key Laboratory of Biorheological Science and Technology Ministry of Education (Chongqing University) Chongqing University Cancer Hospital Department of Rehabilitation Southwest Hospital Third Military Medical University Department of Spine Surgery Second Affiliated Hospital of Xi'an Medical University Department of Orthopedics Chinese PLA Beijing Army General Hospital

Tau protein, a microtubule-associated protein, has a high specific expression in neurons and axons. Because traumatic spinal cord injury mainly affects neurons and axons, we speculated that tau protein may be a promising biomarker to reflect the degree of spinal cord injury and prognosis of motor function. In this study, 160 female Sprague-Dawley rats were randomly divided into a sham group, and mild, moderate, and severe spinal cord injury groups. A laminectomy was performed at the T8 level to expose the spinal cord in all groups. A contusion lesion was made with the NYU-MASCIS impactor by dropping a 10 g rod from heights of 12.5 mm(mild), 25 mm(moderate) and 50 mm(severe) upon the exposed dorsal surface of the spinal cord. Tau protein levels were measured in serum and cerebrospinal fluid samples at 1, 6, 12, 24 hours, 3, 7, 14 and 28 days after operation. Locomotor function of all rats was assessed using the Basso, Beattie and Bresnahan locomotor rating scale. Tau protein concentration in the three spinal cord injury groups(both in serum and cerebrospinal fluid) rapidly increased and peaked at 12 hours after spinal cord injury. Statistically significant positive linear correlations were found between tau protein level and spinal cord injury severity in the three spinal cord injury groups, and between the tau protein level and Basso, Beattie, and Bresnahan locomotor rating scale scores. The tau protein level at 12 hours in the three spinal cord injury groups was negatively correlated with Basso, Beattie, and Bresnahan locomotor rating scale scores at 28 days(serum: r =-0.94; cerebrospinal fluid: r =-0.95). Our data suggest that tau protein levels in serum and cerebrospinal fluid might be a promising biomarker for predicting the severity and functional outcome of traumatic spinal cord injury.

关键词： nerve regeneration spinal cord injury tau injury severity outcome cerebrospinal fluid serum biomarker Basso,Beattie,and Bresnahan locomotor rating scale neural regeneration

The OsBSK1-2-MAPK module regulates blast resistance in rice

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The Crop Journal 2024年第1期12卷 110-120页

作者： Shengping Li Xinquan xiang Zhijuan Diao Na xia ling Lu Jing Zhang Zhiwei Chen Dingzhong Tang State Key Laboratory of Ecological Control of Fujian-Taiwan Crop Pests Key Laboratory of Ministry of Education for GeneticsBreeding and Multiple Utilization of CropsPlant Immunity CenterFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina College of Life Science Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Ministerial and Provincial Joint Innovation Centre for Safety Production of Cross-Strait Crops Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Fujian Provincial Key Laboratory of Crop Breeding by Design Fujian Agriculture and Forestry UniversityFuzhou 350002FujianChina

Receptor-like cytoplasmic kinase OsBSK1-2 was reported to play an important role in regulation of response to rice blast,but the signaling pathway remained *** this study,we identified OsMAPKKK18 and previously uncharacterized MAPKKKs OsMAPKKK16 and OsMAPKKK19 that interact with *** of all three MAPKKKs was induced by Magnaporthe oryzae infection,and all three induced cell death when transiently expressed in Nicotiana benthamiana *** of OsMAPKKK16 and OsMAPKKK18 compromised blast resistance and overexpression of OsMAPKKK19 increased blast resistance,indicating that all three MAPKKKs are involved in regulation of rice blast ***,both OsMAPKKK16 and OsMAPKKK19 interacted with and phosphorylated OsMKK4 and OsMKK5,and chitin-induced MAPK activation was suppressed in osmapkkk16 and osbsk1-2 ***18 was earlier reported to interact with and phosphorylate OsMKK4 and affect chitin-induced MAPK activation,suggesting that OsBSK1-2 is involved in regulation of immunity through multiple MAPK signaling *** BSK1 in Arabidopsis,OsBSK1-2 was not involved in response to avirulent *** *** together,our results revealed important roles of OsMAPKKK16/18/19 and a OsBSK1-2-OsMAPKKK16/18/19-OsMKK4/5 module in regulating response to rice blast.

关键词： Disease resistance Magnaporthe oryzae Oriza sativa Rice blast

不同类型他汀在皮层脑梗死后癫痫中的价值比较

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实用中西医结合临床 2024年第9期24卷 9-12,16页

作者：何敏张小伟吴涛涛韩小建屈新辉蒋玲霞江西省人民医院南昌330006 南昌医学院第一附属医院江西南昌330006

目的比较不同类型他汀降低皮层脑梗死后癫痫的价值。方法选取2016年1月至2022年9月在江西省人民医院神经内科就诊,首次发生急性皮层脑梗死,既往无癫痫病史者,共纳入800例。将未接受他汀治疗者纳入空白组,共200例。其余患者随机接受阿... 详细信息

目的比较不同类型他汀降低皮层脑梗死后癫痫的价值。方法选取2016年1月至2022年9月在江西省人民医院神经内科就诊,首次发生急性皮层脑梗死,既往无癫痫病史者,共纳入800例。将未接受他汀治疗者纳入空白组,共200例。其余患者随机接受阿托伐他汀、瑞舒伐他汀、辛伐他汀治疗,分别纳入阿托伐他汀组、瑞舒伐他汀组、辛伐他汀组,各200例。比较各组卒中后癫痫发生率、早期痫样发作发生率、脑梗死的复发率,监测他汀治疗组肝肾功能、肌酶水平。结果空白组脑梗死后癫痫发生率明显高于阿托伐他汀组、瑞舒伐他汀组及辛伐他汀组,差异有统计学意义(P0.05)。结论他汀可降低皮层脑梗死后癫痫、早期痫样发作的发生,阿托伐他汀在降低卒中后癫痫、早期痫样发作的发生率,降低脑梗死的复发率方面优于瑞舒伐他汀和辛伐他汀,且不增加肝肾功能损害及肌酶升高的副作用。

关键词：卒中后癫痫皮层脑梗死不同类型他汀