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Multi Boost with ENN-based ensemble fault diagnosis method and its application in complicated chemical process

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Journal of Central South University 2016年第5期23卷 1183-1197页

作者：夏崇坤苏成利曹江涛李平 School of Information and Control Engineering Liaoning Shihua University

Fault diagnosis plays an important role in complicated industrial *** is a challenging task to detect,identify and locate faults quickly and accurately for large-scale process *** solve the problem,a novel Multi Boost-based integrated ENN(extension neural network) fault diagnosis method is *** data of complicated chemical process have some difficult-to-handle characteristics,such as high-dimension,non-linear and non-Gaussian distribution,so we use margin discriminant projection(MDP) algorithm to reduce dimensions and extract main ***,the affinity propagation(AP) clustering method is used to select core data and boundary data as training samples to reduce memory consumption and shorten learning ***,an integrated ENN classifier based on Multi Boost strategy is constructed to identify fault *** artificial data sets are tested to verify the effectiveness of the proposed method and make a detailed sensitivity analysis for the key ***,a real industrial system—Tennessee Eastman(TE) process is employed to evaluate the performance of the proposed *** the results show that the proposed method is efficient and capable to diagnose various types of faults in complicated chemical process.

关键词： extension neural network multi-classifier ensembles margin discriminant projection affinity propagation faultdiagnosis TE process

Identification of a Novel Causative Gene in a Adolescent Idiopathic Scoliosis Family

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Identification of a Novel Causative Gene in a Adolescent Idi...

高度均一的AlPO_4-11微晶的高效合成及晶化过程研究

第十四次全国医学遗传学学术会议

作者： Yawei Li Wei Li kun xia Bing Wang Department of Spine Surgery the 2nd Xiangya Hospital of Central South University State Key Laboratory of Medical Genetics Central South University

Purpose:The aim of this study was to identify a novel causative gene in a ChineseHan origin family with autosomal-dominant adolescent idiopathic scoliosis,and carry out the preliminary study on pathogenic ***:We performed wholeexome sequencing in two patients and one normal control from the adolescent idiopathic scoliosis ***,SAMtools,Picard,GATK were used for sequence alignment and variations *** was used for variants *** of mutations and familial segregation was performed using Sanger ***:We identified a novel,heterozygous missense mutation in the IS6 gene,co-segregates with the AIS clinical *** IS6 was exactly mapped to a previously reported AIS linkage locus,and has been implicated involving in skeleton *** mutation was absent in dbSNP138,ESP6500,1000 Genomes and 503 ethnicity-matched controls.

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来源： cnki会议评论

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cnki会议

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高等学校化学学报 2018年第8期39卷 1624-1630页

作者：夏坤周丹杨赟杨水金夏清华湖北大学有机化工新材料湖北省协同创新中心有机功能分子合成与应用教育部重点实验室武汉430062 湖北师范大学污染物分析与资源化技术湖北省重点实验室黄石435002

通过运用动态水热晶化模式(即烘箱内部设置可放置晶化反应釜的转轴),快速、高效合成出高度均一的Al PO4-11微晶分子筛.通过对比研究发现,相同的反应凝胶配比在静态水热条件下晶化24 h仅得到Al PO4-11分子筛的混晶相(长50~70μm的棒状晶... 详细信息

通过运用动态水热晶化模式(即烘箱内部设置可放置晶化反应釜的转轴),快速、高效合成出高度均一的Al PO4-11微晶分子筛.通过对比研究发现,相同的反应凝胶配比在静态水热条件下晶化24 h仅得到Al PO4-11分子筛的混晶相(长50~70μm的棒状晶体聚集体和直径5~10μm的球状晶体聚集体的混合物),而在转动水热条件下(转速为100 r/min)晶化40 min可制得Al PO4-11分子筛纯晶相,不仅大大提高了Al PO4-11分子筛的晶化效率,而且合成出晶粒尺寸分布高度均一的微晶(1μm×0.5μm).此外,运用粉末X射线衍射(XRD)、扫描电子显微镜(SEM)、拉曼光谱(Raman)和傅里叶变换红外光谱(FTIR)等表征技术研究了转动水热条件下Al PO4-11微晶分子筛的晶化过程.

关键词：沸石水热合成转动晶化 AlPO4-11分子筛拉曼光谱

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一种新型永磁球形步进电机伺服控制研究

系统仿真学报 2007年第11期19卷 2530-2534页

作者：王群京夏鲲合肥工业大学电气工程与自动化学院安徽合肥230009

针对一种新型永磁球形步进电机,运用卡尔丹角旋转建立了转子固连坐标系下转子动力学模型。在此基础上按照转子作连续轨迹运动的要求用计算力矩法设计了一种伺服控制策略,进行控制参数整定的同时获得转子运动的期望转矩,并使用李亚普诺... 详细信息

针对一种新型永磁球形步进电机,运用卡尔丹角旋转建立了转子固连坐标系下转子动力学模型。在此基础上按照转子作连续轨迹运动的要求用计算力矩法设计了一种伺服控制策略,进行控制参数整定的同时获得转子运动的期望转矩,并使用李亚普诺夫方法分析了该运动控制的稳定性。最后结合已得的转矩模型,提出了一种定子线圈电流控制的控制方案,并进行了仿真实验。

关键词：永磁球形步进电机运动控制计算力矩法电流控制仿真

Sediment sources and their impacts on a check dam-controlled watershed, Loess Plateau, China

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Journal of Mountain Science 2023年第6期20卷 1660-1673页

作者： BAI Lu-lu SHI Peng WANG Wen LI Zhan-bin YU kun-xia LI Peng CUI Ling-zhou SHEN Rong-jian GUAN Mu-hong DU Xin-chun ZHANG Xun-le CHEN Wen-fu State Key Laboratory of Eco-hydraulics in Northwest Arid Region of China Xi'an University of TechnologyXi'an 710048China Key Laboratory of National Forestry Administration on Ecological Hydrology and Disaster Prevention in Arid Regions Xi'an University of TechnologyXi'an 710048China College of Life and Environmental Science Wenzhou UniversityWenzhou 325035China Anhui Water Resources Development Co. Ltd.Bengbu 233010China

Soil erosion is a major issue in Loess Plateau,China,and quantitative analyses of sediment sources are crucial for soil erosion *** this study,a combination of flood couplet analysis and composite fingerprint identification was used for historical reconstructions of soil erosion in sediment source areas in Loess *** flood couplet was constructed based on sediment 137Cs activity,and past soil erosion was calculated using soil bulk density and storage capacity *** contribution rates of the sediment sources were calculated using the fingerprinting method,and the amount of erosion in the sediment source areas was *** best fingerprint combination(Cr,Ni,V,and TOC)enabled a 97.2%recognition of sediment sources from 29 flood events(1956–1990)in the Loess *** contribution rates of gullies,farmland,grassland,and shrubland were 44.89%,26.38%,10.49%,and 18.24%,*** four land use types contributed 1,227,751,512,and 279 tons of sediments,***-vegetation decreased soil erosion(1966–1983),whereas deforestation increased soil erosion(1956–1965 and 1984–1990).Rational soil and water conservation measures on slopes and check dam construction in gullies are therefore suggested to mitigate erosion.

关键词： Check dam Sediment source Soil and water conservation Land use changes Loess Plateau

CAS FGOALS-g3 Model Datasets for the CMIP6 Scenario Model Intercomparison Project(ScenarioMIP)

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Advances in Atmospheric Sciences 2020年第10期37卷 1081-1092页

作者： Ye PU Hongbo LIU Ruojing YAN Hao YANG kun xia Yiyuan LI Li DONG Lijuan LI He WANG Yan NIE Mirong SONG Jinbo XIE Shuwen ZHAO Kangjun CHEN Bin WANG Jianghao LI and Ling ZUO State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Atmospheric Sciences Yunnan UniversityKunming 650504China

This paper describes the datasets from the Scenario Model Intercomparison Project(ScenarioMIP)simulation experiments run with the Chinese Academy of Sciences Flexible Global Ocean–Atmosphere–Land System Model,GridPoint version 3(CAS FGOALS-g3).FGOALS-g3 is driven by eight shared socioeconomic pathways(SSPs)with different sets of future emission,concentration,and land-use *** Tier 1 and 2 experiments were carried out and were initialized using historical runs.A branch run method was used for the ensemble *** outputs were three-hourly,six-hourly,daily,and/or monthly mean values for the primary variables of the four component *** evaluation and analysis of the simulations is also *** present results are expected to aid research into future climate change and socio-economic development.

关键词： ScenarioMIP CMIP6 CAS FGOALS-g3

Two novel mutations of the LDL receptor gene associated with familial hypercholesterolemia in a Chinese family

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Chinese Medical Journal 2007年第19期120卷 1694-1699页

作者： XIE Li GONG Qi-hua XIE Zhi-guo LIANG Zong-min HU Zheng-mao xia kun xia Jia-hui YANG Yi-feng Department of Cardiothoracic Surgery Second Xiangya Hospital of Central South University Changsha 410011 China National Laboratory of Medical Genetics of China Changsha 410011 China

Background Familial hypercholesterolemia （FH） is a type of dominant autosomal disease that causes high levels of plasma low-density lipoprotein cholesterol （LDL-C）. In the past years, molecular data related to FH were limited in China. Now, to gain more information about FH, we analyzed one proband with a severe FH phenotype as well as his relatives. Methods After the entire coding sequence and the intron-exon junctions of the low-density lipoprotein receptor （LDLR） gene were amplified using PCR, we sequenced the LDLR gene of a Chinese FH family. RT-PCR was used to detect changes in the mRNA. Results Two novel mutations were identified in the LDLR gene of this family. One, W165X, was a G〉A substitution at the third nucleotide of codon 165. The other, IVS5-1G〉A, was also a G〉A substitution at the acceptor splice site of intron 5. The most striking discovery is that the proband was heterozygous for W165X but homozygous for IVS5-1G〉A. The cDNA sequencing showed that the IVS5-1G〉A mutation caused the insertion of 10 nucleotides, namely GCTCTCACAA, between exon 5 and exon 6. Conclusions The two nucleotide variations are thought to be the FH-causing mutations because the co-segregation of the mutant allele with the phenotype of FH has been shown in this Chinese family. These data show an increase in the mutational spectrum of FH in China and verify a scarce mutational form in the LDLR gene.

关键词： familial hypercholesterolemia low-density lipoprotein reverse transcriptase polymerase chain reaction mutation

Clinical classification and gene mutation of Chinese probands with Charcot-Marie-Tooth disease Analysis of 57 cases

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Neural Regeneration Research 2011年第9期6卷 706-711页

作者： Ruxu Zhang xiaobo Li xiaohong Zi Shunxiang Huang Fufeng Zhang kun xia Qian Pan Beisha Tang Department of Neurology the Third Xiangya Hospital Central South University Changsha 410013 Hunan Province China Department of Neurology Xiangya Hospital Central South University Changsha 410008 Hunan Province China National Key Laboratory of Medical Genetics Central South University Changsha 410078 Hunan Province China

Charcot-Marie-Tooth （CMT） disease is the most common inherited peripheral neuropathic disorder. CMT is clinically and genetically heterogeneous. To date, 27 genes associated with the disease have been cloned. The present study carried out clinical classification according to clinical, electrophysiological and pathological features, conducted inheritance classification according to inheritance patterns, and performed mutation analysis of 13 CMT disease genes （PMP22, CX32, HSPB1, MNF2, MPZ, HSPB8, GDAP1, NFL, EGR2, SIMPLE, RAB7, LMNA, MTMR2） in 57 Chinese probands with CMT. Five cases of AD-CMT1 and 13 cases of sporadic CMT1 were diagnosed as CMT1A; five cases of X-CMT1, one case of X-CMT2 and one case of sporadic CMT1 were diagnosed as CMTXl; four cases of AD-CMT2 were diagnosed as CMT2F; one case of AD-CMT2 and one case of sporadic CMT2 were diagnosed as CMT2A2; one case of AD-CMT2 was diagnosed as CMT2L; one case of AD-CMT2 was diagnosed as CMT2J; one case of AR-CMT1 was diagnosed as CMT4A. Among the 57 CMT probands, seven genotypes were determined among 34 patients, with a detection rate of 59.6%. The results indicated that the clinical classification and inheritance classification are indispensable for selecting potential disease genes for mutation detection, and for efficient molecular diagnosis.

关键词： Charcot-Marie-Tooth disease clinical classification gene mutation analysis

近代中国黑热病防治述论(1904—1937年)

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山东社会科学 2022年第6期 139-145页

作者：徐畅夏坤山东大学历史文化学院山东济南250100

黑热病是致死率较高的慢性传染病,近代曾在苏鲁豫皖广泛流行,造成严重的社会危害。中国黑热病的防治发端于教会医院,有关人员通过问卷调查、实地考察和病患诊疗等方式开展研究和治疗,为后续防治奠定了基础。1930年代黑热病迅速蔓延,南... 详细信息

黑热病是致死率较高的慢性传染病,近代曾在苏鲁豫皖广泛流行,造成严重的社会危害。中国黑热病的防治发端于教会医院,有关人员通过问卷调查、实地考察和病患诊疗等方式开展研究和治疗,为后续防治奠定了基础。1930年代黑热病迅速蔓延,南京国民政府和地方政府相继设立防治机构,采取病患救治、实地调研、病理研究与科学宣传等举措,主导了防治工作。与此同时,在政府的大力倡导和鼓励下,社会各界纷纷捐资助药、组织协调,积极参与其中。在苏鲁豫皖黑热病防治过程中,西方与中国、政府与社会等不同主体更迭参与,一定程度上可以视为近代中国卫生防疫现代化的缩影。

关键词：苏鲁豫皖黑热病医疗卫生现代化